Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM80732
Substrate
n/a
Meas. Tech.
ChEMBL_839676 (CHEMBL2090790)
IC50
9000±n/a nM
Citation
Qin, J; Xie, P; Ventocilla, C; Zhou, G; Vultur, A; Chen, Q; Liu, Q; Herlyn, M; Winkler, J; Marmorstein, R Identification of a novel family of BRAF(V600E) inhibitors. J Med Chem 55:5220-30 (2012) [PubMed] Article
More Info.:
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
Inhibitor
Name:
BDBM80732
Synonyms:
MLS001221393 | N-(4-hydroxy-1-naphthalenyl)-2-thiophenesulfonamide | N-(4-hydroxy-1-naphthyl)thiophene-2-sulfonamide | N-(4-hydroxynaphthalen-1-yl)thiophene-2-sulfonamide | N-(4-oxidanylnaphthalen-1-yl)thiophene-2-sulfonamide | SMR000612136 | Thiophene-2-sulfonic acid (4-hydroxy-naphthalen-1-yl)-amide | cid_697391
Type:
Small organic molecule
Emp. Form.:
C14H11NO3S2
Mol. Mass.:
305.372
SMILES:
Oc1ccc(NS(=O)(=O)c2cccs2)c2ccccc12