Patent: (prefix with "US" like US6078908)
  1. Patent
    Data
    Cmpds
    HGNC*
    Patent Title
    Organization
    Deposition
    Downloads
  2. 15
    Bicyclic inhibitors of histone deacetylase
    Alkermes, Inc.
    05/22/22
  3. 813
    Compounds that inhibits MCL-1 protein
    AMGEN INC.
    05/22/22
  4. 18
    Heterocycles useful as anti-cancer agents
    Hangzhou Innogate Pharma Co., Ltd.
    05/22/22
  5. 275
    Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof
    Whitehead Institute for Biomedical Research; Dana-Farber Cancer Institute, Inc.; The United States of America, as represented by the Secretary, Department of Health and Human Services
    05/22/22
  6. 10
    Substituted pyridines as inhibitors of histone deacetylase
    Alkermes, Inc.
    05/22/22
  7. 122
    Tertiary alcohols as PI3K-γ inhibitors
    Incyte Corporation
    05/22/22
  8. 16
    5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents
    Temple University-Of the Commonwealth System of Higher Education
    05/14/22
  9. 137
    Cyclin dependent kinase inhibitors
    Pfizer Inc.
    05/14/22
  10. 333
    Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
    LA JOLLA INSTITUTE OF ALLERGY & IMMUNOLOGY; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    05/14/22
  11. 23
    Pyridylpyridone compounds
    Sprint Bioscience AB
    05/14/22
  12. 30
    Pyrrole tricyclic compounds as A2A / A2B inhibitors
    Incyte Corporation
    05/14/22
  13. 71
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics Incorporated
    05/14/22
  14. 218
    Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
    MIRATI THERAPEUTICS, INC.
    05/14/22
  15. 93
    Substituted n-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as protein kinase C inhibitors
    PFIZER INC.
    05/14/22
  16. 217
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    05/14/22
  17. 4
    2,3-dihydrofuro[2,3-b]pyridine compounds
    Eli Lilly and Company
    05/08/22
  18. 42
    Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
    Incyte Holdings Corporation; Incyte Corporation
    05/08/22
  19. 17
    Cannabinoid receptor modulators
    Arena Pharmaceuticals, Inc.
    05/08/22
  20. 88
    Compositions for treating neurodegenerative diseases
    Cognition Therapeutics, Inc.
    05/08/22
  21. 341
    Compound, compositions, and methods
    DENALI THERAPEUTICS INC.
    05/08/22
  22. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
    SHY Therapeutics LLC
    05/08/22
  23. 103
    Histone demethylase inhibitors
    CELGENE QUANTICEL RESEARCH, INC.
    05/08/22
  24. 52
    Indoleamine 2,3-dioxygenase inhibitor, method for preparation and use thereof
    NANJING HUAWE MEDICINE TECHNOLOGY GROUP CO., LTD.
    05/08/22
  25. 21
    Linear glycosidase inhibitors
    Asceneuron SA
    05/08/22
  26. 42
    MAGL inhibitors
    H. LUNDBECK A/S
    05/08/22
  27. 16
    Phenylpyrazolylacetamide compounds and derivatives as CDK8/CDK19 inhibitors
    Boehringer Ingelheim International GmbH
    05/08/22
  28. 49
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics, Incorporated
    05/08/22
  29. 52
    Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators
    JANSSEN PHARMACEUTICA NV
    05/08/22
  30. 7
    Substituted pyridine derivatives useful as C-FMS kinase inhibitors
    Janssen Pharmaceutica NV
    05/08/22
  31. 32
    Compositions and methods for treating parasitic diseases
    The Regents of the University of California; Washington University
    05/03/22
  32. 109
    Compounds useful as inhibitors of ALCAT 1
    PERENNA PHARMACEUTICALS, INC.
    05/03/22
  33. 80
    Ectonucleotidase inhibitors and methods of use thereof
    CALITHERA BIOSCIENCES, INC.
    05/03/22
  34. 5
    Nitrogenous tricyclic compounds and uses thereof in medicine
    SUNSHINE LAKE PHARMA CO., LTD.
    05/03/22
  35. 31
    Prognostic biomarkers for TTK inhibitor chemotherapy
    NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
    05/03/22
  36. 20
    Pyridinamine-pyridone and pyrimidinamine- pyridone compounds
    Sprint Bioscience AB
    05/03/22
  37. 121
    Pyridone derivatives having tetrahydropyranylmethyl groups
    Daiichi Sankyo Company, Limited
    05/03/22
  38. 41
    Selective inhibitors of protein arginine methytransterase 5 (PRMT5)
    Prelude Therapeutics Incorporated
    05/03/22
  39. 53
    Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors
    Bayer Pharma Aktiengesellschaft; Bayer Aktiengesellschaft
    05/03/22
  40. 376
    Substituted indole Mcl-1 inhibitors
    Vanderbilt University
    05/03/22
  41. 20
    1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
    Incyte Corporation; Incyte Holdings Corporation
    05/02/22
  42. 119
    3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof
    ALLERGAN, INC.
    05/02/22
  43. 96
    Certain chemical entities, compositions, and methods
    NEUPHARMA, INC
    05/02/22
  44. 27
    HDAC6 inhibitors and imaging agents
    The General Hospital Corporation
    05/02/22
  45. 55
    Indole derivatives and their use as protein kinase inhibitors
    RESPIVERT LIMITED
    05/02/22
  46. 204
    Metallo-beta-lactamase inhibitors and methods of use thereof
    Merck Sharp & Dohme Corp.
    05/02/22
  47. 117
    NLRP3 inflammasome inhibitors
    Novartis AG
    05/02/22
  48. 595
    Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GLUN2B receptor modulators
    JANSSEN PHARMACEUTICA NV
    05/02/22
  49. 526
    Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    05/02/22
  50. 1
    Sulfinylpyridines and their use in the treatment of cancer
    Oblique Therapeutics AB
    05/02/22
  51. 243
    Triazolopyrimidine compounds and uses thereof
    Novartis AG
    05/02/22
  52. 28
    Anti-proliferative agents for treating PAH
    Pfizer Inc.
    04/29/22
  53. 13
    Aza-indazole compounds for use in tendon and/or ligament injuries
    NOVARTIS AG
    04/29/22
  54. 247
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    04/29/22
  55. 37
    Iridinesulfonamide compound and use method thereof
    Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd.
    04/29/22
  56. 281
    Kinase inhibitors and uses thereof
    DENALI THERAPEUTICS INC.
    04/29/22
  57. 14
    Personal care compositions comprising fatty acid amide derivatives
    Conopco, Inc.
    04/29/22
  58. 302
    Substituted 6-azabenzimidazole compounds
    Gilead Sciences, Inc.
    04/29/22
  59. 100
    Sulfonamides as modulators of sodium channels
    VERTEX PHARMACEUTICALS INCORPORATED
    04/29/22
  60. 19
    Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof
    The Broad Institute, Inc.; Biogen MA Inc.
    04/29/22
  61. 56
    Compounds targeting PRMT5
    Aligos Therapeutics, Inc.
    04/25/22
  62. 573
    Fused ring derivative having MGAT-2 inhibitory activity
    SHIONOGI & CO., LTD.
    04/25/22
  63. 113
    Aminopyrimidinyl compounds
    Pfizer Inc.
    04/24/22
  64. 16
    Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
    GLYCOMIMETICS. INC.
    04/24/22
  65. 115
    Heteroaryl inhibitors of PAD4
    Padlock Therapeutics, Inc.
    04/24/22
  66. 92
    N-((het)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
    KalVista Pharmaceuticals Limited
    04/24/22
  67. 13
    Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
    BioAxone BioSciences, Inc.
    04/24/22
  68. 30
    5-hydroxytryptamine receptor 7 activity modulators and their method of use
    Temple University-Of The Commonwealth System of Higher Education
    04/17/22
  69. 111
    Alkyl substituted triazole compounds as agonists of the APJ Receptor
    AMGEN INC.
    04/17/22
  70. 377
    Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
    Janssen Pharmaceutica NV
    04/17/22
  71. 8
    Glutaminase inhibitor discovery and nanoparticle-enhanced delivery for cancer therapy
    THE JOHNS HOPKINS UNIVERSITY
    04/17/22
  72. 44
    Heterocyclic compounds for the inhibition of PASK
    BioEnergenix LLC
    04/17/22
  73. 246
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    04/17/22
  74. 36
    N-aryl oxamic acids
    Purdue Research Foundation
    04/17/22
  75. 6
    Pyrazoloquinazolinone antitumor agents
    The Rockefeller University
    04/17/22
  76. 43
    Quinoline compounds as modulators of RAGE activity and uses thereof
    TBA
    04/17/22
  77. 4
    Quinolone compounds as inhibitors of the BCL6 BTB domain protein-protein interaction and/or as BCL6 degraders
    ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR)
    04/17/22
  78. 68
    Substituted 1,6-dihydropyridinones and 1,2-dihydroisoquinolinones as bet inhibitors
    Nuvation Bio Inc.
    04/17/22
  79. 88
    6-heterocyclyl-4-morpholin-4-ylpyridine-2-one compounds useful for the treatment of cancer and diabetes
    SPRINT BIOSCIENCE AB
    04/10/22
  80. 73
    6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivative
    AYUMI PHARMACEUTICAL CORPORATION
    04/10/22
  81. 40
    Amino pyrimidine derivatives
    Novartis AG
    04/10/22
  82. 46
    Anilinopyrimidines as haematopoietic progenitor kinase 1 (HPK1) inhibitors
    ARIAD Pharmaceuticals, Inc.
    04/10/22
  83. 14
    Azaspiro[4.5]decane derivatives and use thereof
    Purdue Pharma L.P.
    04/10/22
  84. 8
    Cannabinoid receptor antagonists/inverse agonists useful for treating disease conditions, including metabolic disorders and cancers
    Jenrin Discovery, LLC
    04/10/22
  85. 32
    Compound as ACC inhibitor and use thereof
    NANJING SANHOME PHARMACEUTICAL CO., LTD.
    04/10/22
  86. 161
    Compounds for the treatment of pain
    TBA
    04/10/22
  87. 4
    Crystalline forms of a phosphoinositide 3-kinase (PI3K) inhibitor
    Incyte Corporation
    04/10/22
  88. 95
    Cyanoindoline derivatives as NIK inhibitors
    Janssen Pharmaceutica NV
    04/10/22
  89. 145
    Imidazopyrimidine derivatives
    Gilead Sciences, Inc.
    04/10/22
  90. 38
    Purine inhibitors of human phosphatidylinositol 3-kinase delta
    Merck Sharp & Dohme Corp.
    04/10/22
  91. 59
    Pyrazole derivatives as plasma kallikrein inhibitors
    KalVista Pharmaceuticals Limited
    04/10/22
  92. 130
    Pyrazolo[1,5-A][1,3,5]triazine and pyrazolo[1,5-A]pyrimidine derivatives as CDK inhibitors
    Aurigene Discovery Technologies Limited
    04/10/22
  93. 23
    Somatostatin modulators and uses thereof
    CRINETICS PHARMACEUTICALS, INC.
    04/10/22
  94. 562
    Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as PDE2 inhibitors
    Dart Neuroscience, (Cayman) LTD.
    04/10/22
  95. 183
    Substituted amino acids as integrin inhibitors
    Pliant Therapeutics, Inc.
    04/10/22
  96. 254
    Substituted oxopyridine derivatives
    Bayer Pharma Aktiengesellschaft
    04/10/22
  97. 6
    Substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines as tyrosine kinase inhibitors
    Shenzhen TargetRx, Inc.
    04/10/22
  98. 35
    Therapeutic heterocyclic compounds
    Gilead Sciences, Inc.
    04/10/22
  99. 212
    Vasopressin receptor antagonists and products and methods related thereto
    BLACKTHORN THERAPEUTICS, INC.
    04/10/22
  100. 13
    [1,2,4]Triazolo[4,3-A]pyrazin-6(5H)-one derivatives
    ELI LILLY AND COMPANY
    04/10/22
  101. 27
    3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
    Novartis AG
    04/09/22
  102. 50
    Methods for modulating taste receptors
    MARS, INCORPORATED
    04/09/22
  103. 64
    Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
    Vertex Pharmaceuticals Incorporated
    04/09/22
  104. 164
    Non-fused tricyclic compounds
    VIVACE THERAPEUTICS, INC.
    04/09/22
  105. 45
    Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
    Bristol-Myers Squibb Company
    04/09/22
  106. 73
    4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139
    Takeda Pharmaceutical Company Limited
    04/03/22
  107. 8
    Adrenergic receptor modulating compounds and methods of using the same
    The Board of Trustees of the Leland Stanford Junior University
    04/03/22
  108. 17
    Aniline-substituted 1,2-dihydropyrrol[3,4-C]pyridin/pyrimidin-3-one derivative and use thereof
    YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.; SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.
    04/03/22
  109. 333
    Benzenesulfonamide compouds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    04/03/22
  110. 124
    Benzimidazole compounds and derivatives as EGFR inhibitors
    Boehringer Ingelheim International GmbH
    04/03/22
  111. 187
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte Corporation
    04/03/22
  112. 59
    Compositions and methods to modulate chloride ion channel activity
    The Board of Trustees of the Leland Stanford Junior University
    04/03/22
  113. 18
    Compounds, compositions and methods
    Denali Therapeutics Inc.
    04/03/22
  114. 133
    Heterocyclic compounds as kinase inhibitors
    NUVATION BIO INC.
    04/03/22
  115. 29
    Indazolyl-spiro[2.3]hexane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
    Merck Sharp & Dohme Corp.
    04/03/22
  116. 303
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    BioSplice Therapeutics, Inc.
    04/03/22
  117. 7
    Neprilysin inhibitors
    Theravance Biopharma R&D IP, LLC
    04/03/22
  118. 126
    Substituted carboxamides as inhibitors of WDR5 protein-protein binding
    Propellon Therapeutics Inc.
    04/03/22
  119. 89
    Substituted heterocyclyl derivatives as CDK inhibitors
    Aurigene Discovery Technologies Limited
    04/03/22
  120. 19
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    04/03/22
  121. 5
    Matriptase inhibitors and uses thereof
    SOCIÉTÉ DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUÉE SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C.
    03/30/22
  122. 11
    3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
    Rugen Holdings (Cayman) Limited
    03/27/22
  123. 71
    3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof
    Board of Trustees of the Southern Illinois University
    03/27/22
  124. 20
    4-pyrazin-2-ylmethyl-morpholine derivatives and the use thereof as medicament
    Boehringer Ingelheim International GmbH
    03/27/22
  125. 173
    ASK1 inhibiting agents
    BIOGEN MA INC.
    03/27/22
  126. 13
    Amino-triazolopyridine compounds and their use in treating cancer
    AstraZeneca AB
    03/27/22
  127. 135
    Bicyclic heteroaryl compounds and uses thereof
    Revolution Medicines, Inc.
    03/27/22
  128. 35
    CXCR2 antagonist
    MEDSHINE DISCOVERY INC.
    03/27/22
  129. 34
    Compounds and their use for reducing uric acid levels
    Acquist LLC
    03/27/22
  130. 67
    Dynamin-1-like protein inhibitors
    Mitobridge, Inc.
    03/27/22
  131. 10
    Functionalized pyrano[2,3-D]pyrimidin-7-one derivatives and methods for their preparation and use
    The Texas A&M University System
    03/27/22
  132. 34
    Fused pyrimidine derivatives as A2A / A2B inhibitors
    Incyte Corporation
    03/27/22
  133. 25
    Fused ring derivative used as FGFR4 inhibitor
    JACOBIO PHARMACEUTICALS CO., LTD.
    03/27/22
  134. 214
    Heteroaromatic derivatives as NIK inhibitors
    Janssen Pharmaceutica NV
    03/27/22
  135. 6
    Heterocyclylsulfonyl-substituted pyridines and their use in the treatment of cancer
    Oblique Therapeutics AB
    03/27/22
  136. 8
    Indane-amines as PD-L1 antagonists
    ChemoCentryx, Inc.
    03/27/22
  137. 66
    Inhibitors of Plasma Kallikrein and uses thereof
    Takeda Pharmaceutical Company Limited
    03/27/22
  138. 42
    Inhibitors of dihydroceramide desaturase for treating disease
    Centaurus Therapeutics
    03/27/22
  139. 55
    Inhibitors of integrated stress response pathway
    PRAXIS BIOTECH LLC
    03/27/22
  140. 118
    JAK inhibitors
    VIMALAN BIOSCIENCES, INC.
    03/27/22
  141. 77
    Macrocycles as factor XIA inhibitors
    Bristol-Myers Squibb Company
    03/27/22
  142. 42
    Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors
    Boehringer Ingelheim International GmbH
    03/27/22
  143. 56
    Pyridylamino substituted heterotricyclic compounds, and preparation method and pharmaceutical use thereof
    TBA
    03/27/22
  144. 95
    Pyrrolo[2,3-C]pyridines and related analogs as LSD-1 inhibitors
    THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    03/27/22
  145. 7
    Pyrrolopyrimidine and pyrrolopyridine derivatives
    GALAPAGOS NV
    03/27/22
  146. 96
    Pyrrolopyrimidine derivatives as TAM inhibitors
    Incyte Corporation
    03/27/22
  147. 239
    Substituted N-arylethyl-2-arylquinoline-4-carboxamides and use thereof
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    03/27/22
  148. 38
    Substituted imidazoles as apoptosis signal regulating kinase 1 inhibitors
    Jiangsu Hansoh Pharmaceutical Group Co., Ltd.; Shanghai Hansoh Biomedical Co., Ltd.
    03/27/22
  149. 115
    Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
    Array BioPharma Inc.
    03/27/22
  150. 125
    Therapeutic compounds and uses thereof
    GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.
    03/27/22
  151. 135
    Thienopyridine inhibitors of RIPK2
    Celgene Corporation
    03/27/22
  152. 22
    Thienopyrimidones
    Boehringer Ingelheim International GmbH
    03/27/22
  153. 186
    2-quinolone derived inhibitors of BCL6
    The Institute of Cancer Research: Royal Cancer Hospital; Cancer Research Technology Limited
    03/20/22
  154. 15
    Compounds and their use for reducing uric acid levels
    Acquist LLC
    03/20/22
  155. 37
    Cyclic substituted imidazo[4,5-c]quinoline derivatives
    PFIZER INC.
    03/20/22
  156. 113
    Fused pyrazine derivatives as A2A / A2B inhibitors
    Incyte Corporation
    03/20/22
  157. 13
    Heterocyclic derivatives as PI3K inhibitors
    Incyte Corporation
    03/20/22
  158. 33
    Hydrocarbylsulfonyl-substituted pyridines and their use in the treatment of cancer
    Oblique Therapeutics AB
    03/20/22
  159. 77
    Indazolyl-spiro[2.2]pentane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
    Merck Sharp & Dohme Corp.
    03/20/22
  160. 6
    Inhibiting the transient receptor potential al ion channel
    Eli Lilly and Company
    03/20/22
  161. 44
    Inhibitors of NEK7 kinase
    HALIA THERAPEUTICS, INC.
    03/20/22
  162. 530
    Purinones as ubiquitin-specific protease 1 inhibitors
    FORMA Therapeutics, Inc.
    03/20/22
  163. 48
    Pyridinone derivatives and their use as selective ALK-2 inhibitors
    NOVARTIS AG
    03/20/22
  164. 76
    Sting agonists
    VENENUM BIODESIGN, LLC
    03/20/22
  165. 97
    Tricyclic fused thiophene derivatives as JAK inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    03/20/22
  166. 71
    4,6,7-trisubstituted 1,2-dihydropyrrolo[3,4-c]pyridin/pyrimidin-3-one derivatives and uses thereof
    SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.
    03/13/22
  167. 4
    Amide derivatives as Nav1.7 and Nav1.8 blockers
    RaQualia Pharma Inc.
    03/13/22
  168. 66
    Antagonists of the muscarinic acetylcholine receptor M4
    Vanderbilt University
    03/13/22
  169. 13
    C7 substituted oxysterols and methods of use thereof
    SAGE THERAPEUTICS, INC.
    03/13/22
  170. 2
    Crystal form of urate transporter 1 inhibitor and preparation method and use thereof
    TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.
    03/13/22
  171. 129
    Cyclopropylamines as LSD1 inhibitors
    Incyte Corporation
    03/13/22
  172. 30
    Dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
    TOPADUR PHARMA AG
    03/13/22
  173. 35
    Fused piperidinyl bicyclic and related compounds as modulators of C5A receptor
    InflaRx GmbH
    03/13/22
  174. 38
    Fused triazole agonists of the APJ receptor
    Amgen Inc.
    03/13/22
  175. 57
    Heterocycle comprising tyrosine kinase inhibitors
    Principia Biopharma Inc.
    03/13/22
  176. 46
    MAP kinase modulators and uses thereof
    The Trustees of Columbia University in the City of New York; Northwestern University
    03/13/22
  177. 157
    Oxysterols and methods of use thereof
    SAGE THERAPEUTICS, INC.
    03/13/22
  178. 1
    Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof
    Arena Pharmaceuticals, Inc.
    03/13/22
  179. 37
    Pyrazole MAGL inhibitors
    H. LUNDBECK A/S
    03/13/22
  180. 140
    Pyrazolopyrimidine compounds and methods of use thereof
    Genentech, Inc.
    03/13/22
  181. 17
    Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders
    DANA-FARBER CANCER INSTITUTE, INC.
    03/13/22
  182. 251
    Substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
    Sanofi
    03/13/22
  183. 272
    Substituted N-arylethyl-2-aminoquinoline-4-carboxamides and use thereof
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    03/13/22
  184. 12
    Substituted nucleosides, nucleotides and analogs thereof
    JANSSEN BIOPHARMA, INC.
    03/13/22
  185. 70
    Substituted triazole derivatives and uses thereof
    Bayer Pharma Aktiengesellschaft
    03/13/22
  186. 33
    Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors
    UNIVERSITÄT DUISBURG-ESSEN
    03/13/22
  187. 15
    Thrombospondin 1-binding peptide
    DAIICHI SANKYO COMPANY, LIMITED; PEPTIDREAM INC.
    03/13/22
  188. 8
    Composition for inducing differentiation and protection of neural stem cells and method for inducing neuro-regeneration using the same composition
    GENUV Inc.
    03/12/22
  189. 17
    Compositions and methods for treating CNS disorders
    Sage Therapeutics, Inc.
    03/12/22
  190. 2
    Compounds as neurokinin-1 receptor antagonists and uses thereof
    XWPHARMA LTD.
    03/12/22
  191. 5
    Methods for treating GI tract disorders
    NEUROGASTRX, INC.
    03/12/22
  192. 29
    Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
    Aurigene Discovery Technologies Limited
    03/12/22
  193. 215
    2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
    BAYER AKTIENGELLSCHAFT; BAYER PHARMA AKTIEGELLSCHAFT; THE BROAD INSTITUTE INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION
    03/08/22
  194. 715
    2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
    IDEAYA BIOSCIENCE, INC.
    03/08/22
  195. 38
    Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
    Incyte Corporation
    03/08/22
  196. 15
    Calcium channel inhibitors
    CAVION, INC.
    03/08/22
  197. 78
    Compounds
    MISSION THERAPEUTICS LIMITED
    03/08/22
  198. 60
    Dual MAGL and FAAH inhibitors
    Abide Therapeutics, Inc.
    03/08/22
  199. 66
    Pyridazinone compounds and their use as DAAO inhibitors
    Takeda Pharmaceutical Company Limited
    03/08/22
  200. 308
    Spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (MCL-1) protein
    Prelude Therapeutics, Incorporated
    03/08/22
  201. 17
    Substituted 2,3-dihydro-1H-indene analogs and methods using same
    Arbutus Biopharma Corporation
    03/08/22
  202. 95
    Substituted benzamides as RIPK2 inhibitors
    Boehringer Ingelheim International GmbH
    03/08/22
  203. 179
    Azalactam compounds as HPK1 inhibitors
    PFIZER INC.
    03/04/22
  204. 61
    Benzimidazoles and indoles as taro inhibitors
    MERCK SHARP & DOHME CORP
    03/04/22
  205. 58
    Compositions for APP-selective BACE inhibition and uses therefor
    The Regents of the University of California
    03/04/22
  206. 13
    Cyano substituted heteroarylpyrimidinone derivative, preparation method and use thereof
    ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
    03/04/22
  207. 99
    Dihydropyrimidine compounds and uses thereof in medicine
    SUNSHINE LAKE PHARMA CO., LTD.
    03/04/22
  208. 21
    Heterocyclic compound as Syk inhibitor and/or Syk-HDAC dual inhibitor
    Hangzhou Innogate Pharma Co., Ltd.
    03/04/22
  209. 35
    Inhibitors of cyclin-dependent kinases
    Dana-Farber Cancer Institute, Inc.
    03/04/22
  210. 37
    LDHA activity inhibitors
    ARCTIC PHARMA AS
    03/04/22
  211. 3
    Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
    Poxel SA
    03/04/22
  212. 99
    Oxazolidinones as taro inhibitors
    MERCK SHARP & DOHME CORP
    03/04/22
  213. 187
    Spirocycle compounds and methods of making and using same
    H. LUNDBECK A/S
    03/04/22
  214. 51
    Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics
    STINGRAY THERAPEUTICS, INC.
    03/04/22
  215. 8
    Inhibitors of bromodomain-containing protein 4 (BRD4)
    Board of Regents, The University Of Texas System
    03/02/22
  216. 34
    2,6-dioxaspiro [4,5] decane derivatives and preparation method therefor and pharmaceutical applications thereof
    TBA
    02/26/22
  217. 24
    Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof
    DYNAVAX TECHNOLOGIES CORPORATION
    02/26/22
  218. 37
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    ASTRAZENECA AB
    02/26/22
  219. 3
    Combination of pure 5-HT6 receptor antagonists with NMDA receptor antagonist
    Suven Life Sciences Limited
    02/26/22
  220. 546
    Compounds useful as inhibitors of ATR kinase
    VERTEX PHARMACEUTICALS INCORPORATED
    02/26/22
  221. 38
    Disubstituted pyrazole compounds
    Eli Lilly and Company
    02/26/22
  222. 33
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    02/26/22
  223. 7
    Imidazolidine compounds
    Eli Lilly and Company
    02/26/22
  224. 101
    Inhibitors of glucocorticoid receptor
    ORIC PHARMACEUTICALS, INC.
    02/26/22
  225. 4
    Isoquinolin and naphthydrin compounds
    Eli Lilly and Company
    02/26/22
  226. 184
    Kappa opioid receptor antagonists and products and methods related thereto
    THE SCRIPPS RESEARCH INSTITUTE; BLACKTHORN THERAPEUTICS, INC.
    02/26/22
  227. 28
    L,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-one analogs
    Recurium IP Holdings, LLC
    02/26/22
  228. 635
    Methods and compositions of inhibiting DCN1-UBC12 interaction
    MEMORIAL SLOAN KETTERING CANCER CENTER; ST. JUDE CHILDREN''S RESEARCH HOSPITAL
    02/26/22
  229. 62
    Neuroactive steroids, compositions, and uses thereof
    Sage Therapeutics, Inc.
    02/26/22
  230. 127
    Phenylpyrrolidinone formyl peptide 2 receptor agonists
    Bristol-Myers Squibb Company
    02/26/22
  231. 7
    Pyrazolo-heteroaryl derivative, preparation method and medical use thereof
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    02/26/22
  232. 39
    Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases
    TBA
    02/26/22
  233. 22
    Selective estrogen receptor degraders
    Eli Lilly and Company
    02/26/22
  234. 32
    Tetrahydroisoquinolines and terahydronaphthyridines for the treatment of hepatitis B virus infection
    Hoffmann-La Roche, Inc.
    02/26/22
  235. 50
    Tri-substituted imidazoles for the inhibition of TGF beta and methods of treatment
    Clavius Pharmaceuticals, LLC.
    02/26/22
  236. 117
    6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity
    University of Pittsburgh—Of the Commonwealth System of Higher Education
    02/22/22
  237. 39
    Inhibitor of apoptosis protein (IAP) antagonists
    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    02/22/22
  238. 81
    Pyrazolopyrimidine compounds and uses thereof
    Incyte Corporation
    02/22/22
  239. 12
    Pyrimidine compounds and pyrimido indole compounds and methods of use
    Duquesne University of The Holy Spirit
    02/22/22
  240. 1227
    6-membered heterocyclic derivatives and pharmaceutical composition comprising the same
    SHIONOGI & CO., LTD.
    02/21/22
  241. 64
    Amino pyrimidine compound for inhibiting protein tyrosine kinase activity
    Shenzhen TargetRx, Inc.
    02/21/22
  242. 71
    Aryl heterocyclic piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
    Bristol-Myers Squibb Company
    02/21/22
  243. 23
    Autotaxin inhibitors
    UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION; UNIVERSITY OF MEMPHIS
    02/21/22
  244. 250
    Bicyclic compound and use thereof
    SK BIOPHARMACEUTICALS CO., LTD.
    02/21/22
  245. 164
    Compounds, compositions, and methods
    DENALI THERAPEUTICS INC.
    02/21/22
  246. 53
    EPAC antagonists
    Board of Regents, the University of Texas System
    02/21/22
  247. 17
    Imidazopyrazine inhibitors of Bruton's tyrosine kinase
    Acerta Pharma B.V.
    02/21/22
  248. 62
    Methods of treating mental disorders
    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    02/21/22
  249. 43
    Pyrimidine compounds as JAK kinase inhibitors
    Theravance Biopharma R&D IP, LLC
    02/21/22
  250. 315
    Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides
    Pfizer Inc.
    02/21/22
  251. 27
    Sultam compound and application method thereof
    Chai Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd.
    02/21/22
  252. 27
    1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones as PDE1 inhibitors
    H. Lundbeck A/S
    02/13/22
  253. 47
    4,5,6-trisubstituted indazole derivatives, and preparation method and pharmaceutical use thereof
    TBA
    02/13/22
  254. 843
    4-azaindole compounds
    Bristol-Myers Squibb Company
    02/13/22
  255. 13
    4-pyrimidin-5-ylmethyl-morpholine derivatives and the use thereof as medicament
    Boehringer Ingelheim International GmbH
    02/13/22
  256. 262
    Apoptosis signal-regulating kinase inhibitors
    Gilead Sciences, Inc.
    02/13/22
  257. 15
    Benzimidazole derivatives, preparation methods and uses thereof
    BETTA PHARMACEUTICALS CO., LTD.
    02/13/22
  258. 199
    Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
    Merck Sharp & Dohme Corp.
    02/13/22
  259. 20
    Inhibitors of bruton's tyrosine kinase
    Hoffmann-La Roche Inc.; Chugai Pharmaceutical Co.
    02/13/22
  260. 50
    Inhibitors of hepatitis C virus replication
    Merck Sharp & Dohme Corp.
    02/13/22
  261. 26
    JAK1 pathway inhibitors for the treatment of cytokine-related disorders
    Incyte Corporation
    02/13/22
  262. 379
    KRAS G12C inhibitors and methods of using the same
    AMGEN INC.
    02/13/22
  263. 223
    Macrocyclic compounds for treatment of medical disorders
    Achillion Pharmaceuticals, Inc.
    02/13/22
  264. 21
    PTPN11 inhibitors
    NAVIRE PHARMA, INC.
    02/13/22
  265. 188
    Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases
    Array BioPharma Inc.
    02/13/22
  266. 14
    Pyridazines
    Boehringer Ingelheim International GmbH
    02/13/22
  267. 138
    Pyrimidine derivative compound, optical isomer thereof, or pharmaceutically acceptable salt thereof, and composition for preventing or treating Tyro 3 related disease comprising same as active ingredient
    KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    02/13/22
  268. 8
    Pyrimidinones as factor XIA inhibitors
    Bristol-Myers Squibb Company
    02/13/22
  269. 10
    Pyrrolo[1,2-b]pyridazine derivatives
    Gilead Sciences, Inc.
    02/13/22
  270. 2
    Salts of TAM inhibitors
    Incyte Corporation
    02/13/22
  271. 106
    Substituted pyridines as TYK2 inhibitors
    Esker Therapeutics, Inc.
    02/13/22
  272. 233
    Substituted tricyclic compounds as FGFR inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    02/13/22
  273. 96
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    02/13/22
  274. 156
    [9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11BH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto
    Neurocrine Biosciences, Inc.
    02/13/22
  275. 71
    5-alkyl pyrrolidine orexin receptor agonists
    Merck Sharp & Dohme Corp.
    02/07/22
  276. 64
    Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
    Hoffmann-La Roche Inc.
    02/07/22
  277. 149
    Bicyclic ketone compounds and methods of use thereof
    Genentech, Inc.
    02/07/22
  278. 113
    Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    02/07/22
  279. 116
    Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
    Pharmaxis Ltd.
    02/07/22
  280. 179
    Heteroaryl compounds as BTK inhibitors and uses thereof
    Merck Patent GmbH
    02/07/22
  281. 103
    Imidazopyridinyl compounds and use thereof for treatment of neurodegenerative disorders
    1ST Biotherapeutics, Inc.
    02/07/22
  282. 126
    Inhibitors of RAF kinases
    KINNATE BIOPHARMA INC.
    02/07/22
  283. 126
    MK2 inhibitors and uses thereof
    Celgene CAR LLC
    02/07/22
  284. 32
    Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof
    CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
    02/07/22
  285. 40
    Macrocyclic compounds as TRK kinase inhibitors and uses thereof
    ANGEX PHARMACEUTICAL, INC.
    02/07/22
  286. 26
    PRMT5 inhibitors
    Merck Sharp & Dohme Corp.
    02/07/22
  287. 4
    Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
    ARENA PHARMACEUTICALS, INC.
    02/07/22
  288. 116
    1-cyano-pyrrolidine compounds as USP30 inhibitors
    MISSION THERAPEUTICS LIMITED
    02/06/22
  289. 10
    Anti-HIV compounds
    Gilead Sciences, Inc.
    02/06/22
  290. 184
    Aryl-or heteroaryl-substituted benzene compounds
    Epizyme, Inc.
    02/06/22
  291. 21
    BRK inhibitory compound
    ONO PHARMACEUTICAL CO., LTD.
    02/06/22
  292. 165
    Carbazole derivatives
    Bristol-Myers Squibb Company
    02/06/22
  293. 49
    Combination therapies using immuno-dash inhibitors and PGE2 antagonists
    Trustees of Tufts College
    02/06/22
  294. 36
    Compounds and methods of use
    Medivation Technologies LLC
    02/06/22
  295. 47
    Heterocyclic compounds and uses thereof
    Celgene CAR LLC
    02/06/22
  296. 168
    Heterocyclic compounds useful as Pim kinase inhibitors
    Incyte Corporation
    02/06/22
  297. 18
    Indoleamine-2,3-dioxygenase inhibitor and preparation method therefor
    Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
    02/06/22
  298. 252
    Pharmaceutical compounds
    ALMAC DISCOVERY LIMITED
    02/06/22
  299. 19
    Substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase
    Merck Sharp & Dohme Corp.; IOmet Pharma Ltd.
    02/06/22
  300. 26
    Substituted indoline derivatives as dengue viral replication inhibitors
    Janssen Pharmaceuticals, Inc.; Kathalieke Universiteif Leuven
    02/06/22
  301. 96
    1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
    Incyte Corporation
    02/02/22
  302. 129
    CXCR7 antagonists
    ChemoCentryx, Inc.
    02/02/22
  303. 25
    Compounds and compositions useful for treating disorders related to NTRK
    Blueprint Medicines Corporation
    02/02/22
  304. 10
    Compounds that participate in cooperative binding and uses thereof
    Revolution Medicines, Inc.
    02/02/22
  305. 60
    Difluoroketamide derivatives as HtrA1 inhibitors
    Hoffmann-La Roche Inc.
    02/02/22
  306. 376
    Disubstituted octahydropyrrolo[3,4-C]pyrroles as orexin receptor modulators
    Janssen Pharmaceutica NV
    02/02/22
  307. 25
    MAGL inhibitors
    H. LUNDBECK A/S
    02/02/22
  308. 24
    Macrocyclic immunomodulators
    ChemoCentryx, Inc.
    02/02/22
  309. 30
    Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases
    University of South Carolina
    02/02/22
  310. 15
    Small molecule inhibitors of the JAK family of kinases
    Janssen Pharmaceutica NV
    02/02/22
  311. 30
    Substituted purines as TLR7 agonists
    Primmune Therapeutics, Inc.
    02/02/22
  312. 56
    Triazolopyridine inhibitors of myeloperoxidase
    Bristol-Myers Squibb Company
    02/02/22
  313. 78
    1-cyano-pyrrolidine derivatives as inhibitors of USP30
    MISSION THERAPEUTICS LIMITED
    01/30/22
  314. 4
    Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation
    UCB Biopharma SRL
    01/30/22
  315. 6
    Compounds, process for obtaining the compounds, pharmaceutical composition, use of the compounds and method for treating psychiatric disorders and/or sleep disorders
    ACHÉ LABORATÓRIOS FARMACÊUTICOS S.A.
    01/30/22
  316. 7
    Hydantoins that modulate BACE-mediated app processing
    BUCK INSTITUTE FOR RESEARCH ON AGING
    01/30/22
  317. 40
    Imidazo[1′,2′:1,6]pyrido[2,3-d]pyrimidine compound as protein kinase inhibitor
    SHENGKE PHARMACEUTICALS (JIANGSU) LTD.
    01/30/22
  318. 200
    Isoxazolyl ether derivatives as GABAA α5 PAM
    Hoffmann-La Roche Inc.
    01/30/22
  319. 63
    Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators
    ARDELYX, INC.
    01/30/22
  320. 113
    PI-kinase inhibitors with anti-infective activity
    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    01/30/22
  321. 46
    Protein kinase inhibitors, preparation method and medical use thereof
    Gan & Lee Pharmaceuticals
    01/30/22
  322. 70
    SHMT inhibitors and uses thereof
    RAZE THERAPEUTICS, INC.
    01/30/22
  323. 218
    Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
    MIRATI THERAPEUTICS, INC.
    01/30/22
  324. 270
    Tricyclic heterocycles as BET protein inhibitors
    Incyte Corporation
    01/30/22
  325. 20
    (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
    Centrexion Therapeutics Corporation
    01/24/22
  326. 27
    Cyanopyrrolidine derivatives with activity as inhibitors of USP30
    MISSION THERAPEUTICS LIMITED
    01/24/22
  327. 92
    N-((HET)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
    KalVista Pharmaceuticals Limited
    01/24/22
  328. 107
    Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    01/24/22
  329. 51
    Pyrazolopyrimidine derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating cancer, autoimmune disease and brain disease containing the same as an active ingredient
    KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    01/24/22
  330. 26
    Salts and processes of preparing a PI3K inhibitor
    Incyte Corporation
    01/24/22
  331. 51
    Substituted pyrrolo[2,1-f][1,2,4]triazines as kinase inhibitors
    Daewoong Pharmaceutical Co., Ltd.
    01/24/22
  332. 713
    2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
    IDEAYA BIOSCIENCES, INC.
    01/23/22
  333. 565
    Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
    Achillion Pharmaceuticals, Inc.
    01/23/22
  334. 33
    Benzofuran derivative, preparation method thereof and use thereof in medicine
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    01/23/22
  335. 6
    Ethynyl derivatives
    Hoffmann-La Roche Inc.
    01/23/22
  336. 70
    Heterocyclic compounds useful as dual ATX/CA inhibitors
    Hoffmann-La Roche Inc.
    01/23/22
  337. 28
    Imidazolyl tricyclic enones as antioxidant inflammation modulators
    REATA PHARMACEUTICALS, INC.
    01/23/22
  338. 122
    Imidazopiperazine inhibitors of transcription activating proteins
    Board of Regents, The University of Texas System
    01/23/22
  339. 9
    Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases
    Regents of the University of Colorado, a body corporate; Colorado Research Partners. LLC
    01/23/22
  340. 118
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research, Inc.
    01/23/22
  341. 21
    Isoquinoline-steroid conjugates and uses thereof
    Aerie Pharmaceuticals, Inc.
    01/23/22
  342. 84
    Methods to induce targeted protein degradation through bifunctional molecules
    DANA-FARBER CANCER INSTITUTE, INC.
    01/23/22
  343. 31
    Oxime ether compounds
    Bristol-Myers Squibb Company
    01/23/22
  344. 21
    Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof
    PHARMAKEA, INC.
    01/23/22
  345. 7
    ROR-gamma modulators and uses thereof
    PIRAMAL ENTERPRISES LIMITED
    01/23/22
  346. 12
    Substituted bicyclic compounds
    Bristol-Myers Squibb Company
    01/23/22
  347. 7
    Substituted cyanopyrrolidines with activity as DUB inhibitors
    MISSION THERAPEUTICS LIMITED
    01/23/22
  348. 158
    5-membered and bicyclic heterocyclic amides as inhibitors of rock
    Bristol-Myers Squibb Company
    01/16/22
  349. 17
    6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes
    SPRINT BIOSCIENCE AB
    01/16/22
  350. 14
    Amino-fluoropiperidine derivatives as kinase inhibitor
    Daewoong Pharmaceutical Co., Ltd.
    01/16/22
  351. 69
    Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof
    TBA
    01/16/22
  352. 39
    Dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and use thereof
    SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    01/16/22
  353. 201
    Ectonucleotidase inhibitors and methods of use thereof
    Calithera Biosciences, Inc.
    01/16/22
  354. 32
    Heteroaromatic compounds as Vanin inhibitors
    Boehringer Ingelheim International GmbH
    01/16/22
  355. 13
    Heteroaryl amides as inhibitors of protein aggregation
    UCB Biophama SRL
    01/16/22
  356. 51
    Heterocyclic derivatives as PI3K inhibitors
    Incyte Corporation
    01/16/22
  357. 17
    Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same
    Duquesne University of The Holy Spirit
    01/16/22
  358. 155
    Quinolone derivatives as fibroblast growth factor receptor inhibitors
    PRINCIPIA BIOPHARMA, INC.
    01/16/22
  359. 155
    ROR γ modulators
    Bristol-Myers Squibb Company
    01/16/22
  360. 3
    Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
    Yeda Research and Development Co. Ltd.
    01/16/22
  361. 42
    Selective inhibitors of protein arginine methlytransferase 5 (PRMT5)
    Prelude Therapeutics, Incorporated
    01/16/22
  362. 819
    Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists
    Nimbus Saturn, Inc.
    01/16/22
  363. 354
    Tetrahydroquinoline derivatives as P2X7 receptor antagonists
    RaQualia Pharma Inc.; Asahi Kasei Pharma Corporation
    01/16/22
  364. 60
    Triazolopyrazine
    TBA
    01/16/22
  365. 2
    Use of fused heteroaromatic pyrrolidones for treatment and prevention of diseases in animals
    Bayer Animal Health GmbH
    01/16/22
  366. 229
    COMPOUNDS
    Enterprise Therapeutics Ltd
    01/13/22
  367. 179
    Inhibitors of cysteine proteases and methods of use thereof
    Pardes Biosciences, Inc.
    01/13/22
  368. 116
    Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof
    PHARMAKEA, INC.
    01/09/22
  369. 29
    1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′]bipyridinyl-2′-ones
    Addex Pharmaceuticals S.A.; Janssen Pharmaceuticals, Inc.
    01/07/22
  370. 21
    Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with antiB7H3-antibodies
    BAYER PHARMA AKTIENGESELLSCHAFT
    01/07/22
  371. 101
    Bicyclic amide compounds and methods of use thereof
    Genentech, Inc.
    01/07/22
  372. 223
    Bicyclic sulfones and sulfoxides and methods of use thereof
    Genentech, Inc.
    01/07/22
  373. 215
    Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
    GALAPAGOS NV
    01/07/22
  374. 41
    Inhibitors of RIP1 kinase and methods of use thereof
    Genentech, Inc.
    01/07/22
  375. 13
    Pyrazole[1,5-a] pyrimidine derivatives as kinase JAK inhibitors
    Celon Pharma S.A.
    01/07/22
  376. 31
    Small molecule inhibitors of Galectin-3
    Bristol-Myers Squibb Company
    01/07/22
  377. 201
    Substituted 6-azabenzimidazole compounds
    Gilead Sciences, Inc.
    01/07/22
  378. 275
    Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Epics Therapeutics
    01/07/22
  379. 146
    2,2-difluorodioxolo A2A receptor antagonists
    Merck Sharp & Dohme Corp.
    12/28/21
  380. 19
    Androgen receptor modulating compounds
    ORION CORPORATION
    12/28/21
  381. 26
    Galactoside inhibitor of galectins
    GALECTO BIOTECH AB
    12/28/21
  382. 175
    Glycosidase inhibitors
    Asceneuron SA
    12/28/21
  383. 198
    Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same
    SK BIOPHARMACEUTICALS CO., LTD.
    12/28/21
  384. 48
    Sulfonamide compounds
    Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute
    12/28/21
  385. 45
    2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma
    DOMPÉ FARMACEUTICI S.P.A.
    12/27/21
  386. 729
    2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
    IDEAYA BIOSCIENCES, INC.
    12/27/21
  387. 5
    Alkylphenyl compounds
    Bristol-Myers Squibb Company
    12/27/21
  388. 127
    Aminopyrazine derivatives as PI3K-γ inhibitors
    Incyte Corporation
    12/27/21
  389. 26
    Azetidine derivative, preparation method therefor, and use thereof
    SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.
    12/27/21
  390. 148
    Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
    Board of Regents, The University of Texas System
    12/27/21
  391. 12
    Dihydropyrimidinyl benzazepine carboxamide compounds
    Hoffmann-La Roche Inc.
    12/27/21
  392. 39
    Fused heterocyclic derivatives, their preparation methods thereof and medical uses thereof
    Beijing Innocare Pharma Tech Co., Ltd
    12/27/21
  393. 198
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    12/27/21
  394. 436
    Heteroaryl-substituted triazoles as APJ receptor agonists
    AMGEN INC.
    12/27/21
  395. 36
    Hydroxamic acids comprising pyrazole moiety and uses thereof
    HAWAII BIOTECH, INC.
    12/27/21
  396. 70
    Indolinones compounds and their use in the treatment of fibrotic diseases
    RespiVert Limited
    12/27/21
  397. 202
    Inhibitor compounds
    Cancer Research Technology Limited
    12/27/21
  398. 35
    Piperazine substituted azapine derivatives and uses thereof
    ALAIRION, INC.
    12/27/21
  399. 27
    Piperazinyl norbenzomorphan compounds and methods for using the same
    BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    12/27/21
  400. 41
    Piperidines as covalent menin inhibitors
    THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    12/27/21
  401. 208
    Piperidinyl-3-(aryloxy)propanamides and propanoates
    Takeda Pharmaceutical Company Limited
    12/27/21
  402. 159
    Selective estrogen receptor down-regulators
    AstraZeneca AB
    12/27/21
  403. 8
    Substituted isoquionline derivatives as immunomudulators
    Bristol-Myers Squibb Company
    12/27/21
  404. 33
    Substituted piperidines for the treatment of cancer
    LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD
    12/27/21
  405. 1145
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    12/27/21
  406. 30
    Thiadiazole IRAK4 compounds
    Gilead Sciences, Inc.
    12/27/21
  407. 271
    1-cyano-pyrrolidine compounds as USP30 inhibitors
    Mission Therapeutics Limited
    12/23/21
  408. 964
    Cot modulators and methods of use thereof
    Gilead Sciences, Inc.
    12/23/21
  409. 57
    Aminopyrimidine five-membered heterocyclic compound, and intermediate, preparation method, pharmaceutical composition and application thereof
    GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
    12/20/21
  410. 211
    Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same
    SHIONOGI & CO., LTD.
    12/20/21
  411. 6
    Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
    Incyte Corporation
    12/20/21
  412. 15
    Small molecule inhibitors of the JAK family of kinases
    Janssen Pharmaceutica NV
    12/20/21
  413. 478
    3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
    MERCK SHARP & DOHME CORP.
    12/19/21
  414. 329
    Arylquinazolines
    MERCK PATENT GMBH
    12/19/21
  415. 55
    Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides
    ARVINAS OPERATIONS, INC.
    12/19/21
  416. 26
    Diacylglycerol acyl transferase 2 inhibitor
    Pfizer Inc.
    12/19/21
  417. 102
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    12/19/21
  418. 13
    Substituted 6,11-dihydro-5H-benzo[B]carbazoles as inhibitors of ALK and SRPK
    DANA-FARBER CANCER INSTITUTE, INC.
    12/19/21
  419. 987
    Benzimidazole-proline derivatives
    IDORSIA PHARMACEUTICALS LTD
    12/14/21
  420. 135
    Metalloenzyme inhibitor compounds
    PHASEBIO PHARMACEUTICALS, INC.
    12/14/21
  421. 10
    Methods of identifying SENP1 inhibitors
    CITY OF HOPE
    12/14/21
  422. 17
    Pyridine derivative as ASK1 inhibitor and preparation method and use thereof
    TBA
    12/14/21
  423. 11
    Quinazoline compound for EGFR inhibition
    MEDSHINE DISCOVERY INC.
    12/14/21
  424. 32
    Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
    Principia Biopharma Inc.
    12/14/21
  425. 4
    Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR
    Blueprint Medicines Corporation
    12/14/21
  426. 11
    TYK2 inhibitors, uses, and methods for production thereof
    Nimbus Lakshmi, Inc.
    12/14/21
  427. 42
    VMAT2 inhibitor compounds and compositions thereof
    Neurocrine Biosciences, Inc.
    12/14/21
  428. 146
    Ectonucleotidase inhibitors and methods of use thereof
    Calithera Biosciences, Inc.
    12/06/21
  429. 11
    Farnesoid X receptor modulators
    Intercept Pharmaceuticals, Inc.
    12/06/21
  430. 5
    Methods to determine KDM1A target engagement and chemoprobes useful therefor
    Oryzon Genomics S.A.
    12/06/21
  431. 99
    Apoptosis signal-regulating kinase inhibitors and uses thereof
    SICHUAN HAISCO PHARMACEUTICAL CO., LTD.
    12/05/21
  432. 100
    Carboxamide-pyrimidine derivatives as SHP2 antagonists
    Merck Patent GmbH
    12/05/21
  433. 551
    Compounds of formulas (VII), (VIII), (IX), (XI), (XII), (XIII), and (XIV) as muscarinic receptor 4(M4) antagonists for treating neurological diseases
    Neurocrine Biosciences, Inc.
    12/05/21
  434. 16
    Diacylglycerol acyl transferase 2 inhibitors
    Pfizer Inc.
    12/05/21
  435. 17
    Ethynyl derivatives
    Hoffmann-La Roche Inc.
    12/05/21
  436. 52
    Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors
    Nikang Therapeutics, Inc.
    12/05/21
  437. 390
    Naphthyridines as inhibitors of HPK1
    Genentech, Inc.
    12/05/21
  438. 53
    Poly-ADP ribose polymerase (PARP) inhibitors
    Mitobridge, Inc.
    12/05/21
  439. 94
    Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators
    Genentech, Inc.
    12/05/21
  440. 65
    Pyridinyl pyrazoles as modulators of RORγT
    Janssen Pharmaceutica NV
    12/05/21
  441. 366
    Sphinogosine-1 -phosphate receptor modulators for treatment of cardiopulmonary disorders
    THE SCRIPPS RESEARCH INSTITUTE
    12/05/21
  442. 67
    Substituted N′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase IDO inhibitors
    Merck Sharp & Dohme Corp.
    12/05/21
  443. 825
    Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists
    Nimbus Saturn, Inc.
    12/05/21
  444. 35
    1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitors
    Merck Patent GmbH
    11/29/21
  445. 166
    1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
    Amgen Inc.
    11/29/21
  446. 192
    1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
    H. Lundbeck A/S
    11/29/21
  447. 3
    3-oxa-8-azabicyclo[3.2.1]octane derivatives and their use in the treatment of cancer and hemoglobinopathies
    CTXT PTY LTD
    11/29/21
  448. 205
    4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors
    ARRAY BIOPHARMA INC.; CELGENE CORPORATION
    11/29/21
  449. 35
    Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
    Bristol-Myers Squibb Company
    11/29/21
  450. 6
    Cyclic dinucleotides as sting agonists
    Janssen Biotech, Inc.
    11/29/21
  451. 145
    Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases
    Board of Regents, The University of Texas System
    11/29/21
  452. 134
    Heteroaryl inhibitors of PAD4
    Padlock Therapeutics, Inc.
    11/29/21
  453. 7
    Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer
    Oblique Therapeutics AB
    11/29/21
  454. 12
    Heterocyclic compounds as adenosine antagonists
    NUVATION BIO INC.
    11/29/21
  455. 23
    Indolizine derivatives and their application in medicine
    KIND PHARMACEUTICAL
    11/29/21
  456. 97
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research, Inc.
    11/29/21
  457. 131
    Phosphatidylinositol 3-kinase inhibitors
    Gilead Sciences, Inc.
    11/29/21
  458. 34
    Piperidinyl-propanone derivatives
    Merck Patent GmbH
    11/29/21
  459. 18
    Second generation GRP94-selective inhibitors
    University of Kansas
    11/29/21
  460. 36
    Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors
    Merck Sharp & Dohme Corp.
    11/29/21
  461. 812
    Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists
    Nimbus Saturn, Inc.
    11/29/21
  462. 823
    Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as hpk1 antagonists
    Nimbus Saturn, Inc.
    11/29/21
  463. 60
    Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors
    Merck Sharp & Dohme Corp.
    11/29/21
  464. 36
    Substituted pyrimidines as LRKK2 inhibitors
    DENALI THERAPEUTICS INC.
    11/29/21
  465. 7
    Tetrahydroquinoline-based bromodomain inhibitors
    St. Jude Children''s Research Hospital
    11/29/21
  466. 90
    Therapeutic compounds and methods of use thereof
    Genentech, Inc.
    11/29/21
  467. 145
    Therapeutic inhibitory compounds
    ATTUNE PHARMACEUTICALS, INC.
    11/29/21
  468. 207
    Therapeutically active compounds and their methods of use
    Agios Pharmaceuticals, Inc.
    11/29/21
  469. 76
    Tricyclic heterocyclic derivatives and uses thereof
    AUCKLAND UNISERVICES LIMITED
    11/29/21
  470. 42
    Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
    MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.
    11/29/21
  471. 491
    [1,2,4]Triazolo[4,3-a]quinoxaline derivative, method for preparing same, and pharmaceutical composition for preventing or treating BET protein-related diseases, containing same as active ingredient
    Dong Wha Pharm. Co., Ltd.; Korea Research Institute of Chemical Technology
    11/29/21
  472. 299
    Amino-pyrrolopyrimidinone compounds and methods of use thereof
    ArQule, Inc.
    11/28/21
  473. 169
    Biaryloxy derivatives as TTX-S blockers
    RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.
    11/28/21
  474. 150
    Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof
    WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.
    11/28/21
  475. 44
    Compounds and their use for reducing uric acid levels
    Acquist LLC
    11/28/21
  476. 115
    Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
    AMGEN INC.
    11/28/21
  477. 396
    Therapeutic compounds
    CELGENE QUANTICEL RESEARCH, INC.
    11/28/21
  478. 27
    Type of aryl benzofuran amidated derivative and medical use thereof
    CHINA PHARMACEUTICAL UNIVERSITY
    11/28/21
  479. 36
    2,6-disubstituted pyridine derivative
    SUMITOMO DAINIPPON PHARMA CO., LTD.
    11/22/21
  480. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte Corporation
    11/22/21
  481. 569
    CDK2 inhibitors
    Pfizer Inc.
    11/22/21
  482. 68
    Cyanopyrrolidine derivatives with activity as inhibitors of USP30
    MISSION THERAPEUTICS LIMITED
    11/22/21
  483. 35
    Factor XIIa inhibitors
    Merck Sharp & Dohme Corp.
    11/22/21
  484. 78
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    11/22/21
  485. 72
    Heteroaromatic compounds and their use as dopamine D1 ligands
    Pfizer Inc.
    11/22/21
  486. 9
    LSD1 inhibitors and medical uses thereof
    Constellation Pharmaceuticals, Inc.
    11/22/21
  487. 126
    Pyrazolopyrimidine compounds and uses thereof
    Incyte Corporation
    11/22/21
  488. 800
    Pyridazinones as PARP7 inhibitors
    Ribon Therapeutics, Inc.
    11/22/21
  489. 30
    Pyrrolo-, pyrazolo-, imidazo-pyrimidine and pyridine compounds that inhibit MNK1 and MNK2
    eFFECTOR Therapeutics, Inc.
    11/22/21
  490. 79
    Triazolopyrimidine, triazolopyridine compounds, and the composition thereof for treating PRC2-mediated diseases
    SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.
    11/22/21
  491. 202
    Trifluoromethylpropanamide derivatives as HTRA1 inhibitors
    Hoffmann-La Roche Inc.
    11/22/21
  492. 25
    C5-C6-oxacyclic fused iminothiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme Corp.
    11/15/21
  493. 155
    Compounds and methods for modulating interleukin-2-inducible t-cell kinase
    Corvus Pharmaceuticals, Inc.
    11/15/21
  494. 8
    Compounds useful for inhibiting RORγt
    Eli Lilly and Company
    11/15/21
  495. 8
    Cycloalkyl-diamines for the treatment of pain
    MediSynergics, LLC
    11/14/21
  496. 21
    Piperidinone formyl peptide 2 receptor agonists
    Bristol-Myers Squibb Company
    11/14/21
  497. 359
    Pyridazine derivatives as RORc modulators
    Genentech, Inc.
    11/14/21
  498. 420
    Quinazolinones as PARP14 inhibitors
    Ribon Therapeutics Inc.
    11/14/21
  499. 85
    Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    11/14/21
  500. 15
    1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
    ASTRAZENECA AB
    11/08/21
  501. 8
    7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
    Eli Lilly and Company
    11/08/21
  502. 88
    Alkyl pyrrolopyrimidine analogs and methods of making and using same
    The University of North Carolina at Chapel Hill
    11/08/21
  503. 6
    Aminopyrimidinecarboxamides as CXCR2 modulators
    Syntrix Biosystems Inc.
    11/08/21
  504. 899
    Benzolactam compounds as protein kinase inhibitors
    OTSUKA PHARMACEUTICAL CO., LTD.
    11/08/21
  505. 11
    Compound useful for the treatment of degenerative and inflammatory diseases
    GALAPAGOS NV
    11/08/21
  506. 59
    Compounds and their uses as ACC inhibitors
    Nanjing Ruijie Pharmatech Co., Ltd.
    11/08/21
  507. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
    Shy Therapeutics LLC
    11/08/21
  508. 22
    Difluoroketamide derivatives as HTRA1 inhibitors
    Hoffman-La Roche Inc.
    11/08/21
  509. 16
    Dihydropyrrolopyridine inhibitors of ROR-gamma
    Vitae Pharmaceuticals, LLC
    11/08/21
  510. 13
    Disubstituted compounds for treatment of medical disorders
    Achillion Pharmaceuticals, Inc.
    11/08/21
  511. 44
    Histone demethylase inhibitors
    CELGENE QUANTICEL RESEARCH, INC.
    11/08/21
  512. 92
    N-((HET)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
    KALVISTA PHARMACEUTICALS LIMITED
    11/08/21
  513. 51
    Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors
    ASTRAZENECA AB
    11/08/21
  514. 13
    Pyrimidine compounds and pyrimido indole compounds and methods of use
    Duquesne University of The Holy Spirit
    11/08/21
  515. 10
    Pyrimidine derivative, method for preparing same and use thereof in medicine
    TBA
    11/08/21
  516. 136
    Pyrimidinone derivatives as SHP2 antagonists
    Merck Patent GmbH
    11/08/21
  517. 81
    SSAO inhibitor
    TBA
    11/08/21
  518. 15
    Acetyl-CoA carboxylase modulators
    Monsanto Technology LLC
    11/04/21
  519. 108
    EGFR proteolysis targeting chimeric molecules and associated methods of use
    ARVINAS OPERATIONS, INC.; YALE UNIVERSITY
    11/04/21
  520. 57
    Inhibitors of protease-activated receptor-2
    Heptares Therapeutics Limited
    11/04/21
  521. 162
    Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
    THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
    11/04/21
  522. 218
    PARG inhibitory compounds
    Cancer Research Technology Limited
    11/04/21
  523. 116
    Pyrrolidine derivative
    KISSEI PHARMACEUTICAL CO., LTD.
    11/04/21
  524. 19
    Substituted dihydrobenzofuran glycosidase inhibitors
    Asceneuron SA
    11/04/21
  525. 92
    Zaindole derivatives and their use as ERK kinase inhibitors
    AGV DISCOVERY; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE MONTPELLIER
    11/04/21
  526. 53
    1,2,4-triazine-4-amine derivatives
    Heptares Therapeutics Limited
    11/01/21
  527. 32
    Alpha-D-galactoside inhibitors of galectins
    GALECTO BIOTECH AB
    11/01/21
  528. 70
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    11/01/21
  529. 77
    Bicyclic lactams and methods of use thereof
    Genentech, Inc.
    11/01/21
  530. 136
    Compounds
    AstraZeneca AB
    11/01/21
  531. 99
    IRAK4 inhibitor and use thereof
    BEIJING HANMI PHARMACEUTICAL CO., LTD.
    11/01/21
  532. 2
    Immunomodulators
    bristol-myers squibb company
    11/01/21
  533. 23
    Inhibitors of influenza virus replication and uses thereof
    SUNSHINE LAKE PHARMA CO., LTD.
    11/01/21
  534. 440
    MCL-1 inhibitors
    Gilead Sciences, Inc.
    11/01/21
  535. 20
    Potent and selective mu opioid receptor modulators
    Virginia Commonwealth University
    11/01/21
  536. 37
    Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof
    Japan Tobacco Inc.
    11/01/21
  537. 532
    Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
    Genentech, Inc.
    11/01/21
  538. 55
    Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
    Pfizer Inc.
    11/01/21
  539. 204
    Substituted n′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
    Merck Sharp & Dohme Corp.
    11/01/21
  540. 140
    Substituted pyrimidines as cyclin-dependent kinase inhibitors
    SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
    11/01/21
  541. 229
    Heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
    Daewoong Pharmaceutical Co., Ltd.
    10/27/21
  542. 25
    Substituted pyrazolopyrimidinone compounds as PDE2 inhibitors
    DART NEUROSCIENCE, LLC
    10/27/21
  543. 1
    Substituted thiohydantoin derivatives as androgen receptor antagonists
    Janssen Pharmaceutica NV
    10/27/21
  544. 11
    Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
    Bristol-Myers Squibb Companay
    10/27/21
  545. 61
    1,3,4-thiadiazole compounds and their use in treating cancer
    Cancer Research Technology Limited
    10/26/21
  546. 18
    6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
    Purdue Research Foundation
    10/26/21
  547. 113
    Aminopyrimidinyl compounds
    Pfizer Inc.
    10/26/21
  548. 25
    Benzothiophene estrogen receptor modulators
    G1 Therapeutics, Inc.
    10/26/21
  549. 236
    Biaryl kinase inhibitors
    Bristol-Myers Squibb Company
    10/26/21
  550. 19
    Compound for inhibiting IDO, a manufacturing method and a use thereof
    Shanghai JOYU Pharmatech Ltd.
    10/26/21
  551. 8
    FXR (NR1H4) modulating compounds
    Gilead Sciences, Inc.
    10/26/21
  552. 49
    Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    10/26/21
  553. 210
    Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
    Janssen Pharmaceutica NV
    10/26/21
  554. 22
    Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase
    BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    10/26/21
  555. 5
    Inhibitors of soluble adenylyl cyclase
    Cornell University; Tri-Institutional Therapeutics Discovery Institute
    10/26/21
  556. 85
    Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
    ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED
    10/26/21
  557. 329
    PRMT5 inhibitors and uses thereof
    Epizyme, Inc.
    10/26/21
  558. 51
    Substituted pyrrolopyridine JAK inhibitors and methods of making and using the same
    ACLARIS THERAPEUTICS, INC.
    10/26/21
  559. 30
    Therapeutic inhibitory compounds
    ATTUNE PHARMACEUTICALS, INC.
    10/26/21
  560. 164
    Thioether triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase
    Bristol-Myers Squibb Company
    10/26/21
  561. 95
    Urea-substituted aromatic ring-linked dioxane-quinazoline and -linked dioxane-quinoline compounds, preparation method therefor and use thereof
    BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
    10/26/21
  562. 135
    4-aminoquinazolinyl compounds as prolyl hydroxylase inhibitors
    TBA
    10/20/21
  563. 92
    6-aminopyridin-3-yl pyrazoles as modulators of RORgT
    Janssen Pharmaceutica NV
    10/20/21
  564. 440
    6-aminopyridin-3-yl thiazoles as modulators of RORγT
    Janssen Pharmaceutica NV
    10/20/21
  565. 25
    Bis-heteroaryl derivatives as modulators of protein aggregation
    UCB Biopharma SRL
    10/20/21
  566. 71
    Compounds and compositions for inhibiting the activity of SHP2
    NOVARTIS AG
    10/20/21
  567. 28
    Grp94 selective inhibitors and uses thereof
    University of Kansas; University of South Florida
    10/20/21
  568. 134
    Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
    Merck Patent GmbH
    10/20/21
  569. 4
    Imidazolyl kinase inhibitors and uses thereof
    Dana-Farber Cancer Institute, Inc.
    10/20/21
  570. 185
    KDM5 inhibitors
    Merck Sharp & Dohme Corp.
    10/20/21
  571. 22
    Nicotinyl alcohol ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
    Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD
    10/20/21
  572. 146
    Pharmaceutical compounds
    SENTINEL ONCOLOGY LIMITED
    10/20/21
  573. 225
    Phenyl substituted pyrazoles as modulators of RORγt
    Janssen Pharmaceutica NV
    10/20/21
  574. 150
    Pyridine derivative
    Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.
    10/20/21
  575. 27
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals, Inc.
    10/20/21
  576. 16
    Substituted fused pyrazole compounds and their use as LRRK2 inhibitors
    GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    10/20/21
  577. 644
    Substituted pyridines as inhibitors of DNMT1
    GlaxoSmithKline Intellectual Property Development Limited; Cancer Research Technology Ltd.
    10/20/21
  578. 297
    4,5-annulated 1,2,4-triazolones
    BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION
    10/09/21
  579. 34
    Alpha-truxillic acid derivatives and pharmaceutical compositions thereof
    The Research Foundation for the State University of New York
    10/09/21
  580. 114
    Benzothiazol compounds and methods using the same for treating neurodegenerative disorders
    1st Biotherapeutics, Inc.
    10/09/21
  581. 35
    Biaryltriazole inhibitors of macrophage migration inhibitory factor
    Yale University
    10/09/21
  582. 29
    Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    10/09/21
  583. 35
    Cyclopentane-based modulators of STING (stimulator of interferon genes)
    Pfizer Inc.
    10/09/21
  584. 107
    Cyclopropanamine compound and use thereof
    Takeda Pharmaceutical Company Limited
    10/09/21
  585. 155
    Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors
    Proximagen, LLC
    10/09/21
  586. 45
    Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    10/09/21
  587. 13
    Macrocyclic compounds as ROS1 kinase inhibitors
    Array BioPharma Inc.
    10/09/21
  588. 189
    Pyrido five-element aromatic ring compound, preparation method therefor and use thereof
    SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    10/09/21
  589. 273
    Pyrrolo[2,3-d]pyrimidine derivatives
    Pfizer Inc.
    10/09/21
  590. 13
    Substituted [1,2,4]triazolo[1,5-a]pyrazines as LSD1 inhibitors
    Incyte Corporation
    10/09/21
  591. 22
    Synergistic combination of immunologic inhibitors for the treatment of cancer
    The University of Chicago
    10/09/21
  592. 91
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    10/09/21
  593. 23
    Therapeutic compounds and uses thereof
    Kala Pharmaceuticals, Inc.
    10/09/21
  594. 90
    USP30 inhibitors
    Mitobridge, Inc.
    10/09/21
  595. 63
    (S)-2-(1-cyclopropylethyl)-5-(4-methyl-2-((6-(2-oxopyrrolidin-1-yl)pyridin-2-yl)amino) thiazol-5-yl)-7-(methylsulfonyl)isoindolin-1-one as a phosphatidylinositol 3-kinase inhibitor
    AstraZeneca AB
    10/04/21
  596. 66
    Chemical compounds
    AstraZeneca AB
    10/04/21
  597. 80
    Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
    LegoChem Biosciences, Inc.
    10/04/21
  598. 66
    Farnesoid X receptor agonists and uses thereof
    METACRINE, INC.
    10/04/21
  599. 145
    Inhibiting agents for Bruton's tyrosine kinase
    BIOGEN MA INC.
    10/04/21
  600. 66
    JAK1 selective inhibitors
    ASTRAZENECA AB
    10/04/21
  601. 21
    Modulators of the sigma-2 receptor and their method of use
    TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    10/04/21
  602. 45
    Oxazole derivatives for use in the treatment of cancer
    LIFEARC
    10/04/21
  603. 3
    PRMT5 inhibitors
    CTXT PTY LTD
    10/04/21
  604. 180
    Pyrazolopyrimidine derivatives as kinase inhibitor
    Daewoong Pharmaceutical Co., Ltd.
    10/04/21
  605. 34
    Quinazoline and indole compounds to treat medical disorders
    Achillion Pharmaceuticals, Inc.
    10/04/21
  606. 512
    Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; VANDERBILT UNIVERSITY; THE UAB RESEARCH FOUNDATION; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    10/04/21
  607. 568
    Substituted pyrazines as ATR kinase inhibitors
    VERTEX PHARMACEUTICALS INCORPORATED
    10/04/21
  608. 119
    Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas
    CELGENE QUANTICEL RESEARCH, INC.
    10/04/21
  609. 145
    1 H-pyrazol-1-yl-thiazoles as inhibitors of lactate dehydrogenase and methods of use thereof
    THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; THE UAB RESEARCH FOUNDATION; VANDERBILT UNIVERSITY; NATIONAL INSTITUTES OF HEALTH, UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES
    09/28/21
  610. 75
    1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one derivative as Wee1 inhibitor
    SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.
    09/28/21
  611. 27
    Azaindoles as inhibitors of HPK1
    Genentech, Inc.
    09/28/21
  612. 90
    BMP-signal-inhibiting compound
    RIKEN; THE UNIVERSITY OF TOKYO
    09/28/21
  613. 11
    Compounds and uses thereof
    Kala Pharmaceuticals, Inc.
    09/28/21
  614. 60
    Compounds inhibiting leucine-rich repeat kinase enzyme activity
    Merck Sharp & Dohme Corp.
    09/28/21
  615. 108
    Heterocyclic compounds as ret kinase inhibitors
    Cancer Research Technology Limited
    09/28/21
  616. 239
    Heterocyclic compounds for the inhibition of pask
    BioEnergenix LLC
    09/28/21
  617. 19
    JAK inhibitors containing a 4-membered heterocyclic amide
    Theravance Biopharma R&D IP, LLC
    09/28/21
  618. 261
    Methods for treating ulcerative colitis using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
    Theravance Biopharma R&D IP, LLC
    09/28/21
  619. 97
    Methods of treating intraocular pressure with activators of Tie-2
    AERPIO PHARMACEUTICALS, INC.
    09/28/21
  620. 444
    Pyrazole derivatives as MALT1 inhibitors
    Janssen Pharmaceutica NV
    09/28/21
  621. 15
    Selective NR2B antagonists
    Bristol-Myers Squibb Company
    09/28/21
  622. 43
    Sigma receptor binders
    BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    09/28/21
  623. 22
    Substituted heterocyclic inhibitors of PTPN11
    NAVIRE PHARMA, INC.
    09/28/21
  624. 134
    Substituted indole Mcl-1 inhibitors
    Vanderbilt University
    09/28/21
  625. 556
    Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors
    Array Biopharma Inc.
    09/28/21
  626. 88
    1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
    ST. JUDE CHILDREN''S RSEARCH HOSPITAL
    09/26/21
  627. 87
    Aminopyridine derivatives and their use as selective ALK-2 inhibitors
    NOVARTIS AG
    09/26/21
  628. 4
    Beta adrenergic agonist and methods of using the same
    CuraSen Therapeutics, Inc.
    09/26/21
  629. 54
    Bicyclic heterocycles as FGFR inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    09/26/21
  630. 23
    Bicyclic pyridone lactams and methods of use thereof
    Genentech, Inc.
    09/26/21
  631. 3
    Combinations comprising a pyrrolidine-2,5-dione IDO1 inhibitor and an anti-body
    Pfizer Inc.; iTEOS THERAPEUTICS
    09/26/21
  632. 12
    Dimethyl amino azetidine amides as JAK inhibitors
    Theravance Biopharma R&D IP, LLC
    09/26/21
  633. 79
    Heteroaryl SYK inhibitors
    Boehringer Ingelheim International GmbH
    09/26/21
  634. 449
    Heteroaryl compounds and their use as therapeutic drugs
    Dong-A Socio Holdings Co., Ltd.
    09/26/21
  635. 72
    Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
    Merck Sharp & Dohme Corp.
    09/26/21
  636. 135
    Inhibitors of Hepatitis C virus polymerase
    COCRYSTAL PHARMA, INC.
    09/26/21
  637. 547
    Inhibitors of KEAP1-Nrf2 protein-protein interaction
    Janssen Pharmaceutica NV
    09/26/21
  638. 33
    Nurr1:RXR activating compounds for simultaneous treatment of symptoms and pathology of Parkinson's disease
    TBA
    09/26/21
  639. 12
    PRMT5 inhibitors
    Merck Sharp & Dohme Corp.
    09/26/21
  640. 26
    Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same
    Seoul National University Hospital
    09/26/21
  641. 18
    Substituted oxazines as beta-secretase inhibitors
    Amgen Inc.
    09/26/21
  642. 11
    Tank-binding kinase-1 PROTACs and associated methods of use
    ARVINAS OPERATIONS, INC.
    09/26/21
  643. 38
    Therapeutic compounds and methods of use thereof
    GENENTECH, INC.
    09/26/21
  644. 391
    Therapeutically active compounds and their methods of use
    Agios Pharmaceuticals, Inc.
    09/26/21
  645. 6
    Treatment and diagnosis of melanoma
    The Rockefeller University
    09/26/21
  646. 1
    [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compound
    Janssen Pharmaceutica NV
    09/26/21
  647. 26
    Benzyl phenyl ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
    Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD
    09/20/21
  648. 499
    Bromodomain inhibitors
    Celgene Quanticel Research, Inc.
    09/20/21
  649. 29
    Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
    Ogeda SA
    09/20/21
  650. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
    Shy Therapeutics LLC
    09/20/21
  651. 8
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals, Inc.
    09/20/21
  652. 72
    Kinase inhibitors
    Oxular Acquisitions Limited
    09/20/21
  653. 31
    Methods for inhibiting fascin
    NOVITA PHARMACEUTICALS, INC.; CORNELL UNIVERSITY
    09/20/21
  654. 88
    Quinoline and isoquinoline derivatives for treating pain and pain related conditions
    ESTEVE PHARMACEUTICALS, S.A.
    09/20/21
  655. 131
    4-imidazopyridazin-1-yl-benzamides as Btk inhibitors
    Merck Sharp & Dohme B.V.
    09/12/21
  656. 143
    5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof
    Samumed, LLC
    09/12/21
  657. 28
    Aryl ethene derivative and pharmaceutical composition containing same as active ingredient
    DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION; KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL; KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    09/12/21
  658. 214
    Bruton's tyrosine kinase inhibitors
    Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.
    09/12/21
  659. 61
    Compounds and compositions for inhibiting the activity of SHP2
    NOVARTIS AG
    09/12/21
  660. 472
    Inhibitors of Bruton's tyrosine kinase and method of their use
    Janssen Pharmaceutica NV
    09/12/21
  661. 236
    Pyrazolopyridine compounds and uses thereof
    Incyte Corporation
    09/12/21
  662. 32
    SHMT inhibitors
    The Trustees of Princeton University
    09/12/21
  663. 288
    SHP2 phosphatase inhibitors and methods of use thereof
    Relay Therapeutics, Inc.
    09/12/21
  664. 87
    Spirocyclic compounds
    Recurium IP Holdings, LLC
    09/12/21
  665. 60
    Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors
    Merck Sharp & Dohme Corp.
    09/12/21
  666. 44
    Benzothiazole derivatives as DYRK1 inhibitors
    PHARMASUM THERAPEUTICS AS
    09/06/21
  667. 45
    CDK inhibitors
    GI Therapeutics, Inc.
    09/06/21
  668. 31
    Cyano-subtituted heterocycles with activity as inhibitors of USP30
    MISSION THERAPEUTICS LIMITED
    09/06/21
  669. 48
    HSP90B N-terminal isoform-selective inhibitors
    University of Kansas
    09/06/21
  670. 62
    Inhibitors of RAF kinases
    KINNATE BIOPHARMA INC.
    09/06/21
  671. 69
    Intermediate compound of novel tetrahydronaphthyl urea derivative
    MOCHIDA PHARMACEUTICAL CO., LTD.
    09/06/21
  672. 35
    Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto
    Arena Pharmaceuticals, Inc.
    09/06/21
  673. 112
    Oxadiazaspiro compounds for the treatment of drug abuse and addiction
    ESTEVE PHARMACEUTICALS. S.A.
    09/06/21
  674. 248
    Pyrazole MAGL inhibitors
    LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    09/06/21
  675. 48
    Substituted sulfoximine compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
    Merck Sharp & Dohme Corp.
    09/06/21
  676. 7
    Treatment of conditions associated with hyperinsulinaemia
    Tensha Therapeutics, Inc.
    09/06/21
  677. 26
    Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
    The USA, as represented by the Secretary, Department of Health and Human Services; SRI International
    09/06/21
  678. 8
    Amide compounds for treatment of immune and inflammatory disorders
    Achillion Pharmaceuticals, Inc.
    09/02/21
  679. 18
    Azetidine derivatives
    Vernalis (R&D) Ltd.
    09/02/21
  680. 56
    Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
    Boehringer Ingelheim International GmbH
    09/02/21
  681. 9
    Cannabidiol derivatives as inhibitors of the HIF prolyl hydroxylases activity
    Emerald Health Pharmaceuticals Inc.
    09/02/21
  682. 463
    Compounds and uses thereof
    Yumanity Therapeutics, Inc.
    09/02/21
  683. 18
    Cyclohexene compounds and use thereof
    GUANGZHOU HENOVCOM BIOSCIENCE CO. LTD.
    09/02/21
  684. 6
    Fused imidazoles as mIDH1 inhibitors
    BAYER PHARMA AKTIENGESELLSCHAFT
    09/02/21
  685. 23
    Hetero-halo inhibitors of histone deacetylase
    Alkermes, Inc.
    09/02/21
  686. 3
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals, Inc.
    09/02/21
  687. 5
    Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
    Incyte Holdings Corporation; Incyte Corporation
    09/02/21
  688. 12
    Imidazopyrazine compounds, preparation methods and uses thereof
    DONGGUAN ZHENXING-BEITE MEDICINE TECHNOLOGY CO., LTD.
    09/02/21
  689. 407
    Immunomodulator compounds
    ChemoCentryx, Inc.
    09/02/21
  690. 68
    N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors
    Nerviano Medical Sciences S.R.L.
    09/02/21
  691. 1
    Salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
    GALAPAGOS NV
    09/02/21
  692. 56
    Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors
    Boehringer Ingelheim International GmbH
    09/02/21
  693. 51
    Substituted tricyclic heterocyclic compounds and use thereof
    LIFEARC; SUZHOU YABAO PHARMACEUTICAL R&D CO., LTD.
    09/02/21
  694. 49
    Thiazole derivative and applications
    EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    09/02/21
  695. 70
    Thioacetate compounds, compositions and methods of use
    Ardea Biosciences, Inc
    09/02/21
  696. 37
    Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
    Bristol-Myers Squibb Company
    09/02/21
  697. 80
    Tricyclic ASK1 inhibitors
    TERNS, INC.
    09/02/21
  698. 99
    Benzene disulfonamide for the treatment of cancer
    Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V
    08/30/21
  699. 14
    Bis-heteroaryl derivatives as modulators of protein aggregation
    UCB Biopharma SRL
    08/30/21
  700. 107
    Combinations comprising substituted imidazo[1,5-a]pyrazinones as PDE1 inhibitors
    H. Lundbeck A/S
    08/30/21
  701. 16
    JAK kinase inhibitor compounds for treatment of respiratory disease
    Theravance Biopharma R&D IP, LLC
    08/30/21
  702. 20
    LRRK2 inhibitors and methods of making and using the same
    DANA-FARBER CANCER INSTITUTE, INC.
    08/30/21
  703. 47
    Octahydro-pyrrolo[3,4-c]-pyrrole derivatives and analogs thereof as autotaxin inhibitors
    Hoffmann-La Roche Inc.
    08/30/21
  704. 110
    Oxadiazolones as transient receptor potential channel inhibitors
    Genentech, Inc.
    08/30/21
  705. 59
    Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    08/30/21
  706. 67
    Pyrimidine FGFR4 inhibitors
    EISAI R&D MANAGEMENT CO., LTD.
    08/30/21
  707. 111
    Substituted 4-phenylpiperidines, their preparation and use
    The Trustees of Columbia University in the City of New York
    08/30/21
  708. 50
    Substituted piperidines thiazolyl acetamides as glycosidase inhibitors and uses thereof
    Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.
    08/30/21
  709. 219
    Thienopyridine carboxamides as ubiquitin-specific protease inhibitors
    VALO EARLY DISCOVERY, INC.
    08/30/21
  710. 111
    Combinations comprising substituted imidazo[1,5-α]pyrazinones as PDE1 inhibitors
    H. Lundbeck A/S
    08/22/21
  711. 42
    Compositions and methods for inhibiting kinases
    Inhibikase Therapeutics, Inc.
    08/22/21
  712. 14
    Compounds for using in imaging and particularly for the diagnosis of neurodegenerative diseases
    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE D''ORLEANS; UNIVERSITE DE TOURS; CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    08/22/21
  713. 52
    Five-membered heteroaryl ring bridged ring derivative, preparation method therefor and medical use thereof
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    08/22/21
  714. 65
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    08/22/21
  715. 7
    Kinase inhibitors for the treatment of disease
    DANA FARBER CANCER INSTITUTE, INC.
    08/22/21
  716. 198
    Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
    Pfizer Inc.
    08/22/21
  717. 20
    Substituted piperazines as ROR-gamma modulators
    ESCALIER BIOSCIENCES B.V.
    08/22/21
  718. 370
    Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
    LEO Pharma A/S
    08/22/21
  719. 103
    Triazole phenyl compounds as agonists of the APJ receptor
    AMGEN INC.
    08/22/21
  720. 34
    IRAK4 modulators
    Genentech, Inc.
    08/16/21
  721. 71
    IRAK4 modulators
    Genentech, Inc.
    08/16/21
  722. 4
    3,4-bipyridyl pyrazole derivative, and preparation method therefor and medical application thereof
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    08/15/21
  723. 32
    Benzothiazole compounds and uses thereof
    Incyte Corporation
    08/15/21
  724. 33
    Imidazo isoindole derivative, preparation method therefor and medical use thereof
    JIANGSU HENGRUI MEDICINE CO., LTD.; SHANGHAI HENGRUI PHRMACEUTICAL CO., LTD.
    08/15/21
  725. 124
    Imidazopiperazinone inhibitors of transcription activating proteins
    Board of Regents, The University of Texas System
    08/15/21
  726. 110
    Inhibiting agents for Bruton's tyrosine kinase
    BIOGEN MA INC.
    08/15/21
  727. 427
    PD-1/PD-L1 inhibitors
    Gilead Sciences, Inc.
    08/15/21
  728. 23
    Phosphodiesterase inhibitors and uses thereof
    The Trustees of Columbia University in the City of New York
    08/15/21
  729. 378
    Piperidines as menin inhibitors
    THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    08/15/21
  730. 38
    Pyrazine compounds and uses thereof
    TBA
    08/15/21
  731. 49
    Antitumor drug for intermittent administration of FGFR inhibitor
    Taiho Pharmaceutical Co., Ltd.
    08/14/21
  732. 51
    Fused tricyclic ring derivatives as SRC homology-2 phosphatase inhibitors
    Nikang Therapeutics, Inc.
    08/14/21
  733. 165
    Halo-substituted piperidines as orexin receptor modulators
    ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
    08/14/21
  734. 648
    Heteroarylbenzimidazole compounds
    BAYER PHARMA AKTIENGESELLSCHAFT
    08/14/21
  735. 35
    Heterocyclic inhibitors of ATR kinase
    Board of Regents, The University of Texas System; ChemPartner Corporation
    08/14/21
  736. 19
    Indolizine derivatives, composition and methods of use
    SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.
    08/14/21
  737. 161
    Inhibitors of cyclin-dependent kinases
    KINNATE BIOPHARMA INC.
    08/14/21
  738. 120
    Modulators of P97 AAA ATPase activity
    University of Pittsburgh—Of the Commonwealth System of Higher Education
    08/14/21
  739. 4
    Multi-functionalized polysaccharide compounds and use thereof for targeting the cation-independent mannose 6-phosphate receptor
    NANOMEDSYN; Centre National de la Recherche Scientifique; Universite de Montpellier
    08/14/21
  740. 102
    PSMA imaging agents
    Siemens Medical Solutions USA, Inc.
    08/14/21
  741. 3
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as antidiabetics
    King Abdulaziz University
    08/14/21
  742. 46
    Substituted pyrazole derivatives as selective CDK12/13 inhibitors
    Aurigene Discovery Technologies Limited
    08/14/21
  743. 74
    Alkynyl pyridine prolyl hydroxylase inhibitor, and preparation method and medical use thereof
    Jiangsu Hengrui Medicine Co., Ltd.
    08/09/21
  744. 22
    Alpha-D-galactoside inhibitors of galectins
    GALECTO BIOTECH AB
    08/09/21
  745. 157
    Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain
    Array BioPharma Inc.
    08/09/21
  746. 14
    CGRP receptor antagonists
    Heptares Therapeutics Limited
    08/09/21
  747. 32
    Condensed ring group azacyclobutyl triazole derivative, preparation method therefor and use thereof in medicine
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    08/09/21
  748. 40
    Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
    Amgen Inc.
    08/09/21
  749. 29
    Dihydroxybenzamide compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof
    ONCOZEN CO.. LTD.
    08/09/21
  750. 95
    Inhibitors of TRPC6
    Boehringer Ingelheim International GmbH
    08/09/21
  751. 78
    Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
    Auckland UniServices Limited
    08/09/21
  752. 69
    PDE9 inhibitor and use thereof
    Nanjing TransThera Biosciences Co. Ltd.
    08/09/21
  753. 215
    Substituted benzoimidazoles and imidazo[4,5-c]pyridines for treating certain leukemias
    Terns, Inc.
    08/09/21
  754. 268
    Sulfonamide compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    08/09/21
  755. 52
    Tetrahydroindazoles and medical uses thereof
    Genase Therapeutics B.V.
    08/09/21
  756. 17
    Thiazine derivatives as β-secretase inhibitors and methods of use
    Amgen Inc.
    08/09/21
  757. 21
    Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors
    VALO EARLY DISCOVERY, INC.
    08/09/21
  758. 7
    [1,3]thiazin-2-amine compound, application, and pharmaceutical composition
    TETRANOV PHARMACEUTICAL CO., LTD.
    08/09/21
  759. 33
    Pyrazole derivatives as MALT1 inhibitors
    Janssen Pharmaceutica NV
    08/08/21
  760. 6
    Acetamide thienotriazolodiazepines and uses thereof
    Dana-Farber Cancer Institute, Inc.
    08/01/21
  761. 17
    Bicyclic compounds as ATX inhibitors
    Hoffmann-La Roche Inc.
    08/01/21
  762. 61
    Cannabinergic compounds and uses thereof
    NORTHEASTERN UNIVERSITY
    08/01/21
  763. 48
    Compounds useful as immunomodulators
    Bristol-Myers Squibb Company
    08/01/21
  764. 27
    KDM1A inhibitors for the treatment of disease
    Imago Biosciences, Inc.
    08/01/21
  765. 3
    Kinase inhibitors
    TOPIVERT PHARMA LIMITED
    08/01/21
  766. 22
    Pharmaceutical compounds
    Sareum Limited
    08/01/21
  767. 16
    Phenylate derivative, preparation method therefor, and pharmaceutical composition and uses thereof
    Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD
    08/01/21
  768. 137
    Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
    Boehringer Ingelheim International GmbH
    08/01/21
  769. 812
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Array Biopharma Inc.
    08/01/21
  770. 19
    Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases
    ONO PHARMACEUTICAL CO., LTD.
    08/01/21
  771. 8
    Tyrosine kinase inhibitor and application thereof
    LaNova Medicines Limited
    08/01/21
  772. 25
    Compounds and their use as BACE1 inhibitors
    ALLGENESIS BIOTHERAPEUTICS, INC.
    07/26/21
  773. 40
    Inhibitors of cyclin-dependent kinase 7 (CDK7)
    Dana-Farber Cancer Institute, Inc.
    07/26/21
  774. 138
    Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
    SHIONOGI & CO., LTD.
    07/26/21
  775. 825
    Pyridazinones as PARP7 inhibitors
    Ribon Therapeutics, Inc.
    07/26/21
  776. 18
    Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
    HANMI PHARM. CO.. LTD.
    07/26/21
  777. 10
    Zwitterionic propargyl-linked antifolates useful for treating bacterial infections
    UNIVERSITY OF CONNECTICUT
    07/26/21
  778. 9
    Aminopyrazoles as selective janus kinase inhibitors
    Intervet Inc.
    07/25/21
  779. 2
    Azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
    INTEGRATIVE RESEARCH LABORATORIES SWEDEN AB
    07/25/21
  780. 4
    Compositions and methods for inhibiting brain trauma-induced neurodegeneration and related conditions
    Aristea Translational Medicine Corporation
    07/25/21
  781. 91
    Compositions and methods of modulating short-chain dehydrogenase activity
    CASE WESTERN RESERVE UNIVERSITY; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    07/25/21
  782. 23
    Compounds and methods for inhibiting CYP26 enzymes
    Queen''s University at Kingston
    07/25/21
  783. 90
    Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide
    Boehringer Ingelheim International GmbH
    07/25/21
  784. 174
    Factor XIIa inhibitors
    MERCK SHARP & DOHME CORP.
    07/25/21
  785. 151
    Heteroaromatic compounds as BTK inhibitors
    Boehringer Ingelheim International GmbH
    07/25/21
  786. 3
    Highly active compounds against COVID-19
    Atea Pharmaceuticals, Inc.
    07/25/21
  787. 30
    Histone deacetylase inhibitors and uses thereof
    MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
    07/25/21
  788. 26
    N4-hydroxycytidine and derivatives and anti-viral uses related thereto
    Emory University
    07/25/21
  789. 16
    Neuroprotective agents for treatment of neurodegenerative diseases
    WAYNE STATE UNIVERSITY
    07/25/21
  790. 22
    Phosphonate linkers and their use to facilitate cellular retention of compounds
    MERCK SHARP & DOHME CORP.
    07/25/21
  791. 34
    Pteridine dione monocarboxylate transporter inhibitors
    THE SCRIPPS RESEARCH INSTITUTE
    07/25/21
  792. 25
    RIPK2 inhibitors and method of treating cancer with same
    UNIVERSITY HEALTH NETWORK
    07/25/21
  793. 102
    Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors
    SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC.
    07/25/21
  794. 3
    Substituted pyrimidines for treating bacterial infections
    FORGE THERAPEUTICS, INC.
    07/25/21
  795. 136
    Substituted pyrrolizine compounds and uses thereof
    GILEAD SCIENCES, INC.
    07/25/21
  796. 34
    Triazolopyridines
    Hoffmann-La Roche Inc.
    07/25/21
  797. 23
    Trifluoromethylpropanamide derivatives as HTRA1 inhibitors
    Hoffmann-La Roche Inc.
    07/25/21
  798. 47
    2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis
    Agency for Science, Technology and Research; National University of Singapore
    07/18/21
  799. 229
    ATG7 inhibitors and the uses thereof
    MILLENNIUM PHARMACEUTICALS, INC.
    07/18/21
  800. 3
    Dab2 inhibitors for the prevention and treatment of cystic fibrosis
    TRUSTEES OF DARTMOUTH COLLEGE
    07/18/21
  801. 17
    Difluoroketamide derivatives as HtrA1 inhibitors
    Hoffmann-La Roche Inc.
    07/18/21
  802. 57
    Heteroaromatic compounds as Vanin inhibitors
    Boehringer Ingelheim International GmbH
    07/18/21
  803. 15
    Inhibitors of cyclin-dependent kinase 7 (CDK7)
    Syros Pharmaceuticals, Inc.
    07/18/21
  804. 75
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research, Inc.
    07/18/21
  805. 12
    Opioid agonists and uses thereof
    Nektar Therapeutics
    07/18/21
  806. 7
    Pet imaging agents
    Novartis AG
    07/18/21
  807. 39
    Biaryl urea derivative or salt thereof and preparation process and use for the same
    FUDAN UNIVERSITY
    07/13/21
  808. 116
    Octahydro-cyclobuta[1,2-c;3,4-c′]dipyrrol-2-yl
    Hoffmann-La Roche Inc.
    07/13/21
  809. 140
    Arf6 inhibitors and methods of synthesis and use thereof
    Navigen, Inc.; The University of Utah Research Foundation
    07/12/21
  810. 185
    Benzoimidazoles as prolyl hydroxylase inhibitors
    Janssen Pharmaceutica NV
    07/12/21
  811. 377
    Benzopyrazole compounds and analogues thereof
    BioCryst Pharmaceuticals, Inc.
    07/12/21
  812. 21
    Benzoxazepin oxazolidinone compounds and methods of use
    Genentech, Inc.
    07/12/21
  813. 43
    Bicyclic amines as novel JAK kinase inhibitors
    LEO Pharma A/S
    07/12/21
  814. 12
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte Corporation
    07/12/21
  815. 64
    C3-carbon linked glutarimide degronimers for target protein degradation
    C4 Therapeutics, Inc.
    07/12/21
  816. 92
    Heterocyclic inhibitors of PTPN11
    BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    07/12/21
  817. 52
    Imidazole and triazole containing bicyclic compounds as JAK inhibitors
    Theravance Biopharma R&D IP, LLC
    07/12/21
  818. 30
    Matrix metalloproteinase (MMP) inhibitors and methods of use thereof
    Foresee Pharmaceuticals Co., Ltd.
    07/12/21
  819. 31
    Methods of treatment using pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds
    Array Biopharma Inc.
    07/12/21
  820. 3
    Pyridine compound
    Daiichi Sankyo Company, Limited
    07/12/21
  821. 227
    Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2)
    Northwestern University
    07/12/21
  822. 7
    Substituted bicyclic heterocyclic compounds
    Bristol-Myers Squibb Company
    07/12/21
  823. 118
    Treatment of relapsed and/or refractory solid tumors and non-Hodgkin's lymphomas
    CELGENE QUANTICEL RESEARCH, INC.
    07/12/21
  824. 112
    Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases
    Boehringer Ingelheim International GmbH
    07/11/21
  825. 26
    Diarylalkanes as potent inhibitors of binuclear enzymes
    Unigen, Inc.
    07/11/21
  826. 3
    HDAC inhibitors for the treatment of diabetic peripheral neuropathy
    REGENACY PHARMACEUTICALS, LLC
    07/11/21
  827. 6
    Heterocyclic ring derivatives useful as SHP2 inhibitors
    JACOBIO PHARMACEUTICALS CO., LTD.
    07/11/21
  828. 53
    Heterocyclic spiro compounds as MAGL inhibitors
    Pfizer Inc.
    07/11/21
  829. 20
    Hydantoin containing deoxyuridine triphosphatase inhibitors
    CV6 Therapeutics (NI) Limited
    07/11/21
  830. 3
    Imidazopyrazine inhibitors of Bruton's tyrosine kinase
    Acerta Pharma B.V.
    07/11/21
  831. 111
    Imidazopyrazinones as PDE1 inhibitors
    H. Lundbeck A/S
    07/11/21
  832. 34
    Inhibitors of phosphatidylinositol 3-kinase gamma
    AstraZeneca AB
    07/11/21
  833. 22
    Modulators of the 5-hydroxytryptamine receptor 7 and their method of use
    TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; PRAEVENTIX, LLC
    07/11/21
  834. 5
    Oxazoline pseudodimers, pharmaceutical compositions and the use thereof
    PURDUE PHARMA L.P.
    07/11/21
  835. 80
    Pyrazolopyridine derivative having GLP-1 receptor agonist effect
    Chugai Seiyaku Kabushiki Kaisha
    07/11/21
  836. 98
    Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof
    UNIVERSITY OF MARYLAND, BALTIMORE
    07/11/21
  837. 119
    Triazolo-pyrimidine compounds and uses thereof
    TBA
    07/11/21
  838. 41
    Tricyclic compounds useful to treat orthomyxovirus infections
    Novartis AG
    07/11/21
  839. 16
    1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions
    SABILA BIOSCIENCES LLC
    07/06/21
  840. 63
    Fused amino pyridine as HSP90 inhibitors
    Curis, Inc.
    07/06/21
  841. 86
    Heterocyclic compounds as RET kinase inhibitors
    Cancer Research Technology Limited
    07/06/21
  842. 100
    Imidazopyridines Syk inhibitors
    KRONOS BIO, INC.
    07/06/21
  843. 13
    Process for preparing JAK inhibitors and intermediates thereof
    Theravance Biopharma R&D IP, LLC
    07/06/21
  844. 92
    Pyridine derivative inhibiting RAF kinase and vascular endothelial growth factor receptor, method for preparing same, pharmaceutical composition containing same, and use thereof
    Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.
    07/06/21
  845. 146
    Pyrrolotriazine compounds as TAM inhibitors
    Incyte Corporation
    07/06/21
  846. 107
    Serine/threonine kinase inhibitors
    GENENTECH, INC.
    07/06/21
  847. 271
    Substituted benzofuran, benzothiophene and indole Mcl-1 inhibitors
    Vanderbilt University
    07/06/21
  848. 22
    Thiazolyl-containing compounds for treating proliferative diseases
    Dana-Farber Cancer Institute, Inc.
    07/06/21
  849. 359
    WDR5 inhibitors and modulators
    Vanderbilt University
    07/06/21
  850. 12
    5 to 7 membered heterocyclic amides as JAK inhibitors
    Theravance Biopharma R&D IP, LLC
    06/30/21
  851. 55
    5-HT2C receptor agonists and compositions and methods of use
    Arena Pharmaceuticals, Inc.
    06/30/21
  852. 6
    6-fluoro-2-methylbenzo[d]thiazol-5-yl compounds
    Eli Lilly and Company
    06/30/21
  853. 73
    Acyl sulfonamide NaV1.7 inhibitors
    BRISTOL-MYERS SQUIBB COMPANY
    06/30/21
  854. 57
    Bicyclic heterocyclic derivatives
    Merck Patent GmbH
    06/30/21
  855. 58
    Fluorinated cyclopropylamine compound, preparation method therefor, pharmaceutical composition thereof, and uses thereof
    SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    06/30/21
  856. 13
    Inhibitors of integrin alpha 5 beta 1 and methods of use
    The Regents of the University of California
    06/30/21
  857. 47
    N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
    Ogeda SA
    06/30/21
  858. 15
    N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals
    Neomed Institute
    06/30/21
  859. 12
    Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
    Valo Early Discovery, Inc.
    06/30/21
  860. 11
    Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same
    Mebias Discovery, Inc.
    06/30/21
  861. 55
    Substituted pyrrolizine compounds and uses thereof
    GILEAD SCIENCES, INC.
    06/30/21
  862. 50
    Therapeutic agent for FGFR inhibitor-resistant cancer
    Taiho Pharmaceutical Co., Ltd.
    06/30/21
  863. 22
    N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
    THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    06/29/21
  864. 51
    2,4-pyrimidinediamine compounds and their uses
    Rigel Pharmceuticals, Inc.
    06/28/21
  865. 153
    3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives
    GRUENENTHAL GMBH
    06/28/21
  866. 150
    5-[3-[piperazin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating e.g. osteoarthritis
    GALAPAGOS NV
    06/28/21
  867. 50
    Amino pyrazolopyrimidine compound used as neurotrophic factor tyrosine kinase receptor inhibitor
    CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
    06/28/21
  868. 155
    Aryl sulfonohydrazides
    MONASH UNIVERSITY; The Walter and Eliza Hall Institute of Medical Research
    06/28/21
  869. 189
    Benzimidazole derivatives as modulators of ROR-gamma
    Vitae Pharmaceuticals, LLC
    06/28/21
  870. 149
    Benzylamino substituted pyridopyrimidinones and derivatives as SOS1 inhibitors
    Boehringer Ingelheim International GmbH
    06/28/21
  871. 23
    Compositions and methods for treating KIT- and PDGFRA-mediated diseases
    Blueprint Medicines Corporation
    06/28/21
  872. 7
    Crystalline monomesylate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
    KRONOS BIO, INC.
    06/28/21
  873. 7
    Neprilysin inhibitors
    Theravance Biopharma R&D IP, LLC
    06/28/21
  874. 5
    Pyridyl-triazabicycles
    Hoffmann-La Roche Inc.
    06/28/21
  875. 82
    Pyrimidinones as PI3K inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    06/28/21
  876. 22
    Pyrimido[5,4-B]indolizine or pyrimido[5,4-B]pyrrolizine compound, preparation method and use thereof
    SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACAD
    06/28/21
  877. 244
    Substituted 2,4-diaminopyrimidines as kinase inhibitors
    Celgene CAR LLC
    06/28/21
  878. 111
    Substituted benzoimidazoles as modulators of ROR-γ
    Vitae Pharmaceuticals, LLC
    06/28/21
  879. 9
    Substituted dihydropyrazino[1 ′,2′:1,5]pyrrolo[2,3-d]pyrimidine-based antiproliferative agents
    GI Therapeutics, Inc.
    06/28/21
  880. 108
    Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    06/28/21
  881. 27
    Thienopyridines and benzothiophenes useful as IRAK4 inhibitors
    Bristol-Myers Squibb Company
    06/28/21
  882. 103
    Thiophene, manufacturing method thereof, and pharmaceutical application of same
    CSTONE PHARMACEUTICAL (SUZHOU) CO., LTD.; CSTONE PHARMACEUTICALS (SHANGHAI) CO., LTD.; CSTONE PHARMACEUTICALS
    06/28/21
  883. 703
    Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders
    Achillion Pharmaceuticals, Inc.
    06/21/21
  884. 2
    Crystal of DPP-IV long-acting inhibitor and salt
    CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.
    06/21/21
  885. 30
    ErbB receptor inhibitors
    TBA
    06/21/21
  886. 789
    Inhibitors of Bruton's tyrosine kinase and methods of their use
    Janssen Pharmaceutica NV
    06/21/21
  887. 63
    KV1.3 inhibitors and their medical application
    4SC AG
    06/21/21
  888. 1
    Processes for preparing ATR inhibitors
    VERTEX PHARMACEUTICALS INCORPORATED
    06/21/21
  889. 37
    Pyrazolo[1,5-a]pyrazin-4-yl derivatives
    Pfizer Inc.
    06/21/21
  890. 12
    Pyrazolopyrimidine derivatives as NIK inhibitors
    Janssen Pharmaceutica NV
    06/21/21
  891. 74
    Substituted aminoquinazoline compounds as A2A antagonist
    Merck Sharp & Dohme Corp.
    06/21/21
  892. 797
    Compounds that inhibit Mcl-1 protein
    AMGEN INC.
    06/20/21
  893. 115
    Histone demethylase inhibitors
    CELGENE QUANTICEL RESEARCH, INC.
    06/14/21
  894. 10
    Isoidide derivatives and methods of making and using same
    RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    06/14/21
  895. 10
    Optically active azabicyclo ring derivative
    Sumitomo Dainippon Pharma Co., Ltd.
    06/14/21
  896. 31
    1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as P38 MAP knase inhibitors
    Respivert Limited
    06/13/21
  897. 215
    2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
    BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION
    06/13/21
  898. 325
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    06/13/21
  899. 140
    Bruton's tyrosine kinase inhibitors
    Pfizer Inc.
    06/13/21
  900. 4
    Method for preparing 2-hydroxyl-4-(2, 3-disubstituted benzyloxy)-5-substituted benzaldehyde derivative
    Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD
    06/13/21
  901. 90
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals, Inc.
    06/13/21
  902. 107
    Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
    Incyte Corporation; Incyte Holdings Corporation
    06/13/21
  903. 17
    Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of ASGPR
    Pfizer Inc.
    06/13/21
  904. 192
    1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
    H. Lundbeck A/S
    06/11/21
  905. 382
    3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
    Grünenthal GmbH
    06/11/21
  906. 289
    3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
    GRÜNENTHAL GMBH
    06/11/21
  907. 104
    Bromodomain inhibitors
    Celgene Quanticel Research, Inc.
    06/11/21
  908. 59
    Chromane, isochromane and dihydroisobenzofuran derivatives as mGluR2-negative allosteric modulators, compositions, and their use
    Merck Sharp & Dohme Corp.
    06/11/21
  909. 124
    Compositions useful for treating disorders related to kit
    Blueprint Medicines Corporation
    06/11/21
  910. 101
    Compounds for treatment of immune inflammatory disorders
    Achillion Pharmaceuticals, Inc.
    06/11/21
  911. 51
    Dihydrochromene derivatives
    Sumitomo Dainippon Pharma Co., Ltd.
    06/11/21
  912. 156
    Dihydropyrrolopyridine inhibitors of ROR-gamma
    Vitae Pharmaceuticals, LLC
    06/11/21
  913. 200
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    06/11/21
  914. 42
    HDAC inhibitor compounds and methods of treatment
    University of Florida Research Foundation, Inc.; The Scripps Research Institute
    06/11/21
  915. 97
    Heterocyclic compounds and uses thereof
    NUVATION BIO INC.
    06/11/21
  916. 16
    Heterocyclic compounds as kinase inhibitors
    Translational Drug Development, LLC
    06/11/21
  917. 101
    Histone demethylase inhibitors
    CELGENE QUANTICEL RESEARCH, INC.
    06/11/21
  918. 191
    Immunomodulator compounds and methods of use
    Incyte Corporation
    06/11/21
  919. 161
    Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
    The Institute of Cancer Research: Royal Cancer Hospital
    06/11/21
  920. 28
    Protease inhibitors having enhanced features
    Nektar Therapeutics
    06/11/21
  921. 17
    Pyrrolidinone compounds
    Eli Lilly and Company
    06/11/21
  922. 51
    Selective androgen receptor degrader (SARD) ligands and methods of use thereof
    University of Tennessee Research Foundation
    06/11/21
  923. 42
    Spiro-cyclic amine derivatives as S1P modulators
    AbbVie B.V.; AbbVie, Inc.
    06/11/21
  924. 260
    WDR5-MLL1 inhibitors and modulators
    Vanderbilt University
    06/11/21
  925. 38
    2,6-disubstituted pyridine derivative
    SUMITOMO DAINIPPON PHARMA CO., LTD.
    06/01/21
  926. 20
    4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors
    NERVIANO MEDICAL SCIENCES S.R.L.
    06/01/21
  927. 155
    5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors
    Leo Pharma A/S
    06/01/21
  928. 20
    Arylpropionyl-triketone antibacterial agents
    TBA
    06/01/21
  929. 40
    Beta-lactamase inhibitor compounds
    Entasis Therapeutics Limited
    06/01/21
  930. 32
    Bicyclic compounds as ATX inhibitors
    Hoffman-La Roche Inc.
    06/01/21
  931. 218
    CDK2/4/6 inhibitors
    Pfizer Inc.
    06/01/21
  932. 105
    Carboxamide compounds and uses thereof
    Incyte Corporation
    06/01/21
  933. 22
    Combination of respiratory electron transport chain inhibitors with a cytochrome bd inhibitor
    TBA
    06/01/21
  934. 7
    Conjugate comprising a neurotensin receptor ligand and use thereof
    3B Pharmaceuticals GMBH
    06/01/21
  935. 25
    Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof
    Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    06/01/21
  936. 138
    Heterocyclic compounds as LSD1 inhibitors
    Incyte Corporation
    06/01/21
  937. 266
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    06/01/21
  938. 122
    Heterocyclic inhibitors of ATR kinase
    Board of Regents, The University of Texas System; ChemPartner Corporation
    06/01/21
  939. 32
    Heterocyclic inhibitors of ATR kinase
    Board of Regents, The University of Texas System; ChemPartner Corporation
    06/01/21
  940. 12
    Hybrid galactoside inhibitor of galectins
    TBA
    06/01/21
  941. 41
    Imidazole derivatives as formyl peptide receptor modulators
    ALLERGAN, INC.
    06/01/21
  942. 62
    Indole derivative used as CRTH2 inhibitor
    CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    06/01/21
  943. 912
    Inhibitors of Bruton's tyrosine kinase and method of their use
    Janssen Pharmaceutica NV
    06/01/21
  944. 94
    Inhibitors of TRPC6
    Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC
    06/01/21
  945. 9
    Methotrexate adjuvants to reduce toxicity and methods for using the same
    Tosk, Inc.
    06/01/21
  946. 123
    Nitrogen-containing heterocyclic amide compound and pharmaceutical use thereof
    JAPAN TOBACCO INC.
    06/01/21
  947. 11
    Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
    BAYER PHARMA AKTIENGESELLSCHAFT
    06/01/21
  948. 7
    Pyrazolyl pyrrolo[2,3-b]pyrmidine-5-carboxylate analogs and methods of making the same
    ACLARIS THERAPEUTICS, INC.
    06/01/21
  949. 6
    Substituted pyridine derivatives useful as C-FMS kinase inhibitors
    Janssen Pharmaceutica NV
    06/01/21
  950. 85
    Substituted pyrrolo[2,3-d]pyridazin-4-ones and pyrazolo[3,4-d]pyridazin-4-ones as protein kinase inhibitors
    Shanghai Fochon Pharmaceutical Co., Ltd.; Fochon Pharmaceuticals, Ltd.
    06/01/21
  951. 7
    Tetrahydrothiophene-based GABA aminotransferase inactivators and analogs thereof for treating neurological disorders
    Northwestern University
    06/01/21
  952. 36
    Thyroid hormone receptor beta agonist compounds
    Terns, Inc.
    06/01/21
  953. 179
    Use of agonists of formyl peptide receptor 2 for treating dermatological diseases
    ALLERGAN, INC.
    06/01/21
  954. 2
    1,8-naphthyridinone compounds and uses thereof
    NUVATION BIO INC.
    05/14/21
  955. 73
    3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
    GRÜNENTHAL GMBH
    05/14/21
  956. 34
    8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
    GRUENENTHAL GMBH
    05/14/21
  957. 144
    Amino acid compounds and methods of use
    PLIANT THERAPEUTICS, INC.
    05/14/21
  958. 3
    Amino pyrimidine ssao inhibitors
    ELI LILLY AND COMPANY
    05/14/21
  959. 84
    Bicyclic heterocyclic compound
    MITSUBISHI TANABE PHARMA CORPORATION
    05/14/21
  960. 15
    Bicyclic inhibitors of histone deacetylase
    Rodin Therapeutics, Inc.
    05/14/21
  961. 361
    Bicyclic-fused heteroaryl or aryl compounds
    Pfizer Inc.
    05/14/21
  962. 123
    Bruton's tyrosine kinase inhibitors
    ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    05/14/21
  963. 126
    Compound used as Bruton's tyrosine kinase inhibitor and preparation method and application thereof
    CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.
    05/14/21
  964. 502
    GCN2 inhibitors and uses thereof
    MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED
    05/14/21
  965. 19
    Glutamine transport inhibitors and methods for treating cancer
    Vanderbilt University
    05/14/21
  966. 4
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    05/14/21
  967. 45
    Heterocyclic glutaminase inhibitors
    Calithera Biosciences, Inc.
    05/14/21
  968. 336
    Hormone receptor modulators for treating metabolic conditions and disorders
    ARDELYX, INC.
    05/14/21
  969. 59
    Oxoisoquinoline derivatives
    CARNA BIOSCIENCES, INC.
    05/14/21
  970. 7
    Quinoline analogs as phosphatidylinositol 3-kinase inhibitors
    HANGZHOU ZHENGXIANG PHARMACEUTICALS CO., LTD.
    05/14/21
  971. 22
    Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs
    Bayer Pharma Aktiengesellschaft
    05/14/21
  972. 15
    Substituted nucleosides, nucleotides and analogs thereof
    Janssen BioPharma, Inc.
    05/14/21
  973. 310
    Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors
    LEO Pharma A/S
    05/14/21
  974. 4
    Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators
    ARENA PHARMACEUTICALS, INC.
    05/14/21
  975. 59
    Sulfuryl-substituted benzoheterocyclic derivative, preparation method and medical use thereof
    SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.
    05/14/21
  976. 217
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    05/14/21
  977. 555
    Compounds useful as inhibitors of ATR kinase
    VERTEX PHARMACEUTICALS INCORPORATED
    05/11/21
  978. 56
    ASK1 inhibitor and preparation method and use thereof
    Fuijan Cosunter Pharmaceutical Co. Ltd.
    05/09/21
  979. 9
    Benzopiperdine derivatives and their use in the treatment of cancer and hemoglobinopathies
    CTXT PTY, LTD
    05/09/21
  980. 3
    Bicyclic compounds as ATX inhibitors
    Hoffmann-La Roche Inc.
    05/09/21
  981. 90
    Cannabinoid receptor mediating iminopyrazole compounds
    The United States of America, as represented by the Secretary, Department of Health and Human Services
    05/09/21
  982. 78
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    05/09/21
  983. 40
    Inhibitors of cyclin-dependent kinase 7 (CDK7)
    Dana-Farber Cancer Institute, Inc.
    05/09/21
  984. 2
    Octahydropyrrolopyrroles their preparation and use
    The Trustees of Columbia University in the City of New York
    05/09/21
  985. 23
    Prodrugs of pyridone amides useful as modulators of sodium channels
    Vertex Pharmaceuticals Incorporated
    05/09/21
  986. 253
    Spiro-fused cyclic ureas as inhibitors of rock
    Bristol-Myers Squibb Company
    05/09/21
  987. 18
    Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
    Pfizer Inc.
    05/09/21
  988. 105
    Thiazolidinedione derivative and use thereof
    INDUSTRY-ACADEMIC COOPERATION FOUNDATION CHOSUN UNIVERSITY
    05/09/21
  989. 93
    1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
    Incyte Corporation
    05/03/21
  990. 2
    2,6-diamino pyridine compounds
    Eli Lilly and Company
    05/03/21
  991. 4
    3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
    Arena Pharmaceuticals, Inc.
    05/03/21
  992. 10
    Azetidinyloxyphenylpyrrolidine compounds
    Eli Lilly and Company
    05/03/21
  993. 6
    Compounds, process for obtaining the compounds, pharmaceutical composition, use of the compounds and method for treating psychiatric disorders and/or sleep disorders
    ACHÉ LABORATÓRIOS FARMACÊUTICOS S.A.
    05/03/21
  994. 108
    Heterocyclic compounds for the inhibition of PASK
    BioEnergenix LLC
    05/03/21
  995. 108
    N-((het) arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
    KALVISTA PHARMACEUTICALS LIMITED
    05/03/21
  996. 260
    Spirocycle compounds and methods of making and using same
    LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    05/03/21
  997. 163
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    05/03/21
  998. 137
    Therapeutic inhibitory compounds
    ATTUNE PHARMACEUTICALS, INC.
    05/03/21
  999. 25
    Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists
    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    05/02/21
  1000. 151
    Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators
    Merck Sharp & Dohme Corp.
    05/02/21
  1001. 352
    Heteroaryl compounds useful as inhibitors of SUMO activating enzyme
    Millennium Pharmaceuticals, Inc.
    05/02/21
  1002. 3
    Macrocycle and composition comprising thereof
    Shenzhen TargetRx, Inc.
    05/02/21
  1003. 7
    Mu opioid receptor modulators
    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; FRIEDRICH-ALEXANDER-UNIVERSITÄT; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    05/02/21
  1004. 287
    Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Epics Therapeutics
    05/02/21
  1005. 242
    1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
    H. Lundbeck A/S
    04/26/21
  1006. 83
    2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases
    Array Biopharma Inc.
    04/26/21
  1007. 9
    Aminopyrazoles as janus kinase inhibitors
    Merck Sharp & Dohme Corp.
    04/26/21
  1008. 13
    Aza-indazole compounds for use in tendon and/or ligament injuries
    NOVARTIS AG
    04/26/21
  1009. 137
    Cyclin dependent kinase inhibitors
    Pfizer Inc.
    04/26/21
  1010. 155
    Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors
    PROXIMAGEN, LLC
    04/26/21
  1011. 106
    Morphinan derivatives for the treatment of neuropathic pain
    Nektar Therapeutics
    04/26/21
  1012. 243
    Piperidine derivatives as inhibitors of ubiquitin specific protease 7
    ALMAC DISCOVERY LIMITED
    04/26/21
  1013. 19
    Substituted benzamides and methods of use thereof
    GENENTECH, INC.; XENON PHARMACEUTICALS INC.
    04/26/21
  1014. 33
    Sulfonylcycloalkyl carboxamide compounds
    Genentech, Inc.
    04/26/21
  1015. 43
    Trk-inhibiting compound
    ONO PHARMACEUTICAL CO., LTD.
    04/26/21
  1016. 96
    Wee-1 inhibiting pyrazolopyrimidinone compounds
    ALMAC DISCOVERY LIMITED
    04/26/21
  1017. 22
    1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
    NOVARTIS AG
    04/25/21
  1018. 432
    2-(morpholin-4-yl)-1,7-naphthyridines
    BAYER PHARMA AKTIENGESELLSCHAFT
    04/25/21
  1019. 39
    2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
    BLUEPRINT MEDICINES CORPORATION
    04/25/21
  1020. 1204
    6-membered heterocyclic derivatives and pharmaceutical composition comprising the same
    SHIONOGI & CO., LTD.
    04/25/21
  1021. 123
    Composition and methods for inhibiting mammalian sterile 20-like kinase 1
    THE SCRIPPS RESEARCH INSTITUTE; UNIVERSITÄT BREMEN
    04/25/21
  1022. 3
    Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
    PHARMAKEA, INC.
    04/25/21
  1023. 8
    FXR (NR1H4) modulating compounds
    Gilead Sciences, Inc.
    04/25/21
  1024. 106
    Galactoside inhibitor of galectins
    Galecto Biotech AB
    04/25/21
  1025. 352
    HIV protease inhibitors
    Gilead Sciences, Inc.
    04/25/21
  1026. 191
    Heteroaryl compounds and uses thereof
    Celgene CAR LLC; Sanofi
    04/25/21
  1027. 54
    Indazole compounds and uses thereof
    Incyte Corporation
    04/25/21
  1028. 24
    Materials and method for inhibiting replication protein A and uses thereof
    Indiana University Research and Technology Corporation
    04/25/21
  1029. 105
    Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
    ARRAY BIOPHARMA INC.
    04/25/21
  1030. 381
    PD-1/PD-L1 inhibitors
    Gilead Sciences, Inc.
    04/25/21
  1031. 71
    Substituted piperazines as selective HDAC1,2 inhibitors
    REGENACY PHARMACEUTICALS, INC.
    04/25/21
  1032. 343
    ULK1 inhibitors and methods using same
    SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY
    04/25/21
  1033. 43
    Compounds that are ERK inhibitors
    Merck Sharp & Dohme Corp.
    04/19/21
  1034. 20
    Indazole containing macrocycles and therapeutic uses thereof
    Samumed, LLC
    04/19/21
  1035. 220
    Neprilysin inhibitors
    Theravance Biopharma R&D IP, LLC
    04/19/21
  1036. 15
    Thienopyrimidine derivative and use thereof in medicine
    Sunshine Lake Pharma Co., Ltd.
    04/19/21
  1037. 106
    2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors
    Almirall, S.A.
    04/18/21
  1038. 77
    2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders
    BAYER PHARMA AKTIENGESELLSCHAFT
    04/18/21
  1039. 33
    Benzofuran derivative, preparation method thereof and use thereof in medicine
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    04/18/21
  1040. 138
    CXCR4 inhibitors and uses thereof
    X4 PHARMACEUTICALS, INC.
    04/18/21
  1041. 26
    CaMKII inhibitors and uses thereof
    The Johns Hopkins University
    04/18/21
  1042. 138
    Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators
    Synchronicity Pharma, Inc.
    04/18/21
  1043. 20
    Carboxamide derivatives useful as rsk inhibitors
    PHOENIX MOLECULAR DESIGNS
    04/18/21
  1044. 32
    Certain chemical entities, compositions, and methods
    NEUPHARMA, INC.
    04/18/21
  1045. 46
    Glucosylceramide synthase inhibitors for the treatment of diseases
    TBA
    04/18/21
  1046. 24
    Mammalian and bacterial nitric oxide synthase inhibitors
    Northwestern University
    04/18/21
  1047. 2
    Pharmaceutical uses of pyridine carboxamide derivatives
    JIANGSU HENGRUI MEDICINE CO., LTD.; SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.
    04/18/21
  1048. 232
    Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors
    Array BioPharma Inc.
    04/18/21
  1049. 7
    Therapeutic compounds and uses thereof
    Kala Pharmaceuticals, Inc.
    04/18/21
  1050. 8
    1,3,5-triazine derivative and method of using same
    Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd.
    04/13/21
  1051. 66
    6-(5-membered heteroaryl)isoquinolin-3-yl-(5-membered heteroaryl) carboxamides and preparation and use thereof
    Samumed, LLC
    04/13/21
  1052. 6
    Adenosine A3 receptor modulators
    Palobiofarma, S.L.
    04/13/21
  1053. 19
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    04/13/21
  1054. 190
    Condensed lactam derivative
    SUMITOMO DAINIPPON PHARMA CO., LTD.
    04/13/21
  1055. 57
    Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
    Merck Patent GmbH
    04/13/21
  1056. 16
    Indazole compounds and uses thereof
    Incyte Corporation
    04/13/21
  1057. 2
    Pyridine derivatives and their use in the treatment of cancer and hemoglobinopathies
    CTXT PTY LTD
    04/13/21
  1058. 18
    Substituted [5,6]cyclic-4(3H)-pyrimidinones as anticancer agents
    ZENJI RESEARCH LABORATORIES
    04/13/21
  1059. 420
    Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
    Lycera Corporation; Merck Sharp & Dohme Corp.
    04/13/21
  1060. 96
    Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase
    Board of Regents, The University of Texas System; ChemPartner Corporation
    04/13/21
  1061. 40
    Neprilysin inhibitors
    Theravance Biopharma R&D IP, LLC
    04/12/21
  1062. 5
    PPARG modulators for the treatment of osteoporosis
    The Scripps Research Institute; The University of Toledo
    04/12/21
  1063. 75
    4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
    Eastern Virginia Medical School; The Regents of the University of California Santa; The United States of America Department of Health; Thomas Jefferson University
    04/11/21
  1064. 6
    6-fluoro 2-methylbenzo[d]thiazol-5-yl compounds
    Eli Lilly and Company
    04/11/21
  1065. 20
    Aryldiazepine derivatives as RSV inhibitors
    Enanta Pharmaceuticals, Inc.
    04/11/21
  1066. 46
    Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists
    King''s College London
    04/11/21
  1067. 20
    C-glucoside derivative containing fused phenyl ring or pharmaceutically acceptable salt thereof, process for preparing same, and pharmaceutical composition comprising same
    Je II Pharmaceutical Co., Ltd.
    04/11/21
  1068. 15
    Compounds and their use for reducing uric acid levels
    Acquist LLC
    04/11/21
  1069. 27
    Dopamine D2 receptor ligands
    The Broad Institute, Inc.; Massachusetts Institute of Technology
    04/11/21
  1070. 62
    Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
    Xenon Pharmaceuticals Inc.
    04/11/21
  1071. 12
    Heterocyclic compounds as FGFR inhibitors
    Guangzhou Innocare Pharma Tech Co., Ltd.
    04/11/21
  1072. 25
    Iso-citrate dehydrogenase (IDH) inhibitor
    SHANGHAI METON PHARMACEUTICAL CO., LTD
    04/11/21
  1073. 38
    Morphan and morphinan analogues, and methods of use
    ALKERMES PHARMA IRELAND LIMITED
    04/11/21
  1074. 152
    Nitrogen-containing heteroaryl compound and pharmaceutical use thereof
    JAPAN TOBACCO INC.
    04/11/21
  1075. 28
    Signaling-biased mu opioid receptor agonists
    THE SCRIPPS RESEARCH INSTITUTE
    04/11/21
  1076. 148
    Spirocyclic containing compounds and pharmaceutical uses thereof
    GB005, Inc.
    04/11/21
  1077. 14
    Substituted aminopyrimidine compounds and methods of use
    SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC
    04/11/21
  1078. 42
    1,3-diaza-spiro-[3.4]-octane derivatives
    GRÜNENTHAL GMBH
    04/04/21