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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50181060
Substrate
n/a
Meas. Tech.
ChEMBL_1584462 (CHEMBL3820109)
Ki
0.500000±n/a nM
Citation
 Weber, F; Brune, S; Börgel, F; Lange, C; Korpis, K; Bednarski, PJ; Laurini, E; Fermeglia, M; Pricl, S; Schepmann, D; Wünsch, B Rigidity versus Flexibility: Is This an Issue ins1 Receptor Ligand Affinity and Activity? J Med Chem 59:5505-19 (2016) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50181060
Synonyms:
CHEMBL3817940
Type:
Small organic molecule
Emp. Form.:
C24H32N2O
Mol. Mass.:
364.5237
SMILES:
[H][C@]12C[C@H](O)[C@]([H])(CN1Cc1cccc3ccccc13)N(CC1CCCCC1)C2 |r,THB:4:3:20.28:7.8|
Structure:
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