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Target
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Ligand
BDBM292797
Substrate
n/a
Meas. Tech.
ChEMBL_1661920 (CHEMBL4011532)
IC50
2300±n/a nM
Citation
 Dyck, B; Branstetter, B; Gharbaoui, T; Hudson, AR; Breitenbucher, JG; Gomez, L; Botrous, I; Marrone, T; Barido, R; Allerston, CK; Cedervall, EP; Xu, R; Sridhar, V; Barker, R; Aertgeerts, K; Schmelzer, K; Neul, D; Lee, D; Massari, ME; Andersen, CB; Sebring, K; Zhou, X; Petroski, R; Limberis, J; Augustin, M; Chun, LE; Edwards, TE; Peters, M; Tabatabaei, A Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties. J Med Chem 60:3472-3483 (2017) [PubMed]  Article 
Target
Name:
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Synonyms:
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | PDE11A | PDE11_HUMAN | Phosphodiesterase 11 | Phosphodiesterase 11A | Phosphodiesterase 11A (PDE11A4) | Phosphodiesterase 11A4 | cAMP and cGMP phosphodiesterase 11A
Type:
Enzyme
Mol. Mass.:
104751.53
Organism:
Homo sapiens (Human)
Description:
Q9HCR9
Residue:
933
Sequence:
MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSSLAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
  
Inhibitor
Name:
BDBM292797
Synonyms:
US10105367, Example 82 | US10376514, Example 82
Type:
Small organic molecule
Emp. Form.:
C18H15ClN4OS
Mol. Mass.:
370.856
SMILES:
Clc1ccc(Cn2c3sc4CCCCc4c3c3ncnn3c2=O)cc1
Structure:
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