Compile Data Set for Download or QSAR
Report error Found 483 of affinity data for UniProtKB/TrEMBL: P29350
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162435(H-Glu-Gly-Leu-Asn-pTyr-Nle-Val-Phe-NH2 | CHEMBL274...)
Affinity DataEC50:  5.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162436((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{2-[(S)-2-((S)-2-Ami...)
Affinity DataEC50:  6.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162437((4S)-4-amino-4-[({[(1S)-1-{[(8R,11R,14S,17S)-8-{[(...)
Affinity DataKd:  210nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162438((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{(S)-2-[(S)-2-((S)-2...)
Affinity DataEC50:  5.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162439(H-Glu-Gly-Leu-Asn-pTyr-Hfe-Val-Leu-NH2 | CHEMBL439...)
Affinity DataKd:  270nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162440(H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Leu-NH2 | CHEMBL371...)
Affinity DataKd:  1.44E+3nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162438((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{(S)-2-[(S)-2-((S)-2...)
Affinity DataKd:  240nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162441((4S)-4-amino-4-[({[(1S)-1-{[(7R,10R,13S,16S)-7-{[(...)
Affinity DataKd:  110nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162442(H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Phe-NH2 | CHEMBL386...)
Affinity DataKd:  1.00E+3nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162443(H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Abu(betaPh)-NH2 | C...)
Affinity DataKd:  250nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162438((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{(S)-2-[(S)-2-((S)-2...)
Affinity DataEC50:  5.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162444(H-Glu-Gly-Leu-Asn-pTyr-Phe-Val-Leu-NH2 | CHEMBL273...)
Affinity DataEC50:  7.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162435(H-Glu-Gly-Leu-Asn-pTyr-Nle-Val-Phe-NH2 | CHEMBL274...)
Affinity DataKd:  120nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162445(H-Glu-Gly-Leu-Asn-pTyr-Ser(betaPh)-Val-leu-NH2 | C...)
Affinity DataEC50:  2.20E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162445(H-Glu-Gly-Leu-Asn-pTyr-Ser(betaPh)-Val-leu-NH2 | C...)
Affinity DataKd:  1.08E+3nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162438((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{(S)-2-[(S)-2-((S)-2...)
Affinity DataKd:  240nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162446((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{2-[(S)-2-((S)-2-Ami...)
Affinity DataEC50:  1.40E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162446((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{2-[(S)-2-((S)-2-Ami...)
Affinity DataKd:  900nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162440(H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Leu-NH2 | CHEMBL371...)
Affinity DataEC50:  1.60E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162436((S)-2-[2-((S)-2-{(S)-2-[(S)-2-{2-[(S)-2-((S)-2-Ami...)
Affinity DataKd:  230nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162447(H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Abu(betaPh)-NH2 | C...)
Affinity DataEC50:  1.80E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162449(H-Glu-Gly-Leu-Asn-pTyr-Phe-Val-Phe-NH2 | CHEMBL269...)
Affinity DataEC50:  1.50E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162443(H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Abu(betaPh)-NH2 | C...)
Affinity DataEC50:  8.00E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162442(H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Phe-NH2 | CHEMBL386...)
Affinity DataEC50:  1.40E+5nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162439(H-Glu-Gly-Leu-Asn-pTyr-Hfe-Val-Leu-NH2 | CHEMBL439...)
Affinity DataEC50:  7.50E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162449(H-Glu-Gly-Leu-Asn-pTyr-Phe-Val-Phe-NH2 | CHEMBL269...)
Affinity DataKd:  530nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162448(H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Ser(betaPh)-NH2 | C...)
Affinity DataEC50:  8.50E+4nMAssay Description:Concentration required to stimulate SHP-1 enzymatic activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162448(H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Ser(betaPh)-NH2 | C...)
Affinity DataKd:  290nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50162444(H-Glu-Gly-Leu-Asn-pTyr-Phe-Val-Leu-NH2 | CHEMBL273...)
Affinity DataKd:  690nMAssay Description:Dissociation constant for the interaction with the GST-N-SH2 domain of SHP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50098803(CHEMBL3329937)
Affinity DataKd: >1.50E+4nMAssay Description:Binding affinity to SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2016
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 0.335nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50610515(CHEMBL5270661)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50610516(CHEMBL5287377)
Affinity DataIC50: 16nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50202437(CHEMBL502013)
Affinity DataIC50: 18nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50610514(CHEMBL5276767)
Affinity DataIC50: 30nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 92nMAssay Description:First, the GST fusion of the PTP domains of SHP2, SHP1, and PTP1B were produced and purified as reported by us previously.32 The reactions were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 92nMAssay Description:First, the GST fusion of the PTP domains of SHP2, SHP1, and PTP1B were produced and purified as reported by us previously.32 The reactions were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50556732(CHEMBL4750435)
Affinity DataIC50: 130nMAssay Description:Inhibition of PTPN6 (unknown origin) pre-incubated for 20 mins followed by fluorescence substrate addition and measured after 120 mins by DiFMUP assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM680881(US20240199525, Compound BPDA6)
Affinity DataIC50: 216nMAssay Description:First, the GST fusion of the PTP domains of SHP2, SHP1, and PTP1B were produced and purified as reported by us previously.32 The reactions were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM680881(US20240199525, Compound BPDA6)
Affinity DataIC50: 216nMAssay Description:First, the GST fusion of the PTP domains of SHP2, SHP1, and PTP1B were produced and purified as reported by us previously.32 The reactions were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50594492(CHEMBL3322530)
Affinity DataIC50: 290nMAssay Description:Inhibition of human SHP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50335865(6-Hydroxy-2-(4-methoxyphenyl)-3-(1-(4-(naphthalen-...)
Affinity DataIC50: 335nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM152210(US8987474, NSC-87877)
Affinity DataIC50: 355nMAssay Description:NSC-87877 ranked among top 10% (175th) of the compounds with the best GLIDE scores for the docking to the human Shp2 PTP domain in our virtual screen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 355nMAssay Description:Inhibition of recombinant GST-fused human SHP1 (205 to 597 residues) using DiFMUP as substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 360nMAssay Description:Inhibition of human SHP1 catalytic domain (205 to 597 residues) expressed in Escherichia coli DH5alpha using 6,8-difluoro-4-methylumbelliferyl phosph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 360nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50335867(3-(1-(4-(4-Chloronaphthalen-1-ylamino)-4-oxobutyl)...)
Affinity DataIC50: 378nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50335868(6-Hydroxy-3-(1-(4-(naphthalen-1-ylamino)-4-oxobuty...)
Affinity DataIC50: 408nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50335870(6-Hydroxy-3-(1-(4-(6-methoxybenzo[d]thiazol-2-ylam...)
Affinity DataIC50: 486nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50246668(3-(benzo[d][1,3]dioxol-5-yl)-2-(5-((4aR,6aS,6bR,8a...)
Affinity DataIC50: 710nMAssay Description:Inhibition of human recombinant SHP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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