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Target
D(4) dopamine receptor
Ligand
BDBM50027261
Substrate
n/a
Meas. Tech.
ChEMBL_1439005 (CHEMBL3383112)
Ki
1070±n/a nM
Citation
 Berry, CB; Bubser, M; Jones, CK; Hayes, JP; Wepy, JA; Locuson, CW; Daniels, JS; Lindsley, CW; Hopkins, CR Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity. ACS Med Chem Lett 5:1060-4 (2014) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50027261
Synonyms:
CHEMBL3335545
Type:
Small organic molecule
Emp. Form.:
C19H21F2NO
Mol. Mass.:
317.3729
SMILES:
Fc1cccc(F)c1CN1CCOC(CCc2ccccc2)C1
Structure:
Search PDB for entries with ligand similarity: