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PubMed code 8421282

Compile data set for download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic receptor M1 and M2


(RAT)
BDBM50230694
PNG
(CHEMBL295388)
Show SMILES CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C28H38N4O2/c1-3-30(4-2)18-10-9-11-22-16-19-31(20-17-22)21-27(33)32-25-14-7-5-12-23(25)28(34)29-24-13-6-8-15-26(24)32/h5-8,12-15,22H,3-4,9-11,16-21H2,1-2H3,(H,29,34)
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0.300n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heart


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230695
PNG
(CHEMBL43258)
Show SMILES CN(C)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C26H34N4O2/c1-28(2)16-8-7-9-20-14-17-29(18-15-20)19-25(31)30-23-12-5-3-10-21(23)26(32)27-22-11-4-6-13-24(22)30/h3-6,10-13,20H,7-9,14-19H2,1-2H3,(H,27,32)
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3.70n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heart


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM81900
PNG
(AQ-RA 741 | CAS_129989 | NSC_129989)
Show SMILES CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C27H37N5O2/c1-3-30(4-2)17-8-7-10-21-14-18-31(19-15-21)20-25(33)32-24-13-6-5-11-22(24)27(34)29-23-12-9-16-28-26(23)32/h5-6,9,11-13,16,21H,3-4,7-8,10,14-15,17-20H2,1-2H3,(H,29,34)
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3.70n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heart


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230694
PNG
(CHEMBL295388)
Show SMILES CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C28H38N4O2/c1-3-30(4-2)18-10-9-11-22-16-19-31(20-17-22)21-27(33)32-25-14-7-5-12-23(25)28(34)29-24-13-6-8-15-26(24)32/h5-8,12-15,22H,3-4,9-11,16-21H2,1-2H3,(H,29,34)
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4n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to A9 L cells transfected with muscarinic M1 receptor of rat brain


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230695
PNG
(CHEMBL43258)
Show SMILES CN(C)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C26H34N4O2/c1-28(2)16-8-7-9-20-14-17-29(18-15-20)19-25(31)30-23-12-5-3-10-21(23)26(32)27-22-11-4-6-13-24(22)30/h3-6,10-13,20H,7-9,14-19H2,1-2H3,(H,27,32)
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11n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to A9 L cells transfected with muscarinic M1 receptor of rat brain


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230698
PNG
(CHEMBL43599)
Show SMILES CCN(CC)CCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C26H34N4O2/c1-3-28(4-2)16-13-20-14-17-29(18-15-20)19-25(31)30-23-11-7-5-9-21(23)26(32)27-22-10-6-8-12-24(22)30/h5-12,20H,3-4,13-19H2,1-2H3,(H,27,32)
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16n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heart


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230697
PNG
(CHEMBL295099)
Show SMILES CN(C)CCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C24H30N4O2/c1-26(2)14-11-18-12-15-27(16-13-18)17-23(29)28-21-9-5-3-7-19(21)24(30)25-20-8-4-6-10-22(20)28/h3-10,18H,11-17H2,1-2H3,(H,25,30)
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20n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heart


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230692
PNG
(CHEMBL296938)
Show SMILES CCCN(CCC)CCC1CCCCN1CC(=O)N1c2ccccc2NC(=O)c2ccccc12
Show InChI InChI=1S/C28H38N4O2/c1-3-17-30(18-4-2)20-16-22-11-9-10-19-31(22)21-27(33)32-25-14-7-5-12-23(25)28(34)29-24-13-6-8-15-26(24)32/h5-8,12-15,22H,3-4,9-11,16-21H2,1-2H3,(H,29,34)
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34n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heart


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM81900
PNG
(AQ-RA 741 | CAS_129989 | NSC_129989)
Show SMILES CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C27H37N5O2/c1-3-30(4-2)17-8-7-10-21-14-18-31(19-15-21)20-25(33)32-24-13-6-5-11-22(24)27(34)29-23-12-9-16-28-26(23)32/h5-6,9,11-13,16,21H,3-4,7-8,10,14-15,17-20H2,1-2H3,(H,29,34)
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34n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to A9 L cells transfected with muscarinic M1 receptor of rat brain


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230698
PNG
(CHEMBL43599)
Show SMILES CCN(CC)CCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C26H34N4O2/c1-3-28(4-2)16-13-20-14-17-29(18-15-20)19-25(31)30-23-11-7-5-9-21(23)26(32)27-22-10-6-8-12-24(22)30/h5-12,20H,3-4,13-19H2,1-2H3,(H,27,32)
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35n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M1 receptor of rat brain


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230700
PNG
(CHEMBL43371)
Show SMILES CCCCN(CCCC)CCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C30H42N4O2/c1-3-5-18-32(19-6-4-2)20-15-24-16-21-33(22-17-24)23-29(35)34-27-13-9-7-11-25(27)30(36)31-26-12-8-10-14-28(26)34/h7-14,24H,3-6,15-23H2,1-2H3,(H,31,36)
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47n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heart


