Patent: (prefix with "US" like US6078908)
  1. Patent
    Data
    Cmpds
    HGNC*
    Patent Title
    Organization
    Deposition
    Downloads
  2. 53
    AMPK activators
    KALLYOPE, INC.
    11/05/22
  3. 22
    Tryptophan hydroxylase inhibitor and pharmaceutical composition including same
    Gwangju Institute of Science and Technolgy; Korea Advanced Institute of Science and Technology; KyungPook National University Industry-Academic Cooperation Foundation; Curacle Co., LTD.
    11/05/22
  4. 149
    Compounds and uses thereof
    Foghorn Therapeutics Inc.
    10/30/22
  5. 80
    Compounds for the treatment of BRAF-associated diseases and disorders
    Array BioPharma Inc.
    10/30/22
  6. 5
    Compounds useful as immunomodulators
    Bristol-Myers Squibb Company
    10/30/22
  7. 97
    Formulations of Tie-2 activators and methods of use thereof
    EYEPOINT PHARMACEUTICALS, INC.
    10/30/22
  8. 55
    Heterocyclic compound as JAK inhibitor, and salts and therapeutic use thereof
    Suzhou Longbiotech Pharmaceuticals Co., Ltd.
    10/30/22
  9. 66
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    10/30/22
  10. 136
    Heterocyclic compounds as modulators of mGluR7
    Pragma Therapeutics
    10/30/22
  11. 212
    Inhibitors of protein kinases
    Alexion Pharmaceuticals, Inc.
    10/30/22
  12. 19
    Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
    Auckland UniServices Limited
    10/30/22
  13. 103
    Oxoacridinyl acetic acid derivatives and methods of use
    STINGTHERA, INC.
    10/30/22
  14. 379
    P300/CBP hat inhibitors
    Constellation Pharmaceuticals, Inc.
    10/30/22
  15. 1022
    Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors
    Nimbus Lakshmi, Inc.
    10/30/22
  16. 37
    Sulfonamide-substituted cyanopyrrolidines with activity as DUB inhibitors
    MISSION THERAPEUTICS LIMITED
    10/30/22
  17. 6
    Acetamide thienotriazolodiazepines and uses thereof
    Dana-Farber Cancer Institute, Inc.
    10/28/22
  18. 58
    Antibacterial compounds
    FORGE THERAPEUTICS, INC.
    10/28/22
  19. 121
    Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
    Achillion Pharmaceuticals, Inc.
    10/28/22
  20. 80
    CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
    AMGEN INC.
    10/28/22
  21. 3
    Derivatives of an FGFR inhibitor
    Incyte Corporation
    10/28/22
  22. 36
    Dioxinoquinoline compounds, preparation method and uses thereof
    BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
    10/28/22
  23. 114
    Heterocycle compounds as Tyro3, Axl and MerTK (TAM) family of receptor tyrosine kinase inhibitors
    Development Center for Biotechnology
    10/28/22
  24. 27
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    10/28/22
  25. 85
    Inhibitors of RAF kinases
    KINNATE BIOPHARMA INC.
    10/28/22
  26. 26
    JAK1 pathway inhibitors for the treatment of chronic lung allograft dysfunction
    Incyte Corporation
    10/28/22
  27. 118
    Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
    Washington University
    10/28/22
  28. 16
    Pyrazolopyridine compounds and uses thereof
    Incyte Corporation
    10/28/22
  29. 208
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals, Inc.
    10/28/22
  30. 13
    Substituted piperidines as kinase inhibitors
    Daewoong Pharmaceutical Co., Ltd.
    10/28/22
  31. 13
    Treatment of upper aerodigestive tract disorders and cough
    TBA
    10/28/22
  32. 79
    Tropomyosin-related kinase (TRK) inhibitors
    Genzyme Corporation
    10/28/22
  33. 22
    1-Pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
    NOVARTIS AG
    10/23/22
  34. 153
    Alcoxyamino derivatives for treating pain and pain related conditions
    ESTEVE PHARMACEUTICALS, S.A.
    10/23/22
  35. 1
    Biochemical binding of RET9 and VEGFR2 inhibitors
    Kala Pharmaceuticals, Inc.
    10/23/22
  36. 23
    Cyclic dinucleotide compound and uses thereof
    SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD.; JIANGXI JEMINCARE GROUP CO., LTD.
    10/23/22
  37. 64
    Dihydroquinolinones for medical treatment
    C4 Therapeutics, Inc.
    10/23/22
  38. 307
    Heteroaryl inhibitors of PDE4
    Tetra Discovery Partners, LLC
    10/23/22
  39. 138
    Heterocyclic compounds as LSD1 inhibitors
    Incyte Corporation
    10/23/22
  40. 11
    Isoquinoline derivatives and use thereof
    Purdue Pharma L.P.
    10/23/22
  41. 62
    Macrocyclic indole derivatives
    The Broad Institute, Inc.; Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    10/23/22
  42. 40
    Pyrido[3,2-d]pyrimidine compounds as immunomodulators
    Incyte Corporation
    10/23/22
  43. 81
    Pyrimidinones as PI3K inhibitors
    Incyte Holdings Corporation; Incyte Corportion
    10/23/22
  44. 41
    Small molecule activators of Parkin enzyme function
    Mayo Foundation for Medical Education and Research
    10/23/22
  45. 8
    [1,2,4]Triazolo derivatives as PDE1 inhibitors for the treatment of diabetes
    ELI LILLY AND COMPANY
    10/23/22
  46. 24
    1,4-substituted isoquinoline inhibitors of KEAP1/NRF2 protein-protein interaction
    THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    10/17/22
  47. 34
    Amine compound for inhibiting SSAO/VAP-1 and use thereof
    SUNSHINE LAKE PHARMA CO., LTD.
    10/17/22
  48. 15
    Amino acid compounds with unbranched linkers and methods of use
    Pliant Therapeutics, Inc.
    10/17/22
  49. 21
    Aryl-phosphorus-oxygen compound as EGFR kinase inhibitor
    CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    10/17/22
  50. 479
    Benzodiazepine derivatives as RSV inhibitors
    Enanta Pharmaceuticals, Inc.
    10/17/22
  51. 218
    CDK2/4/6 inhibitors
    Pfizer Inc.
    10/17/22
  52. 45
    Substituted heterocyclic derivatives as PI3K inhibitors
    Incyte Corporation
    10/17/22
  53. 601
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    10/17/22
  54. 2
    Tricyclic compounds as Cyp1 inhibitors
    The General Hospital Corporation
    10/17/22
  55. 267
    1-cyano-pyrrolidine compounds as USP30 inhibitors
    Mission Therapeutics Limited
    10/16/22
  56. 66
    Arginase inhibitors as therapeutics
    Mars, Incorporated
    10/16/22
  57. 104
    Compounds and methods for treating oxalate-related diseases
    OxaluRx, Inc.
    10/16/22
  58. 34
    Compounds for targeting mutant huntingtin protein and uses thereof
    CHDI Foundation, Inc.
    10/16/22
  59. 159
    Inhibitors of cyclin-dependent kinases
    KINNATE BIOPHARMA INC.
    10/16/22
  60. 7
    Pentafluorosulfanyl-substituted amide derivatives, preparation methods thereof and medical uses thereof
    Beijing Innocare Pharma Tech Co., Ltd.
    10/16/22
  61. 215
    Piperazine derivatives as MAGL inhibitors
    Hoffmann-La Roche Inc.
    10/16/22
  62. 47
    Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors
    Incyte Corporation
    10/16/22
  63. 314
    Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof
    BEIJING TIDE PHARMACEUTICAL CO., LTD.
    10/16/22
  64. 38
    Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application
    GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
    10/09/22
  65. 1
    Diphenylaminopyrimidine compound for inhibiting kinase activity
    Shenzhen TargetRx, Inc.
    10/09/22
  66. 20
    Heterocyclic compound as CSF-1R inhibitor and use thereof
    MEDSHINE DISCOVERY INC.
    10/09/22
  67. 45
    Heterocyclic compounds useful as aurora a selective inhibitors
    Jacobio Pharmaceuticals Co., Ltd.
    10/09/22
  68. 120
    Spiropyrrolidine derived antiviral agents
    Enanta Pharmaceuticals, Inc.
    10/09/22
  69. 7
    Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors
    UNION therapeutics A/S
    10/09/22
  70. 19
    Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
    Incyte Corporation
    10/09/22
  71. 209
    2-amino-n-heteroaryl-nicotinamides as Nav1.8 inhibitors
    Merck Sharp & Dohme LLC
    10/06/22
  72. 132
    CD73 inhibitors
    ORIC PHARMACEUTICALS, INC.
    10/06/22
  73. 106
    Galactoside inhibitor of galectins
    Galecto Biotech AB
    10/06/22
  74. 164
    Heterocyclic prolinamide derivatives
    ORION OPHTHALMOLOGY LLC
    10/06/22
  75. 41
    Acetyl-CoA carboxylase modulators
    Monsanto Technology LLC
    10/05/22
  76. 20
    Inhibiting mutant IDH-1
    FORMA Therapeutics, Inc.
    10/05/22
  77. 56
    Inhibitors of RAF kinases
    KINNATE BIOPHARMA INC.
    10/05/22
  78. 19
    Inhibitors of histone deacetylase
    The Broad Institute, Inc.; The General Hospital Corporation
    10/05/22
  79. 34
    Purine derivatives and the use thereof as medicament
    Boehringer Ingelheim International GmbH
    10/05/22
  80. 94
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals, Inc.
    10/05/22
  81. 177
    Serine/threonine kinase inhibitors
    Genentech, Inc.
    10/05/22
  82. 32
    3-arylindazoles as selective MEK4 inhibitors
    NORTHWESTERN UNIVERSITY
    09/25/22
  83. 10
    Antimalarial compounds, process for preparation and their use for drug resistant malaria
    Council of Scientific and Industrial Research; International Centre for Genetic Engineering and Biotechnology (ICGEB)
    09/25/22
  84. 229
    Compounds
    TMEM16A LIMITED
    09/25/22
  85. 23
    Compounds and methods for inhibiting CPY26 enzymes
    Queen''s University at Kingston
    09/25/22
  86. 54
    Compounds that inhibit Mcl-1 protein
    AMGEN INC.
    09/25/22
  87. 549
    Compounds useful as inhibitors of ATR kinase
    VERTEX PHARMACEUTICALS INCORPORATED
    09/25/22
  88. 92
    Cyano-substituted heterocycles with activity as inhibitors of USP30
    MISSION THERAPEUTICS LIMITED
    09/25/22
  89. 79
    FGFR inhibitor and application thereof
    Betta Pharmaceuticals Co., Ltd.
    09/25/22
  90. 598
    GLS1 inhibitors for treating disease
    Board of Regents, The University of Texas System
    09/25/22
  91. 21
    Heteroaryl plasma kallikrein inhibitors
    Takeda Pharmaceutical Company Limited
    09/25/22
  92. 60
    Heterocyclic inhibitors of tyrosine kinase
    Board of Regents, The University of Texas System
    09/25/22
  93. 124
    Imidazolidin-2-one compounds as PRMT5 modulators
    AURIGENE DISCOVERY TECHNOLOGIES LIMITED
    09/25/22
  94. 27
    Lysophosphatidic acid receptor 1 (LPAR1) inhibitor compounds
    Eli Lilly and Company
    09/25/22
  95. 365
    Melt-extruded solid dispersions containing an apoptosis-inducing agent
    AbbVie Inc.; AbbVie Deutschland GMBH & Co KG
    09/25/22
  96. 10
    Optically active azabicyclo ring derivative
    Sumitomo Dainippon Pharma Co., Ltd.
    09/25/22
  97. 17
    P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof
    SHANGHAI ZHIMENG BIOPHARMA INC.
    09/25/22
  98. 47
    Pharmaceutical composition for preventing or treating acute myeloid leukemia or metastatic breast cancer
    PELEMED CO., LTD.
    09/25/22
  99. 5
    Process for the synthesis of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
    Imara Inc.
    09/25/22
  100. 447
    Pyridine compound substituted with azole
    TAISHO PHARMACEUTICAL CO., LTD.
    09/25/22
  101. 94
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals Inc.
    09/25/22
  102. 14
    Substituted benzimidazoles, their preparation and their use as pharmaceuticals
    EPIGENETIX, INC.
    09/25/22
  103. 528
    Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
    BioCryst Pharmaceuticals, Inc.
    09/25/22
  104. 185
    Substituted cyclohexyl compounds as NOP inhibiiors
    Dart NeuroScience, LLC
    09/25/22
  105. 73
    Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
    Union therapeutics A/S
    09/25/22
  106. 62
    Substituted pyrazoles as LRRK2 inhibitors
    OSCOTEC INC.
    09/25/22
  107. 7
    Therapeutic compounds and uses thereof
    Kala Pharmaceuticals, Inc.
    09/25/22
  108. 31
    CRBN ligands and uses thereof
    KYMERA THERAPEUTICS, INC.
    09/19/22
  109. 9
    Compounds and methods for inhibiting CYP26 enzymes
    Queen''s University at Kingston
    09/19/22
  110. 29
    Functionalized peptides as antiviral agents
    Enanta Pharmaceuticals, Inc.
    09/19/22
  111. 102
    Lysyl oxidase-like 2 inhibitors and uses thereof
    PharmAkea, Inc.
    09/19/22
  112. 12
    Prodrugs of modulators of the NMDA receptor
    H. Lundbeck A/S
    09/19/22
  113. 56
    Compounds useful as RET inhibitors
    Cancer Research Technology Limited
    09/11/22
  114. 122
    Spiropyrrolidine derived antiviral agents
    Enanta Pharmaceuticals, Inc.
    09/11/22
  115. 305
    TGF-beta inhibitors
    Rigel Pharmaceuticals, hic.; Bristol-Myers Squibb Company
    09/11/22
  116. 198
    1-cyano-pyrrolidine derivatives as DUB inhibitors
    MISSION THERAPEUTICS LIMITED
    09/10/22
  117. 261
    2,4-disubstituted pyrimidines useful as kinase inhibitors
    Celgene CAR LLC
    09/10/22
  118. 163
    Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors
    Jubilant Epicore LLC
    09/10/22
  119. 347
    HIV protease inhibitors
    Gilead Sciences, Inc.
    09/10/22
  120. 324
    Inhibitors of plasma kallikrein and uses thereof
    Takeda Pharmaceutical Company Limited
    09/10/22
  121. 89
    Nitrile-containing antiviral compounds
    Pfizer Inc.
    09/10/22
  122. 210
    Phenoxymethyl derivatives
    Hoffmann-La Roche Inc.
    09/10/22
  123. 281
    Pyridine and pyridimine compounds as PI3K-gamma inhibitors
    Incyte Corporation
    09/10/22
  124. 33
    Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof
    Xiamen University
    09/10/22
  125. 16
    Substituted pyrimidines as CDK4/6 inhibitors
    Beijing Xuanyi PharmaSciences Co., Ltd.
    09/10/22
  126. 241
    2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof
    TBA
    09/05/22
  127. 33
    Apoptosis signal-regulating kinase 1 (ASK 1) inhibitor compounds
    PHARMAKEA, INC.
    09/05/22
  128. 152
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    09/05/22
  129. 28
    Autotaxin inhibitor compounds
    Sabre Therapeutics LLC
    09/05/22
  130. 42
    Benzamide compounds
    Recurium IP Holding, LLC
    09/05/22
  131. 69
    Benzopyrazole compound used as RHO kinase inhibitor
    MEDSHINE DISCOVERY INC.
    09/05/22
  132. 280
    Inhibitors of fibroblast growth factor receptor kinases
    KINNATE BIOPHARMA INC.
    09/05/22
  133. 9
    KRAS mutant protein inhibitors
    JACOBIO PHARMACEUTICALS CO., LTD.
    09/05/22
  134. 137
    Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
    SHIONOGI & CO., LTD.
    09/05/22
  135. 43
    PGDH inhibitors and methods of making and using
    MYOFORTE THERAPEUTICS, INC.
    09/05/22
  136. 128
    Phenyl and pyridinyl substituted imidazoles as modulators of RORγT
    Janssen Pharmaceutica NV
    09/05/22
  137. 20
    Quaternary lactam compound and pharmaceutical use thereof
    SHANGHAI MEIYUE BIOTECH DEVELOPMENT CO., LTD.
    09/05/22
  138. 64
    Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
    Guangzhou Innocare Pharma Tech Co., Ltd.
    09/05/22
  139. 2
    Substituted pyrazolopyrimidines useful as kinases inhibitors
    Teligene Ltd.
    09/05/22
  140. 31
    4H-pyrrolo[3,2-c]pyridin-4-one derivatives
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; Dana-Farber Cancer Institute, Inc.; The Broad Institute, Inc.
    08/29/22
  141. 75
    Aliphatic acid amide derivative
    SUMITOMO DAINIPPON PHARMA CO., LTD.
    08/29/22
  142. 35
    Glycoside derivatives and uses thereof
    Novartis AG
    08/29/22
  143. 52
    Imidazole and triazole containing bicyclic compounds as JAK inhibitors
    Theravance Biopharma R&D IP, LLC
    08/29/22
  144. 55
    Spiropyrrolidine derived antiviral agents
    Enanta Pharmaceuticals, Inc.
    08/29/22
  145. 33
    Substituted piperidines as kinase inhibitors
    Daewoong Pharmaceutical Co., Ltd.
    08/29/22
  146. 207
    Compounds and methods for kinase modulation, and indications therefor
    Plexxikon Inc.
    08/28/22
  147. 34
    Dopamine D3 receptor selective antagonists/partial agonists and uses thereof
    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    08/28/22
  148. 466
    Heteroaryl Rheb inhibitors and uses thereof
    NAVITOR PHARMACEUTICALS, INC.
    08/28/22
  149. 266
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    08/28/22
  150. 34
    Identification of stabilizers of multimeric proteins
    TBA
    08/28/22
  151. 28
    Substituted [1,2,4]triazolo[4,3-A]pyrazines as prolyl endopeptidase inhibitors
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    08/28/22
  152. 11
    hTRPV1 chemical agents
    University of Pittsburgh—Of the Commonwealth System of Higher Education
    08/28/22
  153. 12
    CD73 inhibitors and therapeutic uses thereof
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    08/21/22
  154. 22
    Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same
    KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    08/21/22
  155. 33
    Inhibitors of lysine gingipain
    CORTEXYME, INC.
    08/21/22
  156. 42
    MAGL inhibitors
    H. LUNDBECK A/S
    08/21/22
  157. 94
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals, Inc.
    08/21/22
  158. 30
    Substituted pyrazolo[3,4-d]pyrimidines as Wee1 inhibitors
    NUVATION BIO INC.
    08/21/22
  159. 19
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    08/15/22
  160. 203
    CD73 inhibitors
    ORIC PHARMACEUTICALS, INC.
    08/15/22
  161. 26
    CaMKII inhibitors and uses thereof
    The Johns Hopkins University
    08/15/22
  162. 32
    Chemical compounds
    ASTRAZENECA AB
    08/15/22
  163. 68
    Imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase
    The Governors of the University of Alberta
    08/15/22
  164. 18
    Optically active crosslinked cyclic secondary amine derivative
    Sumitomo Dainippon Pharma Co., Ltd.
    08/15/22
  165. 134
    Spiropyrrolidine derived antiviral agents
    Enanta Pharmaceuticals, Inc.
    08/15/22
  166. 22
    Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors
    VALO HEALTH, INC.
    08/15/22
  167. 26
    Combination therapy for treatment of hematological diseases
    Incyte Corporation
    08/14/22
  168. 67
    Ketone inhibitors of lysine gingipain
    CORTEXYME, INC.
    08/14/22
  169. 42
    Benzamide compounds
    Recurium IP Holdings, LLC
    08/07/22
  170. 147
    Cyanopyrrolidines as dub inhibitors for the treatment of cancer
    MISSION THERAPEUTICS LIMITED
    08/07/22
  171. 415
    Inhibitors of Bruton's tyrosine kinase and methods of their use
    Janssen Pharmaceutica NV
    08/07/22
  172. 22
    Modulators of the 5-hydroxytryptamine receptor 7 and their method of use
    Temple University—Of The Commonwealth System of Higher Education; Praeventix, LLC
    08/07/22
  173. 121
    Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    08/07/22
  174. 708
    Substituted carboxamides as inhibitors of WDR5 protein-protein binding
    Propellon Therapeutics Inc.
    08/07/22
  175. 18
    Tricyclic fused derivatives of 1-(cyclo)alkyl pyrtdin-2-one useful for the treatment of cancer
    JUBILANT BIOSYS LIMITED
    08/07/22
  176. 173
    9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use
    Merck Sharp & Dohme Corp.
    08/06/22
  177. 61
    9H-pyrrolo-dipyridine derivatives
    TBA
    08/06/22
  178. 410
    Azabenzimidazoles and their use as AMPA receptor modulators
    Janssen Pharmaceutica NV
    08/06/22
  179. 17
    Ghrelin O-acyltransferase inhibitors
    Glaxosmithkline Intellectual Property Development Limited
    08/06/22
  180. 46
    Heteroaryl[4,3-C]pyrimidine-5-amine derivative, preparation method therefor, and medical uses thereof
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    08/06/22
  181. 113
    Hsp90 inhibitors and uses thereof
    TRUSTEES OF BOSTON UNIVERSITY; The Governing Council of the University of Toronto
    08/06/22
  182. 91
    Imidazo[4,5-C]quinoline derivatives as LRRK2 inhibitors
    Pfizer Inc.
    08/06/22
  183. 20
    Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)
    FORMA Therapeutics, Inc.
    08/06/22
  184. 177
    Inhibitors of cysteine proteases and methods of use thereof
    Pardes Biosciences, Inc.
    08/06/22
  185. 375
    Macrocyclic flu endonuclease inhibitors
    Janssen BioPharma, Inc.
    08/06/22
  186. 19
    Morpholine derivative
    Hoffmann-La Roche Inc.
    08/06/22
  187. 83
    Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors
    Merck Sharp & Dohme Corp.
    08/06/22
  188. 6
    Protease inhibitors
    Medivir AB
    08/06/22
  189. 182
    Pyranopyrazole and pyrazolopyridine immunomodulators for treatment of autoimmune diseases
    THE ROCKEFELLER UNIVERSITY
    08/06/22
  190. 63
    Pyrazole compound
    SUMITOMO DAINIPPON PHARMA CO., LTD.
    08/06/22
  191. 193
    Substituted dihydroimidazopyridinediones as MKNK1 and MKNK2 inhibitors
    Bayer Pharma Aktiengesellschaft; Bayer Aktiengesellschaft
    08/06/22
  192. 37
    Thienodiazepine derivatives and application thereof
    CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD.
    08/06/22
  193. 54
    Treatment of GVHD
    KADMON CORPORATION, LLC; REGENTS OF THE UNIVERSITY OF MINNESOTA
    08/06/22
  194. 78
    4,6 dihydropyrrolo [3,4-C] pyrazole-5 (1H)-carbonitrile derivates for treating cancer
    MISSION THERAPEUTICS LIMITED
    08/01/22
  195. 25
    Cyano thienotriazolodiazepines and uses thereof
    Dana-Farber Cancer Institute, Inc.
    08/01/22
  196. 23
    Inhibitors of KRAS G12C and methods of using the same
    AMGEN INC.
    08/01/22
  197. 47
    Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
    Venenum Biodesign, LLC
    08/01/22
  198. 85
    3-(5-amino-pyrazin-2-yl)-benzenesulfonamide derivatives and related compounds as PI3K-gamma kinase inhibitors
    Incyte Corporation
    07/31/22
  199. 22
    Benzofuran, benzothiophene, and indole analogs that inhibit the formation of tau oligomers and their method of use
    Oligomerix, Inc.
    07/31/22
  200. 29
    Heterocyclic compounds as adenosine antagonists
    Nuvation Bio Inc.
    07/31/22
  201. 176
    Phenylacetamides as inhibitors of rock
    Bristol-Myers Squibb Company
    07/31/22
  202. 475
    Piperidine CXCR7 receptor modulators
    IDORSIA PHARMACEUTICALS LTD.
    07/31/22
  203. 52
    Substituted quinazolines for inhibiting kinase activity
    NEUPHARMA, INC.
    07/31/22
  204. 213
    Tosylacetate based compounds and derivatives thereof as PHGDH inhibitors
    Boehringer Ingelheim International GmbH
    07/31/22
  205. 26
    Treatment of hidradenitis suppurativa using JAK inhibitors
    Incyte Corporation
    07/31/22
  206. 156
    2-arylsulfonamido-N-arylacetamide derivatized STAT3 inhibitors
    University of Hawaii
    07/28/22
  207. 83
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    07/24/22
  208. 47
    Benzimidazole and indole compounds and uses thereof
    Incyte Corporation
    07/24/22
  209. 10
    Chemical compounds
    GlaxoSmithKline Intellectual Property (No. 2) Limited
    07/24/22
  210. 66
    Five membered-aminoheterocycle and 5,6-or 6,6-membered bicyclic aminoheterocyclic inhibitors of rock for the treatment of heart failure
    Bristol-Myers Squibb Company
    07/24/22
  211. 108
    Heterocyclic compounds and uses thereof
    Nuvation Bio Inc.
    07/24/22
  212. 27
    JAK kinase inhibitor compounds for treatment of respiratory disease
    Theravance Biopharma R&D IP, LLC
    07/24/22
  213. 24
    Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
    UNION therapeutics A/S
    07/24/22
  214. 1
    Combination therapy involving diaryl macrocyclic compounds
    TURNING POINT THERAPEUTICS, INC.
    07/21/22
  215. 3
    Composition for inhibiting growth of SARS-CoV-2 and method of preparing the same
    Medicare Pharmaceuticals Inc.; MEDICARE LC.
    07/21/22
  216. 37
    Diarylhydantoin compounds and methods of use thereof
    Nuvation Bio Inc.
    07/21/22
  217. 237
    Heterocyclic inhibitors of MCT4
    Vettore, LLC
    07/21/22
  218. 18
    Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
    Hanmi Pharm. Co., Ltd.
    07/21/22
  219. 184
    Pyrimidine tricyclic enone derivatives for inhibition of ROR-gamma and other uses
    REATA PHARMACEUTICALS, INC.
    07/21/22
  220. 171
    RAD51 inhibitors
    Cyteir Therapeutics, Inc.
    07/21/22
  221. 16
    Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
    UNION THERAPEUTICS A/S
    07/21/22
  222. 256
    Substituted piperidine compound and use thereof
    TAKEDA PHARMACEUTICAL COMPANY LIMITED
    07/21/22
  223. 781
    Tetrahydro-imidazo quinoline compositions as CBP/P300 inhibitors
    FORMA Therapeutics, Inc.
    07/21/22
  224. 82
    Tricyclic CRBN ligands and uses thereof
    KYMERA THERAPEUTICS, INC.
    07/21/22
  225. 32
    Aryl ethene derivative and pharmaceutical composition containing same as active ingredient
    Daegu-Gyeongbuk Medical Innovation Foundation; KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL; Kyungpook National University Industry-Academic Cooperation Foundation
    07/16/22
  226. 1775
    EIF4E-inhibiting compounds and methods
    eFFECTOR Therapeutics, Inc.
    07/16/22
  227. 33
    Macrocyclic fluorine substituted indole derivatives
    The Broad Institute, Inc.; Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    07/16/22
  228. 390
    Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
    Incyte Corporation; Incyte Holdings Cororation
    07/16/22
  229. 6
    Pyrrolidine compounds
    Eli Lilly and Company
    07/16/22
  230. 369
    Substituted piperazines as KRAS G12C inhibitors
    AMGEN INC.
    07/16/22
  231. 9
    AMPK activators
    KALLYOPE, INC.
    07/10/22
  232. 51
    Aromatic derivative, preparation method for same, and medical applications thereof
    BIOARDIS LLC
    07/10/22
  233. 19
    Compound as selective JAK inhibitor, and salt and therapeutic use thereof
    Suzhou Longbiotech Pharmaceuticals Co., Ltd.
    07/10/22
  234. 435
    Compounds and compositions for the inhibition of NAMPT
    Valo Health, Inc.; Genentech, Inc.
    07/10/22
  235. 9
    Enantiomers of substituted thiazoles as antiviral compounds
    Innovative Molecules GmbG
    07/10/22
  236. 229
    Fused pyrimidine compounds as BRD4 and JAK2 dual inhibitors and methods for use thereof
    APTOSE BIOSCIENCES INC.
    07/10/22
  237. 41
    Inhibitors of RET
    BLUEPRINT MEDICINES CORPORATION
    07/10/22
  238. 61
    Macrocyclic compounds that inhibit MCL-1 protein
    AMGEN INC.
    07/10/22
  239. 63
    Substituted bicyclic pyrimidine-based compounds and compositions and uses thereof
    TBA
    07/10/22
  240. 171
    Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists
    AMGEN INC.
    07/05/22
  241. 291
    Colony stimulating factor-1 receptor (CSF-1R) inhibitors
    GENZYME CORPORATION
    07/05/22
  242. 28
    Tricyclic compounds for use in treatment of proliferative disorders
    ARGONAUT THERAPEUTICS LIMITED
    07/05/22
  243. 32
    Cyclopentane compounds
    Dizal (Jiangsu) Pharmaceutical Co., Ltd.
    07/04/22
  244. 55
    MAPK inhibitors
    EverBrilliant Pharma Pty Ltd
    07/04/22
  245. 16
    Modulators of methyl modifying enzymes, compositions and uses thereof
    Constellation Pharmaceuticals, Inc.
    07/04/22
  246. 375
    P300/CBP HAT inhibitors
    Constellation Pharmaceuticals, Inc.
    07/04/22
  247. 34
    Pharmaceutical composition for ANO1 antagonist with anticancer activity
    INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIVERSITY
    07/04/22
  248. 1
    Aminopyrimidine compound and composition comprising same and use thereof
    Shenzhen TargetRx, Inc.
    06/26/22
  249. 14
    Benzamide derivatives as PPAR-gamma modulators
    Medibiofarma, S.L.
    06/26/22
  250. 48
    Carbocyclic prolinamide derivatives
    ORION OPHTHALMOLOGY LLC
    06/26/22
  251. 19
    Class of amino-substituted nitrogen-containing fused ring compounds, preparation method therefor, and use thereof
    SHANGHAI RINGENE BIOPHARMA CO., LTD.
    06/26/22
  252. 1
    Indazole compound for use in inhibiting kinase activity, composition and application thereof
    Shenzhen TargetRx, Inc.
    06/26/22
  253. 224
    Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
    IDORSIA PHARMACEUTICALS LTD
    06/26/22
  254. 17
    Maslinic and oleanolic acids derivatives for treating SARS-CoV-2 infection
    KING ABDULAZIZ UNIVERSITY
    06/26/22
  255. 105
    Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
    Array BioPharma Inc.
    06/26/22
  256. 331
    Small molecule inhibitors of galectin-3
    Bristol-Myers Squibb Company
    06/26/22
  257. 3
    Substituted 1,2,3,3a,4,5,7,9,13,13a-decahydropyrido[1′,2′:4,5]pyrazino[1,2-a]pyrrolo[1,2-c]pyrimidines having HIV integrase inhibitory activity
    SHIONOGI & CO., LTD.; VIIV HEALTHCARE COMPANY
    06/26/22
  258. 516
    Triaryl compounds for treatment of PD-L1 diseases
    ChemoCentryx, Inc.
    06/26/22
  259. 14
    Tricyclic fused pyridin-2-one derivatives and their use as BRD4 inhibitors
    Jubilant Biosys Limited
    06/26/22
  260. 73
    19-NOR neuroactive steroids and methods of use thereof
    Sage Therapeutics, Inc.
    06/24/22
  261. 15
    Aromatic compound, pharmaceutical composition and use thereof
    Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
    06/24/22
  262. 587
    Biaryl derivative as GPR120 agonist
    LG CHEM. LTD.
    06/24/22
  263. 53
    Bicyclic heterocyclic derivatives
    Merck Patent GmbH
    06/24/22
  264. 48
    Dihydropyrimidine compounds and uses thereof in medicine
    SUNSHINE LAKE PHARMA CO., LTD.
    06/24/22
  265. 205
    Imidazotriaines and imidazopyrimidines as kinase inhibitors
    INCYTE HOLDINGS CORPORATION; INCYTE CORPORATION
    06/24/22
  266. 51
    Sulfoximine glycosidase inhibitors
    Asceneuron SA
    06/24/22
  267. 126
    TRPV4 antagonists
    GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
    06/24/22
  268. 41
    [1,6]naphthyridine compounds and derivatives as CDK8/CDK19 inhibitors
    Boehringer Ingelheim International GmbH
    06/24/22
  269. 9
    1,8-naphthyridinone compounds and uses thereof
    NUVATION BIO INC.
    06/19/22
  270. 637
    Compounds and methods for modulating adenosine A2B receptor and adenosine A2A receptor
    Corvus Pharmaceuticals, Inc.
    06/19/22
  271. 11
    Fused imidazo-piperidine JAK inhibitors
    THERAVANCE BIOPHARMA R&D IP, LLC
    06/19/22
  272. 72
    Pyrazole derivative compound and use thereof
    HANMI PHARM. CO., LTD.
    06/19/22
  273. 371
    Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives
    Pfizer Inc.
    06/19/22
  274. 49
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics Incorporated
    06/19/22
  275. 45
    Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
    CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
    06/19/22
  276. 71
    3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators
    Ludwig Institute for Cancer Research Ltd
    06/17/22
  277. 22
    Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
    TES PHARMA S.R.L.
    06/17/22
  278. 43
    N2,N4-diphenylpyrimidine-2,4-diamine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of cancer
    Korea Research Institute of Chemical Technology
    06/17/22
  279. 409
    Substituted bicyclic compounds as farnesoid X receptor modulators
    Bristol-Myers Squibb Company
    06/17/22
  280. 3
    Triple combination of pure 5-HT6 receptor antagonists, acetylcholinesterase inhibitors and NMDA receptor antagonist
    Suven Life Sciences Limited
    06/17/22
  281. 508
    Bicyclic fused pyridine compounds as inhibitors of TAM kinases
    ARRAY BIOPHARMA INC
    06/13/22
  282. 114
    Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
    University of Washington through its Center for Commercialization
    06/13/22
  283. 69
    Compounds and methods for inhibiting JAK
    Dizal (Jiangsu) Pharmaceutical Co., Ltd.
    06/13/22
  284. 116
    Cyclopropylamines as LSD1 inhibitors
    Incyte Corporation
    06/13/22
  285. 11
    FXR (NR1H4) modulating compounds
    Gilead Sciences, Inc.
    06/13/22
  286. 63
    Macrocyclic derivative of pyrazol[3,4-d]pyrimidin-3-one, pharmaceutical composition and use thereof
    SHANGHAI DE NOVO PHARMATECH CO., LTD.
    06/13/22
  287. 4
    Metalloenzyme inhibitor compounds
    Mycovia Pharmaceuticals, Inc.
    06/13/22
  288. 288
    PCSK9 inhibitors and methods of use thereof
    AstraZeneca AB
    06/13/22
  289. 157
    Phenyl indole allosteric inhibitors of P97 ATPase
    University of Pittsburgh—Of the Commonwealth System of Higher Education; National Institutes of Health, A Component of the U.S. Department of Hearth and Human Services; The Regents of the University of California
    06/13/22
  290. 3
    Pyrimidine derivative having effect of inhibiting cancer cell growth and pharmaceutical composition containing same
    ONCOBIX CO., LTD.
    06/13/22
  291. 34
    Quinazoline and indole compounds to treat medical disorders
    Achillion Pharmaceuticals, Inc.
    06/13/22
  292. 172
    Therapeutic compounds and uses thereof
    GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.
    06/13/22
  293. 52
    Tricyclic inhibitors of poly(ADP-ribose)polymerase
    Rakovina Therapeutics Inc.
    06/13/22
  294. 510
    Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
    THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; THE UAB RESEARCH FOUNDATION; VANDERBILT UNIVERSITY; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    06/12/22
  295. 86
    (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof
    Genentech, Inc.
    06/10/22
  296. 12
    2-phenyl-3,4-dihydropyrrolo[2,1-Ff] [1,2,4]triazinone derivatives as phosphodiesterase inhibitors and uses thereof
    TOPADUR PHARMA AG
    06/10/22
  297. 134
    Compounds useful for treating gastrointestinal tract disorders
    ARDELYX, INC.
    06/10/22
  298. 2
    Ethynyl derivatives
    Hoffmann-La Roche Inc.
    06/10/22
  299. 56
    Isoquinoline amine compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    06/10/22
  300. 174
    Proteasome activity enhancing compounds
    Proteostasis Therapeutics, Inc.
    06/10/22
  301. 76
    Pyrazolopyridine compounds and uses thereof
    Incyte Corporation
    06/10/22
  302. 90
    Spirocyclic ROR-gamma modulators
    ESCALIER BIOSCIENCES B.V.
    06/10/22
  303. 61
    Sulfonimidoylpurinone compounds and methods of treatment using the same
    Hoffmann-La Roche Inc.
    06/10/22
  304. 98
    Tricyclic inhibitors of the BCL6 BTB domain protein-protein interaction and uses thereof
    ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR)
    06/10/22
  305. 6
    Dipeptidyl ketoamide meta-methoxyphenyl derivatives and uses thereof
    LANDSTEINER GENMED, S.L.
    06/09/22
  306. 1
    Formulations of an AXL/MER inhibitor
    Incyte Corporation
    06/09/22
  307. 21
    Heteroaryl amide derivatives as selective inhibitors of histone deacetylases 1 and/or 2(HDAC1-2)
    Medibiofarma, S.L.
    06/09/22
  308. 95
    Inhibitors of plasma kallikrein
    Kalvista Pharmaceuticals Limited
    06/09/22
  309. 4
    Organosilicon carriers for use in treating infections and/or diseases caused by SARS viruses
    TBA
    06/09/22
  310. 3
    Aminobenzimidazole derivatives, treatments, and methods of inhibiting histone deacetylase
    Translational Drug Development, LLC
    06/06/22
  311. 274
    Combination of isoindolinone derivatives with SGI-110
    ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED
    06/06/22
  312. 78
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    06/06/22
  313. 99
    Fused ring compounds
    Genentech, Inc.
    06/06/22
  314. 134
    Isoxazole compounds as inhibitors of heat shock proteins
    Cancer Research Technology Limited; The Institute of Cancer Research; Vernalis (R&D) Limited
    06/06/22
  315. 197
    KIF18A inhibitors
    AMGEN INC.
    06/06/22
  316. 8
    Morpholine derivates as inhibitors of Vps34
    Neuropore Therapies, Inc.
    06/06/22
  317. 77
    Protein kinase B inhibitors
    ASTRAZENECA AB
    06/06/22
  318. 116
    Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors
    MISSION THERAPEUTICS LIMITED
    06/06/22
  319. 183
    Substituted heterocyclic sulfonamide compounds useful as TRPA1 modulators
    Genentech, Inc.
    06/06/22
  320. 6
    Substituted pyrrolopyridines as ATR inhibitors
    BlueValley Pharmaceutical LLC
    06/06/22
  321. 36
    Substituted sulfoximine compounds
    Cadila Healthcare Limited
    06/06/22
  322. 11
    2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same
    CrystalGenomics, Inc.
    05/30/22
  323. 166
    KDM1A inhibitors for the treatment of disease
    Imago Biosciences, Inc.
    05/30/22
  324. 99
    Purine inhibitors of human phosphatidylinositol 3-kinase delta
    Merck Sharp & Dohme Corp.
    05/30/22
  325. 244
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    05/29/22
  326. 128
    Myocyte enhancer factor 2 (MEF2) modulators
    STANDARD LLC
    05/29/22
  327. 32
    Selective androgen receptor degrader (SARD) ligands and methods of use thereof
    UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    05/29/22
  328. 38
    Substituted tetrahydroquinolinone compounds as ROR gamma modulators
    AURIGENE DISCOVERY TECHNOLOGIES LIMITED
    05/29/22
  329. 108
    Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    05/29/22
  330. 15
    Bicyclic inhibitors of histone deacetylase
    Alkermes, Inc.
    05/22/22
  331. 812
    Compounds that inhibits MCL-1 protein
    AMGEN INC.
    05/22/22
  332. 18
    Heterocycles useful as anti-cancer agents
    Hangzhou Innogate Pharma Co., Ltd.
    05/22/22
  333. 275
    Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof
    Whitehead Institute for Biomedical Research; Dana-Farber Cancer Institute, Inc.; The United States of America, as represented by the Secretary, Department of Health and Human Services
    05/22/22
  334. 10
    Substituted pyridines as inhibitors of histone deacetylase
    Alkermes, Inc.
    05/22/22
  335. 122
    Tertiary alcohols as PI3K-γ inhibitors
    Incyte Corporation
    05/22/22
  336. 16
    5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents
    Temple University-Of the Commonwealth System of Higher Education
    05/14/22
  337. 137
    Cyclin dependent kinase inhibitors
    Pfizer Inc.
    05/14/22
  338. 333
    Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
    LA JOLLA INSTITUTE OF ALLERGY & IMMUNOLOGY; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    05/14/22
  339. 23
    Pyridylpyridone compounds
    Sprint Bioscience AB
    05/14/22
  340. 30
    Pyrrole tricyclic compounds as A2A / A2B inhibitors
    Incyte Corporation
    05/14/22
  341. 71
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics Incorporated
    05/14/22
  342. 218
    Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
    MIRATI THERAPEUTICS, INC.
    05/14/22
  343. 93
    Substituted n-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as protein kinase C inhibitors
    PFIZER INC.
    05/14/22
  344. 217
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    05/14/22
  345. 4
    2,3-dihydrofuro[2,3-b]pyridine compounds
    Eli Lilly and Company
    05/08/22
  346. 42
    Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
    Incyte Holdings Corporation; Incyte Corporation
    05/08/22
  347. 17
    Cannabinoid receptor modulators
    Arena Pharmaceuticals, Inc.
    05/08/22
  348. 88
    Compositions for treating neurodegenerative diseases
    Cognition Therapeutics, Inc.
    05/08/22
  349. 341
    Compound, compositions, and methods
    DENALI THERAPEUTICS INC.
    05/08/22
  350. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
    SHY Therapeutics LLC
    05/08/22
  351. 103
    Histone demethylase inhibitors
    CELGENE QUANTICEL RESEARCH, INC.
    05/08/22
  352. 52
    Indoleamine 2,3-dioxygenase inhibitor, method for preparation and use thereof
    NANJING HUAWE MEDICINE TECHNOLOGY GROUP CO., LTD.
    05/08/22
  353. 21
    Linear glycosidase inhibitors
    Asceneuron SA
    05/08/22
  354. 42
    MAGL inhibitors
    H. LUNDBECK A/S
    05/08/22
  355. 16
    Phenylpyrazolylacetamide compounds and derivatives as CDK8/CDK19 inhibitors
    Boehringer Ingelheim International GmbH
    05/08/22
  356. 49
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics, Incorporated
    05/08/22
  357. 52
    Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators
    JANSSEN PHARMACEUTICA NV
    05/08/22
  358. 7
    Substituted pyridine derivatives useful as C-FMS kinase inhibitors
    Janssen Pharmaceutica NV
    05/08/22
  359. 32
    Compositions and methods for treating parasitic diseases
    The Regents of the University of California; Washington University
    05/03/22
  360. 109
    Compounds useful as inhibitors of ALCAT 1
    PERENNA PHARMACEUTICALS, INC.
    05/03/22
  361. 80
    Ectonucleotidase inhibitors and methods of use thereof
    CALITHERA BIOSCIENCES, INC.
    05/03/22
  362. 5
    Nitrogenous tricyclic compounds and uses thereof in medicine
    SUNSHINE LAKE PHARMA CO., LTD.
    05/03/22
  363. 31
    Prognostic biomarkers for TTK inhibitor chemotherapy
    NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
    05/03/22
  364. 20
    Pyridinamine-pyridone and pyrimidinamine- pyridone compounds
    Sprint Bioscience AB
    05/03/22
  365. 121
    Pyridone derivatives having tetrahydropyranylmethyl groups
    Daiichi Sankyo Company, Limited
    05/03/22
  366. 41
    Selective inhibitors of protein arginine methytransterase 5 (PRMT5)
    Prelude Therapeutics Incorporated
    05/03/22
  367. 53
    Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors
    Bayer Pharma Aktiengesellschaft; Bayer Aktiengesellschaft
    05/03/22
  368. 376
    Substituted indole Mcl-1 inhibitors
    Vanderbilt University
    05/03/22
  369. 20
    1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
    Incyte Corporation; Incyte Holdings Corporation
    05/02/22
  370. 119
    3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof
    ALLERGAN, INC.
    05/02/22
  371. 96
    Certain chemical entities, compositions, and methods
    NEUPHARMA, INC
    05/02/22
  372. 27
    HDAC6 inhibitors and imaging agents
    The General Hospital Corporation
    05/02/22
  373. 55
    Indole derivatives and their use as protein kinase inhibitors
    RESPIVERT LIMITED
    05/02/22
  374. 204
    Metallo-beta-lactamase inhibitors and methods of use thereof
    Merck Sharp & Dohme Corp.
    05/02/22
  375. 117
    NLRP3 inflammasome inhibitors
    Novartis AG
    05/02/22
  376. 595
    Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GLUN2B receptor modulators
    JANSSEN PHARMACEUTICA NV
    05/02/22
  377. 526
    Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    05/02/22
  378. 1
    Sulfinylpyridines and their use in the treatment of cancer
    Oblique Therapeutics AB
    05/02/22
  379. 243
    Triazolopyrimidine compounds and uses thereof
    Novartis AG
    05/02/22
  380. 28
    Anti-proliferative agents for treating PAH
    Pfizer Inc.
    04/29/22
  381. 13
    Aza-indazole compounds for use in tendon and/or ligament injuries
    NOVARTIS AG
    04/29/22
  382. 247
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    04/29/22
  383. 37
    Iridinesulfonamide compound and use method thereof
    Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd.
    04/29/22
  384. 281
    Kinase inhibitors and uses thereof
    DENALI THERAPEUTICS INC.
    04/29/22
  385. 14
    Personal care compositions comprising fatty acid amide derivatives
    Conopco, Inc.
    04/29/22
  386. 302
    Substituted 6-azabenzimidazole compounds
    Gilead Sciences, Inc.
    04/29/22
  387. 100
    Sulfonamides as modulators of sodium channels
    VERTEX PHARMACEUTICALS INCORPORATED
    04/29/22
  388. 19
    Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof
    The Broad Institute, Inc.; Biogen MA Inc.
    04/29/22
  389. 56
    Compounds targeting PRMT5
    Aligos Therapeutics, Inc.
    04/25/22
  390. 573
    Fused ring derivative having MGAT-2 inhibitory activity
    SHIONOGI & CO., LTD.
    04/25/22
  391. 113
    Aminopyrimidinyl compounds
    Pfizer Inc.
    04/24/22
  392. 16
    Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
    GLYCOMIMETICS. INC.
    04/24/22
  393. 115
    Heteroaryl inhibitors of PAD4
    Padlock Therapeutics, Inc.
    04/24/22
  394. 92
    N-((het)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
    KalVista Pharmaceuticals Limited
    04/24/22
  395. 13
    Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
    BioAxone BioSciences, Inc.
    04/24/22
  396. 30
    5-hydroxytryptamine receptor 7 activity modulators and their method of use
    Temple University-Of The Commonwealth System of Higher Education
    04/17/22
  397. 111
    Alkyl substituted triazole compounds as agonists of the APJ Receptor
    AMGEN INC.
    04/17/22
  398. 377
    Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
    Janssen Pharmaceutica NV
    04/17/22
  399. 8
    Glutaminase inhibitor discovery and nanoparticle-enhanced delivery for cancer therapy
    THE JOHNS HOPKINS UNIVERSITY
    04/17/22
  400. 44
    Heterocyclic compounds for the inhibition of PASK
    BioEnergenix LLC
    04/17/22
  401. 246
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    04/17/22
  402. 36
    N-aryl oxamic acids
    Purdue Research Foundation
    04/17/22
  403. 6
    Pyrazoloquinazolinone antitumor agents
    The Rockefeller University
    04/17/22
  404. 43
    Quinoline compounds as modulators of RAGE activity and uses thereof
    TBA
    04/17/22
  405. 4
    Quinolone compounds as inhibitors of the BCL6 BTB domain protein-protein interaction and/or as BCL6 degraders
    ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR)
    04/17/22
  406. 68
    Substituted 1,6-dihydropyridinones and 1,2-dihydroisoquinolinones as bet inhibitors
    Nuvation Bio Inc.
    04/17/22
  407. 88
    6-heterocyclyl-4-morpholin-4-ylpyridine-2-one compounds useful for the treatment of cancer and diabetes
    SPRINT BIOSCIENCE AB
    04/10/22
  408. 73
    6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivative
    AYUMI PHARMACEUTICAL CORPORATION
    04/10/22
  409. 40
    Amino pyrimidine derivatives
    Novartis AG
    04/10/22
  410. 46
    Anilinopyrimidines as haematopoietic progenitor kinase 1 (HPK1) inhibitors
    ARIAD Pharmaceuticals, Inc.
    04/10/22
  411. 14
    Azaspiro[4.5]decane derivatives and use thereof
    Purdue Pharma L.P.
    04/10/22
  412. 8
    Cannabinoid receptor antagonists/inverse agonists useful for treating disease conditions, including metabolic disorders and cancers
    Jenrin Discovery, LLC
    04/10/22
  413. 32
    Compound as ACC inhibitor and use thereof
    NANJING SANHOME PHARMACEUTICAL CO., LTD.
    04/10/22
  414. 161
    Compounds for the treatment of pain
    TBA
    04/10/22
  415. 4
    Crystalline forms of a phosphoinositide 3-kinase (PI3K) inhibitor
    Incyte Corporation
    04/10/22
  416. 95
    Cyanoindoline derivatives as NIK inhibitors
    Janssen Pharmaceutica NV
    04/10/22
  417. 145
    Imidazopyrimidine derivatives
    Gilead Sciences, Inc.
    04/10/22
  418. 38
    Purine inhibitors of human phosphatidylinositol 3-kinase delta
    Merck Sharp & Dohme Corp.
    04/10/22
  419. 59
    Pyrazole derivatives as plasma kallikrein inhibitors
    KalVista Pharmaceuticals Limited
    04/10/22
  420. 130
    Pyrazolo[1,5-A][1,3,5]triazine and pyrazolo[1,5-A]pyrimidine derivatives as CDK inhibitors
    Aurigene Discovery Technologies Limited
    04/10/22
  421. 23
    Somatostatin modulators and uses thereof
    CRINETICS PHARMACEUTICALS, INC.
    04/10/22
  422. 562
    Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as PDE2 inhibitors
    Dart Neuroscience, (Cayman) LTD.
    04/10/22
  423. 183
    Substituted amino acids as integrin inhibitors
    Pliant Therapeutics, Inc.
    04/10/22
  424. 254
    Substituted oxopyridine derivatives
    Bayer Pharma Aktiengesellschaft
    04/10/22
  425. 6
    Substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines as tyrosine kinase inhibitors
    Shenzhen TargetRx, Inc.
    04/10/22
  426. 35
    Therapeutic heterocyclic compounds
    Gilead Sciences, Inc.
    04/10/22
  427. 212
    Vasopressin receptor antagonists and products and methods related thereto
    BLACKTHORN THERAPEUTICS, INC.
    04/10/22
  428. 13
    [1,2,4]Triazolo[4,3-A]pyrazin-6(5H)-one derivatives
    ELI LILLY AND COMPANY
    04/10/22
  429. 27
    3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
    Novartis AG
    04/09/22
  430. 50
    Methods for modulating taste receptors
    MARS, INCORPORATED
    04/09/22
  431. 64
    Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
    Vertex Pharmaceuticals Incorporated
    04/09/22
  432. 164
    Non-fused tricyclic compounds
    VIVACE THERAPEUTICS, INC.
    04/09/22
  433. 45
    Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
    Bristol-Myers Squibb Company
    04/09/22
  434. 73
    4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139
    Takeda Pharmaceutical Company Limited
    04/03/22
  435. 8
    Adrenergic receptor modulating compounds and methods of using the same
    The Board of Trustees of the Leland Stanford Junior University
    04/03/22
  436. 17
    Aniline-substituted 1,2-dihydropyrrol[3,4-C]pyridin/pyrimidin-3-one derivative and use thereof
    YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.; SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.
    04/03/22
  437. 333
    Benzenesulfonamide compouds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    04/03/22
  438. 124
    Benzimidazole compounds and derivatives as EGFR inhibitors
    Boehringer Ingelheim International GmbH
    04/03/22
  439. 187
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte Corporation
    04/03/22
  440. 59
    Compositions and methods to modulate chloride ion channel activity
    The Board of Trustees of the Leland Stanford Junior University
    04/03/22
  441. 18
    Compounds, compositions and methods
    Denali Therapeutics Inc.
    04/03/22
  442. 133
    Heterocyclic compounds as kinase inhibitors
    NUVATION BIO INC.
    04/03/22
  443. 29
    Indazolyl-spiro[2.3]hexane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
    Merck Sharp & Dohme Corp.
    04/03/22
  444. 303
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    BioSplice Therapeutics, Inc.
    04/03/22
  445. 7
    Neprilysin inhibitors
    Theravance Biopharma R&D IP, LLC
    04/03/22
  446. 126
    Substituted carboxamides as inhibitors of WDR5 protein-protein binding
    Propellon Therapeutics Inc.
    04/03/22
  447. 89
    Substituted heterocyclyl derivatives as CDK inhibitors
    Aurigene Discovery Technologies Limited
    04/03/22
  448. 19
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    04/03/22
  449. 5
    Matriptase inhibitors and uses thereof
    SOCIÉTÉ DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUÉE SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C.
    03/30/22
  450. 11
    3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
    Rugen Holdings (Cayman) Limited
    03/27/22
  451. 71
    3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof
    Board of Trustees of the Southern Illinois University
    03/27/22
  452. 20
    4-pyrazin-2-ylmethyl-morpholine derivatives and the use thereof as medicament
    Boehringer Ingelheim International GmbH
    03/27/22
  453. 173
    ASK1 inhibiting agents
    BIOGEN MA INC.
    03/27/22
  454. 13
    Amino-triazolopyridine compounds and their use in treating cancer
    AstraZeneca AB
    03/27/22
  455. 135
    Bicyclic heteroaryl compounds and uses thereof
    Revolution Medicines, Inc.
    03/27/22
  456. 35
    CXCR2 antagonist
    MEDSHINE DISCOVERY INC.
    03/27/22
  457. 34
    Compounds and their use for reducing uric acid levels
    Acquist LLC
    03/27/22
  458. 67
    Dynamin-1-like protein inhibitors
    Mitobridge, Inc.
    03/27/22
  459. 10
    Functionalized pyrano[2,3-D]pyrimidin-7-one derivatives and methods for their preparation and use
    The Texas A&M University System
    03/27/22
  460. 34
    Fused pyrimidine derivatives as A2A / A2B inhibitors
    Incyte Corporation
    03/27/22
  461. 25
    Fused ring derivative used as FGFR4 inhibitor
    JACOBIO PHARMACEUTICALS CO., LTD.
    03/27/22
  462. 214
    Heteroaromatic derivatives as NIK inhibitors
    Janssen Pharmaceutica NV
    03/27/22
  463. 6
    Heterocyclylsulfonyl-substituted pyridines and their use in the treatment of cancer
    Oblique Therapeutics AB
    03/27/22
  464. 8
    Indane-amines as PD-L1 antagonists
    ChemoCentryx, Inc.
    03/27/22
  465. 66
    Inhibitors of Plasma Kallikrein and uses thereof
    Takeda Pharmaceutical Company Limited
    03/27/22
  466. 42
    Inhibitors of dihydroceramide desaturase for treating disease
    Centaurus Therapeutics
    03/27/22
  467. 55
    Inhibitors of integrated stress response pathway
    PRAXIS BIOTECH LLC
    03/27/22
  468. 118
    JAK inhibitors
    VIMALAN BIOSCIENCES, INC.
    03/27/22
  469. 77
    Macrocycles as factor XIA inhibitors
    Bristol-Myers Squibb Company
    03/27/22
  470. 42
    Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors
    Boehringer Ingelheim International GmbH
    03/27/22
  471. 56
    Pyridylamino substituted heterotricyclic compounds, and preparation method and pharmaceutical use thereof
    TBA
    03/27/22
  472. 95
    Pyrrolo[2,3-C]pyridines and related analogs as LSD-1 inhibitors
    THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    03/27/22
  473. 7
    Pyrrolopyrimidine and pyrrolopyridine derivatives
    GALAPAGOS NV
    03/27/22
  474. 96
    Pyrrolopyrimidine derivatives as TAM inhibitors
    Incyte Corporation
    03/27/22
  475. 239
    Substituted N-arylethyl-2-arylquinoline-4-carboxamides and use thereof
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    03/27/22
  476. 38
    Substituted imidazoles as apoptosis signal regulating kinase 1 inhibitors
    Jiangsu Hansoh Pharmaceutical Group Co., Ltd.; Shanghai Hansoh Biomedical Co., Ltd.
    03/27/22
  477. 115
    Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
    Array BioPharma Inc.
    03/27/22
  478. 125
    Therapeutic compounds and uses thereof
    GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.
    03/27/22
  479. 135
    Thienopyridine inhibitors of RIPK2
    Celgene Corporation
    03/27/22
  480. 22
    Thienopyrimidones
    Boehringer Ingelheim International GmbH
    03/27/22
  481. 186
    2-quinolone derived inhibitors of BCL6
    The Institute of Cancer Research: Royal Cancer Hospital; Cancer Research Technology Limited
    03/20/22
  482. 15
    Compounds and their use for reducing uric acid levels
    Acquist LLC
    03/20/22
  483. 37
    Cyclic substituted imidazo[4,5-c]quinoline derivatives
    PFIZER INC.
    03/20/22
  484. 113
    Fused pyrazine derivatives as A2A / A2B inhibitors
    Incyte Corporation
    03/20/22
  485. 13
    Heterocyclic derivatives as PI3K inhibitors
    Incyte Corporation
    03/20/22
  486. 33
    Hydrocarbylsulfonyl-substituted pyridines and their use in the treatment of cancer
    Oblique Therapeutics AB
    03/20/22
  487. 77
    Indazolyl-spiro[2.2]pentane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
    Merck Sharp & Dohme Corp.
    03/20/22
  488. 6
    Inhibiting the transient receptor potential al ion channel
    Eli Lilly and Company
    03/20/22
  489. 44
    Inhibitors of NEK7 kinase
    HALIA THERAPEUTICS, INC.
    03/20/22
  490. 530
    Purinones as ubiquitin-specific protease 1 inhibitors
    FORMA Therapeutics, Inc.
    03/20/22
  491. 48
    Pyridinone derivatives and their use as selective ALK-2 inhibitors
    NOVARTIS AG
    03/20/22
  492. 76
    Sting agonists
    VENENUM BIODESIGN, LLC
    03/20/22
  493. 97
    Tricyclic fused thiophene derivatives as JAK inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    03/20/22
  494. 71
    4,6,7-trisubstituted 1,2-dihydropyrrolo[3,4-c]pyridin/pyrimidin-3-one derivatives and uses thereof
    SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.
    03/13/22
  495. 4
    Amide derivatives as Nav1.7 and Nav1.8 blockers
    RaQualia Pharma Inc.
    03/13/22
  496. 66
    Antagonists of the muscarinic acetylcholine receptor M4
    Vanderbilt University
    03/13/22
  497. 13
    C7 substituted oxysterols and methods of use thereof
    SAGE THERAPEUTICS, INC.
    03/13/22
  498. 2
    Crystal form of urate transporter 1 inhibitor and preparation method and use thereof
    TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.
    03/13/22
  499. 129
    Cyclopropylamines as LSD1 inhibitors
    Incyte Corporation
    03/13/22
  500. 30
    Dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
    TOPADUR PHARMA AG
    03/13/22
  501. 35
    Fused piperidinyl bicyclic and related compounds as modulators of C5A receptor
    InflaRx GmbH
    03/13/22
  502. 38
    Fused triazole agonists of the APJ receptor
    Amgen Inc.
    03/13/22
  503. 57
    Heterocycle comprising tyrosine kinase inhibitors
    Principia Biopharma Inc.
    03/13/22
  504. 46
    MAP kinase modulators and uses thereof
    The Trustees of Columbia University in the City of New York; Northwestern University
    03/13/22
  505. 157
    Oxysterols and methods of use thereof
    SAGE THERAPEUTICS, INC.
    03/13/22
  506. 1
    Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof
    Arena Pharmaceuticals, Inc.
    03/13/22
  507. 37
    Pyrazole MAGL inhibitors
    H. LUNDBECK A/S
    03/13/22
  508. 140
    Pyrazolopyrimidine compounds and methods of use thereof
    Genentech, Inc.
    03/13/22
  509. 17
    Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders
    DANA-FARBER CANCER INSTITUTE, INC.
    03/13/22
  510. 251
    Substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
    Sanofi
    03/13/22
  511. 272
    Substituted N-arylethyl-2-aminoquinoline-4-carboxamides and use thereof
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    03/13/22
  512. 12
    Substituted nucleosides, nucleotides and analogs thereof
    JANSSEN BIOPHARMA, INC.
    03/13/22
  513. 70
    Substituted triazole derivatives and uses thereof
    Bayer Pharma Aktiengesellschaft
    03/13/22
  514. 33
    Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors
    UNIVERSITÄT DUISBURG-ESSEN
    03/13/22
  515. 15
    Thrombospondin 1-binding peptide
    DAIICHI SANKYO COMPANY, LIMITED; PEPTIDREAM INC.
    03/13/22
  516. 8
    Composition for inducing differentiation and protection of neural stem cells and method for inducing neuro-regeneration using the same composition
    GENUV Inc.
    03/12/22
  517. 17
    Compositions and methods for treating CNS disorders
    Sage Therapeutics, Inc.
    03/12/22
  518. 2
    Compounds as neurokinin-1 receptor antagonists and uses thereof
    XWPHARMA LTD.
    03/12/22
  519. 5
    Methods for treating GI tract disorders
    NEUROGASTRX, INC.
    03/12/22
  520. 29
    Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
    Aurigene Discovery Technologies Limited
    03/12/22
  521. 215
    2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
    BAYER AKTIENGELLSCHAFT; BAYER PHARMA AKTIEGELLSCHAFT; THE BROAD INSTITUTE INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION
    03/08/22
  522. 715
    2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
    IDEAYA BIOSCIENCE, INC.
    03/08/22
  523. 38
    Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
    Incyte Corporation
    03/08/22
  524. 15
    Calcium channel inhibitors
    CAVION, INC.
    03/08/22
  525. 78
    Compounds
    MISSION THERAPEUTICS LIMITED
    03/08/22
  526. 60
    Dual MAGL and FAAH inhibitors
    Abide Therapeutics, Inc.
    03/08/22
  527. 66
    Pyridazinone compounds and their use as DAAO inhibitors
    Takeda Pharmaceutical Company Limited
    03/08/22
  528. 308
    Spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (MCL-1) protein
    Prelude Therapeutics, Incorporated
    03/08/22
  529. 17
    Substituted 2,3-dihydro-1H-indene analogs and methods using same
    Arbutus Biopharma Corporation
    03/08/22
  530. 95
    Substituted benzamides as RIPK2 inhibitors
    Boehringer Ingelheim International GmbH
    03/08/22
  531. 179
    Azalactam compounds as HPK1 inhibitors
    PFIZER INC.
    03/04/22
  532. 61
    Benzimidazoles and indoles as taro inhibitors
    MERCK SHARP & DOHME CORP
    03/04/22
  533. 58
    Compositions for APP-selective BACE inhibition and uses therefor
    The Regents of the University of California
    03/04/22
  534. 13
    Cyano substituted heteroarylpyrimidinone derivative, preparation method and use thereof
    ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
    03/04/22
  535. 99
    Dihydropyrimidine compounds and uses thereof in medicine
    SUNSHINE LAKE PHARMA CO., LTD.
    03/04/22
  536. 21
    Heterocyclic compound as Syk inhibitor and/or Syk-HDAC dual inhibitor
    Hangzhou Innogate Pharma Co., Ltd.
    03/04/22
  537. 35
    Inhibitors of cyclin-dependent kinases
    Dana-Farber Cancer Institute, Inc.
    03/04/22
  538. 37
    LDHA activity inhibitors
    ARCTIC PHARMA AS
    03/04/22
  539. 3
    Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
    Poxel SA
    03/04/22
  540. 99
    Oxazolidinones as taro inhibitors
    MERCK SHARP & DOHME CORP
    03/04/22
  541. 187
    Spirocycle compounds and methods of making and using same
    H. LUNDBECK A/S
    03/04/22
  542. 51
    Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics
    STINGRAY THERAPEUTICS, INC.
    03/04/22
  543. 8
    Inhibitors of bromodomain-containing protein 4 (BRD4)
    Board of Regents, The University Of Texas System
    03/02/22
  544. 34
    2,6-dioxaspiro [4,5] decane derivatives and preparation method therefor and pharmaceutical applications thereof
    TBA
    02/26/22
  545. 24
    Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof
    DYNAVAX TECHNOLOGIES CORPORATION
    02/26/22
  546. 37
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    ASTRAZENECA AB
    02/26/22
  547. 3
    Combination of pure 5-HT6 receptor antagonists with NMDA receptor antagonist
    Suven Life Sciences Limited
    02/26/22
  548. 546
    Compounds useful as inhibitors of ATR kinase
    VERTEX PHARMACEUTICALS INCORPORATED
    02/26/22
  549. 38
    Disubstituted pyrazole compounds
    Eli Lilly and Company
    02/26/22
  550. 33
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    02/26/22
  551. 7
    Imidazolidine compounds
    Eli Lilly and Company
    02/26/22
  552. 101
    Inhibitors of glucocorticoid receptor
    ORIC PHARMACEUTICALS, INC.
    02/26/22
  553. 4
    Isoquinolin and naphthydrin compounds
    Eli Lilly and Company
    02/26/22
  554. 184
    Kappa opioid receptor antagonists and products and methods related thereto
    THE SCRIPPS RESEARCH INSTITUTE; BLACKTHORN THERAPEUTICS, INC.
    02/26/22
  555. 28
    L,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-one analogs
    Recurium IP Holdings, LLC
    02/26/22
  556. 635
    Methods and compositions of inhibiting DCN1-UBC12 interaction
    MEMORIAL SLOAN KETTERING CANCER CENTER; ST. JUDE CHILDREN''S RESEARCH HOSPITAL
    02/26/22
  557. 62
    Neuroactive steroids, compositions, and uses thereof
    Sage Therapeutics, Inc.
    02/26/22
  558. 127
    Phenylpyrrolidinone formyl peptide 2 receptor agonists
    Bristol-Myers Squibb Company
    02/26/22
  559. 7
    Pyrazolo-heteroaryl derivative, preparation method and medical use thereof
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    02/26/22
  560. 39
    Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases
    TBA
    02/26/22
  561. 22
    Selective estrogen receptor degraders
    Eli Lilly and Company
    02/26/22
  562. 32
    Tetrahydroisoquinolines and terahydronaphthyridines for the treatment of hepatitis B virus infection
    Hoffmann-La Roche, Inc.
    02/26/22
  563. 50
    Tri-substituted imidazoles for the inhibition of TGF beta and methods of treatment
    Clavius Pharmaceuticals, LLC.
    02/26/22
  564. 117
    6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity
    University of Pittsburgh—Of the Commonwealth System of Higher Education
    02/22/22
  565. 39
    Inhibitor of apoptosis protein (IAP) antagonists
    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    02/22/22
  566. 81
    Pyrazolopyrimidine compounds and uses thereof
    Incyte Corporation
    02/22/22
  567. 12
    Pyrimidine compounds and pyrimido indole compounds and methods of use
    Duquesne University of The Holy Spirit
    02/22/22
  568. 1227
    6-membered heterocyclic derivatives and pharmaceutical composition comprising the same
    SHIONOGI & CO., LTD.
    02/21/22
  569. 64
    Amino pyrimidine compound for inhibiting protein tyrosine kinase activity
    Shenzhen TargetRx, Inc.
    02/21/22
  570. 71
    Aryl heterocyclic piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
    Bristol-Myers Squibb Company
    02/21/22
  571. 23
    Autotaxin inhibitors
    UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION; UNIVERSITY OF MEMPHIS
    02/21/22
  572. 250
    Bicyclic compound and use thereof
    SK BIOPHARMACEUTICALS CO., LTD.
    02/21/22
  573. 164
    Compounds, compositions, and methods
    DENALI THERAPEUTICS INC.
    02/21/22
  574. 53
    EPAC antagonists
    Board of Regents, the University of Texas System
    02/21/22
  575. 17
    Imidazopyrazine inhibitors of Bruton's tyrosine kinase
    Acerta Pharma B.V.
    02/21/22
  576. 62
    Methods of treating mental disorders
    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    02/21/22
  577. 43
    Pyrimidine compounds as JAK kinase inhibitors
    Theravance Biopharma R&D IP, LLC
    02/21/22
  578. 315
    Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides
    Pfizer Inc.
    02/21/22
  579. 27
    Sultam compound and application method thereof
    Chai Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd.
    02/21/22
  580. 27
    1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones as PDE1 inhibitors
    H. Lundbeck A/S
    02/13/22
  581. 47
    4,5,6-trisubstituted indazole derivatives, and preparation method and pharmaceutical use thereof
    TBA
    02/13/22
  582. 843
    4-azaindole compounds
    Bristol-Myers Squibb Company
    02/13/22
  583. 13
    4-pyrimidin-5-ylmethyl-morpholine derivatives and the use thereof as medicament
    Boehringer Ingelheim International GmbH
    02/13/22
  584. 262
    Apoptosis signal-regulating kinase inhibitors
    Gilead Sciences, Inc.
    02/13/22
  585. 15
    Benzimidazole derivatives, preparation methods and uses thereof
    BETTA PHARMACEUTICALS CO., LTD.
    02/13/22
  586. 199
    Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
    Merck Sharp & Dohme Corp.
    02/13/22
  587. 20
    Inhibitors of bruton's tyrosine kinase
    Hoffmann-La Roche Inc.; Chugai Pharmaceutical Co.
    02/13/22
  588. 50
    Inhibitors of hepatitis C virus replication
    Merck Sharp & Dohme Corp.
    02/13/22
  589. 26
    JAK1 pathway inhibitors for the treatment of cytokine-related disorders
    Incyte Corporation
    02/13/22
  590. 379
    KRAS G12C inhibitors and methods of using the same
    AMGEN INC.
    02/13/22
  591. 223
    Macrocyclic compounds for treatment of medical disorders
    Achillion Pharmaceuticals, Inc.
    02/13/22
  592. 21
    PTPN11 inhibitors
    NAVIRE PHARMA, INC.
    02/13/22
  593. 188
    Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases
    Array BioPharma Inc.
    02/13/22
  594. 14
    Pyridazines
    Boehringer Ingelheim International GmbH
    02/13/22
  595. 138
    Pyrimidine derivative compound, optical isomer thereof, or pharmaceutically acceptable salt thereof, and composition for preventing or treating Tyro 3 related disease comprising same as active ingredient
    KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    02/13/22
  596. 8
    Pyrimidinones as factor XIA inhibitors
    Bristol-Myers Squibb Company
    02/13/22
  597. 10
    Pyrrolo[1,2-b]pyridazine derivatives
    Gilead Sciences, Inc.
    02/13/22
  598. 2
    Salts of TAM inhibitors
    Incyte Corporation
    02/13/22
  599. 106
    Substituted pyridines as TYK2 inhibitors
    Esker Therapeutics, Inc.
    02/13/22
  600. 233
    Substituted tricyclic compounds as FGFR inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    02/13/22
  601. 96
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    02/13/22
  602. 156
    [9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11BH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto
    Neurocrine Biosciences, Inc.
    02/13/22
  603. 71
    5-alkyl pyrrolidine orexin receptor agonists
    Merck Sharp & Dohme Corp.
    02/07/22
  604. 64
    Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
    Hoffmann-La Roche Inc.
    02/07/22
  605. 149
    Bicyclic ketone compounds and methods of use thereof
    Genentech, Inc.
    02/07/22
  606. 113
    Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders
    Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
    02/07/22
  607. 116
    Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
    Pharmaxis Ltd.
    02/07/22
  608. 179
    Heteroaryl compounds as BTK inhibitors and uses thereof
    Merck Patent GmbH
    02/07/22
  609. 103
    Imidazopyridinyl compounds and use thereof for treatment of neurodegenerative disorders
    1ST Biotherapeutics, Inc.
    02/07/22
  610. 126
    Inhibitors of RAF kinases
    KINNATE BIOPHARMA INC.
    02/07/22
  611. 126
    MK2 inhibitors and uses thereof
    Celgene CAR LLC
    02/07/22
  612. 32
    Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof
    CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
    02/07/22
  613. 40
    Macrocyclic compounds as TRK kinase inhibitors and uses thereof
    ANGEX PHARMACEUTICAL, INC.
    02/07/22
  614. 26
    PRMT5 inhibitors
    Merck Sharp & Dohme Corp.
    02/07/22
  615. 4
    Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
    ARENA PHARMACEUTICALS, INC.
    02/07/22
  616. 116
    1-cyano-pyrrolidine compounds as USP30 inhibitors
    MISSION THERAPEUTICS LIMITED
    02/06/22
  617. 10
    Anti-HIV compounds
    Gilead Sciences, Inc.
    02/06/22
  618. 184
    Aryl-or heteroaryl-substituted benzene compounds
    Epizyme, Inc.
    02/06/22
  619. 21
    BRK inhibitory compound
    ONO PHARMACEUTICAL CO., LTD.
    02/06/22
  620. 165
    Carbazole derivatives
    Bristol-Myers Squibb Company
    02/06/22
  621. 49
    Combination therapies using immuno-dash inhibitors and PGE2 antagonists
    Trustees of Tufts College
    02/06/22
  622. 36
    Compounds and methods of use
    Medivation Technologies LLC
    02/06/22
  623. 47
    Heterocyclic compounds and uses thereof
    Celgene CAR LLC
    02/06/22
  624. 168
    Heterocyclic compounds useful as Pim kinase inhibitors
    Incyte Corporation
    02/06/22
  625. 18
    Indoleamine-2,3-dioxygenase inhibitor and preparation method therefor
    Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
    02/06/22
  626. 252
    Pharmaceutical compounds
    ALMAC DISCOVERY LIMITED
    02/06/22
  627. 19
    Substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase
    Merck Sharp & Dohme Corp.; IOmet Pharma Ltd.
    02/06/22
  628. 26
    Substituted indoline derivatives as dengue viral replication inhibitors
    Janssen Pharmaceuticals, Inc.; Kathalieke Universiteif Leuven
    02/06/22
  629. 96
    1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
    Incyte Corporation
    02/02/22
  630. 129
    CXCR7 antagonists
    ChemoCentryx, Inc.
    02/02/22
  631. 25
    Compounds and compositions useful for treating disorders related to NTRK
    Blueprint Medicines Corporation
    02/02/22
  632. 10
    Compounds that participate in cooperative binding and uses thereof
    Revolution Medicines, Inc.
    02/02/22
  633. 60
    Difluoroketamide derivatives as HtrA1 inhibitors
    Hoffmann-La Roche Inc.
    02/02/22
  634. 376
    Disubstituted octahydropyrrolo[3,4-C]pyrroles as orexin receptor modulators
    Janssen Pharmaceutica NV
    02/02/22
  635. 25
    MAGL inhibitors
    H. LUNDBECK A/S
    02/02/22
  636. 24
    Macrocyclic immunomodulators
    ChemoCentryx, Inc.
    02/02/22
  637. 30
    Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases
    University of South Carolina
    02/02/22
  638. 15
    Small molecule inhibitors of the JAK family of kinases
    Janssen Pharmaceutica NV
    02/02/22
  639. 30
    Substituted purines as TLR7 agonists
    Primmune Therapeutics, Inc.
    02/02/22
  640. 56
    Triazolopyridine inhibitors of myeloperoxidase
    Bristol-Myers Squibb Company
    02/02/22
  641. 78
    1-cyano-pyrrolidine derivatives as inhibitors of USP30
    MISSION THERAPEUTICS LIMITED
    01/30/22
  642. 4
    Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation
    UCB Biopharma SRL
    01/30/22
  643. 6
    Compounds, process for obtaining the compounds, pharmaceutical composition, use of the compounds and method for treating psychiatric disorders and/or sleep disorders
    ACHÉ LABORATÓRIOS FARMACÊUTICOS S.A.
    01/30/22
  644. 7
    Hydantoins that modulate BACE-mediated app processing
    BUCK INSTITUTE FOR RESEARCH ON AGING
    01/30/22
  645. 40
    Imidazo[1′,2′:1,6]pyrido[2,3-d]pyrimidine compound as protein kinase inhibitor
    SHENGKE PHARMACEUTICALS (JIANGSU) LTD.
    01/30/22
  646. 200
    Isoxazolyl ether derivatives as GABAA α5 PAM
    Hoffmann-La Roche Inc.
    01/30/22
  647. 63
    Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators
    ARDELYX, INC.
    01/30/22
  648. 113
    PI-kinase inhibitors with anti-infective activity
    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    01/30/22
  649. 46
    Protein kinase inhibitors, preparation method and medical use thereof
    Gan & Lee Pharmaceuticals
    01/30/22
  650. 70
    SHMT inhibitors and uses thereof
    RAZE THERAPEUTICS, INC.
    01/30/22
  651. 218
    Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
    MIRATI THERAPEUTICS, INC.
    01/30/22
  652. 270
    Tricyclic heterocycles as BET protein inhibitors
    Incyte Corporation
    01/30/22
  653. 20
    (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
    Centrexion Therapeutics Corporation
    01/24/22
  654. 27
    Cyanopyrrolidine derivatives with activity as inhibitors of USP30
    MISSION THERAPEUTICS LIMITED
    01/24/22
  655. 92
    N-((HET)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
    KalVista Pharmaceuticals Limited
    01/24/22
  656. 107
    Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    01/24/22
  657. 51
    Pyrazolopyrimidine derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating cancer, autoimmune disease and brain disease containing the same as an active ingredient
    KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    01/24/22
  658. 26
    Salts and processes of preparing a PI3K inhibitor
    Incyte Corporation
    01/24/22
  659. 51
    Substituted pyrrolo[2,1-f][1,2,4]triazines as kinase inhibitors
    Daewoong Pharmaceutical Co., Ltd.
    01/24/22
  660. 713
    2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
    IDEAYA BIOSCIENCES, INC.
    01/23/22
  661. 565
    Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
    Achillion Pharmaceuticals, Inc.
    01/23/22
  662. 33
    Benzofuran derivative, preparation method thereof and use thereof in medicine
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    01/23/22
  663. 6
    Ethynyl derivatives
    Hoffmann-La Roche Inc.
    01/23/22
  664. 70
    Heterocyclic compounds useful as dual ATX/CA inhibitors
    Hoffmann-La Roche Inc.
    01/23/22
  665. 28
    Imidazolyl tricyclic enones as antioxidant inflammation modulators
    REATA PHARMACEUTICALS, INC.
    01/23/22
  666. 122
    Imidazopiperazine inhibitors of transcription activating proteins
    Board of Regents, The University of Texas System
    01/23/22
  667. 9
    Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases
    Regents of the University of Colorado, a body corporate; Colorado Research Partners. LLC
    01/23/22
  668. 118
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research, Inc.
    01/23/22
  669. 21
    Isoquinoline-steroid conjugates and uses thereof
    Aerie Pharmaceuticals, Inc.
    01/23/22
  670. 84
    Methods to induce targeted protein degradation through bifunctional molecules
    DANA-FARBER CANCER INSTITUTE, INC.
    01/23/22
  671. 31
    Oxime ether compounds
    Bristol-Myers Squibb Company
    01/23/22
  672. 21
    Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof
    PHARMAKEA, INC.
    01/23/22
  673. 7
    ROR-gamma modulators and uses thereof
    PIRAMAL ENTERPRISES LIMITED
    01/23/22
  674. 12
    Substituted bicyclic compounds
    Bristol-Myers Squibb Company
    01/23/22
  675. 7
    Substituted cyanopyrrolidines with activity as DUB inhibitors
    MISSION THERAPEUTICS LIMITED
    01/23/22
  676. 158
    5-membered and bicyclic heterocyclic amides as inhibitors of rock
    Bristol-Myers Squibb Company
    01/16/22
  677. 17
    6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes
    SPRINT BIOSCIENCE AB
    01/16/22
  678. 14
    Amino-fluoropiperidine derivatives as kinase inhibitor
    Daewoong Pharmaceutical Co., Ltd.
    01/16/22
  679. 69
    Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof
    TBA
    01/16/22
  680. 39
    Dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and use thereof
    SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    01/16/22
  681. 201
    Ectonucleotidase inhibitors and methods of use thereof
    Calithera Biosciences, Inc.
    01/16/22
  682. 32
    Heteroaromatic compounds as Vanin inhibitors
    Boehringer Ingelheim International GmbH
    01/16/22
  683. 13
    Heteroaryl amides as inhibitors of protein aggregation
    UCB Biophama SRL
    01/16/22
  684. 51
    Heterocyclic derivatives as PI3K inhibitors
    Incyte Corporation
    01/16/22
  685. 17
    Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same
    Duquesne University of The Holy Spirit
    01/16/22
  686. 155
    Quinolone derivatives as fibroblast growth factor receptor inhibitors
    PRINCIPIA BIOPHARMA, INC.
    01/16/22
  687. 155
    ROR γ modulators
    Bristol-Myers Squibb Company
    01/16/22
  688. 3
    Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
    Yeda Research and Development Co. Ltd.
    01/16/22
  689. 42
    Selective inhibitors of protein arginine methlytransferase 5 (PRMT5)
    Prelude Therapeutics, Incorporated
    01/16/22
  690. 819
    Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists
    Nimbus Saturn, Inc.
    01/16/22
  691. 354
    Tetrahydroquinoline derivatives as P2X7 receptor antagonists
    RaQualia Pharma Inc.; Asahi Kasei Pharma Corporation
    01/16/22
  692. 60
    Triazolopyrazine
    TBA
    01/16/22
  693. 2
    Use of fused heteroaromatic pyrrolidones for treatment and prevention of diseases in animals
    Bayer Animal Health GmbH
    01/16/22
  694. 229
    COMPOUNDS
    Enterprise Therapeutics Ltd
    01/13/22
  695. 179
    Inhibitors of cysteine proteases and methods of use thereof
    Pardes Biosciences, Inc.
    01/13/22
  696. 116
    Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof
    PHARMAKEA, INC.
    01/09/22
  697. 29
    1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′]bipyridinyl-2′-ones
    Addex Pharmaceuticals S.A.; Janssen Pharmaceuticals, Inc.
    01/07/22
  698. 21
    Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with antiB7H3-antibodies
    BAYER PHARMA AKTIENGESELLSCHAFT
    01/07/22
  699. 101
    Bicyclic amide compounds and methods of use thereof
    Genentech, Inc.
    01/07/22
  700. 223
    Bicyclic sulfones and sulfoxides and methods of use thereof
    Genentech, Inc.
    01/07/22
  701. 215
    Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
    GALAPAGOS NV
    01/07/22
  702. 41
    Inhibitors of RIP1 kinase and methods of use thereof
    Genentech, Inc.
    01/07/22
  703. 13
    Pyrazole[1,5-a] pyrimidine derivatives as kinase JAK inhibitors
    Celon Pharma S.A.
    01/07/22
  704. 31
    Small molecule inhibitors of Galectin-3
    Bristol-Myers Squibb Company
    01/07/22
  705. 201
    Substituted 6-azabenzimidazole compounds
    Gilead Sciences, Inc.
    01/07/22
  706. 275
    Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Epics Therapeutics
    01/07/22
  707. 146
    2,2-difluorodioxolo A2A receptor antagonists
    Merck Sharp & Dohme Corp.
    12/28/21
  708. 19
    Androgen receptor modulating compounds
    ORION CORPORATION
    12/28/21
  709. 26
    Galactoside inhibitor of galectins
    GALECTO BIOTECH AB
    12/28/21
  710. 175
    Glycosidase inhibitors
    Asceneuron SA
    12/28/21
  711. 198
    Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same
    SK BIOPHARMACEUTICALS CO., LTD.
    12/28/21
  712. 48
    Sulfonamide compounds
    Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute
    12/28/21
  713. 45
    2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma
    DOMPÉ FARMACEUTICI S.P.A.
    12/27/21
  714. 729
    2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
    IDEAYA BIOSCIENCES, INC.
    12/27/21
  715. 5
    Alkylphenyl compounds
    Bristol-Myers Squibb Company
    12/27/21
  716. 127
    Aminopyrazine derivatives as PI3K-γ inhibitors
    Incyte Corporation
    12/27/21
  717. 26
    Azetidine derivative, preparation method therefor, and use thereof
    SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.
    12/27/21
  718. 148
    Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
    Board of Regents, The University of Texas System
    12/27/21
  719. 12
    Dihydropyrimidinyl benzazepine carboxamide compounds
    Hoffmann-La Roche Inc.
    12/27/21
  720. 39
    Fused heterocyclic derivatives, their preparation methods thereof and medical uses thereof
    Beijing Innocare Pharma Tech Co., Ltd
    12/27/21
  721. 198
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    12/27/21
  722. 436
    Heteroaryl-substituted triazoles as APJ receptor agonists
    AMGEN INC.
    12/27/21
  723. 36
    Hydroxamic acids comprising pyrazole moiety and uses thereof
    HAWAII BIOTECH, INC.
    12/27/21
  724. 70
    Indolinones compounds and their use in the treatment of fibrotic diseases
    RespiVert Limited
    12/27/21
  725. 202
    Inhibitor compounds
    Cancer Research Technology Limited
    12/27/21
  726. 35
    Piperazine substituted azapine derivatives and uses thereof
    ALAIRION, INC.
    12/27/21
  727. 27
    Piperazinyl norbenzomorphan compounds and methods for using the same
    BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    12/27/21
  728. 41
    Piperidines as covalent menin inhibitors
    THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    12/27/21
  729. 208
    Piperidinyl-3-(aryloxy)propanamides and propanoates
    Takeda Pharmaceutical Company Limited
    12/27/21
  730. 159
    Selective estrogen receptor down-regulators
    AstraZeneca AB
    12/27/21
  731. 8
    Substituted isoquionline derivatives as immunomudulators
    Bristol-Myers Squibb Company
    12/27/21
  732. 33
    Substituted piperidines for the treatment of cancer
    LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD
    12/27/21
  733. 1145
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    12/27/21
  734. 30
    Thiadiazole IRAK4 compounds
    Gilead Sciences, Inc.
    12/27/21
  735. 271
    1-cyano-pyrrolidine compounds as USP30 inhibitors
    Mission Therapeutics Limited
    12/23/21
  736. 964
    Cot modulators and methods of use thereof
    Gilead Sciences, Inc.
    12/23/21
  737. 57
    Aminopyrimidine five-membered heterocyclic compound, and intermediate, preparation method, pharmaceutical composition and application thereof
    GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
    12/20/21
  738. 211
    Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same
    SHIONOGI & CO., LTD.
    12/20/21
  739. 6
    Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
    Incyte Corporation
    12/20/21
  740. 15
    Small molecule inhibitors of the JAK family of kinases
    Janssen Pharmaceutica NV
    12/20/21
  741. 478
    3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
    MERCK SHARP & DOHME CORP.
    12/19/21
  742. 329
    Arylquinazolines
    MERCK PATENT GMBH
    12/19/21
  743. 55
    Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides
    ARVINAS OPERATIONS, INC.
    12/19/21
  744. 26
    Diacylglycerol acyl transferase 2 inhibitor
    Pfizer Inc.
    12/19/21
  745. 102
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    12/19/21
  746. 13
    Substituted 6,11-dihydro-5H-benzo[B]carbazoles as inhibitors of ALK and SRPK
    DANA-FARBER CANCER INSTITUTE, INC.
    12/19/21
  747. 987
    Benzimidazole-proline derivatives
    IDORSIA PHARMACEUTICALS LTD
    12/14/21
  748. 135
    Metalloenzyme inhibitor compounds
    PHASEBIO PHARMACEUTICALS, INC.
    12/14/21
  749. 10
    Methods of identifying SENP1 inhibitors
    CITY OF HOPE
    12/14/21
  750. 17
    Pyridine derivative as ASK1 inhibitor and preparation method and use thereof
    TBA
    12/14/21
  751. 11
    Quinazoline compound for EGFR inhibition
    MEDSHINE DISCOVERY INC.
    12/14/21
  752. 32
    Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
    Principia Biopharma Inc.
    12/14/21
  753. 4
    Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR
    Blueprint Medicines Corporation
    12/14/21
  754. 11
    TYK2 inhibitors, uses, and methods for production thereof
    Nimbus Lakshmi, Inc.
    12/14/21
  755. 42
    VMAT2 inhibitor compounds and compositions thereof
    Neurocrine Biosciences, Inc.
    12/14/21
  756. 146
    Ectonucleotidase inhibitors and methods of use thereof
    Calithera Biosciences, Inc.
    12/06/21
  757. 11
    Farnesoid X receptor modulators
    Intercept Pharmaceuticals, Inc.
    12/06/21
  758. 5
    Methods to determine KDM1A target engagement and chemoprobes useful therefor
    Oryzon Genomics S.A.
    12/06/21
  759. 99
    Apoptosis signal-regulating kinase inhibitors and uses thereof
    SICHUAN HAISCO PHARMACEUTICAL CO., LTD.
    12/05/21
  760. 100
    Carboxamide-pyrimidine derivatives as SHP2 antagonists
    Merck Patent GmbH
    12/05/21
  761. 551
    Compounds of formulas (VII), (VIII), (IX), (XI), (XII), (XIII), and (XIV) as muscarinic receptor 4(M4) antagonists for treating neurological diseases
    Neurocrine Biosciences, Inc.
    12/05/21
  762. 16
    Diacylglycerol acyl transferase 2 inhibitors
    Pfizer Inc.
    12/05/21
  763. 17
    Ethynyl derivatives
    Hoffmann-La Roche Inc.
    12/05/21
  764. 52
    Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors
    Nikang Therapeutics, Inc.
    12/05/21
  765. 390
    Naphthyridines as inhibitors of HPK1
    Genentech, Inc.
    12/05/21
  766. 53
    Poly-ADP ribose polymerase (PARP) inhibitors
    Mitobridge, Inc.
    12/05/21
  767. 94
    Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators
    Genentech, Inc.
    12/05/21
  768. 65
    Pyridinyl pyrazoles as modulators of RORγT
    Janssen Pharmaceutica NV
    12/05/21
  769. 366
    Sphinogosine-1 -phosphate receptor modulators for treatment of cardiopulmonary disorders
    THE SCRIPPS RESEARCH INSTITUTE
    12/05/21
  770. 67
    Substituted N′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase IDO inhibitors
    Merck Sharp & Dohme Corp.
    12/05/21
  771. 825
    Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists
    Nimbus Saturn, Inc.
    12/05/21
  772. 35
    1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitors
    Merck Patent GmbH
    11/29/21
  773. 166
    1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
    Amgen Inc.
    11/29/21
  774. 192
    1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
    H. Lundbeck A/S
    11/29/21
  775. 3
    3-oxa-8-azabicyclo[3.2.1]octane derivatives and their use in the treatment of cancer and hemoglobinopathies
    CTXT PTY LTD
    11/29/21
  776. 205
    4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors
    ARRAY BIOPHARMA INC.; CELGENE CORPORATION
    11/29/21
  777. 35
    Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
    Bristol-Myers Squibb Company
    11/29/21
  778. 6
    Cyclic dinucleotides as sting agonists
    Janssen Biotech, Inc.
    11/29/21
  779. 145
    Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases
    Board of Regents, The University of Texas System
    11/29/21
  780. 134
    Heteroaryl inhibitors of PAD4
    Padlock Therapeutics, Inc.
    11/29/21
  781. 7
    Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer
    Oblique Therapeutics AB
    11/29/21
  782. 12
    Heterocyclic compounds as adenosine antagonists
    NUVATION BIO INC.
    11/29/21
  783. 23
    Indolizine derivatives and their application in medicine
    KIND PHARMACEUTICAL
    11/29/21
  784. 97
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research, Inc.
    11/29/21
  785. 131
    Phosphatidylinositol 3-kinase inhibitors
    Gilead Sciences, Inc.
    11/29/21
  786. 34
    Piperidinyl-propanone derivatives
    Merck Patent GmbH
    11/29/21
  787. 18
    Second generation GRP94-selective inhibitors
    University of Kansas
    11/29/21
  788. 36
    Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors
    Merck Sharp & Dohme Corp.
    11/29/21
  789. 812
    Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists
    Nimbus Saturn, Inc.
    11/29/21
  790. 823
    Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as hpk1 antagonists
    Nimbus Saturn, Inc.
    11/29/21
  791. 60
    Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors
    Merck Sharp & Dohme Corp.
    11/29/21
  792. 36
    Substituted pyrimidines as LRKK2 inhibitors
    DENALI THERAPEUTICS INC.
    11/29/21
  793. 7
    Tetrahydroquinoline-based bromodomain inhibitors
    St. Jude Children''s Research Hospital
    11/29/21
  794. 90
    Therapeutic compounds and methods of use thereof
    Genentech, Inc.
    11/29/21
  795. 145
    Therapeutic inhibitory compounds
    ATTUNE PHARMACEUTICALS, INC.
    11/29/21
  796. 207
    Therapeutically active compounds and their methods of use
    Agios Pharmaceuticals, Inc.
    11/29/21
  797. 76
    Tricyclic heterocyclic derivatives and uses thereof
    AUCKLAND UNISERVICES LIMITED
    11/29/21
  798. 42
    Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
    MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.
    11/29/21
  799. 491
    [1,2,4]Triazolo[4,3-a]quinoxaline derivative, method for preparing same, and pharmaceutical composition for preventing or treating BET protein-related diseases, containing same as active ingredient
    Dong Wha Pharm. Co., Ltd.; Korea Research Institute of Chemical Technology
    11/29/21
  800. 299
    Amino-pyrrolopyrimidinone compounds and methods of use thereof
    ArQule, Inc.
    11/28/21
  801. 169
    Biaryloxy derivatives as TTX-S blockers
    RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.
    11/28/21
  802. 150
    Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof
    WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.
    11/28/21
  803. 44
    Compounds and their use for reducing uric acid levels
    Acquist LLC
    11/28/21
  804. 115
    Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
    AMGEN INC.
    11/28/21
  805. 396
    Therapeutic compounds
    CELGENE QUANTICEL RESEARCH, INC.
    11/28/21
  806. 27
    Type of aryl benzofuran amidated derivative and medical use thereof
    CHINA PHARMACEUTICAL UNIVERSITY
    11/28/21
  807. 36
    2,6-disubstituted pyridine derivative
    SUMITOMO DAINIPPON PHARMA CO., LTD.
    11/22/21
  808. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte Corporation
    11/22/21
  809. 569
    CDK2 inhibitors
    Pfizer Inc.
    11/22/21
  810. 68
    Cyanopyrrolidine derivatives with activity as inhibitors of USP30
    MISSION THERAPEUTICS LIMITED
    11/22/21
  811. 35
    Factor XIIa inhibitors
    Merck Sharp & Dohme Corp.
    11/22/21
  812. 78
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    11/22/21
  813. 72
    Heteroaromatic compounds and their use as dopamine D1 ligands
    Pfizer Inc.
