Reaction Details Report a problem with these data
Target
Somatostatin receptor type 3
Ligand
BDBM50091414
Substrate
n/a
Meas. Tech.
ChEMBL_1498161 (CHEMBL3583381)
IC50
2.3±n/a nM
Citation
 Shah, SK; He, S; Guo, L; Truong, Q; Qi, H; Du, W; Lai, Z; Liu, J; Jian, T; Hong, Q; Dobbelaar, P; Ye, Z; Sherer, E; Feng, Z; Yu, Y; Wong, F; Samuel, K; Madiera, M; Karanam, BV; Reddy, VB; Mitelman, S; Tong, SX; Chicchi, GG; Tsao, KL; Trusca, D; Feng, Y; Wu, M; Shao, Q; Trujillo, ME; Eiermann, GJ; Li, C; Pachanski, M; Fernandez, G; Nelson, D; Bunting, P; Morissette, P; Volksdorf, S; Kerr, J; Zhang, BB; Howard, AD; Zhou, YP; Pasternak, A; Nargund, RP; Hagmann, WK Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes. ACS Med Chem Lett 6:513-7 (2015) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 3
Synonyms:
SOMATOSTATIN SST3 | SS-3-R | SS3-R | SS3R | SSR-28 | SSR3_HUMAN | SSTR3 | Somatostatin receptor type 3 (SSTR3)
Type:
Protein
Mol. Mass.:
45855.97
Organism:
Homo sapiens (Human)
Description:
P32745
Residue:
418
Sequence:
MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL
  
Inhibitor
Name:
BDBM50091414
Synonyms:
CHEMBL3582336
Type:
Small organic molecule
Emp. Form.:
C27H24FN9O2
Mol. Mass.:
525.537
SMILES:
CCn1cc(cn1)[C@]1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccc(F)cn1)c1nn(C)c(=O)o1 |r|
Structure:
Search PDB for entries with ligand similarity: