Reaction Details Report a problem with these data
Target
Oxidized low-density lipoprotein receptor 1
Ligand
BDBM454243
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>300±n/a nM
Citation
 Findlay, AD; Turner, CI; Deodhar, M; Foot, JS; Jarolimek, W; Zhou, W; Robertson, AD Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof US Patent  US10717733 Publication Date 7/21/2020 
Target
Name:
Oxidized low-density lipoprotein receptor 1
Synonyms:
LOX-1 | LOX1 | Lectin-like oxLDL receptor 1 | Lectin-like oxidized LDL receptor 1 | Lectin-type oxidized LDL receptor 1 | OLR1 | OLR1_BOVIN | Ox-LDL receptor 1 | bLOX-1
Type:
Protein
Mol. Mass.:
30894.65
Organism:
Bovine
Description:
P79391
Residue:
270
Sequence:
MTVDDPKGMKDQLDQKPNGKTAKGFVSSWRWYPAAVTLGVLCLGLLVTVILLILQLSQVSDLIKKQQANITHQEDILEGQILAQRRSEKSAQESQKELKEMIETLAHKLDEKSKKLMELHRQNLNLQEVLKEAANYSGPCPQDWLWHEENCYQFSSGSFNWEKSQENCLSLDAHLLKINSTDELEFIQQMIAHSSFPFWMGLSMRKPNYSWLWEDGTPLTPHLFRIQGAVSRMYPSGTCAYIQRGTVFAENCILTAFSICQKKANLLRAQ
  
Inhibitor
Name:
BDBM454243
Synonyms:
(Z)-1-(4-amino-2-fluorobut-2-en-1-yl)-3- (3-(N,N-dimethylsulfamoyl)phenyl)-N- isopropyl-N,2-dimethyl-1H-indole-5- carboxamide | US10717733, Compound 36 | US11098045, Compound 36
Type:
Small organic molecule
Emp. Form.:
C26H33FN4O3S
Mol. Mass.:
500.629
SMILES:
CC(C)N(C)C(=O)c1ccc2n(C\C(F)=C\CN)c(C)c(-c3cccc(c3)S(=O)(=O)N(C)C)c2c1
Structure:
Search PDB for entries with ligand similarity: