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Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM50444649
Substrate
n/a
Meas. Tech.
ChEMBL_1281258 (CHEMBL3100993)
IC50
2.4±n/a nM
Citation
 Zheng, X; Baumeister, T; Buckmelter, AJ; Caligiuri, M; Clodfelter, KH; Han, B; Ho, YC; Kley, N; Lin, J; Reynolds, DJ; Sharma, G; Smith, CC; Wang, Z; Dragovich, PS; Oh, A; Wang, W; Zak, M; Wang, Y; Yuen, PW; Bair, KW Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Bioorg Med Chem Lett 24:337-43 (2013) [PubMed]  Article 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM50444649
Synonyms:
CHEMBL3098608
Type:
Small organic molecule
Emp. Form.:
C21H16F3N5O2S
Mol. Mass.:
459.444
SMILES:
FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(NC#N)=Nc2ccncc2)cc1 |w:23.24|
Structure:
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