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Target
Caspase-3
Ligand
BDBM50435973
Substrate
n/a
Meas. Tech.
ChEMBL_964097 (CHEMBL2394604)
IC50
795±n/a nM
Citation
 Limpachayaporn, P; Riemann, B; Kopka, K; Schober, O; Schäfers, M; Haufe, G Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7. Eur J Med Chem 64:562-78 (2013) [PubMed]  Article 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM50435973
Synonyms:
CHEMBL2391866
Type:
Small organic molecule
Emp. Form.:
C18H23FN2O5S
Mol. Mass.:
398.449
SMILES:
CCCCN1C(=O)C(=O)c2cc(ccc12)S(=O)(=O)N1C[C@H](F)C[C@H]1COC |r|
Structure:
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