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Target
L-ornithine N(5)-monooxygenase
Ligand
BDBM205457
Substrate
n/a
Meas. Tech.
ADP-TAMRA Binding Assay
pH
7±n/a
Kd
1.4e+3± 3e+2 nM
Comments
extracted
Citation
 Martín Del Campo, JS; Vogelaar, N; Tolani, K; Kizjakina, K; Harich, K; Sobrado, P Inhibition of the Flavin-Dependent Monooxygenase Siderophore A (SidA) Blocks Siderophore Biosynthesis and Aspergillus fumigatus Growth. ACS Chem Biol 11:3035-3042 (2016) [PubMed]  Article 
Target
Name:
L-ornithine N(5)-monooxygenase
Synonyms:
Flavin-Dependent Monooxygenase Siderophore A (SidA) | SIDA_ASPFU | sidA
Type:
Protein
Mol. Mass.:
56889.65
Organism:
Aspergillus fumigatus (Fungus)
Description:
E9QYP0
Residue:
501
Sequence:
MESVERKSESSYLGMRNMQPEQRLSLDPPRLRSTPQDELHDLLCVGFGPASLAIAIALHDALDPRLNKSASNIHAQPKICFLERQKQFAWHSGMLVPGSKMQISFIKDLATLRDPRSSFTFLNYLHQKGRLIHFTNLSTFLPARLEFEDYMRWCAQQFSDVVAYGEEVVEVIPGKSDPSSSVVDFFTVRSRNVETGEISARRTRKVVIAIGGTAKMPSGLPQDPRIIHSSKYCTTLPALLKDKSKPYNIAVLGSGQSAAEIFHDLQKRYPNSRTTLIMRDSAMRPSDDSPFVNEIFNPERVDKFYSQSAAERQRSLLADKATNYSVVRLELIEEIYNDMYLQRVKNPDETQWQHRILPERKITRVEHHGPQSRMRIHLKSSKPESEGAANDVKETLEVDALMVATGYNRNAHERLLSKVQHLRPTGQDQWKPHRDYRVEMDPSKVSSEAGIWLQGCNERTHGLSDSLLSVLAVRGGEMVQSIFGEQLERAAVQGHQLRAML
  
Inhibitor
Name:
BDBM205457
Synonyms:
(2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid | Celastrol | US11660306, Example Celastrol | acs.jmedchem.1c00409_ST.357
Type:
Small organic molecule
Emp. Form.:
C29H38O4
Mol. Mass.:
450.6096
SMILES:
CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(O)=O |r,c:1,6,11,t:9|
Structure:
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