Reaction Details Report a problem with these data
Target
Thyrotropin subunit beta
Ligand
BDBM189327
Substrate
n/a
Meas. Tech.
Antagonist Activity Assay
IC50
368±0.0 nM
Citation
 Karstens, WF; Conti, PG; Timmers, CM; Plate, R; Van Koppen, CJ TSH receptor antagonizing tetrahydroquinoline compounds US Patent  US9174940 Publication Date 11/3/2015 
Target
Name:
Thyrotropin subunit beta
Synonyms:
TSHB | TSHB_BOVIN | Thyroid-stimulating hormone subunit beta (bTSH)
Type:
Enzyme
Mol. Mass.:
15628.77
Organism:
Bos taurus (Bovine)
Description:
P01223
Residue:
138
Sequence:
MTATFLMSMIFGLACGQAMSFCIPTEYMMHVERKECAYCLTINTTVCAGYCMTRDVNGKLFLPKYALSQDVCTYRDFMYKTAEIPGCPRHVTPYFSYPVAISCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYMVGFSI
  
Inhibitor
Name:
BDBM189327
Synonyms:
Hexanoic acid (Compound A) | US9174940, Compound A
Type:
Small organic molecule
Emp. Form.:
C21H24N2O2
Mol. Mass.:
336.4275
SMILES:
CC(=O)N1c2ccc(cc2C(C)(CC1(C)C)c1ccccc1)C(N)=O
Structure:
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