Reaction Details
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Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Ligand
BDBM50119
Substrate
n/a
Meas. Tech.
Fluorescence Polarization-Based Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
2640±460 nM
IC50
13700±2400 nM
Comments
extracted
Citation
Nikolovska-Coleska, Z; Abulwerdi, F; Showalter, H; Miao, L; Stuckey, J; Mady, A Small molecule inhibitors of MCL-1 and uses thereof US Patent US9394303 Publication Date 7/19/2016 More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Synonyms:
Bcl-2-related protein EAT/mcl1 | MCL1_MOUSE | Mcl-1 | Mcl1
Type:
Developmental protein
Mol. Mass.:
35215.08
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
331
Sequence:
MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Inhibitor
Name:
BDBM50119
Synonyms:
1-(3-chlorophenyl)-6-(2-furanyl)-3-methyl-4-pyrazolo[3,4-b]pyridinecarboxylic acid | 1-(3-chlorophenyl)-6-(2-furyl)-3-methyl-pyrazolo[3,4-b]pyridine-4-carboxylic acid | 1-(3-chlorophenyl)-6-(furan-2-yl)-3-methyl-pyrazolo[3,4-b]pyridine-4-carboxylic acid | 1-(3-chlorophenyl)-6-(furan-2-yl)-3-methylpyrazolo[3,4-b]pyridine-4-carboxylic acid | MLS000564133 | SMR000151728 | US9394303, 1 | cid_4178486
Type:
Small organic molecule
Emp. Form.:
C18H12ClN3O3
Mol. Mass.:
353.759
SMILES:
Cc1nn(-c2cccc(Cl)c2)c2nc(cc(C(O)=O)c12)-c1ccco1
Structure:
