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Target
Somatostatin receptor type 3
Ligand
BDBM50154534
Substrate
n/a
Meas. Tech.
ChEMBL_1560970 (CHEMBL3779603)
IC50
25±n/a nM
Citation
 He, S; Dobbelaar, PH; Guo, L; Ye, Z; Liu, J; Jian, T; Truong, Q; Shah, SK; Du, W; Qi, H; Bakshi, RK; Hong, Q; Dellureficio, JD; Sherer, E; Pasternak, A; Feng, Z; Reibarkh, M; Lin, M; Samuel, K; Reddy, VB; Mitelman, S; Tong, SX; Chicchi, GG; Tsao, KL; Trusca, D; Wu, M; Shao, Q; Trujillo, ME; Fernandez, G; Nelson, D; Bunting, P; Kerr, J; Fitzgerald, P; Morissette, P; Volksdorf, S; Eiermann, GJ; Li, C; Zhang, BB; Howard, AD; Zhou, YP; Nargund, RP; Hagmann, WK SAR exploration at the C-3 position of tetrahydro-ß-carboline sstr3 antagonists. Bioorg Med Chem Lett 26:1529-35 (2016) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 3
Synonyms:
SOMATOSTATIN SST3 | SS-3-R | SS3-R | SS3R | SSR-28 | SSR3_HUMAN | SSTR3 | Somatostatin receptor type 3 (SSTR3)
Type:
Protein
Mol. Mass.:
45855.97
Organism:
Homo sapiens (Human)
Description:
P32745
Residue:
418
Sequence:
MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL
  
Inhibitor
Name:
BDBM50154534
Synonyms:
CHEMBL3775851
Type:
Small organic molecule
Emp. Form.:
C29H36N4O
Mol. Mass.:
456.6223
SMILES:
C1CC(CCO1)C1NC(Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)C12CC3CC(CC(C3)C1)C2 |TLB:31:26:33:30.32.29,31:30:33:25.26.27,THB:29:28:25:31.30.32,29:30:25:33.27.28|
Structure:
Search PDB for entries with ligand similarity: