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Target
Oxidized low-density lipoprotein receptor 1
Ligand
BDBM454226
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>300±n/a nM
Citation
 Findlay, AD; Turner, CI; Deodhar, M; Foot, JS; Jarolimek, W; Zhou, W; Robertson, AD Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof US Patent  US10717733 Publication Date 7/21/2020 
Target
Name:
Oxidized low-density lipoprotein receptor 1
Synonyms:
LOX-1 | LOX1 | Lectin-like oxLDL receptor 1 | Lectin-like oxidized LDL receptor 1 | Lectin-type oxidized LDL receptor 1 | OLR1 | OLR1_BOVIN | Ox-LDL receptor 1 | bLOX-1
Type:
Protein
Mol. Mass.:
30894.65
Organism:
Bovine
Description:
P79391
Residue:
270
Sequence:
MTVDDPKGMKDQLDQKPNGKTAKGFVSSWRWYPAAVTLGVLCLGLLVTVILLILQLSQVSDLIKKQQANITHQEDILEGQILAQRRSEKSAQESQKELKEMIETLAHKLDEKSKKLMELHRQNLNLQEVLKEAANYSGPCPQDWLWHEENCYQFSSGSFNWEKSQENCLSLDAHLLKINSTDELEFIQQMIAHSSFPFWMGLSMRKPNYSWLWEDGTPLTPHLFRIQGAVSRMYPSGTCAYIQRGTVFAENCILTAFSICQKKANLLRAQ
  
Inhibitor
Name:
BDBM454226
Synonyms:
(Z)-ethyl 1-(4-amino-2-fluorobut-2-en-1- yl)-3-(5-(N,N-dimethylsulfamoyl)-2- methylphenyl)-2-methyl-1H-indole-5- carboxylate | US10717733, Compound 19 | US11098045, Compound 19
Type:
Small organic molecule
Emp. Form.:
C25H30FN3O4S
Mol. Mass.:
487.587
SMILES:
CCOC(=O)c1ccc2n(C\C(F)=C\CN)c(C)c(-c3cc(ccc3C)S(=O)(=O)N(C)C)c2c1 |(-7.56,-.23,;-6.23,-1,;-4.9,-.23,;-3.56,-1,;-3.56,-2.54,;-2.23,-.23,;-2.23,1.31,;-.89,2.08,;.44,1.31,;1.9,1.79,;2.3,3.28,;3.79,3.68,;4.88,2.59,;4.19,5.16,;5.68,5.56,;6.08,7.05,;2.81,.54,;4.35,.54,;1.9,-.7,;2.3,-2.19,;3.79,-2.59,;4.19,-4.08,;3.1,-5.16,;1.61,-4.77,;1.21,-3.28,;-.27,-2.88,;5.68,-4.47,;6.08,-2.99,;7.16,-4.08,;6.08,-5.96,;4.99,-7.05,;7.56,-6.36,;.44,-.23,;-.89,-1,)|
Structure:
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