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Target
Histamine H4 receptor
Ligand
BDBM50414380
Substrate
n/a
Meas. Tech.
ChEMBL_576569 (CHEMBL1034550)
Ki
158.49±n/a nM
Citation
 Lim, HD; Istyastono, EP; van de Stolpe, A; Romeo, G; Gobbi, S; Schepers, M; Lahaye, R; Menge, WM; Zuiderveld, OP; Jongejan, A; Smits, RA; Bakker, RA; Haaksma, EE; Leurs, R; de Esch, IJ Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies. Bioorg Med Chem 17:3987-94 (2009) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Human
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50414380
Synonyms:
CHEMBL561651
Type:
Small organic molecule
Emp. Form.:
C21H23N5
Mol. Mass.:
345.4408
SMILES:
NC(=NCCCc1cnc[nH]1)N=CC(c1ccccc1)c1ccccc1 |w:2.2,11.11|
Structure:
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