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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50412728
Substrate
n/a
Meas. Tech.
ChEMBL_562391 (CHEMBL1018824)
Kd
0.2±n/a nM
Citation
 Budzik, B; Wang, Y; Shi, D; Wang, F; Xie, H; Wan, Z; Zhu, C; Foley, JJ; Nuthulaganti, P; Kallal, LA; Sarau, HM; Morrow, DM; Moore, ML; Rivero, RA; Palovich, M; Salmon, M; Belmonte, KE; Laine, DI; Jin, J M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines. Bioorg Med Chem Lett 19:1686-90 (2009) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50412728
Synonyms:
CHEMBL521523
Type:
Small organic molecule
Emp. Form.:
C32H39FN4O
Mol. Mass.:
514.6767
SMILES:
C[C@H]1CN(Cc2cccc(c2)-c2cc(CNC(=O)c3cccc(CC4CCNCC4)c3)ccc2F)CCN1 |r|
Structure:
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