Patent: (prefix with "US" like US6078908)
  1. Patent
    Data
    Cmpds
    HGNC*
    Patent Title
    Organization
    Deposition
    Downloads
  2. 86
    Compounds and their uses as MIF inhibitors
    Nanjing Immunophage Biotech Co.
    03/25/24
  3. 51
    Purinone compounds and their use in treating cancer
    Astrazeneca
    03/21/24
  4. 2
    Substituted oxopyridine derivative
    Bayer Pharma Aktiengesellschaft
    03/21/24
  5. 258
    AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF
    Genentech
    03/19/24
  6. 29
    COMPOUND USED AS KINASE INHIBITOR AND USE THEREOF
    Tyk Medicines
    03/19/24
  7. 503
    COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
    Dong-A St Co.
    03/19/24
  8. 3
    Compositions and Methods for Managing Weight
    Unigen
    03/19/24
  9. 289
    PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES
    Hoffmann-La Roche
    03/19/24
  10. 248
    PYRIMIDINE-AND NITROGEN-CONTAINING BICYCLIC COMPOUND
    Asahi Kasei Pharma
    03/19/24
  11. 108
    RIPK1 INHIBITORS AND METHODS OF USE
    Merck Sharp & Dohme
    03/19/24
  12. 66
    SALT INDUCIBLE KINASE INHIBITORS
    The General Hospital
    03/19/24
  13. 9
    TETRACYCLIC COMPOUNDS AS DGK INHIBITORS
    Incyte
    03/19/24
  14. 187
    TETRAHYDROPYRIDO[3,4-d]PYRIMIDINES AS HPK1 INHIBITORS
    Merck Patent
    03/19/24
  15. 11
    TRIHETEROCYCLIC DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
    Shanghai De Novo Pharmatech Co.
    03/19/24
  16. 139
    Bicyclic compounds and their uses
    Novartis
    03/14/24
  17. 320
    Inhibitors of peptidylarginine deiminases
    Gilead Sciences
    03/14/24
  18. 35
    BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF
    2692372 Ontario
    03/13/24
  19. 5
    BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE
    Prelude Therapeutics
    03/13/24
  20. 26
    COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS
    Kineta
    03/13/24
  21. 46
    COMPOUND HAVING INHIBITORY ACTIVITY AGAINST O-GLUSACASE AND USE THEREOF
    Medifron Dbt
    03/13/24
  22. 210
    CYCLIC COMPOUNDS AND METHODS OF USING SAME
    SchröDinger
    03/13/24
  23. 83
    MODIFIED IMIDAZOPYRIDINES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
    Merck Sharp & Dohme
    03/13/24
  24. 24
    MODULATORS OF FPR1 AND METHODS OF USING THE SAME
    Biofront
    03/13/24
  25. 18
    NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME
    Tme Therapeutics
    03/13/24
  26. 188
    PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS
    Chiesi Farmaceutici
    03/13/24
  27. 24
    PYRIDO[4,3-b]INDOLE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
    Ventus Therapeutics U.S.
    03/13/24
  28. 1
    SALT OF COMPOUND FOR DEGRADING BTK, CRYSTAL FORM THEREOF, AND USE THEREOF IN MEDICINE
    Haisco Pharmaceuticals
    03/13/24
  29. 4
    BROMODOMAIN INHIBITORS FOR ANDROGEN RECEPTOR-DRIVEN CANCERS
    Forma Therapeutics
    03/12/24
  30. 11
    COMPOUNDS AND METHODS FOR TREATING VIRAL INFECTIONS
    Beth Israel Deaconess Medical Center
    03/12/24
  31. 34
    Fused pyrimidine derivatives as A2A/A2B inhibitors
    Incyte
    03/07/24
  32. 49
    Indanes as PD-L1 inhibitors
    Chemocentryx
    03/07/24
  33. 178
    Pyridazinone compounds and uses thereof
    Edgewise Therapeutics
    03/07/24
  34. 42
    Trans-indoline cyclopropylamine chemical compound, and method for preparation, pharmaceutical composition, and use thereof
    Shanghai Institute of Materia Medica
    03/07/24
  35. 20
    ABHD6 ANTAGONIST
    Ono Pharmaceutical Co.
    03/04/24
  36. 89
    MASP INHIBITORY COMPOUNDS AND USES THEREOF
    Bayer Aktiengesellschaft
    03/04/24
  37. 18
    MODULATORS OF PROGRAMMED DEATH-LIGAND-1
    Southern Research Institute
    03/04/24
  38. 32
    PYRIMIDINYL SULFONAMIDES AS INHIBITORS OF ACK1/TNK2 TYROSINE KINASE
    H. Lee Moffitt Cancer Center and Research Institute
    03/04/24
  39. 51
    TETRAZOLE DERIVATIVES
    Merck Patent
    03/04/24
  40. 16
    TRIAZINE DIONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICINE
    Jiangsu Hengrui Pharmaceuticals Co.
    03/04/24
  41. 181
    Benzo[c][2,6]naphthyridine derivatives, compositions and therapeutic uses thereof
    Cambridge Enterprise
    03/02/24
  42. 83
    Heteroaryl-biphenyl amines for the treatment of PD-L1 diseases
    Chemocentryx
    03/02/24
  43. 210
    Modulators of Cystic Fibrosis Transmembrane Conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulators
    Vertex Pharmaceuticals
    03/02/24
  44. 288
    Naphthyridinone compounds useful as T cell activators
    Bristol-Myers Squibb
    03/02/24
  45. 136
    Streptococcus mutans glucosyl transferase inhibitors for dental caries therapy
    Uab Research Foundation
    03/02/24
  46. 107
    Substituted indazoles as IRAK4 inhibitors
    Astrazeneca
    03/02/24
  47. 421
    4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF
    Biosplice Therapeutics
    02/28/24
  48. 11
    ANTICHOLINERGIC AGENTS
    Rezubio Pharmaceuticals Co.
    02/28/24
  49. 126
    COMBINATION OF AN ALPHA2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONIST WITH A TASK1/3 CHANNEL BLOCKER FOR THE TREATMENT OF SLEEP APNEA
    Bayer Aktiengesellschaft
    02/28/24
  50. 12
    COMPOUNDS AND USE THEREOF IN METHODS OF TREATMENT
    University of Queensland
    02/28/24
  51. 1
    DEUTERIUM-MODIFIED THIENOPYRIDONE COMPOUND
    Chia Tai Tianqing Pharmaceutical Group Co.
    02/28/24
  52. 1
    METHOD FOR PREPARING BTK DEGRADING AGENT
    Haisco Pharmaceuticals
    02/28/24
  53. 3
    PYRIDAZINE AND 1,2,4-TRIAZINE DERIVATIVES AS FGFR KINASE INHIBITORS
    Beta Pharma
    02/28/24
  54. 78
    PYRIMIDINONE COMPOUNDS AND USES THEREOF
    Hutchison Medipharma
    02/28/24
  55. 5
    PYRROLOPYRIDINE COMPOUND AND APPLICATION THEREOF
    Medshine Discovery
    02/28/24
  56. 26
    REV-ERB AGONISTS
    Saint Louis University
    02/28/24
  57. 1
    SALT OF PYRROLOPYRIMIDINE COMPOUND, CRYSTALLINE FORM THEREOF, AND APPLICATION THEREOF
    Guangzhou Joyo Pharmatech Co.
    02/28/24
  58. 44
    SUBSTITUTED BENZO[f][l ,2,4JTRIAZOL0[4,3-a][l ,4JDIAZEPINES AS GABA A GAMMA! POSITIVE ALLOSTERIC MODULATORS
    Hoffmann-La Roche
    02/28/24
  59. 93
    THERAPEUTIC COMPOUNDS AND METHODS
    University of Minnesota
    02/28/24
  60. 5
    4-[[(7-aminopyrazolo[1,5-a]pyrimidin-5-yl)amino]methyl]piperidin-3-ol compounds as CDK inhibitors
    Carrick Therapeutics
    02/22/24
  61. 21
    Alkyne-containing antiviral agents
    Enanta Pharmaceuticals
    02/22/24
  62. 48
    Cathepsin L inhibitors
    Biofront Therapeutics (Beijing) Co.
    02/22/24
  63. 46
    Glycyrrhetinic acid derivatives for use in treating hyperkalemia
    Ardelyx
    02/22/24
  64. 144
    Inhibiting agents for bruton's tyrosine kinase
    Biogen Ma
    02/22/24
  65. 15
    Peptidomimetics for the treatment of Norovirus infection
    Emory University
    02/22/24
  66. 11
    Pharmaceutical compositions comprising substituted nucleotides and nucleosides for treating viral infections
    Emory University
    02/22/24
  67. 24
    ADENOSINE ANALOGS FOR THE TREATMENT OF DISEASE
    Biointervene
    02/19/24
  68. 37
    AMIDE COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Artivila (Shenzhen) Innovation Center
    02/19/24
  69. 3
    BENZODIAZEPINE COMPOUNDS, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    China Pharmaceutical University
    02/19/24
  70. 35
    DIHYDROISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AND USES THEREOF
    Hefei Institutes Of Physical Science, Chinese Academy Of Sciences
    02/19/24
  71. 51
    HETEROARYLQUINAZOLINE COMPOUNDS AS PROTEIN KINASE INHIBITORS
    Chengdu Cynogen Bio-Pharmaceutical Technology
    02/19/24
  72. 88
    PYRIMIDINONE-CONTAINING 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 13 INHIBITORS
    Enanta Pharmaceuticals
    02/19/24
  73. 8
    INHIBITION OF THE HIV-1 REPLICATION BY COMPOUNDS DIRECTED AGAINST A NEW TARGET OF THE VIRAL CYCLE
    Centre National De La Recherche Scientifique
    02/18/24
  74. 7
    PSMA INHIBITOR, COMPOUND AND APPLICATION
    Peking University First Hospital
    02/18/24
  75. 14
    SARM1 ENZYME ACTIVITY INHIBITOR AND USE THEREOF IN NEURODEGENERATIVE DISEASES
    Artivila Biopharma
    02/18/24
  76. 3
    USE OF PRIDOPIDINE AND ANALOGS FOR TREATING RETT SYNDROME
    Prilenia Neurotherapeutics
    02/18/24
  77. 137
    Bicyclic amines as CDK2 inhibitors
    Incyte
    02/15/24
  78. 13
    Fused bicyclic pyrimidine derivatives and uses thereof
    The Regents Of The University Of Colorado, A Body Corporate
    02/15/24
  79. 114
    Substituted pyrazolo[1,5-A]pyrazine compounds as ret kinase inhibitors
    Array Biopharma
    02/15/24
  80. 118
    Arginase inhibitors
    Rijksuniversiteit Groningen
    02/12/24
  81. 22
    COMBINATIONS OF DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS AND ACETYL-COA CARBOXYLASE INHIBITOR
    Pfizer
    02/12/24
  82. 48
    N-(2-(3-CYANO-2-AZABICYCLO[3.1.0]HEXAN-2-YL)-2-OXOETHYL)QUINOLINE-4-CARBOXAMIDES
    Astrazeneca
    02/12/24
  83. 2
    SUBSTITUTED PYRROLO [2, 3-b] PYRIDINE AND PYRAZOLO [3, 4-b] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS
    Fochon Biosciences
    02/12/24
  84. 118
    1,3-substituted cyclobutyl derivatives and uses thereof
    Novartis
    02/08/24
  85. 818
    Diacylglycerol kinase modulating compounds
    Gilead Sciences
    02/08/24
  86. 10
    Glutaminyl cyclase inhibitors and the use thereof in treatment of various diseases
    Ltd “Valenta-Intellekt”
    02/08/24
  87. 8
    Opioid compounds and uses thereof
    Rhodes Technologies
    02/08/24
  88. 1
    Oral compositions of MK2 pathway inhibitor for treatment of immune conditions
    Aclaris Therapeutics
    02/08/24
  89. 140
    USP30 inhibitors and uses thereof
    Vincere Biosciences
    02/08/24
  90. 7
    ANTIBODIES FOR OPIOID TREATMENTS
    The Scripps Research Institute
    02/03/24
  91. 413
    Acylsulfamide Compound and Pharmaceutical Use Therefor
    Japan Tobacco
    02/03/24
  92. 20
    CD73 INHIBITOR AND USE THEREOF
    Wuhan Humanwell Innovative Drug Research And Development Center
    02/03/24
  93. 99
    HIGH ACTIVITY HPK1 KINASE INHIBITOR
    Adlai Nortye Biopharma Co.
    02/03/24
  94. 27
    IMIDAZO[1,2-a]PYRAZINE OR PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND USE THEREOF
    TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITED
    02/03/24
  95. 7
    RNA VIRUS INHIBITOR COMPOUNDS WITH IMPROVED METABOLIC STABILITY AND USES THEREOF
    The Governors Of The University Of Alberta
    02/03/24
  96. 136
    TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS
    Incyte
    02/03/24
  97. 25
    Alkynyl(hetero)aromatic compound for inhibiting protein kinase activity
    Shenzhen Targetrx
    02/02/24
  98. 15
    CDK8/19 inhibitors
    Joint Stock Company “Biocad”
    02/02/24
  99. 4
    IRE1α inhibitors and uses thereof
    The Regents Of The University Of California
    02/02/24
  100. 4
    Imidazopyridazine compounds and uses thereof
    Incyte
    02/02/24
  101. 6
    Pyridinone-based epigenetic modifiers and uses thereof
    The Board Of Trustees Of The University Of Illinois
    02/02/24
  102. 1
    Radiolabelled MGL pet ligands
    Janssen Pharmaceutica
    02/02/24
  103. 62
    Substituted nicotinimide inhibitors of BTK for treating cancer
    Guangzhou Innocare Pharma Tech Co.
    02/02/24
  104. 456
    Pyrimidine derivatives as PGE2 receptor modulators
    Idorsia Pharmaceuticals
    02/01/24
  105. 25
    3-TETRAZOLYLMETHYL-1,3,5-TRIAZIN-2,4-DIONE COMPOUND INHIBITING CORONAVIRUS 3CL PROTEASE ACTIVITY AND PREPARATION METHOD AND USE THEREOF
    Shaanxi Panlong Pharmaceutical Co.
    01/28/24
  106. 120
    BICYCLIC INHIBITORS OF IRAK
    Rigel Pharmaceuticals
    01/28/24
  107. 12
    BIPHENYL PYRROLIDINE AND BIPHENYL DIHYDROIMIDAZOLE DERIVATIVES FOR INHIBITING ACTIVITY OF 5-HT7 SEROTONIN RECEPTOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT
    Korea Institute Of Science And Technology
    01/28/24
  108. 27
    IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF
    Dana-Farber Cancer Institute
    01/28/24
  109. 331
    INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF
    Epirium Bio
    01/28/24
  110. 123
    INHIBITORS OF THE INTERACTION BETWEEN TRIP8B AND HCN CHANNELS AND USES THEREOF FOR TREATING NEUROLOGICAL DISEASES AND DISORDERS
    Northwestern University
    01/28/24
  111. 65
    MALT1 MODULATORS AND USES THEREOF
    Rheos Medicines
    01/28/24
  112. 49
    METTL3 INHIBITORY COMPOUNDS
    Storm Therapeutics
    01/28/24
  113. 39
    MODIFIED BENZOFURAN-CARBOXAMIDES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
    Merck Sharp & Dohme
    01/28/24
  114. 12
    MODULATORS OF PD-L1/PD-1 INTERACTION AND USES THEREOF
    Ramot at Tel-Aviv University
    01/28/24
  115. 22
    SUBSTITUTED DIARYLAMINE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Suzhou Yabao Pharmaceutical R&D Co.
    01/28/24
  116. 17
    SUBSTITUTED S-ALANINATE DERIVATIVES
    Bayer Aktiengesellschaft
    01/28/24
  117. 3
    USE OF PRIDOPIDINE AND ANALOGS FOR THE TREATMENT OF ANXIETY AND DEPRESSION
    Prilenia Neurotherapeutics
    01/28/24
  118. 322
    cGAS INHIBITORS
    Eli Lilly
    01/28/24
  119. 304
    Substituted indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors
    1St Biotherapeutics
    01/24/24
  120. 15
    1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use
    Modern Biosciences
    01/23/24
  121. 16
    Anti-cancer nuclear hormone receptor-targeting compounds
    Nuvation Bio
    01/23/24
  122. 101
    Beta-lactam derivatives for the treatment of diseases
    Insilico Medicine Ip
    01/23/24
  123. 119
    Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase
    Agency For Science, Technology And Research
    01/23/24
  124. 23
    Heterocyclic compounds as pad inhibitors
    Jubilant Epipad
    01/23/24
  125. 1
    SSTR4 agonist salts
    Eli Lilly
    01/23/24
  126. 23
    Substituted amino six-membered nitric heterocyclic ring compound and preparation and use thereof
    Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences
    01/23/24
  127. 483
    Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors
    Array Biopharma
    01/23/24
  128. 152
    COMPOUNDS FOR INHIBITING KIF18A
    Volastra Therapeutics
    01/19/24
  129. 2
    CSF1R KINASE INHIBITOR AND USE THEREOF
    Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences
    01/19/24
  130. 55
    FUSED TETRACYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2
    Enliven Therapeutics
    01/19/24
  131. 30
    GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF
    Deciphera Pharmaceuticals
    01/19/24
  132. 316
    HDAC6 INHIBITORS FOR TREATMENT OF METABOLIC DISEASE AND HFPEF
    Tenaya Therapeutics
    01/19/24
  133. 6
    HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Hutchison Medipharma
    01/19/24
  134. 45
    MEK INHIBITORS AND USES THEREOF
    Ikena Oncology
    01/19/24
  135. 31
    N-AROMATIC AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
    Shenzhen Edk Pharmaceutical Technology
    01/19/24
  136. 4
    OXA- IBOGAINE INSPIRED ANALOGUES FOR TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
    The Trustees Of Columbia University In The City Of New York
    01/19/24
  137. 78
    PYRAZOLEAMIDE DERIVATIVES
    Hoffmann-La Roche
    01/19/24
  138. 7
    Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1receptor positive allosteric modulators
    Eli Lilly
    01/19/24
  139. 390
    SUBSTITUTED 4-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES AND USE THEREOF
    The Johns Hopkins University
    01/19/24
  140. 16
    Anti-cancer nuclear hormone receptor-targeting compounds
    Nuvation Bio
    01/17/24
  141. 6
    Conduritol aziridine derivatives and uses thereof
    University Of Saskatchewan
    01/17/24
  142. 43
    Pyrazine derivative and application thereof in inhibiting SHP2
    Suzhou Genhouse Pharmaceutical
    01/17/24
  143. 39
    MACROCYCLIC PEPTIDE BORONATE IMMUNOMODULATORS
    Bristol-Myers Squibb
    01/16/24
  144. 212
    5-SUBSTITUTED INDOLE 3-AMIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF
    Origiant Pharmaceutical
    01/12/24
  145. 13
    BIPHENYL COMPOUND AS IMMUNOMODULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Shenzhen Chipscreen Biosciences
    01/12/24
  146. 49
    FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28
    Dana-Farber Cancer Institute
    01/12/24
  147. 84
    HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER
    SchrÖDinger
    01/12/24
  148. 64
    INHIBITOR OF ENHANCER OF ZESTE HOMOLOGUE 2, AND USE THEREOF
    Haisco Pharmaceuticals
    01/12/24
  149. 23
    N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE
    Pliant Therapeutics
    01/12/24
  150. 135
    PLK1 POLO BOX DOMAIN INHIBITORS AND METHOD OF TREATING CANCER
    The United States Of America,As Represented By The Secretary,Department Of Health And Human Services
    01/12/24
  151. 38
    SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF
    The Broad Institute
    01/12/24
  152. 20
    TETRAHYDROISOQUINOLINE DERIVATIVE AND USE THEREOF
    Medshine Discovery
    01/12/24
  153. 79
    BACTERIAL DNA GYRASE INHIBITORS AND METHODS OF USE THEREOF
    The Florida International University Board Of Trustees
    01/11/24
  154. 154
    COMPOUND AS BRAIN-PERMEABLE BTK OR HER2 INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Chengdu Hyperway Pharmaceuticals
    01/11/24
  155. 271
    POLO LIKE KINASE 4 INHIBITORS
    Oric Pharmaceuticals
    01/11/24
  156. 88
    QUINAZOLINE-2,4-DIAMINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING SAME AS ACTIVE INGREDIENT
    The Asean Foundation
    01/11/24
  157. 47
    TRUXILLIC ACID MONOESTER-DERIVATIVES AS SELECTIVE FABP5 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
    The Research Foundation For The State University Of New York
    01/11/24
  158. 22
    Fused pyrrolines which act as ubiquitin-specific protease 30 (USP30) inhibitors
    Forma Therapeutics
    01/08/24
  159. 784
    Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof
    Maze Therapeutics
    01/08/24
  160. 92
    Inhibtors of Raf kinases
    Kinnate Biopharma
    01/08/24
  161. 54
    Macrocyclic compounds for the treatment of medical disorders
    Achillion Pharmaceuticals
    01/08/24
  162. 8
    Substituted pyrrolo[2,3-d]pyrimidines and pyrazolo[3,4-d]pyrimidines as inhibitors for multi-resistant cancers
    Ferris State University
    01/08/24
  163. 6
    1H-PYRROLO[2,3-C]PYRIDINE COMPOUNDS AND APPLICATION THEREOF
    Medshine Discovery
    01/04/24
  164. 192
    AGONISTS OF STIMULATOR OF INTERFERON GENES STING
    The Scripps Research Institute
    01/04/24
  165. 64
    MACROCYCLIC COMPOUND
    Asahi Kasei Pharma
    01/04/24
  166. 169
    NEW MACROCYCLIC LRRK2 KINASE INHIBITORS
    Les Laboratoires Servier
    01/04/24
  167. 10
    PREPARATION OF BIARYL RING-LINKED AROMATIC HETEROCYCLIC DERIVATIVE AS IMMUNOMODULATOR AND USE THEREOF
    Shanghai Longwood Biopharmaceuticals
    01/04/24
  168. 69
    PYRIDO[2,3-D]PYRIMIDIN-4-AMINES AS SOS1 INHIBITORS
    Bayer Aktiengesellschaft
    01/04/24
  169. 11
    PYRROLOPYRIMIDINE COMPOUND AS BTK INHIBITOR AND USE THEREOF
    Medshine Discovery
    01/04/24
  170. 42
    SMALL MOLECULE INHIBITORS OF BACTERIAL TOXINS
    Artizan Biosciences
    01/04/24
  171. 334
    4-hydroxypiperidine derivatives and their use as inhibitors of ubiquitin specific protease 19 (USP19)
    Almac Discovery
    12/29/23
  172. 57
    Fused tetracyclic quinazoline derivatives as inhibitors of ErbB2
    Enliven Therapeutics
    12/29/23
  173. 12
    Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof
    Haisco Pharmaceuticals
    12/29/23
  174. 31
    Prevention and/or treatment of CNS disorders
    Ildong Pharmaceutical
    12/29/23
  175. 1
    Site specific homogeneous with KSP inhibitors
    Bayer Pharma Aktiengesellschaft
    12/29/23
  176. 13
    Substituted pyrimidinones as agonists of the APJ receptor
    Amgen
    12/29/23
  177. 44
    Sulfonamide derivatives for protein degradation
    Dana-Farber Cancer Institute
    12/29/23
  178. 100
    INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING
    Abbvie
    12/25/23
  179. 127
    NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLOEOTIDE PYROPHOSPHATASE/PHOSPHODIESTE RASE INHIBITORY ACTIVITY, AND USE THEREOF
    Txinno Bioscience
    12/25/23
  180. 8
    Toll-like receptor ligands
    Inimmune
    12/24/23
  181. 46
    2-AMINOPYRIMIDINE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF
    Guangzhou Salustier Biosciences
    12/20/23
  182. 53
    5-HT2A RECEPTOR INHIBITOR OR INVERSE AGONIST, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
    Geneora Pharma (Shijiazhuang) Co.
    12/20/23
  183. 37
    A COMPOUND HAVING INHIBITORY ACTIVITY AGAINST KRAS G12D MUTATION
    Taiho Pharmaceutical
    12/20/23
  184. 16
    BIOPROBES FOR LYSYL OXIDASES AND USES THEREOF
    Pharmaxis
    12/20/23
  185. 33
    BISPECIFIC ANTAGONISTS OF RETINOL-BINDING PROTEIN 4 THAT STABILIZE TRANSTHYRETIN TETRAMERS, THEIR PREPARATION, AND USE IN THE TREATMENT OF COMMON AGE-RELATED COMORBIDITIES
    The Trustees Of Columbia University In The City Of New York
    12/20/23
  186. 32
    Benzimidazole derivatives
    Hoffmann-La Roche
    12/20/23
  187. 319
    CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE
    Genzyme
    12/20/23
  188. 176
    GALECTIN-3 INHIBITING 2-HYDROXYCYCLOALKANE-1-CARBAMOYL DERIVATIVES
    Idorsia Pharmaceuticals
    12/20/23
  189. 29
    HALOGENATED-HETEROARYL AND OTHER HETEROCYCLIC KINASE INHIBITORS, AND USES THEREOF
    Iomx Therapeutics
    12/20/23
  190. 262
    HETEROCYCLIC COMPOUNDS AND METHODS OF USE
    SchröDinger
    12/20/23
  191. 23
    Heteroaryl Derivative, Preparation Method Therefor, And Use Thereof
    Zhejiang Hisun Pharmaceutical
    12/20/23
  192. 27
    IMIDAZO[4,5-C]QUINOLINE COMPOUNDS AND THEIR USE AS ATM KINASE INHIBITORS
    Deutsches Krebsforschungszentrum
    12/20/23
  193. 623
    OXOPYRROLIDINE FPR2 AGONISTS
    Bristol-Myers Squibb
    12/20/23
  194. 3
    PYRROLIDINE COMPOUND AND USE THEREOF
    Simcere Pharmaceutical
    12/20/23
  195. 163
    QUINAZOLINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME
    Repare Therapeutics
    12/20/23
  196. 30
    SUBSTITUTED PYRIDINES AS PARP1 INHIBITORS
    Xinthera
    12/20/23
  197. 7
    SULFONYLUREA DERIVATIVE AND MEDICAL USES THEREOF
    Shanghai Senhui Medicine
    12/20/23
  198. 24
    2-amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl-tRNA synthetase
    Oxford Drug Design
    12/13/23
  199. 105
    2-oxoimidazolidine-4-carboxamides as NAv1.8 inhibitors
    Merck Sharp & Dohme
    12/13/23
  200. 64
    Azetidine and pyrrolidine PARP1 inhibitors and uses thereof
    Xinthera
    12/13/23
  201. 21
    Compounds for the modulation of cyclophilins function
    The University Court Of The University Of Edinburgh
    12/13/23
  202. 481
    Cyclobutyl amide monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    12/13/23
  203. 76
    Glutarimides for medical treatment
    C4 Therapeutics
    12/13/23
  204. 188
    Heterocyclic compounds as monoacylglycerol lipase inhibitors
    Hoffmann-La Roche
    12/13/23
  205. 131
    AMINO ALCOHOL COMPOUNDS AND USES THEREOF
    Kineta
    12/10/23
  206. 264
    BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS
    Otsuka Pharmaceutical
    12/10/23
  207. 153
    CASEIN KINASE 1 DELTA MODULATORS
    Janssen Pharmaceutica
    12/10/23
  208. 29
    COMPOUNDS FOR PREVENTION OR TREATMENT OF NEURODEGENERATIVE DISORDERS
    1St Biotherapeutics
    12/10/23
  209. 9
    HPK1 INHIBITORS AND USES THEREOF
    Qilu Regor Therapeutics
    12/10/23
  210. 4
    INDAZOLE DERIVATIVES AS CANNABINOID RECEPTOR PARTIAL AGONISTS
    Research Triangle Institute
    12/10/23
  211. 197
    KRAS G12D MODULATING COMPOUNDS
    Gilead Sciences
    12/10/23
  212. 187
    MACROCYCLIC HETEROCYCLES AND USES THEREOF
    Kumquat Biosciences
    12/10/23
  213. 59
    MODULATORS OF ALPHA-1 ANTITRYPSIN
    Vertex Pharmaceuticals
    12/10/23
  214. 19
    NOVEL PHARMACOLOGICAL CHAPERONE COMPOUNDS OF HUMAN ACID ALPHA-GLUCOSIDASE AND THE THERAPEUTIC USE THEREOF
    UniversitÉ
    12/10/23
  215. 60
    SHP2 INHIBITOR AND COMPOSITION AND APPLICATION THEREOF
    Betta Pharmaceuticals
    12/10/23
  216. 555
    STEROIDAL COMPOSITIONS AND METHODS OF TREATING LIPOGENIC CANCERS
    Asteroid Therapeutics
    12/10/23
  217. 54
    SUBSTITUTED 1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
    Bayer Aktiengesellschaft
    12/10/23
  218. 128
    URACIL DERIVATIVES AS MER-AXL INHIBITORS
    Bristol-Myers Squibb
    12/10/23
  219. 37
    Compounds and pharmaceutical uses thereof
    SyneuRx International (Taiwan)
    12/05/23
  220. 9
    Compounds for the treatment of SARS
    Purdue Research Foundation
    12/05/23
  221. 97
    MAP4K4 inhibitors
    Imperial College Innovations
    12/05/23
  222. 122
    Pyrrolotriazinones and imidazotriazinones as ubiquitin-specific protease 7 inhibitors
    Valo Health
    12/05/23
  223. 30
    Substituted pyridines as PARP1 inhibitors
    Xinthera
    12/05/23
  224. 51
    Tetrahydro-benzoazepine glycosidase inhibitors
    Asceneuron
    12/05/23
  225. 3
    Uses of a lysyl oxidase-like 2 inhibitor
    Pharmakea
    12/05/23
  226. 78
    AROMATIC ETHYLENE COMPOUND AND PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
    Guangzhou Maxinovel Pharmaceuticals
    12/01/23
  227. 1
    INDOLO HEPTAMYL OXIME ANALOG CRYSTAL AS PARP INHIBITOR AND METHOD FOR PREPARING SAME
    Chia Tai Tianqing Pharmaceutical Group
    12/01/23
  228. 73
    INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY
    University Of Virginia Patent Foundation
    12/01/23
  229. 1
    N-((1-BENZYLPIPERIDIN-3-YL)METHYL)-N-(2-METHOXYETHYL)NAPHTHALENE-2-SULFONAMIDE FOR THE TREATMENT OF CANINE COGNITIVE DYSFUNCTION AND OTHER FORMS OF DEMENTIA IN DOGS
    Univerza V Ljubljani
    12/01/23
  230. 7
    NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS
    Enanta Pharmaceuticals
    12/01/23
  231. 15
    Pyrazolopyridine Compounds and Methods of Inhibiting IRE1 Using Same
    Optikira
    12/01/23
  232. 18
    5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2 Pyridyl]Amino]Pyrazine-2-carbonitrile and therapeutic uses thereof
    Cancer Research Technology
    11/29/23
  233. 165
    Aryl piperidines as monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    11/29/23
  234. 79
    Compound having PD-L1 inhibitory activity, preparation method therefor and use thereof
    Shanghai Ennovabio Pharmaceuticals
    11/29/23
  235. 142
    Diacylglyceride O-acyltransferase 2 inhibitors
    Merck Sharp & Dohme
    11/29/23
  236. 157
    Dihydrobenzimidazolones for medical treatment
    C4 Therapeutics
    11/29/23
  237. 7
    Inhibiting ataxia telangiectasia and RAD3-related protein (ATR)
    Celator Pharmaceuticals
    11/29/23
  238. 94
    Inhibitors of VAP-1
    Acucela
    11/29/23
  239. 2
    Isoquinolinyl triazolone complexes
    Takeda Pharmaceutical
    11/29/23
  240. 8
    Methods of inhibiting cyclooxygenase
    King Faisal University
    11/29/23
  241. 150
    Plasma Kallikrein inhibitors and uses thereof
    Takeda Pharmaceutical
    11/29/23
  242. 46
    Pyrazolopyrimidine compounds as adenosine receptor antagonists
    Exscientia
    11/29/23
  243. 255
    Quaternary indazole glucocorticoid receptor antagonists
    Corcept Therapeutics
    11/29/23
  244. 2
    Solid forms of an HPK1 inhibitor
    Incyte
    11/29/23
  245. 34
    Substituted pyrazolo[4,3-d]pyrimidines and imidazo[5,1 -f][1,2,4]triazines as androgen receptor and phosphodiesterase dual inhibitors
    Ildong Pharmaceutical
    11/29/23
  246. 46
    Therapeutic compounds and methods of use
    Genentech
    11/29/23
  247. 27
    ARYL PHOSPHOROUS OXIDE COMPOUNDS AND USE THEREOF
    Chengdu Di''Ao Jiuhong Pharmaceutical Factory
    11/22/23
  248. 137
    ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF
    Bayer Aktiengesellschaft
    11/22/23
  249. 85
    BROAD SPECTRUM ANTI-CANCER COMPOUNDS
    The Regents Of The University Of California
    11/22/23
  250. 14
    CDK9 INHIBITORS
    Biolexis Therapeutics
    11/22/23
  251. 3
    COMBINATION THERAPY
    Pfizer
    11/22/23
  252. 5
    FUSED IMIDAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF
    Jiangsu Hengrui Medicine
    11/22/23
  253. 37
    FUSED TRICYCLIC DERIVATIVE AND PHARMACEUTICAL APPLICATION THEREOF
    Chia Tai Tianqing Pharmaceutical Group
    11/22/23
  254. 32
    HETEROAROMATIC RING COMPOUND AS RET KINASE INHIBITOR, AND PREPARATION AND USE THEREOF
    Jiangsu Chia Tai Fenghai Pharmaceutical
    11/22/23
  255. 29
    IMIDAZOTRIAZINE AND PYRROLOPYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS
    Beigene
    11/22/23
  256. 326
    NEUROACTIVE STEROIDS AND THEIR METHODS OF USE
    Sage Therapeutics
    11/22/23
  257. 32
    NOVEL BIARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR, AND USE THEREOF
    Lg Chem
    11/22/23
  258. 178
    OXADIAZOLE HDAC6 INHIBITORS AND USES THEREOF
    Eikonizo Therapeutics
    11/22/23
  259. 174
    PYRAZOLOPYRIDAZINONE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Broadenbio
    11/22/23
  260. 16
    TRIAZOLE DERIVATIVES AND THEIR USE AS TANKYRASE INHIBITORS
    Oslo Universitetssykehus
    11/22/23
  261. 9
    UNIT DOSAGE COMPOSITION OF AKT INHIBITOR
    Nanjing Chia Tai Tianqing Pharmaceutical
    11/22/23
  262. 1441
    FGFR inhibitors and methods of use thereof
    Relay Therapeutics
    11/17/23
  263. 253
    Imino sulfanone inhibitors of ENPP1
    Volastra Therapeutics
    11/17/23
  264. 56
    LRRK2 inhibitors
    H. Lundbeck
    11/17/23
  265. 281
    Methods for treating Crohn's disease using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
    Theravance Biopharma R&D Ip
    11/17/23
  266. 57
    Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors
    Orsobio
    11/17/23
  267. 15
    Prolyl hydroxylase domain-containing protein (PHD) inhibitors and uses thereof
    Insilico Medicine Ip
    11/17/23
  268. 20
    Pyridinamine-pyridone and pyrimidinamine-pyridone compounds
    Sprint Bioscience
    11/17/23
  269. 46
    Substituted 3-phenoxyazetidin-1-yl-pyrazines
    Boehringer Ingelheim International
    11/17/23
  270. 93
    Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors
    Pfizer
    11/17/23
  271. 34
    TYK2 pseudokinase ligands
    Ventyx Biosciences
    11/17/23
  272. 9
    1-(5-(2-CYANOPYRIDIN-4-YL)OXAZOLE-2-CARBONYL)-4-METHYLHEXAHYDROPYRROLO[3,4-B]PYR ROLE-5(1H)-CARBONITRILE AS USP30 INHIBITOR FOR USE IN THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION, CANCER AND FIBROSIS
    Mission Therapeutics
    11/13/23
  273. 21
    1H-IMIDAZO [4,5-H] QUINAZOLINE COMPOUND AS NOVEL SELECTIVE FLT3 INHIBITORS
    Shengke Pharmaceuticals (Jiangsu)
    11/13/23
  274. 176
    2-OXO-IMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS
    Merck Sharp & Dohme
    11/13/23
  275. 118
    4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER
    Centre National De La Recherche Scientifique
    11/13/23
  276. 87
    ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Sichuan Kelun-Biotech Biopharmaceutical
    11/13/23
  277. 27
    COMPOUNDS WITH SEMIOCHEMICAL PROPERTIES AND BIOSENSORS
    Rothamsted Research
    11/13/23
  278. 51
    CYP46A1 INHIBITORS AND METHODS OF USE THEREOF
    Sage Therapeutics
    11/13/23
  279. 67
    HYDROXYPYRROLIDINE DERIVATIVE AND MEDICINAL APPLICATION THEREOF
    Mitsubishi Tanabe Pharma
    11/13/23
  280. 229
    N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)-QUINOLINE-4-CARBOXAMIDES
    Astrazeneca
    11/13/23
  281. 46
    PTERIDINONE COMPOUNDS AND USES THEREOF
    Vertex Pharmaceuticals
    11/13/23
  282. 13
    PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF
    Wenzhou Medical University
    11/13/23
  283. 236
    PYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF
    Biosplice Therapeutics
    11/13/23
  284. 1
    QUINOLINE COMPOUNDS
    Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory
    11/13/23
  285. 12
    RING-MODIFIED PROLINE SHORT PEPTIDE COMPOUND AND USE THEREOF
    Fujian Akeylink Biotechnology
    11/13/23
  286. 2
    Salts Of Nitrogen-Containing Heterocyclic Compound, And Solid Forms Of Salts, Pharmaceutical Composition And Use Thereof
    Wuhan Humanwell Innovative Drug Research And Development Center
    11/13/23
  287. 39
    THIAZOLO[5,4-B]PYRIDINE MALT-1 INHIBITORS
    Abbvie
    11/13/23
  288. 396
    Furin inhibitors
    Glaxosmithkline Intellectual Property Development
    11/07/23
  289. 84
    Methods and compounds for treating disorders
    Foghorn Therapeutics
    11/07/23
  290. 8
    Substituted pyridines as DNMT1 inhibitors
    Glaxosmithkline Intellectual Property Development
    11/07/23
  291. 258
    2-AMINOQUINAZOLINES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
    Merck Sharp & Dohme
    11/06/23
  292. 59
    4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE SUMO INHIBITORS AND USES THEREOF
    Suvalent Therapeutics
    11/06/23
  293. 39
    BENZYLAMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF
    Academy Of Military Medical Sciences
    11/06/23
  294. 9
    BENZYLAMINE OR BENZYL ALCOHOL DERIVATIVE AND USES THEREOF
    Chengdu Hyperway Pharmaceuticals
    11/06/23
  295. 53
    CDK6/DYRK2 DUAL-TARGET INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Jiangsu Tasly Diyi Pharmaceutical
    11/06/23
  296. 5
    COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA
    Stealth Biotherapeutics
    11/06/23
  297. 1
    CRYSTALLINE FORM OF TLR8 AGONIST
    Chia Tai Tianqing Pharmaceutical Group
    11/06/23
  298. 91
    MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF
    Children'S Hospital Medical Center
    11/06/23
  299. 12
    N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS
    Mission Therapeutics
    11/06/23
  300. 2
    ORALLY BIOAVAILABLE, BRAIN-PENETRANT COMPOUND WITH SELECTIVITY FOR THE CANNABINOID TYPE 2 RECEPTOR WITH POTENTIAL USE TOWARDS VISCERAL PAIN MANAGEMENT AND NEURODEGENERATIVE DISORDERS
    University Of Mississippi
    11/06/23
  301. 73
    OXOPYRROLIDINE UREA FPR2 AGONISTS
    Bristol-Myers Squibb
    11/06/23
  302. 13
    PIPERAZINE SUBSTITUTED INDAZOLE COMPOUNDS AS INHIBITORS OF PARG
    Ideaya Biosciences
    11/06/23
  303. 11
    PYRAZOLE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Sichuan Kelun-Biotech Biopharmaceutical
    11/06/23
  304. 13
    PYRIMIDINE RING COMPOUND
    Medshine Discovery
    11/06/23
  305. 13
    Advantageous benzofuran compositions for mental disorders or enhancement
    Tactogen
    11/02/23
  306. 43
    Glucose-sensitive albumin-binding derivatives
    Novo Nordisk
    11/02/23
  307. 18
    Nicotinamide RIPK1 inhibitors
    Abbvie
    11/02/23
  308. 44
    Tricyclic pyridone compounds as JAK2 V617F inhibitors
    Incyte
    11/02/23
  309. 357
    3-(1H-IMIDAZOL-2-YL)-2,3,8,8A-TETRAHYDROINDOLIZIN-5(1H)-ONE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS
    Janssen Pharmaceutica
    10/30/23
  310. 258
    ANTAGONIST COMPOUNDS
    Adorx Therapeutics
    10/30/23
  311. 47
    ATR INHIBITORS AND USES THEREOF
    Antengene Discovery
    10/30/23
  312. 29
    ATX INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Suzhou Ark Biopharmaceutical
    10/30/23
  313. 32
    CD73 INHIBITORS AND PHARMACEUTICAL USES THEREOF
    Risen (Suzhou) Pharma Tech
    10/30/23
  314. 170
    COMPOUND USEFUL AS CDK7 KINASE INHIBITOR AND USE THEREOF
    Tyk Medicines
    10/30/23
  315. 128
    FUSED HETEROAROMATIC PYRROLIDINONES
    Calithera Biosciences
    10/30/23
  316. 6
    INHIBITOR OF APOPTOSIS (IAP) PROTEIN ANTAGONISTS
    Sanford Burnham Prebys Medical Discovery Institute
    10/30/23
  317. 94
    INHIBITORS OF VAP-1
    Acucela
    10/30/23
  318. 137
    INTEGRIN INHIBITORS AND USES THEREOF IN COMBINATION WITH OTHER AGENTS
    Pliant Therapeutics
    10/30/23
  319. 36
    NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
    Chong Kun Dang Pharmaceutical
    10/30/23
  320. 67
    PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
    Akebia Therapeutics
    10/30/23
  321. 115
    SPIRO DERIVATIVES OF ALPHA-D-GALACTOPYRANOSIDES
    Idorsia Pharmaceuticals
    10/30/23
  322. 329
    SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES
    Gossamer Bio Services
    10/30/23
  323. 44
    Carboxylic acid, acyl sulfonamide and acyl sulfamide-derivatized bicyclic aza-heteroaromatics as selective Mcl-1 inhibitors and as dual Mcl-1/Bcl-2 inhibitors
    University Of Maryland, Baltimore
    10/29/23
  324. 75
    Methods and compositions for targeting PD-L1
    Aligos Therapeutics
    10/29/23
  325. 9
    Steroids and protein-conjugates thereof
    Regeneron Pharmaceuticals
    10/29/23
  326. 11
    TKI permeability enhancers
    City Of Hope
    10/29/23
  327. 59
    1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDINE-4-ON AND DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, AND COMPOSITION COMPRISING SAME FOR PREVENTING, ALLEVIATING OR TREATING NEURODEGENERATIVE DISEASES
    Duksung Women''S University Industry-Academic Cooperation Foundation
    10/23/23
  328. 96
    ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE
    Petra Pharma
    10/23/23
  329. 120
    BCL6 INHIBITORS
    Cancer Research Technology
    10/23/23
  330. 90
    Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity
    Board Of Regents Of The University Of Texas System
    10/23/23
  331. 56
    HALOALKYLPYRIDYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR
    Huyabio International
    10/23/23
  332. 139
    IL-17A MODULATORS
    Sanofi
    10/23/23
  333. 13
    INDAZOLE DERIVATIVES AS INHIBITORS OF SARM1
    Disarm Therapeutics
    10/23/23
  334. 238
    ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF
    Biosplice Therapeutics
    10/23/23
  335. 47
    KCNT1 INHIBITORS AND METHODS OF USE
    Praxis Precision Medicines
    10/23/23
  336. 10
    METHOD FOR TREATING GRAFT VERSUS HOST DISEASE CAUSED BY HEMATOPOIETIC STEM CELL TRANSPLANTATION
    Beijing Tide Pharmaceutical
    10/23/23
  337. 58
    NEPRILYSIN INHIBITORS
    Theravance Biopharma R&D Ip
    10/23/23
  338. 417
    NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS
    Italfarmaco
    10/23/23
  339. 33
    PHENYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR
    Huyabio International
    10/23/23
  340. 185
    PLASMA KALLIKREIN INHIBITORS
    Merck Sharp & Dohme
    10/23/23
  341. 32
    QUINAZOLINONE HSD17B13 INHIBITORS AND USES THEREOF
    Inipharm
    10/23/23
  342. 3
    SALT OF DIHYDROPYRIDO[2,3-D]PYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Nanjing Chia Tai Tianqing Pharmaceutical
    10/23/23
  343. 30
    Disulfiram derivatives as ALDH1A1 and MAGL inhibitors
    Batterjee Medical College
    10/20/23
  344. 295
    EIF4E inhibitors and uses thereof
    Pic Therapeutics
    10/20/23
  345. 34
    Muscarinic acetylcholine M1 receptor antagonists
    Pipeline Therapeutics
    10/20/23
  346. 55
    Protease inhibitors as antivirals
    Acea Therapeutics
    10/20/23
  347. 137
    Treating primary or idiopathic hyperoxaluria with small molecule inhibitors of lactate dehydrogenase
    Vanderbilt University
    10/20/23
  348. 57
    Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders
    Rugen Holdings (Cayman)
    10/20/23
  349. 187
    DICHLOROPHENOL HSD17B13 INHIBITORS AND USES THEREOF
    Inipharm
    10/18/23
  350. 54
    Benzimidazole Derivative Compounds and Uses Thereof
    Pfizer
    10/17/23
  351. 1030
    CARM1 INHIBITORS AND USES THEREOF
    Epizyme
    10/17/23
  352. 37
    CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE 1 INHIBITORS
    Astrazeneca
    10/17/23
  353. 207
    COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Plexxikon
    10/17/23
  354. 143
    Compound containing structure of a five-membered heteroaromatic ring, pharmaceutical compositions thereof and applications thereof
    280 Bio
    10/17/23
  355. 5
    DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO
    Arena Pharmaceuticals
    10/17/23
  356. 34
    ENPP1 Inhibitors and Their Use for the Treatment of Cancer
    The Board Of Trustees Of The Leland Stanford Junior University
    10/17/23
  357. 4
    IMIDAZO[1,2-A]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Hoffmann-La Roche
    10/17/23
  358. 90
    INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER
    Universite Claude Bernard Lyon 1
    10/17/23
  359. 461
    KRAS G12D INHIBITORS
    Mirati Therapeutics
    10/17/23
  360. 160
    N/O-Linked Degrons and Degronimers for Protein Degradation
    C4 Therapeutics
    10/17/23
  361. 7
    NOVEL TRICYCLIC AROMATIC HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Shanghai Longwood Biopharmaceuticals
    10/17/23
  362. 26
    PTGR2 INHIBITORS AND THEIR USE
    National Health Research Institutes
    10/17/23
  363. 20
    ROR-GAMMA MODULATORS
    Escalier Biosciences
    10/17/23
  364. 29
    TRIAZINE COMPOUND AND COMPOSITION AND USE THEREOF
    Beijing Findcure Biosciences
    10/17/23
  365. 188
    YKL-40 INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS
    Molecure
    10/17/23
  366. 98
    5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER
    Astrazeneca
    10/16/23
  367. 100
    AMIDE DERIVATIVES
    Merck Patent
    10/16/23
  368. 144
    AMINO ACID COMPOUNDS AND METHODS OF USE
    Pliant Therapeutics
    10/16/23
  369. 44
    COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF
    Ono Pharmaceutical
    10/16/23
  370. 549
    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
    Vertex Pharmaceuticals
    10/16/23
  371. 250
    COMPOUNDS USEFUL AS T CELL ACTIVATORS
    Gossamer Bio Services
    10/16/23
  372. 20
    CONDENSED PYRAZOLE DERIVATIVES AS INHIBITORS OF SARM1
    Disarm Therapeutics
    10/16/23
  373. 5
    PRPK INHIBITORS
    Dana-Farber Cancer Institute
    10/16/23
  374. 24
    PYRAZOLOPYRIMIDINE COMPOUND USED AS ATR KINASE INHIBITOR
    Beijing Tide Pharmaceutical
    10/16/23
  375. 3
    SALT AND CRYSTAL FORM OF DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATE
    Nanjing Chia Tai Tianqing Pharmaceutical
    10/16/23
  376. 42
    4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS
    Ip2Ipo Innovations
    10/15/23
  377. 210
    BENZODIAZEPINE DERIVATIVES USEFUL IN TREATING A RESPIRATORY SYNCYTIAL VIRUS INFECTION
    Reviral
    10/15/23
  378. 164
    CARBOXYLIC ACID AROMATIC AMIDES AS ANTAGONISTS OF BRADYKININ B1 RECEPTOR
    Bayer Pharma Aktiengesellschaft
    10/15/23
  379. 176
    COMPOSITION CONTAINING ARYLAMIDE DERIVATIVE
    Chugai Seiyaku Kabushiki Kaisha
    10/15/23
  380. 124
    COMPOUNDS ACTIVE TOWARDS NUCLEAR RECEPTORS
    Nuevolution
    10/15/23
  381. 76
    COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY
    Ifm Due
    10/15/23
  382. 412
    GLP-1R MODULATING COMPOUNDS
    Ascletis Bioscience
    10/15/23
  383. 129
    INHIBITORS OF APOL1 AND METHODS OF USING SAME
    Vertex Pharmaceuticals
    10/15/23
  384. 135
    SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF
    Gilead Sciences
    10/15/23
  385. 162
    2-amino-3-carbonyl imidazopyridine and pyrazolopyridine compounds
    1St Biotherapeutics
    10/06/23
  386. 56
    ALK-5 inhibitors and uses thereof
    Sumitomo Pharma Oncology
    10/06/23
  387. 16
    Alkynyl (hetero) aromatic ring compounds used for inhibiting protein kinase activity
    Shenzhen Targetrx
    10/06/23
  388. 43
    Labelled cannabinergic ligands and related analogs
    Individual
    10/06/23
  389. 10
    Method of increasing platelet counts of a subject
    Korea Basic Science Institute
    10/06/23
  390. 31
    Acetamido-phenyltetrazole derivatives and methods of using the same
    Athenex
    10/01/23
  391. 125
    Methods of inhibiting kinases
    Insilico Medicine Ip
    10/01/23
  392. 22
    Small molecule inhibitors of ubiquitin specific protease 1 (USP1) and uses thereof
    Insilico Medicine Ip
    10/01/23
  393. 10
    Substituted pyrazlo[3,4-c]pyridines as selective BTK kinase inhibitors
    Jumbo Drug Bank
    10/01/23
  394. 5
    Substituted pyrazolopyrazines, imidazopyrazines and [1,2,4]triazolopyrazines as allosteric SHP2 inhibitors
    Revolution Medicines
    10/01/23
  395. 105
    Carboxamide compounds and uses thereof
    Incyte
    09/26/23
  396. 36
    Histone demethylase inhibitors
    Celgene Quanticel Research
    09/26/23
  397. 47
    N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
    Ogeda
    09/26/23
  398. 93
    SARS-CoV-2 inhibitors for treating coronavirus infections
    Insilico Medicine Ip
    09/26/23
  399. 58
    Spiro compounds as glycosidase inhibitors
    Asceneuron
    09/26/23
  400. 106
    Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors
    Alumis
    09/26/23
  401. 31
    Substituted pyrazolo[3,4-d]pyrimidines as mTOR inhibitors
    Galderma Research & Development
    09/26/23
  402. 41
    HDAC inhibitor compounds and methods of treatment
    University Of Florida Research Foundation
    09/25/23
  403. 298
    Therapeutic compounds, compositions and methods of use thereof
    Genentech
    09/25/23
  404. 20
    (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
    Centrexion Therapeutics
    09/23/23
  405. 253
    Bicyclic compound and use thereof
    Sk Biopharmaceuticals
    09/23/23
  406. 3
    Bicyclic urea kinase inhibitors and uses thereof
    The General Hospital
    09/23/23
  407. 43
    Compositions and methods for inhibiting kinases
    Inhibikase Therapeutics
    09/23/23
  408. 151
    Polyheterocyclic compounds as METTL3 inhibitors
    Storm Therapeutics
    09/23/23
  409. 415
    Apoptosis inhibitors
    National Institute Of Biological Sciences, Beijing
    09/21/23
  410. 176
    Compounds and compositions for treating conditions associated with NLRP activity
    Novartis
    09/21/23
  411. 80
    MCT4 inhibitors for treating disease
    Vettore
    09/21/23
  412. 49
    Methods of improving cell-based therapy
    The Regents Of The University Of California
    09/21/23
  413. 52
    Quinazoline derivatives as antitumor agents
    Suzhou Zanrong Pharma
    09/21/23
  414. 222
    Heterocyclic adenosine receptor antagonists
    Exelixis
    09/17/23
  415. 63
    Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators
    Ardelyx
    09/17/23
  416. 27
    JAK kinase inhibitor compounds for treatment of respiratory disease
    Theravance Biopharma R&D Ip
    09/17/23
  417. 223
    Macrocyclic compounds for treatment of medical disorders
    Achillion Pharmaceuticals
    09/17/23
  418. 19
    N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors
    The Regents Of The University Of Michigan
    09/17/23
  419. 106
    Substituted pyrido[2,1-a]isoquinolines as VMAT2 inhibitors
    Neurocrine Biosciences
    09/17/23
  420. 1
    Benzenesulfonylbenazamide compound for inhibiting BCL-2 protein and composition and use thereof
    Shenzhen Targetrx
    09/15/23
  421. 570
    CDK2 inhibitors
    Pfizer
    09/15/23
  422. 164
    Compositions and methods of modulating short-chain dehydrogenase
    Case Western Reserve University
    09/15/23
  423. 25
    Heparanase inhibitors and use thereof
    Beta Therapeutics
    09/15/23
  424. 13
    Heterocyclic compounds as immunomodulators
    Incyte
    09/15/23
  425. 70
    Inhibitors of receptor interacting protein kinase I for the treatment of disease
    Board Of Regents, The University Of Texas System
    09/15/23
  426. 3
    Treatment of spondyloarthritis
    Pharmacyl
    09/15/23
  427. 107
    Azole derivatives as apelin receptor agonist
    Sanford Burnham Prebys Medical Discovery Institute
    09/08/23
  428. 5
    Bismuth(III) compounds and methods thereof
    The University Of Hong Kong
    09/08/23
  429. 3
    Crystal form, salt type of substituted 2-hydro-pyrazole derivative and preparation method therefor
    Chia Tai Tianqing Pharmaceutical Group
    09/08/23
  430. 187
    Cyanotriazole compounds
    Otsuka Pharmaceutical
    09/08/23
  431. 9
    Heterocyclic indoles for use in influenza virus infection
    Janssen Sciences Ireland Uc
    09/08/23
  432. 420
    Heterocyclic sulfonamide derivative and medicine comprising same
    Ea Pharma
    09/08/23
  433. 117
    Inhibitor of lysine specific demethylase-1
    Celgene Quanticel Research
    09/08/23
  434. 332
    Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
    Sanford Burnham Prebys Medical Discovery Institute
    09/08/23
  435. 42
    Peptide derivatives and uses thereof
    Nosopharm
    09/08/23
  436. 14
    Phosphodiesterase inhibitors and uses thereof
    The Trustees Of Columbia University In The City Of New York
    09/08/23
  437. 216
    2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
    Bayer Aktiengesellschaft
    09/04/23
  438. 12
    5 to 7 membered heterocyclic amides as JAK inhibitors
    Theravance Biopharma R&D Ip
    09/04/23
  439. 143
    5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof
    Biosplice Therapeutics
    09/04/23
  440. 39
    5-substituted difluoropiperidine compounds with blood-brain barrier penetrable capability
    Wayshine Biopharm Holding
    09/04/23
  441. 44
    GSK-3 inhibitors
    Bristol-Myers Squibb
    09/04/23
  442. 26
    Heteroaryl heterocyclyl compounds for the treatment of autoimmune disease
    Hoffmann-La Roche
    09/04/23
  443. 102
    Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases
    Chemocentryx
    09/04/23
  444. 44
    Inhibitors of NEK7 kinase
    Halia Therapeutics
    09/04/23
  445. 218
    Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1
    Cancer Research Technology
    08/31/23
  446. 44
    Hydroxyalkyl-piperazine derivatives as CXCR3 receptor modulators
    Idorsia Pharmaceuticals
    08/31/23
  447. 267
    Protein kinase modulators
    Cylene Pharmaceuticals
    08/31/23
  448. 563
    Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
    Achillion Pharmaceuticals
    08/27/23
  449. 92
    Azaindole derivatives and their use as ERK kinase inhibitors
    Agv Discovery
    08/27/23
  450. 30
    Compounds for the treatment of kinase-dependent disorders
    Exelixis
    08/27/23
  451. 34
    ENPP1 inhibitors and their use for the treatment of cancer
    The Board Of Trustees Of The Leland Stanford Junior University
    08/27/23
  452. 89
    FAP-targeted radiopharmaceuticals and imaging agents, and uses related thereto
    Trustees Of Tufts College
    08/27/23
  453. 34
    Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof
    Novartis
    08/27/23
  454. 250
    Human plasma kallikrein inhibitors
    Biocryst Pharmaceuticals
    08/27/23
  455. 410
    Immunomodulator compounds
    Chemocentryx
    08/27/23
  456. 122
    Monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    08/27/23
  457. 536
    Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
    Biocryst Pharmaceuticals
    08/27/23
  458. 98
    1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
    Incyte
    08/18/23
  459. 364
    Bicyclic-fused heteroaryl or aryl compounds
    Pfizer
    08/18/23
  460. 8
    Composition for inducing differentiation and protection of neural stem cells and method for inducing neuro-regeneration using the same composition
    Genuv
    08/18/23
  461. 36
    Compounds and methods of use
    Medivation Technologies
    08/18/23
  462. 2
    Crystalline hydrate of a JAK inhibitor compound
    Theravance Biopharma R&D Ip
    08/18/23
  463. 34
    ENPP1 inhibitors and their use for the treatment of cancer
    The Board Of Trustees Of The Leland Stanford Junior University
    08/18/23
  464. 647
    Methods, compositions, and uses of novel FYN kinase inhibitors
    Pathways Neuro Pharma
    08/18/23
  465. 42
    Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors
    D. E. Shaw Research
    08/18/23
  466. 94
    Pyrazolyl derivatives useful as anti-cancer agents
    Novartis
    08/18/23
  467. 34
    Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors
    Revolution Medicines
    08/18/23
  468. 143
    Pyrimidinone derivatives as SHP2 antagonists
    Merck Patent
    08/18/23
  469. 365
    SOS1 inhibitors
    Mirati Therapeutics
    08/18/23
  470. 9
    Substituted bicyclic compounds
    Bristol-Myers Squibb
    08/18/23
  471. 303
    Thiadiazole IRAK4 inhibitors
    Gilead Sciences
    08/18/23
  472. 79
    Agent enhancing antitumor effect using pyrazolo[3,4-d]pyrimidine compound
    Taiho Pharmaceutical
    08/11/23
  473. 100
    Carboxamide-pyrimidine derivatives as SHP2 antagonists
    Merck Patent
    08/11/23
  474. 42
    Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitors
    Eil Therapeutics
    08/11/23
  475. 264
    Fused pyrimidine pyridinone compounds as JAK inhibitors
    Theravance Biopharma R&D Ip
    08/11/23
  476. 318
    Substituted benzamides
    Hoffmann-La Roche
    08/11/23
  477. 15
    2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamide derivatives and the use thereof as medicament
    Boehringer Ingelheim International
    08/06/23
  478. 234
    6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
    Ajax Therapeutics
    08/06/23
  479. 44
    Compound having KDM5 inhibitory activity and pharmaceutical use thereof
    Ono Pharmaceutical
    08/06/23
  480. 82
    Cyclic ether derivatives of pyrazolo[1,5-A]pyrimidine-3-carboxyamide
    Boehringer Ingelheim International
    08/06/23
  481. 80
    Heterocyclic compounds, preparation methods therefor, and methods of uses thereof
    Inventisbio
    08/06/23
  482. 101
    Inhibitors of receptor interacting protein kinase I for the treatment of disease
    Board Of Regents, The University Of Texas System
    08/06/23
  483. 93
    Isoindoline compositions and methods for treating neurodegenerative disease
    Cognition Therapeutics
    08/06/23
  484. 21
    Isoquinoline-steroid conjugates and uses thereof
    Aerie Pharmaceuticals
    08/06/23
  485. 25
    MAGL inhibitors
    H. Lundbeck
    08/06/23
  486. 25
    Macrocyclic immunomodulators
    Chemocentryx
    08/06/23
  487. 51
    Macrocyclic indoles as Mcl-1 inhibitors
    Ascentage Pharma (Suzhou)
    08/06/23
  488. 1
    Method for preparing pyrrolidinyl urea derivative
    Zhangzhou Pien Tze Huang Pharmaceutical
    08/06/23
  489. 24
    Naphthyridinone compounds as JAK2 V617F inhibitors
    Incyte
    08/06/23
  490. 96
    Pyridazinones as PARP7 inhibtors
    Ribon Therapeutics
    08/06/23
  491. 217
    Therapeutic compounds and compositions
    Exithera Pharmaceuticals
    08/06/23
  492. 121
    ATM kinase inhibitors and compositions and methods of use thereof
    Chdi Foundation
    07/31/23
  493. 106
    Azalactam compounds as HPK1 inhibitors
    Pfizer
    07/31/23
  494. 82
    C5a receptor modulators
    Idorsia Pharmaceuticals
    07/31/23
  495. 123
    CDK inhibitors and their use as pharmaceuticals
    Prelude Therapeutics
    07/31/23
  496. 14
    Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof
    Ocuterra Therapeutics
    07/31/23
  497. 245
    Human plasma kallikrein inhibitors
    Biocryst Pharmaceuticals
    07/31/23
  498. 491
    MYST family histone acetyltransferase inhibitors
    Epizyme
    07/31/23
  499. 24
    Pyridinone MK2 inhibitors and uses thereof
    Xinthera
    07/31/23
  500. 385
    Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors
    Dart Neuroscience
    07/31/23
  501. 138
    Bicycloheptane pyrrolidine orexin receptor agonists
    Merck Sharp & Dohme
    07/25/23
  502. 37
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    07/25/23
  503. 22
    Compounds and compositions as protein kinase inhibitors
    Array Biopharma
    07/25/23
  504. 55
    Compounds useful as RET inhibitors
    Cancer Research Technology
    07/25/23
  505. 82
    MK2 inhibitors and uses thereof
    Xinthera
    07/25/23
  506. 2
    Methods of treating disorders using CSF1R inhibitors
    Deciphera Pharmaceuticals
    07/25/23
  507. 16
    Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors
    Mekanistic Therapeutics
    07/19/23
  508. 155
    5-membered and bicyclic heterocyclic amides as inhibitors of ROCK
    Bristol-Myers Squibb
    07/16/23
  509. 40
    Amino pyrimidine derivatives
    Novartis
    07/16/23
  510. 17
    Bicyclic compounds as ATX inhibitors
    Hoffmann-La Roche
    07/16/23
  511. 88
    CDK inhibitors and their use as pharmaceuticals
    Prelude Therapeutics
    07/16/23
  512. 35
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    07/16/23
  513. 11
    Compounds for the treatment of kinase-dependent disorders
    Exelixis
    07/16/23
  514. 51
    Heterocyclic compounds as immunomodulators
    Incyte
    07/16/23
  515. 13
    Histone deacetylase inhibitors for immunomodulation in tumor microenvironment
    Great Novel Therapeutics Biotech & Medicals
    07/16/23
  516. 96
    Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors
    Incyte
    07/16/23
  517. 303
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    Biosplice Therapeutics
    07/16/23
  518. 12
    Matrix metalloproteinase (MMP) inhibitors and methods of use thereof
    Foresee Pharmaceuticals
    07/16/23
  519. 21
    Pharmaceutical compounds
    Sareum
    07/16/23
  520. 82
    Polycyclic compounds as allosteric SHP2 inhibitors
    Revolution Medicines
    07/16/23
  521. 159
    Pyridone amides as modulators of sodium channels
    Vertex Pharmaceuticals
    07/16/23
  522. 7
    Tetrahydro-1H-pyrido [3,4-b]indole anti-estrogenic drugs
    Olema Pharmaceuticals
    07/16/23
  523. 50
    4-substitued cytisine analogues
    University Of Bristol
    07/09/23
  524. 7
    Antibody-drug conjugates comprising a cyclic dinucleotide
    Takeda Pharmaceutical
    07/09/23
  525. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    07/09/23
  526. 36
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    07/09/23
  527. 378
    Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
    Janssen Pharmaceutica
    07/09/23
  528. 56
    FGFR4 inhibitor, preparation method therefor, and applications thereof
    Jiangsu Hansoh Pharmaceutical Group
    07/09/23
  529. 11
    Fused imidazo-piperidine JAK inhibitors
    Theravance Biopharma R&D Ip
    07/09/23
  530. 148
    Granzyme B directed imaging and therapy
    Cytosite Biopharma
    07/09/23
  531. 65
    Inhibitors of RAF kinases
    Kinnate Biopharma
    07/09/23
  532. 204
    MCL1 inhibitors
    Gilead Sciences
    07/09/23
  533. 97
    Methods of treating intraocular pressure with activators of Tie-2
    Eyepoint Pharmaceuticals
    07/09/23
  534. 80
    RIP1K inhibitors
    Rigel Pharmaceuticals
    07/09/23
  535. 206
    Therapeutically active compounds and their methods of use
    Servier Pharmaceuticals
    07/09/23
  536. 86
    Heterocyclic compounds as RET kinase inhibitors
    Cancer Research Technology
    07/03/23
  537. 496
    Imidazole-containing inhibitors of ALK2 kinase
    Biocryst Pharmaceuticals
    07/03/23
  538. 18
    Tetrazole derivatives as TRPA1 inhibitors
    Boehringer Ingelheim International
    07/03/23
  539. 8
    Thienopyrrole compounds
    Gilead Sciences
    07/03/23
  540. 26
    Tricyclic urea compounds as JAK2 V617F inhibitors
    Incyte
    07/03/23
  541. 54
    Benzimidazole derivative compounds and uses thereof
    Pfizer
    07/02/23
  542. 13
    MASP-2 inhibitors and methods of use
    Omeros
    07/02/23
  543. 129
    Substituted 2-azabicyclo[3.1.1]heptane and 2-azabicyclo[3.2.1]octane derivatives as orexin receptor antagonists
    Chronos Therapeutics
    07/02/23
  544. 28
    Treatment of Rett syndrome
    Cold Spring Harbor Laboratory
    07/02/23
  545. 87
    Tricyclic compounds as histone methyltransferase inhibitors
    Global Blood Therapeutics
    07/02/23
  546. 170
    ALK2 inhibitors and methods for inhibiting BMP signaling
    The Brigham And Women'S Hospital
    06/26/23
  547. 4
    Aminopyrimidinyl derivatives
    Pfizer
    06/26/23
  548. 37
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    06/26/23
  549. 32
    Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    06/26/23
  550. 4
    Glucagon-like peptide1 receptor agonists
    Eli Lilly
    06/26/23
  551. 23
    Indolizine derivatives and their application in medicine
    Kind Pharmaceutical
    06/26/23
  552. 252
    Pyrazole MAGL inhibitors
    H. Lundbeck
    06/26/23
  553. 32
    Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
    Hoffmann-La Roche
    06/26/23
  554. 6
    Substituted piperazines as BTK inhibitors
    Hutchison Medipharma
    06/26/23
  555. 8
    7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
    Eli Lilly
    06/19/23
  556. 98
    Allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) for the treatment of disease
    Petra Pharma
    06/19/23
  557. 8
    Amide compounds for treatment of immune and inflammatory disorders
    Achillion Pharmaceuticals
    06/19/23
  558. 81
    C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    06/19/23
  559. 18
    Compound as mTOR inhibitor and use thereof
    Medicinal Bioconvergence Research Center
    06/19/23
  560. 18
    Halo-allylamine SSAO/VAP-1 inhibitor and use thereof
    Nanjing Transthera Biosciences
    06/19/23
  561. 663
    Indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors and methods using same
    1St Biotherapeutics
    06/19/23
  562. 113
    Oxadiazaspiro compounds for the treatment of drug abuse and addiction
    Esteve Pharmaceuticals
    06/19/23
  563. 2
    Pan-tropic entry inhibitors
    Emory University
    06/19/23
  564. 14
    Pyrazolochlorophenyl compounds, compositions and methods of use thereof
    Genentech
    06/19/23
  565. 50
    Selective androgen receptor degrader (SARD) ligands and methods of use
    University Of Tennessee Research Foundation
    06/19/23
  566. 111
    Substituted 4-phenylpiperidines, their preparation and use
    The Trustees Of Columbia University In The City Of New York
    06/19/23
  567. 228
    Substituted imidazo[1,5-a]pyrazines for IRE1 inhibition
    Optikira
    06/19/23
  568. 814
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    06/19/23
  569. 320
    Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling
    Kumquat Biosciences
    06/19/23
  570. 2
    5-HT2A agonists for use in treatment of depression
    Lophora
    06/11/23
  571. 156
    BRD4-kinase inhibitors as cancer therapeutics
    H. Lee Moffitt Cancer Center And Research Institute
    06/11/23
  572. 8
    Compounds for degrading Tau protein aggregates and uses thereof
    Aprinoia Therapeutics
    06/11/23
  573. 9
    Derivatives of 4-aminoantipyrine as anti-Alzheimers butyrylcholinesterase inhibitors
    Individual
    06/11/23
  574. 11
    GLP-1 receptor agonist and use thereof
    Ildong Pharmaceutical
    06/11/23
  575. 443
    MCL-1 inhibitors
    Gilead Sciences
    06/11/23
  576. 10
    Polypeptide compound, pharmaceutical composition, preparation method and application thereof
    Chengdu Sintanovo Biotechnology
    06/11/23
  577. 31
    Substituted 1′,2′-dihydro-3′H-spiro[cyclohexane-1,4′-pyrimido[5′,4′:4,5]pyrrolo[2,1-c][1,2,4]triazin]-3′-ones as cyclin-dependent kinase inhibitors
    G1 Therapeutics
    06/11/23
  578. 46
    Substituted benzene compounds
    Epizyme
    06/11/23
  579. 144
    Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof
    Japan Tobacco
    06/11/23
  580. 155
    Amino acid compounds and methods of use
    Pliant Therapeutics
    06/02/23
  581. 192
    Combination treatments comprising administration of 1H-pyrazolo[4,3-b]pyridines
    H. Lundbeck
    06/02/23
  582. 78
    Compounds for the treatment of BRAF-associated diseases and disorders
    Array Biopharma
    06/02/23
  583. 18
    Diazaindole derivative and use thereof as CHK1 inhibitor
    Medshine Discovery
    06/02/23
  584. 12
    Dimethyl amino azetidine amides as JAK inhibitors
    Theravance Biopharma R&D Ip
    06/02/23
  585. 48
    Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals
    06/02/23
  586. 124
    Pharmaceutical compounds
    Pfizer
    06/02/23
  587. 93
    Pyrazoles
    Janssen Pharmaceuticals
    06/02/23
  588. 22
    Selective estrogen receptor degraders
    Eli Lilly
    06/02/23
  589. 53
    Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
    Pfizer
    06/02/23
  590. 99
    Substituted amino triazoles useful as chitinase inhibitors
    Molecure
    06/02/23
  591. 14
    Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors
    Luoxin Pharmaceutical (Shanghai)
    06/02/23
  592. 17
    6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes
    Sprint Bioscience
    06/01/23
  593. 21
    Compounds and methods useful for treating or preventing cancers
    The Broad Institute
    06/01/23
  594. 253
    Compounds which are inhibitors of Notum
    Ucl Business
    06/01/23
  595. 9
    Method for controlling hematophagous or sap-feeding arthropods
    Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College
    06/01/23
  596. 313
    Opioid receptor modulators
    Epiodyne
    06/01/23
  597. 90
    Selective D3 dopamine receptor agonists and methods of their use
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    06/01/23
  598. 19
    Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor
    Sumitomo Pharma
    06/01/23
  599. 260
    Sulfonamide compound or salt thereof
    Taiho Pharmaceutial
    06/01/23
  600. 14
    7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
    Eli Lilly
    05/27/23
  601. 39
    Lymphoid-specific tyrosine phosphatase (LYP) inhibitors
    Purdue Research Foundation
    05/27/23
  602. 111
    SHP2 phosphatase inhibitors and methods of use thereof
    D. E. Shaw Research
    05/27/23
  603. 46
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as modulators of sodium channel activity
    Praxis Precision Medicines
    05/27/23
  604. 57
    Substituted pyridine derivatives as SARM1 inhibitors
    Nura Bio
    05/27/23
  605. 32
    Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity
    Shionogi
    05/27/23
  606. 21
    Triazolo-pyrimidine compounds and uses thereof
    Dizal (Jiangsu) Pharmaceutical
    05/27/23
  607. 223
    Indole carboxamide compounds
    Bristol-Myers Squibb
    05/22/23
  608. 2
    Method of treatment with histamine-3 receptor inverse agonist
    Suven Life Sciences
    05/22/23
  609. 4
    Protein degraders and uses thereof
    Kymera Therapeutics
    05/22/23
  610. 15
    Spirocyclic compounds
    C4 Therapeutics
    05/22/23
  611. 19
    Uracil compound as c-MET/AXL inhibitor
    Medshine Discovery
    05/22/23
  612. 20
    6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
    Purdue Research Foundation
    05/11/23
  613. 1532
    Aminopyrrolotriazines as kinase inhibitors
    Bristol-Myers Squibb
    05/11/23
  614. 186
    Benzoimidazoles as prolyl hydroxylase inhibitors
    Janssen Pharmaceutica
    05/11/23
  615. 18
    Compounds active towards nuclear receptors
    Nuevolution
    05/10/23
  616. 19
    Heterocyclic compounds as immunomodulators
    Incyte
    05/10/23
  617. 36
    Oxysterols and methods of use thereof
    Sage Therapeutics
    05/10/23
  618. 83
    Substituted pyridotriazine compounds and uses thereof
    Gilead Sciences
    05/10/23
  619. 24
    3-triazolyl methyl-1,3,5-triazine-2,4-dione compounds and preparation method and application thereof
    Shaanxi Panlong Pharmaceutical
    05/09/23
  620. 302
    8-aminoisoquinoline compounds and uses thereof
    Genentech
    05/09/23
  621. 116
    Enzyme inhibitors
    Kalvista Pharmaceuticals
    05/09/23
  622. 123
    Glycosidase inhibitors
    Asceneuron
    05/09/23
  623. 167
    Inhibitors of RHO associated coiled-coil containing protein kinase
    Kadmon
    05/09/23
  624. 10
    Pharmaceutical formulations comprising CCR3 antagonists
    Alkahest
    05/09/23
  625. 62
    Substituted condensed thiophenes as modulators of sting
    Ctxt Pty
    05/09/23
  626. 22
    Beta-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and method for performing an in vivo related application that benefits from the inhibition of a kinase
    Industrial Technology Research Institute
    05/05/23
  627. 106
    Bicyclic amide compounds and methods of use thereof
    Genentech
    05/05/23
  628. 9
    Curcumin analogues as zinc chelators and their uses
    The Research Foundation For The State University Of New York
    05/05/23
  629. 42
    FGFR4 inhibitor and preparation method and use thereof
    Jiangsu Hansoh Pharmaceutical Group
    05/05/23
  630. 40
    Heterocyclic compounds as immunomodulators
    Incyte
    05/05/23
  631. 138
    Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
    Merck Patent
    05/05/23
  632. 161
    Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
    The Institute Of Cancer Research: Royal Cancer Hospital
    05/05/23
  633. 93
    Octahydropyrido[1,2-alpha]pyrazines as MAGL inhibitors
    Hoffmann-La Roche
    05/05/23
  634. 5
    PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
    H. Lundbeck
    05/05/23
  635. 19
    Compounds and therapeutic uses thereof
    Viogen Biosciences
    04/30/23
  636. 64
    MTORC1 modulators and uses thereof
    Aeovian Pharmaceuticals
    04/30/23
  637. 285
    PCSK9 inhibitors and methods of use thereof
    Astrazeneca
    04/30/23
  638. 34
    Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
    Array Biopharma
    04/30/23
  639. 19
    Compounds and compositions for the treatment of parasitic diseases
    Novartis
    04/23/23
  640. 53
    Cyclic dinucleotides as sting agonists
    Janssen Biotech
    04/23/23
  641. 10
    Enhancing CD8+ T cells for adoptive T cell therapy by inhibiting PTPN1 (PTP1B) and PTPN2 (TC-PTP)
    The Royal Institution For The Advancement Of Learning/Mcgill University
    04/23/23
  642. 26
    JAK1 pathway inhibitors for the treatment of gastrointestinal disease
    Incyte
    04/23/23
  643. 427
    Monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    04/23/23
  644. 20
    PD-L1/STING conjugates and methods of use
    Incyte
    04/23/23
  645. 4
    Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
    Mindset Pharma
    04/23/23
  646. 3
    SHP2 inhibitor compositions and methods for treating cancer
    Revolution Medicines
    04/23/23
  647. 719
    Substituted indole Mcl-1 inhibitors
    Vanderbilt University
    04/23/23
  648. 28
    Benzamide compounds
    Recurium Ip Holdings
    04/14/23
  649. 26
    Bicyclic heterocycles as FGFR inhibitors
    Incyte
    04/14/23
  650. 13
    Bipyrazole derivatives as JAK inhibitors
    Incyte
    04/14/23
  651. 27
    Certain chemical compositions and methods of use thereof
    Algen Biotechnologies
    04/14/23
  652. 164
    Compounds, compositions, and methods
    Denali Therapeutics
    04/14/23
  653. 46
    Heterocyclic compound, application thereof and pharmaceutical composition comprising same
    Suzhou Sinovent Pharmaceuticals
    04/14/23
  654. 26
    Highly active CSF1R inhibitor compound
    Xiamen Biotime Biotechnology
    04/14/23
  655. 25
    Indoleamine-2,3-dioxygenase inhibitor, preparation method therefor and use thereof
    Hinova Pharmaceuticals
    04/14/23
  656. 40
    Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and methods of use thereof
    Stingray Therapeutics
    04/14/23
  657. 73
    Inhibitors of protein arginine methyltransferase 5 (PRMT5), pharmaceutical products thereof, and methods thereof
    Pharmablock Sciences (Nanjing)
    04/14/23
  658. 14
    Oxazolidinone antibiotic compounds and process of preparation
    Bugworks Research
    04/14/23
  659. 99
    PARP1 inhibitors and uses thereof
    Xinthera
    04/14/23
  660. 3
    Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
    Mindset Pharma
    04/14/23
  661. 144
    Pyrrolotriazine compounds as TAM inhibitors
    Incyte
    04/14/23
  662. 51
    Small molecule inducers of autophagy
    Board Of Regents, The University Of Texas System
    04/14/23
  663. 514
    Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors
    D. E. Shaw Research
    04/14/23
  664. 4
    Amino alcohol derivative, pharmaceutical composition and application thereof
    Beijing Foreland Pharma
    04/09/23
  665. 15
    Aromatic heterocyclic compound, intermediate thereof, preparation method therefor, and pharmaceutical composition and use thereof
    Shanghai Yingli Pharmaceutical
    04/09/23
  666. 6
    Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia
    Stealth Biotherapeutics
    04/09/23
  667. 13
    Dash inhibitors, and uses related thereto
    Trustees Of Tufts College
    04/09/23
  668. 165
    Dihydrothieno[3,2-b]pyridine compounds
    Ideaya Biosciences
    04/09/23
  669. 33
    Heterocyclic compounds as BET inhibitors
    Nuvation Bio
    04/09/23
  670. 27
    Inhibitors of EGFR and methods of use thereof
    Dana-Farber Cancer Institute
    04/09/23
  671. 479
    MASP-2 inhibitors and methods of use
    Omeros
    04/09/23
  672. 22
    Methods of treatment using 4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
    Heptares Therapeutics
    04/09/23
  673. 57
    RIP1K inhibitors
    Rigel Pharmaceuticals
    04/09/23
  674. 2
    Solid forms of a plasma kallikrein inhibitor and salts thereof
    Kalvista Pharmaceuticals
    04/09/23
  675. 80
    Spirocyclic compounds
    C4 Therapeutics
    04/09/23
  676. 225
    Substituted pyridopyrimidinonyl compounds useful as T cell activators
    Bristol-Myers Squibb
    04/09/23
  677. 145
    Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
    Venenum Biodesign
    04/09/23
  678. 73
    Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (GOAT) inhibitors
    Boehringer Ingelheim International
    04/09/23
  679. 21
    Compounds useful as immunomodulators
    Bristol-Myers Squibb
    03/31/23
  680. 227
    Condensed ring compounds having dopamine D3 receptor antagonistic effect
    Shionogi
    03/31/23
  681. 289
    Fluoroalkyl-oxadiazoles and uses thereof
    Tenaya Therapeutics
    03/31/23
  682. 22
    Heterocyclic RIP1 inhibitory compounds
    Rigel Pharmaceuticals
    03/31/23
  683. 3
    Heterocyclic compounds for inhibiting TYK2 activities
    Beijing Innocare Pharma Tech
    03/31/23
  684. 20
    Inhibiting mutant IDH-1
    Forma Therapeutics
    03/31/23
  685. 282
    Inhibitors of LRRK2 kinase
    Halia Therapeutics
    03/31/23
  686. 72
    Spiro-oxazolones
    Hoffmann-La Roche
    03/31/23
  687. 64
    Therapeutic agent for non-motor symptoms associated with Parkinson's disease
    Sumitomo Pharma
    03/31/23
  688. 23
    Thienopyrimidones
    Boehringer Ingelheim International
    03/31/23
  689. 29
    Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof
    Beijing Innocare Pharma Tech
    03/26/23
  690. 44
    Antibacterial agents: arylalkylcarboxamido phloroglucinols
    Rutgers, The State University Of New Jersey
    03/26/23
  691. 4
    BRD4 inhibitor
    Hinova Pharmaceuticals
    03/26/23
  692. 14
    Cyanoaryl-aniline compounds for treatment of dermal disorders
    Nflection Therapeutics
    03/26/23
  693. 40
    Heterocyclic compounds as immunomodulators
    Incyte
    03/26/23
  694. 26
    Inhibitor of indoleamine 2,3-dioxygenase-1 and methods of manufacture and use thereof
    University Health Network
    03/26/23
  695. 171
    Inhibitors of histone deacetylase
    The General Hospital
    03/26/23
  696. 452
    N-cyano-7-azanorbornane derivatives and uses thereof
    Amgen
    03/26/23
  697. 38
    Pyrazine compounds and uses thereof
    Dizal (Jiangsu) Pharmaceutical
    03/26/23
  698. 73
    Pyrrolo[1,2-b]pyridazine derivatives
    Gilead Sciences
    03/26/23
  699. 69
    Bicyclic heterocycles as FGFR inhibitors
    Incyte
    03/20/23
  700. 4
    Heterocyclic compounds as immunomodulators
    Incyte
    03/20/23
  701. 2
    Inhibiting mutant isocitrate dehydrogenase 1 (mIDH1)
    Forma Therapeutics
    03/20/23
  702. 39
    5-heteroaryl-1H-pyrazol-3-amine derivative
