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Target
Glucagon receptor
Ligand
BDBM50120374
Substrate
n/a
Meas. Tech.
ChEMBL_1518285 (CHEMBL3620260)
IC50
7.6±n/a nM
Citation
 Lin, S; Zhang, F; Jiang, G; Qureshi, SA; Yang, X; Chicchi, GG; Tota, L; Bansal, A; Brady, E; Trujillo, M; Salituro, G; Miller, C; Tata, JR; Zhang, BB; Parmee, ER A novel series of indazole-/indole-based glucagon receptor antagonists. Bioorg Med Chem Lett 25:4143-7 (2015) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50120374
Synonyms:
CHEMBL3616701
Type:
Small organic molecule
Emp. Form.:
C34H30F3N3O4
Mol. Mass.:
601.6149
SMILES:
COc1ccc(cc1-c1nn(C(C)c2ccc(cc2)C(=O)NCCC(O)=O)c2cc(ccc12)-c1ccc(C)cc1)C(F)(F)F
Structure:
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