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Target
Protein-serine O-palmitoleoyltransferase porcupine
Ligand
BDBM50205483
Substrate
n/a
Meas. Tech.
ChEMBL_1628389 (CHEMBL3870974)
EC50
0.300000±n/a nM
Citation
 You, L; Zhang, C; Yarravarapu, N; Morlock, L; Wang, X; Zhang, L; Williams, NS; Lum, L; Chen, C Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett 26:5891-5895 (2016) [PubMed]  Article 
Target
Name:
Protein-serine O-palmitoleoyltransferase porcupine
Synonyms:
PORCN_MOUSE | Porc | Porcn | Ppn | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein-cysteine N-palmitoyltransferase porcupine | mPORC
Type:
PROTEIN
Mol. Mass.:
52528.36
Organism:
Mus musculus
Description:
ChEMBL_941167
Residue:
461
Sequence:
MATFSRQEFFQQLLQGCLLPTVQQGLDQIWLLLTICFACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGAVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSRRWLKKVARSLALALLCLVLSTCVGPYLFPYFIPLDGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSRPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLAQILSACILSKRCLPDCSHRHRLGLGVRALNLLFGALAIFHLSYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
  
Inhibitor
Name:
BDBM50205483
Synonyms:
CHEMBL3935037
Type:
Small organic molecule
Emp. Form.:
C27H19F3N6O
Mol. Mass.:
500.4746
SMILES:
FC(F)(F)c1ccc(cc1)-c1c(nnn1CC(=O)Nc1ccc(cn1)-c1ccccc1)-c1ccncc1
Structure:
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