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Target
G-protein coupled bile acid receptor 1
Ligand
BDBM50437877
Substrate
n/a
Meas. Tech.
ChEMBL_974031 (CHEMBL2410509)
EC50
28±n/a nM
Citation
 Dehmlow, H; Alvarez Sánchez, R; Bachmann, S; Bissantz, C; Bliss, F; Conde-Knape, K; Graf, M; Martin, RE; Obst Sander, U; Raab, S; Richter, HG; Sewing, S; Sprecher, U; Ullmer, C; Mattei, P Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists. Bioorg Med Chem Lett 23:4627-32 (2013) [PubMed]  Article 
Target
Name:
G-protein coupled bile acid receptor 1
Synonyms:
GPBAR_MOUSE | Gpbar1 | M-BAR | Membrane-type receptor for bile acids | Tgr5
Type:
PROTEIN
Mol. Mass.:
35665.78
Organism:
Mus musculus
Description:
ChEMBL_1475560
Residue:
329
Sequence:
MMTPNSTELSAIPMGVLGLSLALASLIVIANLLLALGIALDRHLRSPPAGCFFLSLLLAGLLTGLALPMLPGLWSRNHQGYWSCLLLHLTPNFCFLSLLANLLLVHGERYMAVLQPLRPHGSVRLALFLTWVSSLFFASLPALGWNHWSPDANCSSQAVFPAPYLYLEVYGLLLPAVGATALLSVRVLATAHRQLCEIRRLERAVCRDVPSTLARALTWRQARAQAGATLLFLLCWGPYVATLLLSVLAYERRPPLGPGTLLSLISLGSTSAAAVPVAMGLGDQRYTAPWRTAAQRCLRVLRGRAKRDNPGPSTAYHTSSQCSIDLDLN
  
Inhibitor
Name:
BDBM50437877
Synonyms:
CHEMBL2407930
Type:
Small organic molecule
Emp. Form.:
C28H31N3O3
Mol. Mass.:
457.564
SMILES:
Cc1cc(ccn1)C(C[C@H](c1ccc(cc1)N1CCC(CC1)C(O)=O)c1ccccc1C)N=O |r|
Structure:
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