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Target
Histone deacetylase 8
Ligand
BDBM50146076
Substrate
n/a
Meas. Tech.
ChEMBL_1554292 (CHEMBL3766680)
IC50
230±n/a nM
Citation
 Rodrigues, DA; Ferreira-Silva, GÀ; Ferreira, AC; Fernandes, RA; Kwee, JK; Sant'Anna, CM; Ionta, M; Fraga, CA Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors. J Med Chem 59:655-70 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50146076
Synonyms:
CHEMBL3764525
Type:
Small organic molecule
Emp. Form.:
C17H18N4O3
Mol. Mass.:
326.3498
SMILES:
CN(C)c1ccc(cc1)C(=O)N\N=C\c1ccc(cc1)C(=O)NO
Structure:
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