    11/22/21
  814. 9
    LSD1 inhibitors and medical uses thereof
    Constellation Pharmaceuticals, Inc.
    11/22/21
  815. 126
    Pyrazolopyrimidine compounds and uses thereof
    Incyte Corporation
    11/22/21
  816. 800
    Pyridazinones as PARP7 inhibitors
    Ribon Therapeutics, Inc.
    11/22/21
  817. 30
    Pyrrolo-, pyrazolo-, imidazo-pyrimidine and pyridine compounds that inhibit MNK1 and MNK2
    eFFECTOR Therapeutics, Inc.
    11/22/21
  818. 79
    Triazolopyrimidine, triazolopyridine compounds, and the composition thereof for treating PRC2-mediated diseases
    SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.
    11/22/21
  819. 202
    Trifluoromethylpropanamide derivatives as HTRA1 inhibitors
    Hoffmann-La Roche Inc.
    11/22/21
  820. 25
    C5-C6-oxacyclic fused iminothiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme Corp.
    11/15/21
  821. 155
    Compounds and methods for modulating interleukin-2-inducible t-cell kinase
    Corvus Pharmaceuticals, Inc.
    11/15/21
  822. 8
    Compounds useful for inhibiting RORγt
    Eli Lilly and Company
    11/15/21
  823. 8
    Cycloalkyl-diamines for the treatment of pain
    MediSynergics, LLC
    11/14/21
  824. 21
    Piperidinone formyl peptide 2 receptor agonists
    Bristol-Myers Squibb Company
    11/14/21
  825. 359
    Pyridazine derivatives as RORc modulators
    Genentech, Inc.
    11/14/21
  826. 420
    Quinazolinones as PARP14 inhibitors
    Ribon Therapeutics Inc.
    11/14/21
  827. 85
    Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    11/14/21
  828. 15
    1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
    ASTRAZENECA AB
    11/08/21
  829. 8
    7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
    Eli Lilly and Company
    11/08/21
  830. 88
    Alkyl pyrrolopyrimidine analogs and methods of making and using same
    The University of North Carolina at Chapel Hill
    11/08/21
  831. 6
    Aminopyrimidinecarboxamides as CXCR2 modulators
    Syntrix Biosystems Inc.
    11/08/21
  832. 899
    Benzolactam compounds as protein kinase inhibitors
    OTSUKA PHARMACEUTICAL CO., LTD.
    11/08/21
  833. 11
    Compound useful for the treatment of degenerative and inflammatory diseases
    GALAPAGOS NV
    11/08/21
  834. 59
    Compounds and their uses as ACC inhibitors
    Nanjing Ruijie Pharmatech Co., Ltd.
    11/08/21
  835. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
    Shy Therapeutics LLC
    11/08/21
  836. 22
    Difluoroketamide derivatives as HTRA1 inhibitors
    Hoffman-La Roche Inc.
    11/08/21
  837. 16
    Dihydropyrrolopyridine inhibitors of ROR-gamma
    Vitae Pharmaceuticals, LLC
    11/08/21
  838. 13
    Disubstituted compounds for treatment of medical disorders
    Achillion Pharmaceuticals, Inc.
    11/08/21
  839. 44
    Histone demethylase inhibitors
    CELGENE QUANTICEL RESEARCH, INC.
    11/08/21
  840. 92
    N-((HET)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
    KALVISTA PHARMACEUTICALS LIMITED
    11/08/21
  841. 51
    Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors
    ASTRAZENECA AB
    11/08/21
  842. 13
    Pyrimidine compounds and pyrimido indole compounds and methods of use
    Duquesne University of The Holy Spirit
    11/08/21
  843. 10
    Pyrimidine derivative, method for preparing same and use thereof in medicine
    TBA
    11/08/21
  844. 136
    Pyrimidinone derivatives as SHP2 antagonists
    Merck Patent GmbH
    11/08/21
  845. 81
    SSAO inhibitor
    TBA
    11/08/21
  846. 15
    Acetyl-CoA carboxylase modulators
    Monsanto Technology LLC
    11/04/21
  847. 108
    EGFR proteolysis targeting chimeric molecules and associated methods of use
    ARVINAS OPERATIONS, INC.; YALE UNIVERSITY
    11/04/21
  848. 57
    Inhibitors of protease-activated receptor-2
    Heptares Therapeutics Limited
    11/04/21
  849. 162
    Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
    THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
    11/04/21
  850. 218
    PARG inhibitory compounds
    Cancer Research Technology Limited
    11/04/21
  851. 116
    Pyrrolidine derivative
    KISSEI PHARMACEUTICAL CO., LTD.
    11/04/21
  852. 19
    Substituted dihydrobenzofuran glycosidase inhibitors
    Asceneuron SA
    11/04/21
  853. 92
    Zaindole derivatives and their use as ERK kinase inhibitors
    AGV DISCOVERY; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE MONTPELLIER
    11/04/21
  854. 53
    1,2,4-triazine-4-amine derivatives
    Heptares Therapeutics Limited
    11/01/21
  855. 32
    Alpha-D-galactoside inhibitors of galectins
    GALECTO BIOTECH AB
    11/01/21
  856. 70
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    11/01/21
  857. 77
    Bicyclic lactams and methods of use thereof
    Genentech, Inc.
    11/01/21
  858. 136
    Compounds
    AstraZeneca AB
    11/01/21
  859. 99
    IRAK4 inhibitor and use thereof
    BEIJING HANMI PHARMACEUTICAL CO., LTD.
    11/01/21
  860. 2
    Immunomodulators
    bristol-myers squibb company
    11/01/21
  861. 23
    Inhibitors of influenza virus replication and uses thereof
    SUNSHINE LAKE PHARMA CO., LTD.
    11/01/21
  862. 440
    MCL-1 inhibitors
    Gilead Sciences, Inc.
    11/01/21
  863. 20
    Potent and selective mu opioid receptor modulators
    Virginia Commonwealth University
    11/01/21
  864. 37
    Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof
    Japan Tobacco Inc.
    11/01/21
  865. 532
    Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
    Genentech, Inc.
    11/01/21
  866. 55
    Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
    Pfizer Inc.
    11/01/21
  867. 204
    Substituted n′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
    Merck Sharp & Dohme Corp.
    11/01/21
  868. 140
    Substituted pyrimidines as cyclin-dependent kinase inhibitors
    SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
    11/01/21
  869. 229
    Heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
    Daewoong Pharmaceutical Co., Ltd.
    10/27/21
  870. 25
    Substituted pyrazolopyrimidinone compounds as PDE2 inhibitors
    DART NEUROSCIENCE, LLC
    10/27/21
  871. 1
    Substituted thiohydantoin derivatives as androgen receptor antagonists
    Janssen Pharmaceutica NV
    10/27/21
  872. 11
    Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
    Bristol-Myers Squibb Companay
    10/27/21
  873. 61
    1,3,4-thiadiazole compounds and their use in treating cancer
    Cancer Research Technology Limited
    10/26/21
  874. 18
    6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
    Purdue Research Foundation
    10/26/21
  875. 113
    Aminopyrimidinyl compounds
    Pfizer Inc.
    10/26/21
  876. 25
    Benzothiophene estrogen receptor modulators
    G1 Therapeutics, Inc.
    10/26/21
  877. 236
    Biaryl kinase inhibitors
    Bristol-Myers Squibb Company
    10/26/21
  878. 19
    Compound for inhibiting IDO, a manufacturing method and a use thereof
    Shanghai JOYU Pharmatech Ltd.
    10/26/21
  879. 8
    FXR (NR1H4) modulating compounds
    Gilead Sciences, Inc.
    10/26/21
  880. 49
    Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    10/26/21
  881. 210
    Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
    Janssen Pharmaceutica NV
    10/26/21
  882. 22
    Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase
    BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    10/26/21
  883. 5
    Inhibitors of soluble adenylyl cyclase
    Cornell University; Tri-Institutional Therapeutics Discovery Institute
    10/26/21
  884. 85
    Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
    ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED
    10/26/21
  885. 329
    PRMT5 inhibitors and uses thereof
    Epizyme, Inc.
    10/26/21
  886. 51
    Substituted pyrrolopyridine JAK inhibitors and methods of making and using the same
    ACLARIS THERAPEUTICS, INC.
    10/26/21
  887. 30
    Therapeutic inhibitory compounds
    ATTUNE PHARMACEUTICALS, INC.
    10/26/21
  888. 164
    Thioether triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase
    Bristol-Myers Squibb Company
    10/26/21
  889. 95
    Urea-substituted aromatic ring-linked dioxane-quinazoline and -linked dioxane-quinoline compounds, preparation method therefor and use thereof
    BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
    10/26/21
  890. 135
    4-aminoquinazolinyl compounds as prolyl hydroxylase inhibitors
    TBA
    10/20/21
  891. 92
    6-aminopyridin-3-yl pyrazoles as modulators of RORgT
    Janssen Pharmaceutica NV
    10/20/21
  892. 440
    6-aminopyridin-3-yl thiazoles as modulators of RORγT
    Janssen Pharmaceutica NV
    10/20/21
  893. 25
    Bis-heteroaryl derivatives as modulators of protein aggregation
    UCB Biopharma SRL
    10/20/21
  894. 71
    Compounds and compositions for inhibiting the activity of SHP2
    NOVARTIS AG
    10/20/21
  895. 28
    Grp94 selective inhibitors and uses thereof
    University of Kansas; University of South Florida
    10/20/21
  896. 134
    Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
    Merck Patent GmbH
    10/20/21
  897. 4
    Imidazolyl kinase inhibitors and uses thereof
    Dana-Farber Cancer Institute, Inc.
    10/20/21
  898. 185
    KDM5 inhibitors
    Merck Sharp & Dohme Corp.
    10/20/21
  899. 22
    Nicotinyl alcohol ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
    Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD
    10/20/21
  900. 146
    Pharmaceutical compounds
    SENTINEL ONCOLOGY LIMITED
    10/20/21
  901. 225
    Phenyl substituted pyrazoles as modulators of RORγt
    Janssen Pharmaceutica NV
    10/20/21
  902. 150
    Pyridine derivative
    Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.
    10/20/21
  903. 27
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals, Inc.
    10/20/21
  904. 16
    Substituted fused pyrazole compounds and their use as LRRK2 inhibitors
    GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    10/20/21
  905. 644
    Substituted pyridines as inhibitors of DNMT1
    GlaxoSmithKline Intellectual Property Development Limited; Cancer Research Technology Ltd.
    10/20/21
  906. 297
    4,5-annulated 1,2,4-triazolones
    BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION
    10/09/21
  907. 34
    Alpha-truxillic acid derivatives and pharmaceutical compositions thereof
    The Research Foundation for the State University of New York
    10/09/21
  908. 114
    Benzothiazol compounds and methods using the same for treating neurodegenerative disorders
    1st Biotherapeutics, Inc.
    10/09/21
  909. 35
    Biaryltriazole inhibitors of macrophage migration inhibitory factor
    Yale University
    10/09/21
  910. 29
    Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    10/09/21
  911. 35
    Cyclopentane-based modulators of STING (stimulator of interferon genes)
    Pfizer Inc.
    10/09/21
  912. 107
    Cyclopropanamine compound and use thereof
    Takeda Pharmaceutical Company Limited
    10/09/21
  913. 155
    Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors
    Proximagen, LLC
    10/09/21
  914. 45
    Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    10/09/21
  915. 13
    Macrocyclic compounds as ROS1 kinase inhibitors
    Array BioPharma Inc.
    10/09/21
  916. 189
    Pyrido five-element aromatic ring compound, preparation method therefor and use thereof
    SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    10/09/21
  917. 273
    Pyrrolo[2,3-d]pyrimidine derivatives
    Pfizer Inc.
    10/09/21
  918. 13
    Substituted [1,2,4]triazolo[1,5-a]pyrazines as LSD1 inhibitors
    Incyte Corporation
    10/09/21
  919. 22
    Synergistic combination of immunologic inhibitors for the treatment of cancer
    The University of Chicago
    10/09/21
  920. 91
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    10/09/21
  921. 23
    Therapeutic compounds and uses thereof
    Kala Pharmaceuticals, Inc.
    10/09/21
  922. 90
    USP30 inhibitors
    Mitobridge, Inc.
    10/09/21
  923. 63
    (S)-2-(1-cyclopropylethyl)-5-(4-methyl-2-((6-(2-oxopyrrolidin-1-yl)pyridin-2-yl)amino) thiazol-5-yl)-7-(methylsulfonyl)isoindolin-1-one as a phosphatidylinositol 3-kinase inhibitor
    AstraZeneca AB
    10/04/21
  924. 66
    Chemical compounds
    AstraZeneca AB
    10/04/21
  925. 80
    Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
    LegoChem Biosciences, Inc.
    10/04/21
  926. 66
    Farnesoid X receptor agonists and uses thereof
    METACRINE, INC.
    10/04/21
  927. 145
    Inhibiting agents for Bruton's tyrosine kinase
    BIOGEN MA INC.
    10/04/21
  928. 66
    JAK1 selective inhibitors
    ASTRAZENECA AB
    10/04/21
  929. 21
    Modulators of the sigma-2 receptor and their method of use
    TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    10/04/21
  930. 45
    Oxazole derivatives for use in the treatment of cancer
    LIFEARC
    10/04/21
  931. 3
    PRMT5 inhibitors
    CTXT PTY LTD
    10/04/21
  932. 180
    Pyrazolopyrimidine derivatives as kinase inhibitor
    Daewoong Pharmaceutical Co., Ltd.
    10/04/21
  933. 34
    Quinazoline and indole compounds to treat medical disorders
    Achillion Pharmaceuticals, Inc.
    10/04/21
  934. 512
    Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; VANDERBILT UNIVERSITY; THE UAB RESEARCH FOUNDATION; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    10/04/21
  935. 568
    Substituted pyrazines as ATR kinase inhibitors
    VERTEX PHARMACEUTICALS INCORPORATED
    10/04/21
  936. 119
    Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas
    CELGENE QUANTICEL RESEARCH, INC.
    10/04/21
  937. 145
    1 H-pyrazol-1-yl-thiazoles as inhibitors of lactate dehydrogenase and methods of use thereof
    THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; THE UAB RESEARCH FOUNDATION; VANDERBILT UNIVERSITY; NATIONAL INSTITUTES OF HEALTH, UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES
    09/28/21
  938. 75
    1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one derivative as Wee1 inhibitor
    SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.
    09/28/21
  939. 27
    Azaindoles as inhibitors of HPK1
    Genentech, Inc.
    09/28/21
  940. 90
    BMP-signal-inhibiting compound
    RIKEN; THE UNIVERSITY OF TOKYO
    09/28/21
  941. 11
    Compounds and uses thereof
    Kala Pharmaceuticals, Inc.
    09/28/21
  942. 60
    Compounds inhibiting leucine-rich repeat kinase enzyme activity
    Merck Sharp & Dohme Corp.
    09/28/21
  943. 108
    Heterocyclic compounds as ret kinase inhibitors
    Cancer Research Technology Limited
    09/28/21
  944. 239
    Heterocyclic compounds for the inhibition of pask
    BioEnergenix LLC
    09/28/21
  945. 19
    JAK inhibitors containing a 4-membered heterocyclic amide
    Theravance Biopharma R&D IP, LLC
    09/28/21
  946. 261
    Methods for treating ulcerative colitis using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
    Theravance Biopharma R&D IP, LLC
    09/28/21
  947. 97
    Methods of treating intraocular pressure with activators of Tie-2
    AERPIO PHARMACEUTICALS, INC.
    09/28/21
  948. 444
    Pyrazole derivatives as MALT1 inhibitors
    Janssen Pharmaceutica NV
    09/28/21
  949. 15
    Selective NR2B antagonists
    Bristol-Myers Squibb Company
    09/28/21
  950. 43
    Sigma receptor binders
    BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    09/28/21
  951. 22
    Substituted heterocyclic inhibitors of PTPN11
    NAVIRE PHARMA, INC.
    09/28/21
  952. 134
    Substituted indole Mcl-1 inhibitors
    Vanderbilt University
    09/28/21
  953. 556
    Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors
    Array Biopharma Inc.
