Reaction Details Report a problem with these data
Target
Oxidized low-density lipoprotein receptor 1
Ligand
BDBM454221
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>300±n/a nM
Citation
 Findlay, AD; Turner, CI; Deodhar, M; Foot, JS; Jarolimek, W; Zhou, W; Robertson, AD Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof US Patent  US10717733 Publication Date 7/21/2020 
Target
Name:
Oxidized low-density lipoprotein receptor 1
Synonyms:
LOX-1 | LOX1 | Lectin-like oxLDL receptor 1 | Lectin-like oxidized LDL receptor 1 | Lectin-type oxidized LDL receptor 1 | OLR1 | OLR1_BOVIN | Ox-LDL receptor 1 | bLOX-1
Type:
Protein
Mol. Mass.:
30894.65
Organism:
Bovine
Description:
P79391
Residue:
270
Sequence:
MTVDDPKGMKDQLDQKPNGKTAKGFVSSWRWYPAAVTLGVLCLGLLVTVILLILQLSQVSDLIKKQQANITHQEDILEGQILAQRRSEKSAQESQKELKEMIETLAHKLDEKSKKLMELHRQNLNLQEVLKEAANYSGPCPQDWLWHEENCYQFSSGSFNWEKSQENCLSLDAHLLKINSTDELEFIQQMIAHSSFPFWMGLSMRKPNYSWLWEDGTPLTPHLFRIQGAVSRMYPSGTCAYIQRGTVFAENCILTAFSICQKKANLLRAQ
  
Inhibitor
Name:
BDBM454221
Synonyms:
(Z)-1-(4-amino-2-fluorobut-2-en-1-yl)-2- methyl-3-(3-(methylsulfonyl)phenyl)-1H- indole-5-carboxylic acid | US10717733, Compound 14 | US11098045, Compound 14
Type:
Small organic molecule
Emp. Form.:
C21H21FN2O4S
Mol. Mass.:
416.466
SMILES:
Cc1c(-c2cccc(c2)S(C)(=O)=O)c2cc(ccc2n1C\C(F)=C\CN)C(O)=O
Structure:
Search PDB for entries with ligand similarity: