Reaction Details Report a problem with these data
Target
Histamine H1 receptor
Ligand
BDBM22890
Substrate
n/a
Meas. Tech.
ChEMBL_650262 (CHEMBL1224920)
Ki
50.12±n/a nM
Citation
 Jongejan, A; Bruysters, M; Ballesteros, JA; Haaksma, E; Bakker, RA; Pardo, L; Leurs, R Linking agonist binding to histamine H1 receptor activation. Nat Chem Biol 1:98-103 (2006) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM22890
Synonyms:
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid | CHEMBL1000 | Cetirizine | Levocetirizine
Type:
Small organic molecule
Emp. Form.:
C21H25ClN2O3
Mol. Mass.:
388.888
SMILES:
OC(=O)COCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: