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Target
Oligo-1,6-glucosidase IMA1
Ligand
BDBM173542
Substrate
n/a
Meas. Tech.
α-Glucosidase Inhibitory Activity
IC50
2.66e+4± 8.0e+2 nM
Citation
 Taha, M; Ismail, NH; Javaid, K; Imran, S; Anouar, el H; Wadood, A; Atia-Tul-Wahab, null; Ali, M; Khan, KM; Saad, SM; Rahim, F; Choudhary, MI Evaluation of 2-indolcarbohydrazones as potent a-glucosidase inhibitors, in silico studies and DFT based stereochemical predictions. Bioorg Chem 63:24-35 (2015) [PubMed]  Article 
Target
Name:
Oligo-1,6-glucosidase IMA1
Synonyms:
α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase
Type:
Protein
Mol. Mass.:
68577.59
Organism:
Saccharomyces cerevisiae S288c (Baker's yeast)
Description:
n/a
Residue:
589
Sequence:
MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
  
Inhibitor
Name:
BDBM173542
Synonyms:
(E)-N'-(3-Bromo-4-fluorobenzylidene)-1H-indole-2-carbohydrazide (19)
Type:
Small organic molecule
Emp. Form.:
C16H11BrFN3O
Mol. Mass.:
360.18
SMILES:
Fc1ccc(\C=N\NC(=O)c2cc3ccccc3[nH]2)cc1Br
Structure:
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