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Target
Pantetheinase
Ligand
BDBM408835
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
0.200±n/a nM
Citation
 Bosanac, T; Burke, MJ; Cook, BN; Disalvo, DT; Kirrane, Jr., TM; Shen, Y Heteroaromatic compounds as Vanin inhibitors US Patent  US10364255 Publication Date 7/30/2019 
Target
Name:
Pantetheinase
Synonyms:
Pantetheine hydrolase | Tiff66 | VNN1 | VNN1_HUMAN | Vanin-1 | Vascular non-inflammatory molecule 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57002.46
Organism:
Homo sapiens (Human)
Description:
O95497
Residue:
513
Sequence:
MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLTAQARIIMLIVIAPIVCSLSW
  
Inhibitor
Name:
BDBM408835
Synonyms:
US10364255, Ex. 26
Type:
Small organic molecule
Emp. Form.:
C18H22N4O4
Mol. Mass.:
358.3917
SMILES:
O=C(N1CC[C@@H](C1)N1CCOC1=O)c1cnc2NC3(CC3)CCOc2c1 |r|
Structure:
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