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Target
Oxidized low-density lipoprotein receptor 1
Ligand
BDBM454227
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>300±n/a nM
Citation
 Findlay, AD; Turner, CI; Deodhar, M; Foot, JS; Jarolimek, W; Zhou, W; Robertson, AD Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof US Patent  US10717733 Publication Date 7/21/2020 
Target
Name:
Oxidized low-density lipoprotein receptor 1
Synonyms:
LOX-1 | LOX1 | Lectin-like oxLDL receptor 1 | Lectin-like oxidized LDL receptor 1 | Lectin-type oxidized LDL receptor 1 | OLR1 | OLR1_BOVIN | Ox-LDL receptor 1 | bLOX-1
Type:
Protein
Mol. Mass.:
30894.65
Organism:
Bovine
Description:
P79391
Residue:
270
Sequence:
MTVDDPKGMKDQLDQKPNGKTAKGFVSSWRWYPAAVTLGVLCLGLLVTVILLILQLSQVSDLIKKQQANITHQEDILEGQILAQRRSEKSAQESQKELKEMIETLAHKLDEKSKKLMELHRQNLNLQEVLKEAANYSGPCPQDWLWHEENCYQFSSGSFNWEKSQENCLSLDAHLLKINSTDELEFIQQMIAHSSFPFWMGLSMRKPNYSWLWEDGTPLTPHLFRIQGAVSRMYPSGTCAYIQRGTVFAENCILTAFSICQKKANLLRAQ
  
Inhibitor
Name:
BDBM454227
Synonyms:
(Z)-1-(4-amino-2-fluorobut-2-en-1-yl)-3- (5-(N,N-dimethylsulfamoyl)-2- methylphenyl)-2-methyl-1H-indole-5- carboxylic acid | US10717733, Compound 20 | US11098045, Compound 20
Type:
Small organic molecule
Emp. Form.:
C23H26FN3O4S
Mol. Mass.:
459.534
SMILES:
CN(C)S(=O)(=O)c1ccc(C)c(c1)-c1c(C)n(C\C(F)=C\CN)c2ccc(cc12)C(O)=O |(3.65,-7.05,;4.74,-5.96,;6.23,-6.36,;4.34,-4.47,;4.74,-2.99,;5.83,-4.08,;2.86,-4.08,;1.77,-5.16,;.28,-4.77,;-.12,-3.28,;-1.61,-2.88,;.97,-2.19,;2.46,-2.59,;.57,-.7,;1.48,.54,;3.02,.54,;.57,1.79,;.97,3.28,;2.46,3.68,;3.55,2.59,;2.86,5.16,;4.34,5.56,;4.74,7.05,;-.89,1.31,;-2.23,2.08,;-3.56,1.31,;-3.56,-.23,;-2.23,-1,;-.89,-.23,;-4.9,-1,;-6.23,-.23,;-4.9,-2.54,)|
Structure:
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