    09/28/21
  954. 88
    1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
    ST. JUDE CHILDREN''S RSEARCH HOSPITAL
    09/26/21
  955. 87
    Aminopyridine derivatives and their use as selective ALK-2 inhibitors
    NOVARTIS AG
    09/26/21
  956. 4
    Beta adrenergic agonist and methods of using the same
    CuraSen Therapeutics, Inc.
    09/26/21
  957. 54
    Bicyclic heterocycles as FGFR inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    09/26/21
  958. 23
    Bicyclic pyridone lactams and methods of use thereof
    Genentech, Inc.
    09/26/21
  959. 3
    Combinations comprising a pyrrolidine-2,5-dione IDO1 inhibitor and an anti-body
    Pfizer Inc.; iTEOS THERAPEUTICS
    09/26/21
  960. 12
    Dimethyl amino azetidine amides as JAK inhibitors
    Theravance Biopharma R&D IP, LLC
    09/26/21
  961. 79
    Heteroaryl SYK inhibitors
    Boehringer Ingelheim International GmbH
    09/26/21
  962. 449
    Heteroaryl compounds and their use as therapeutic drugs
    Dong-A Socio Holdings Co., Ltd.
    09/26/21
  963. 72
    Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
    Merck Sharp & Dohme Corp.
    09/26/21
  964. 135
    Inhibitors of Hepatitis C virus polymerase
    COCRYSTAL PHARMA, INC.
    09/26/21
  965. 547
    Inhibitors of KEAP1-Nrf2 protein-protein interaction
    Janssen Pharmaceutica NV
    09/26/21
  966. 33
    Nurr1:RXR activating compounds for simultaneous treatment of symptoms and pathology of Parkinson's disease
    TBA
    09/26/21
  967. 12
    PRMT5 inhibitors
    Merck Sharp & Dohme Corp.
    09/26/21
  968. 26
    Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same
    Seoul National University Hospital
    09/26/21
  969. 18
    Substituted oxazines as beta-secretase inhibitors
    Amgen Inc.
    09/26/21
  970. 11
    Tank-binding kinase-1 PROTACs and associated methods of use
    ARVINAS OPERATIONS, INC.
    09/26/21
  971. 38
    Therapeutic compounds and methods of use thereof
    GENENTECH, INC.
    09/26/21
  972. 391
    Therapeutically active compounds and their methods of use
    Agios Pharmaceuticals, Inc.
    09/26/21
  973. 6
    Treatment and diagnosis of melanoma
    The Rockefeller University
    09/26/21
  974. 1
    [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compound
    Janssen Pharmaceutica NV
    09/26/21
  975. 26
    Benzyl phenyl ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
    Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD
    09/20/21
  976. 499
    Bromodomain inhibitors
    Celgene Quanticel Research, Inc.
    09/20/21
  977. 29
    Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
    Ogeda SA
    09/20/21
  978. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
    Shy Therapeutics LLC
    09/20/21
  979. 8
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals, Inc.
    09/20/21
  980. 72
    Kinase inhibitors
    Oxular Acquisitions Limited
    09/20/21
  981. 31
    Methods for inhibiting fascin
    NOVITA PHARMACEUTICALS, INC.; CORNELL UNIVERSITY
    09/20/21
  982. 88
    Quinoline and isoquinoline derivatives for treating pain and pain related conditions
    ESTEVE PHARMACEUTICALS, S.A.
    09/20/21
  983. 131
    4-imidazopyridazin-1-yl-benzamides as Btk inhibitors
    Merck Sharp & Dohme B.V.
    09/12/21
  984. 143
    5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof
    Samumed, LLC
    09/12/21
  985. 28
    Aryl ethene derivative and pharmaceutical composition containing same as active ingredient
    DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION; KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL; KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    09/12/21
  986. 214
    Bruton's tyrosine kinase inhibitors
    Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.
    09/12/21
  987. 61
    Compounds and compositions for inhibiting the activity of SHP2
    NOVARTIS AG
    09/12/21
  988. 472
    Inhibitors of Bruton's tyrosine kinase and method of their use
    Janssen Pharmaceutica NV
    09/12/21
  989. 236
    Pyrazolopyridine compounds and uses thereof
    Incyte Corporation
    09/12/21
  990. 32
    SHMT inhibitors
    The Trustees of Princeton University
    09/12/21
  991. 288
    SHP2 phosphatase inhibitors and methods of use thereof
    Relay Therapeutics, Inc.
    09/12/21
  992. 87
    Spirocyclic compounds
    Recurium IP Holdings, LLC
    09/12/21
  993. 60
    Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors
    Merck Sharp & Dohme Corp.
    09/12/21
  994. 44
    Benzothiazole derivatives as DYRK1 inhibitors
    PHARMASUM THERAPEUTICS AS
    09/06/21
  995. 45
    CDK inhibitors
    GI Therapeutics, Inc.
    09/06/21
  996. 31
    Cyano-subtituted heterocycles with activity as inhibitors of USP30
    MISSION THERAPEUTICS LIMITED
    09/06/21
  997. 48
    HSP90B N-terminal isoform-selective inhibitors
    University of Kansas
    09/06/21
  998. 62
    Inhibitors of RAF kinases
    KINNATE BIOPHARMA INC.
    09/06/21
  999. 69
    Intermediate compound of novel tetrahydronaphthyl urea derivative
    MOCHIDA PHARMACEUTICAL CO., LTD.
    09/06/21
  1000. 35
    Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto
    Arena Pharmaceuticals, Inc.
    09/06/21
  1001. 112
    Oxadiazaspiro compounds for the treatment of drug abuse and addiction
    ESTEVE PHARMACEUTICALS. S.A.
    09/06/21
  1002. 248
    Pyrazole MAGL inhibitors
    LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    09/06/21
  1003. 48
    Substituted sulfoximine compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
    Merck Sharp & Dohme Corp.
    09/06/21
  1004. 7
    Treatment of conditions associated with hyperinsulinaemia
    Tensha Therapeutics, Inc.
    09/06/21
  1005. 26
    Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
    The USA, as represented by the Secretary, Department of Health and Human Services; SRI International
    09/06/21
  1006. 8
    Amide compounds for treatment of immune and inflammatory disorders
    Achillion Pharmaceuticals, Inc.
    09/02/21
  1007. 18
    Azetidine derivatives
    Vernalis (R&D) Ltd.
    09/02/21
  1008. 56
    Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
    Boehringer Ingelheim International GmbH
    09/02/21
  1009. 9
    Cannabidiol derivatives as inhibitors of the HIF prolyl hydroxylases activity
    Emerald Health Pharmaceuticals Inc.
    09/02/21
  1010. 463
    Compounds and uses thereof
    Yumanity Therapeutics, Inc.
    09/02/21
  1011. 18
    Cyclohexene compounds and use thereof
    GUANGZHOU HENOVCOM BIOSCIENCE CO. LTD.
    09/02/21
  1012. 6
    Fused imidazoles as mIDH1 inhibitors
    BAYER PHARMA AKTIENGESELLSCHAFT
    09/02/21
  1013. 23
    Hetero-halo inhibitors of histone deacetylase
    Alkermes, Inc.
    09/02/21
  1014. 3
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals, Inc.
    09/02/21
  1015. 5
    Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
    Incyte Holdings Corporation; Incyte Corporation
    09/02/21
  1016. 12
    Imidazopyrazine compounds, preparation methods and uses thereof
    DONGGUAN ZHENXING-BEITE MEDICINE TECHNOLOGY CO., LTD.
    09/02/21
  1017. 407
    Immunomodulator compounds
    ChemoCentryx, Inc.
    09/02/21
  1018. 68
    N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors
    Nerviano Medical Sciences S.R.L.
    09/02/21
  1019. 1
    Salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
    GALAPAGOS NV
    09/02/21
  1020. 56
    Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors
    Boehringer Ingelheim International GmbH
    09/02/21
  1021. 51
    Substituted tricyclic heterocyclic compounds and use thereof
    LIFEARC; SUZHOU YABAO PHARMACEUTICAL R&D CO., LTD.
    09/02/21
  1022. 49
    Thiazole derivative and applications
    EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    09/02/21
  1023. 70
    Thioacetate compounds, compositions and methods of use
    Ardea Biosciences, Inc
    09/02/21
  1024. 37
    Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
    Bristol-Myers Squibb Company
    09/02/21
  1025. 80
    Tricyclic ASK1 inhibitors
    TERNS, INC.
    09/02/21
  1026. 99
    Benzene disulfonamide for the treatment of cancer
    Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V
    08/30/21
  1027. 14
    Bis-heteroaryl derivatives as modulators of protein aggregation
    UCB Biopharma SRL
    08/30/21
  1028. 107
    Combinations comprising substituted imidazo[1,5-a]pyrazinones as PDE1 inhibitors
    H. Lundbeck A/S
    08/30/21
  1029. 16
    JAK kinase inhibitor compounds for treatment of respiratory disease
    Theravance Biopharma R&D IP, LLC
    08/30/21
  1030. 20
    LRRK2 inhibitors and methods of making and using the same
    DANA-FARBER CANCER INSTITUTE, INC.
    08/30/21
  1031. 47
    Octahydro-pyrrolo[3,4-c]-pyrrole derivatives and analogs thereof as autotaxin inhibitors
    Hoffmann-La Roche Inc.
    08/30/21
  1032. 110
    Oxadiazolones as transient receptor potential channel inhibitors
    Genentech, Inc.
    08/30/21
  1033. 59
    Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    08/30/21
  1034. 67
    Pyrimidine FGFR4 inhibitors
    EISAI R&D MANAGEMENT CO., LTD.
    08/30/21
  1035. 111
    Substituted 4-phenylpiperidines, their preparation and use
    The Trustees of Columbia University in the City of New York
    08/30/21
  1036. 50
    Substituted piperidines thiazolyl acetamides as glycosidase inhibitors and uses thereof
    Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.
    08/30/21
  1037. 219
    Thienopyridine carboxamides as ubiquitin-specific protease inhibitors
    VALO EARLY DISCOVERY, INC.
    08/30/21
  1038. 111
    Combinations comprising substituted imidazo[1,5-α]pyrazinones as PDE1 inhibitors
    H. Lundbeck A/S
    08/22/21
  1039. 42
    Compositions and methods for inhibiting kinases
    Inhibikase Therapeutics, Inc.
    08/22/21
  1040. 14
    Compounds for using in imaging and particularly for the diagnosis of neurodegenerative diseases
    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE D''ORLEANS; UNIVERSITE DE TOURS; CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    08/22/21
  1041. 52
    Five-membered heteroaryl ring bridged ring derivative, preparation method therefor and medical use thereof
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    08/22/21
  1042. 65
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    08/22/21
  1043. 7
    Kinase inhibitors for the treatment of disease
    DANA FARBER CANCER INSTITUTE, INC.
    08/22/21
  1044. 198
    Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
    Pfizer Inc.
    08/22/21
  1045. 20
    Substituted piperazines as ROR-gamma modulators
    ESCALIER BIOSCIENCES B.V.
    08/22/21
  1046. 370
    Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
    LEO Pharma A/S
    08/22/21
  1047. 103
    Triazole phenyl compounds as agonists of the APJ receptor
    AMGEN INC.
    08/22/21
  1048. 34
    IRAK4 modulators
    Genentech, Inc.
    08/16/21
  1049. 71
    IRAK4 modulators
    Genentech, Inc.
    08/16/21
  1050. 4
    3,4-bipyridyl pyrazole derivative, and preparation method therefor and medical application thereof
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    08/15/21
  1051. 32
    Benzothiazole compounds and uses thereof
    Incyte Corporation
    08/15/21
  1052. 33
    Imidazo isoindole derivative, preparation method therefor and medical use thereof
    JIANGSU HENGRUI MEDICINE CO., LTD.; SHANGHAI HENGRUI PHRMACEUTICAL CO., LTD.
    08/15/21
  1053. 124
    Imidazopiperazinone inhibitors of transcription activating proteins
    Board of Regents, The University of Texas System
    08/15/21
  1054. 110
    Inhibiting agents for Bruton's tyrosine kinase
    BIOGEN MA INC.
    08/15/21
  1055. 427
    PD-1/PD-L1 inhibitors
    Gilead Sciences, Inc.
    08/15/21
  1056. 23
    Phosphodiesterase inhibitors and uses thereof
    The Trustees of Columbia University in the City of New York
    08/15/21
  1057. 378
    Piperidines as menin inhibitors
    THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    08/15/21
  1058. 38
    Pyrazine compounds and uses thereof
    TBA
    08/15/21
  1059. 49
    Antitumor drug for intermittent administration of FGFR inhibitor
    Taiho Pharmaceutical Co., Ltd.
    08/14/21
  1060. 51
    Fused tricyclic ring derivatives as SRC homology-2 phosphatase inhibitors
    Nikang Therapeutics, Inc.
    08/14/21
  1061. 165
    Halo-substituted piperidines as orexin receptor modulators
    ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
    08/14/21
  1062. 648
    Heteroarylbenzimidazole compounds
    BAYER PHARMA AKTIENGESELLSCHAFT
    08/14/21
  1063. 35
    Heterocyclic inhibitors of ATR kinase
    Board of Regents, The University of Texas System; ChemPartner Corporation
    08/14/21
  1064. 19
    Indolizine derivatives, composition and methods of use
    SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.
    08/14/21
  1065. 161
    Inhibitors of cyclin-dependent kinases
    KINNATE BIOPHARMA INC.
    08/14/21
  1066. 120
    Modulators of P97 AAA ATPase activity
    University of Pittsburgh—Of the Commonwealth System of Higher Education
    08/14/21
  1067. 4
    Multi-functionalized polysaccharide compounds and use thereof for targeting the cation-independent mannose 6-phosphate receptor
    NANOMEDSYN; Centre National de la Recherche Scientifique; Universite de Montpellier
    08/14/21
  1068. 102
    PSMA imaging agents
    Siemens Medical Solutions USA, Inc.
    08/14/21
  1069. 3
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as antidiabetics
    King Abdulaziz University
    08/14/21
  1070. 46
    Substituted pyrazole derivatives as selective CDK12/13 inhibitors
    Aurigene Discovery Technologies Limited
    08/14/21
  1071. 74
    Alkynyl pyridine prolyl hydroxylase inhibitor, and preparation method and medical use thereof
    Jiangsu Hengrui Medicine Co., Ltd.
    08/09/21
  1072. 22
    Alpha-D-galactoside inhibitors of galectins
    GALECTO BIOTECH AB
    08/09/21
  1073. 157
    Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain
    Array BioPharma Inc.
    08/09/21
  1074. 14
    CGRP receptor antagonists
    Heptares Therapeutics Limited
    08/09/21
  1075. 32
    Condensed ring group azacyclobutyl triazole derivative, preparation method therefor and use thereof in medicine
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    08/09/21
  1076. 40
    Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
    Amgen Inc.
    08/09/21
  1077. 29
    Dihydroxybenzamide compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof
    ONCOZEN CO.. LTD.
    08/09/21
  1078. 95
    Inhibitors of TRPC6
    Boehringer Ingelheim International GmbH
    08/09/21
  1079. 78
    Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
    Auckland UniServices Limited
    08/09/21
  1080. 69
    PDE9 inhibitor and use thereof
    Nanjing TransThera Biosciences Co. Ltd.
    08/09/21
  1081. 215
    Substituted benzoimidazoles and imidazo[4,5-c]pyridines for treating certain leukemias
    Terns, Inc.
    08/09/21
  1082. 268
    Sulfonamide compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    08/09/21
  1083. 52
    Tetrahydroindazoles and medical uses thereof
    Genase Therapeutics B.V.
    08/09/21
  1084. 17
    Thiazine derivatives as β-secretase inhibitors and methods of use
    Amgen Inc.
    08/09/21
  1085. 21
    Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors
    VALO EARLY DISCOVERY, INC.
    08/09/21
  1086. 7
    [1,3]thiazin-2-amine compound, application, and pharmaceutical composition
    TETRANOV PHARMACEUTICAL CO., LTD.
    08/09/21
  1087. 33
    Pyrazole derivatives as MALT1 inhibitors
    Janssen Pharmaceutica NV
    08/08/21
  1088. 6
    Acetamide thienotriazolodiazepines and uses