Compile Data Set for Download or QSAR
Report error Found 2097 of affinity data for UniProtKB/TrEMBL: P00338
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM86114(LDHA Inhibitor, 8)
Affinity DataKd:  1.28E+4nMpH: 7.4 T: 2°CAssay Description:A BIAcore 3000 or a BIAcore S51 instrument (GE Healthcare) was used to detect binding interactions using a direct binding assay format.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2012
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50339607(LDHA Inhibitor, 4 | CHEMBL1688790 | 1-Hydroxy-6-ph...)
Affinity DataKd:  9.00E+3nMpH: 7.5 T: 2°CAssay Description:NMR spectra were acquired on Bruker Avance 600 MHz spectrometers at 298 K using a 5 mm triple-resonance HCN cryoprobe. Ligand binding was detected u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2012
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50219487(CHEMBL229299 | LDHA Inhibitor, 5 | 1-hydroxy-2-nap...)
Affinity DataKd:  6.40E+5nMpH: 7.5 T: 2°CAssay Description:NMR spectra were acquired on Bruker Avance 600 MHz spectrometers at 298 K using a 5 mm triple-resonance HCN cryoprobe. Ligand binding was detected u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2012
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50192453([(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataKd:  6.50E+5nMpH: 7.5 T: 2°CAssay Description:NMR spectra were acquired on Bruker Avance 600 MHz spectrometers at 298 K using a 5 mm triple-resonance HCN cryoprobe. Ligand binding was detected u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2012
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM86113(LDHA Inhibitor, 7)
Affinity DataKd:  4.00E+6nMpH: 7.5 T: 2°CAssay Description:NMR spectra were acquired on Bruker Avance 600 MHz spectrometers at 298 K using a 5 mm triple-resonance HCN cryoprobe. Ligand binding was detected u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2012
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50250674(CHEMBL4076973 | US10961200, Compound 53 | US112479...)
Affinity DataKd:  370nMAssay Description:Binding affinity to human His-tagged LDHA in presence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50250677(CHEMBL4100845 | US10961200, Compound 52 | US112479...)
Affinity DataKd:  0.330nMAssay Description:Binding affinity to human His-tagged LDHA in presence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50250656(CHEMBL4081890 | US11247971, Cmpd ID 276)
Affinity DataEC50:  170nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50250685(CHEMBL1479261 | US10961200, Compound 62 | US112479...)
Affinity DataEC50: >1.00E+5nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50250648(CHEMBL4080497 | US10961200, Compound 20 | US112479...)
Affinity DataEC50:  2.56E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM86137(LDHA Inhibitor, 33)
Affinity DataEC50:  1.60E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50103568(CHEMBL3335794)
Affinity DataKd:  59nMAssay Description:Binding affinity to human His-tagged LDHA in presence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50250652(CHEMBL4101800 | US10961200, Compound 42 | US112479...)
Affinity DataEC50: >1.00E+5nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50250656(CHEMBL4081890 | US11247971, Cmpd ID 276)
Affinity DataKd:  0.110nMAssay Description:Binding affinity to human His-tagged LDHA in presence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50250674(CHEMBL4076973 | US10961200, Compound 53 | US112479...)
Affinity DataEC50:  3.53E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50250677(CHEMBL4100845 | US10961200, Compound 52 | US112479...)
Affinity DataEC50:  250nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50250655(CHEMBL4059985 | US10961200, Compound 189 | US11247...)
Affinity DataEC50:  70nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50103568(CHEMBL3335794)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to human His-tagged LDHA in absence of NADH by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataEC50:  1.26E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50103568(CHEMBL3335794)
Affinity DataEC50:  8.18E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataEC50:  7.20nMAssay Description:Inhibition of human LDH5 using pyruvate as substrate after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50275213(CHEMBL4126939)
Affinity DataEC50:  670nMAssay Description:Inhibition of human LDH5 using pyruvate as substrate after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2020
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50275214(CHEMBL4126746)
Affinity DataEC50:  390nMAssay Description:Inhibition of human LDH5 using pyruvate as substrate after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2020
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524650(CHEMBL4461387)
Affinity DataEC50:  890nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524651(CHEMBL1559855)
Affinity DataEC50:  90nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524652(CHEMBL4556559)
Affinity DataEC50:  2.14E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524653(CHEMBL4577089)
Affinity DataEC50:  7.50E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524654(CHEMBL4476280)
Affinity DataEC50:  7.80E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524655(CHEMBL4450110)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524656(CHEMBL4515658)
Affinity DataEC50:  340nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524657(CHEMBL4462982)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524658(CHEMBL4583436)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataEC50:  8.90nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524659(CHEMBL1436155)
Affinity DataEC50:  270nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524660(CHEMBL1554905)
Affinity DataEC50:  1.24E+4nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524661(CHEMBL4515017)
Affinity DataEC50:  6.40E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524662(CHEMBL4454634)
Affinity DataEC50:  5.70E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50144744(Sodium Oxamate)
Affinity DataEC50:  1.20E+6nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524663(CHEMBL4475383)
Affinity DataEC50:  4.58E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524664(CHEMBL4441824)
Affinity DataEC50:  4.10E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524665(CHEMBL1888862)
Affinity DataEC50:  9.70E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524666(CHEMBL1440413)
Affinity DataEC50:  680nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524667(CHEMBL4441804)
Affinity DataEC50:  3.30E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524668(CHEMBL4445248)
Affinity DataEC50:  2.90E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524669(CHEMBL1555353)
Affinity DataEC50:  5.60E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50524670(CHEMBL1611057)
Affinity DataEC50:  3.70E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50527803(CHEMBL4557180)
Affinity DataEC50:  1.72E+5nMAssay Description:Binding affinity to human N-terminal His6-tagged human LDH-5 expressed in Escherichia coli Rosetta (DE3) assessed as induction of protein disruption ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50527803(CHEMBL4557180)
Affinity DataKd:  1.17E+5nMAssay Description:Competitive binding affinity to human N-terminal His6-tagged LDH-5 expressed in Escherichia coli Rosetta (DE3) assessed as protein-compound interacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50535762(CHEMBL4563330)
Affinity DataKd:  1.02E+3nMAssay Description:Binding affinity to His-tagged human LDHA in presence of NAD+ by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Astrazeneca

LigandPNGBDBM50535762(CHEMBL4563330)
Affinity DataEC50:  700nMAssay Description:Inhibition of His-tagged human LDHA incubated for 10 mins using NADH and pyruvate by microplate reader based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
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