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230693
PNG
(CHEMBL46484)
Show SMILES CCCN(CCC)CCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C28H38N4O2/c1-3-16-30(17-4-2)18-13-22-14-19-31(20-15-22)21-27(33)32-25-11-7-5-9-23(25)28(34)29-24-10-6-8-12-26(24)32/h5-12,22H,3-4,13-21H2,1-2H3,(H,29,34)
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47n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heart


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230697
PNG
(CHEMBL295099)
Show SMILES CN(C)CCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C24H30N4O2/c1-26(2)14-11-18-12-15-27(16-13-18)17-23(29)28-21-9-5-3-7-19(21)24(30)25-20-8-4-6-10-22(20)28/h3-10,18H,11-17H2,1-2H3,(H,25,30)
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51n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M1 receptor of rat brain


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230692
PNG
(CHEMBL296938)
Show SMILES CCCN(CCC)CCC1CCCCN1CC(=O)N1c2ccccc2NC(=O)c2ccccc12
Show InChI InChI=1S/C28H38N4O2/c1-3-17-30(18-4-2)20-16-22-11-9-10-19-31(22)21-27(33)32-25-14-7-5-12-23(25)28(34)29-24-13-6-8-15-26(24)32/h5-8,12-15,22H,3-4,9-11,16-21H2,1-2H3,(H,29,34)
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57n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M1 receptor of rat brain


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50018056
PNG
((AF-DX 116) 11-[2-(2-Diethylaminomethyl-piperidin-...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)
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73n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heart


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230696
PNG
(CHEMBL432860)
Show SMILES CC(C)CN(CCC1CCCCN1CC(=O)N1c2ccccc2NC(=O)c2ccccc12)CC(C)C
Show InChI InChI=1S/C30H42N4O2/c1-22(2)19-32(20-23(3)4)18-16-24-11-9-10-17-33(24)21-29(35)34-27-14-7-5-12-25(27)30(36)31-26-13-6-8-15-28(26)34/h5-8,12-15,22-24H,9-11,16-21H2,1-4H3,(H,31,36)
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74n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heart


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230699
PNG
(CHEMBL43601)
Show SMILES CCCCN(CCCC)CCC1CCCCN1CC(=O)N1c2ccccc2NC(=O)c2ccccc12
Show InChI InChI=1S/C30H42N4O2/c1-3-5-19-32(20-6-4-2)22-18-24-13-11-12-21-33(24)23-29(35)34-27-16-9-7-14-25(27)30(36)31-26-15-8-10-17-28(26)34/h7-10,14-17,24H,3-6,11-13,18-23H2,1-2H3,(H,31,36)
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88n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M2 receptor of rat heart


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230693
PNG
(CHEMBL46484)
Show SMILES CCCN(CCC)CCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C28H38N4O2/c1-3-16-30(17-4-2)18-13-22-14-19-31(20-15-22)21-27(33)32-25-11-7-5-9-23(25)28(34)29-24-10-6-8-12-26(24)32/h5-12,22H,3-4,13-21H2,1-2H3,(H,29,34)
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97n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M1 receptor of rat brain


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230696
PNG
(CHEMBL432860)
Show SMILES CC(C)CN(CCC1CCCCN1CC(=O)N1c2ccccc2NC(=O)c2ccccc12)CC(C)C
Show InChI InChI=1S/C30H42N4O2/c1-22(2)19-32(20-23(3)4)18-16-24-11-9-10-17-33(24)21-29(35)34-27-14-7-5-12-25(27)30(36)31-26-13-6-8-15-28(26)34/h5-8,12-15,22-24H,9-11,16-21H2,1-4H3,(H,31,36)
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99n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M1 receptor of rat brain


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230700
PNG
(CHEMBL43371)
Show SMILES CCCCN(CCCC)CCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc23)CC1
Show InChI InChI=1S/C30H42N4O2/c1-3-5-18-32(19-6-4-2)20-15-24-16-21-33(22-17-24)23-29(35)34-27-13-9-7-11-25(27)30(36)31-26-12-8-10-14-28(26)34/h7-14,24H,3-6,15-23H2,1-2H3,(H,31,36)
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100n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M1 receptor of rat brain


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50230699
PNG
(CHEMBL43601)
Show SMILES CCCCN(CCCC)CCC1CCCCN1CC(=O)N1c2ccccc2NC(=O)c2ccccc12
Show InChI InChI=1S/C30H42N4O2/c1-3-5-19-32(20-6-4-2)22-18-24-13-11-12-21-33(24)23-29(35)34-27-16-9-7-14-25(27)30(36)31-26-15-8-10-17-28(26)34/h7-10,14-17,24H,3-6,11-13,18-23H2,1-2H3,(H,31,36)
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177n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to muscarinic M1 receptor of rat brain


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50018056
PNG
((AF-DX 116) 11-[2-(2-Diethylaminomethyl-piperidin-...)
Show SMILES CCN(CC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)
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740n/an/an/an/an/an/an/an/a



George Washington University Medical Center

Curated by ChEMBL


Assay Description
Binding affinity by the displacement of [3H]NMS binding to A9 L cells transfected with muscarinic M1 receptor of rat brain


J Med Chem 36: 162-5 (1993)


Article DOI: 10.1021/jm00053a021
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%