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Target
Endothelin-1 receptor
Ligand
BDBM50064000
Substrate
n/a
Meas. Tech.
ChEMBL_1464500 (CHEMBL3405622)
IC50
3.3±n/a nM
Citation
 Cai, J; Liu, L; Hong, KH; Wang, P; Li, L; Cao, M; Sun, C; Wu, X; Zong, X; Chen, J; Ji, M Discovery of phenoxybutanoic acid derivatives as potent endothelin antagonists with antihypertensive activity. Bioorg Med Chem 23:657-67 (2015) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50064000
Synonyms:
CHEMBL3400988
Type:
Small organic molecule
Emp. Form.:
C26H24O7
Mol. Mass.:
448.4646
SMILES:
CC(=O)c1ccc(OCc2ccc3OCOc3c2)cc1OC(CCC(O)=O)c1ccccc1
Structure:
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