    Sumitomo Pharma
    03/19/23
  703. 158
    5-membered heteroaryl carboxamide compounds for treatment of HBV
    Assembly Biosciences
    03/19/23
  704. 145
    Amino acid compounds and methods of use
    Pliant Therapeutics
    03/19/23
  705. 70
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals
    03/19/23
  706. 17
    Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease
    Board Of Regents, The University Of Texas System
    03/19/23
  707. 158
    Cannabinoid receptor type 2 (CB2) modulators and uses thereof
    Teon Therapeutics
    03/19/23
  708. 50
    Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists
    Trustees Of Tufts College
    03/19/23
  709. 478
    Compounds and uses thereof
    Foghorn Therapeutics
    03/19/23
  710. 4
    Compounds for use as inhibitors of alternative oxidase or cytochrome bc1 complex
    Alternox Scientific
    03/19/23
  711. 62
    Fused amino pyridine as HSP90 inhibitors
    Guris
    03/19/23
  712. 377
    Indole compounds and analogues thereof
    Biocryst Pharmaceuticals
    03/19/23
  713. 373
    Isoquinolines as inhibitors of HPK1
    Genentech
    03/19/23
  714. 17
    Morpholinylpyridone compounds
    Sprint Bioscience
    03/19/23
  715. 175
    Proteasome activity enhancing compounds
    Proteostasis Therapeutics
    03/19/23
  716. 22
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals
    03/19/23
  717. 718
    Ras inhibitors
    Revolution Medicines
    03/19/23
  718. 149
    Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors
    Pfizer
    03/19/23
  719. 17
    2-(substituted benzene matrix) aromatic formate FTO inhibitor, preparation method therefor, and applications thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    03/12/23
  720. 474
    ACLY inhibitors and uses thereof
    Nimbus Artemis
    03/12/23
  721. 98
    Amide compounds as kinase inhibitors, compositions and methods of treatment
    Translational Drug Development
    03/12/23
  722. 215
    Bruton's tyrosine kinase inhibitors
    Suzhou Baijibugong Pharmaceutical Technology
    03/12/23
  723. 656
    PD-1/PD-L1 inhibitors
    Gilead Sciences
    03/12/23
  724. 22
    Phosphonate linkers and their use to facilitate cellular retention of compounds
    Merck Sharp & Dohme
    03/12/23
  725. 59
    Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
    The Usa, As Represented By The Secretary, Dhhs
    03/12/23
  726. 46
    Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
    Amgen
    03/06/23
  727. 21
    Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers
    Jazz Pharmaceuticals Ireland
    03/06/23
  728. 109
    Heterocyclic compounds as RET kinase inhibitors
    Cancer Research Technology
    03/06/23
  729. 137
    Oxazino-quinazoline and oxazino-quinoline type compound, preparation method and uses thereof
    Beijing Scitech-Mq Pharmaceuticals
    03/06/23
  730. 23
    Substituted 1,4-methanopyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections
    Gilead Sciences
    03/06/23
  731. 581
    Transglutaminase 2 (TG2) inhibitors
    Sitari Pharma
    03/06/23
  732. 80
    Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
    Legochem Biosciences
    03/05/23
  733. 822
    HPK1 antagonists and uses thereof
    Nimbus Saturn
    03/05/23
  734. 523
    Heterocyclic compounds and uses thereof
    Millennium Pharmaceuticals
    03/05/23
  735. 238
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    Biosplice Therapeutics
    03/05/23
  736. 45
    Kinase inhibitor compounds and compositions and methods of use
    Icahn School Of Medicine At Mount Sinai
    03/05/23
  737. 9
    LSD1 inhibitors and medical uses thereof
    Constellation Pharmaceuticals
    03/05/23
  738. 59
    Neprilysin inhibitors
    Theravance Biopharma R&D Ip
    03/05/23
  739. 13
    Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of CYP17A1 and CYP19A1
    Mangosuthu University Of Technology
    03/05/23
  740. 31
    Therapeutic compounds and methods of use thereof
    Ligature Therapeutics
    03/05/23
  741. 5
    Amide compound having bet proteolysis-inducing action and medicinal application thereof
    Mitsubishi Tanabe Pharma
    02/26/23
  742. 47
    BTK inhibitor compounds
    Eli Lilly
    02/26/23
  743. 10
    Bi-heteroaryl substitute 1,4-benzodiazepines and uses thereof for the treatment of cancer
    Janssen Pharmaceutica
    02/26/23
  744. 230
    Compositions and methods for treating CNS disorders
    Sage Therapeutics
    02/26/23
  745. 6
    Compounds and compositions for the treatment of neurodegenerative and inflammatory diseases
    Sarbonne Universite
    02/26/23
  746. 65
    Compounds for the treatment of kinase-dependent disorders
    Exelixis
    02/26/23
  747. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, Rasopathies, and fibrotic disease
    Shy Therapeutics
    02/26/23
  748. 108
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals
    02/26/23
  749. 6
    IRAK degraders and uses thereof
    Dana-Farber Cancer Institute
    02/26/23
  750. 27
    Methods and composition of 4-substituted benzoylpiperazine-1-substituted carbonyls as beta-catenin/B-cell lymphoma 9 inhibitors
    Universisity Of Utah Research Foundation
    02/26/23
  751. 42
    Phenothiazine derivatives and uses thereof
    Camp4 Therapeutics
    02/26/23
  752. 126
    Pyrazolopyrimidine compounds and uses thereof
    Incyte
    02/26/23
  753. 5
    Quinoline compounds as IRAK inhibitors and uses thereof
    Merck Patent
    02/26/23
  754. 17
    STK19 inhibitors for treatment of cancer
    Trustees Of Boston University
    02/26/23
  755. 46
    Sting modulator compounds, and methods of making and using
    Takeda Pharmaceutical
    02/26/23
  756. 51
    Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors
    Children'S Hospital Medical Center
    02/26/23
  757. 96
    Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors
    Aurigene Discovery Technologies
    02/26/23
  758. 71
    Substituted piperazines as selective HDAC1,2 inhibitors
    Regenacy Pharmaceuticals
    02/26/23
  759. 1
    Substituted piperidines as BTK inhibitors
    Haisco Pharmaceuticals
    02/26/23
  760. 8
    Synthesis of peptide borate ester compound and use thereof
    Jiangsu Chia Tai Fenghai Pharmaceutical
    02/26/23
  761. 5
    Tetrahydroisoquinoline derivatives, preparation process and use thereof
    Sichuan Kelun-Biotech Biopharmaceutical
    02/26/23
  762. 94
    Therapeutic compounds and methods of use thereof
    Agency For Science, Technology And Research (A*Star)
    02/26/23
  763. 16
    Analogs of dextromethorphan with balanced receptor activities
    Center For Neurologic Study
    02/20/23
  764. 11
    Benzisoxazole derivative
    Sumitomo Pharma
    02/20/23
  765. 155
    Dihydropyrrolopyridine inhibitors of ROR-gamma
    Vitae Pharmaceuticals
    02/20/23
  766. 15
    Dioxoloisoquinolinone derivatives and use thereof
    Hanmi Pharmaceutical
    02/20/23
  767. 287
    Heterobicyclic amides as inhibitors of CD38
    Ribon Therapeutics
    02/20/23
  768. 21
    Heterocyclic compounds as immunomodulators
    Incyte
    02/20/23
  769. 26
    Histone deacetylases (HDACs) inhibitors
    Annji Pharmaceutical
    02/20/23
  770. 100
    Isoindolines as HDAC inhibitors
    Valo Health
    02/20/23
  771. 198
    MAP4K1 inhibitors
    Blueprint Medicines
    02/20/23
  772. 39
    Methods for treating depressive symptoms
    Alkermes Pharma Ireland
    02/20/23
  773. 85
    Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors
    H. Lundbeck
    02/20/23
  774. 10
    Pyrrolo[1,2-b] pyridazine derivatives
    Gilead Sciences
    02/20/23
  775. 75
    Quinazoline compounds, preparation method, use, and pharmaceutical composition thereof
    Institute Of Materia Medica, Chinese Academy Of Medical Sciences
    02/20/23
  776. 54
    Bicyclic heterocycles as FGFR inhibitors
    Incyte Holdings
    02/17/23
  777. 228
    Compositions and methods for treating CNS disorders
    Sage Therapeutics
    02/17/23
  778. 59
    Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof
    Nurix Therapeutics
    02/17/23
  779. 382
    Cyclic polypeptides for PCSK9 inhibition
    Merck Sharp & Dohme
    02/17/23
  780. 3
    Deuterated colony stimulating factor-1 receptor (CSF-1R) inhibitors
    Genzyme
    02/17/23
  781. 17
    Ligands to cereblon (CRBN)
    Dana-Farber Cancer Institute
    02/17/23
  782. 93
    Naphthyridinone derivatives and their use in the treatment of arrhythmia
    Novartis
    02/17/23
  783. 16
    Small molecule inhibition of transcription factor SALL4 and uses thereof
    Dana-Farber Cancer Institute
    02/17/23
  784. 291
    Substituted heteroaromatic pyrazolo-pyridines and their use as GLUN2B receptor modulators
    Janssen Pharmaceutica
    02/17/23
  785. 9
    Use of known compounds as D-amino acid oxidase inhibitors
    National Taiwan University
    02/17/23
  786. 431
    2-(morpholin-4-yl)-1,7-naphthyridines
    Bayer Pharma Aktiengesellschaft
    02/16/23
  787. 30
    Alpha-5 beta-1 inhibitors
    The Regents Of The University Of California
    02/16/23
  788. 45
    Analogs for the treatment of disease
    Insilico Medicine Ip
    02/16/23
  789. 45
    Analogs for the treatment of disease
    Insilico Medicine Ip
    02/16/23
  790. 63
    Compositions and methods for treating infections
    Vyera Pharmaceuticals
    02/16/23
  791. 31
    Compounds
    Inflazome
    02/16/23
  792. 9
    Imidazo[4,5-C]pyridine derived SSAO inhibitors
    Proximagen
    02/16/23
  793. 123
    Kinase inhibitors
    The University Of Manchester
    02/16/23
  794. 31
    Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
    Bristol-Myers Squibb
    02/16/23
  795. 17
    Protacs targeting coronavirus 3CL protease and preparation method and application thereof
    Shaanxi Panlong Pharmaceutical
    02/16/23
  796. 51
    SHP2 phosphatase inhibitors and methods of use thereof
    Relay Therapeutics
    02/16/23
  797. 61
    Use of aminomethylenecyclohexane-1,3-dione compound
    Wigen Biomedicine Technology (Shanghai)
    02/16/23
  798. 717
    Heterocyclic compound as a protein kinase inhibitor
    Hk Inno.N
    02/13/23
  799. 14
    JAK kinase inhibitor and preparation method and use thereof
    Shanghai Longwood Biopharmaceuticals
    02/13/23
  800. 31
    Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein arginine methyl transferase 5 (PRMT5)
    Prelude Therapeutics
    02/13/23
  801. 7
    Alkyne substituted quinazoline compound and methods of use
    Newgen Therapeutics
    02/12/23
  802. 10
    Compounds for treating ILK-mediated diseases
    The Cleveland Clinic Foundation
    02/12/23
  803. 1076
    Indole and azaindole inhibitors of pad enzymes
    Bristol-Myers Squibb
    02/12/23
  804. 310
    Inhibitors of cysteine proteases and methods of use thereof
    Pardes Biosciences
    02/12/23
  805. 7
    Metabolites of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4 yl}-phenoxy)-propyl]-diethyl-amine
    Vtv Therapeutics
    02/12/23
  806. 15
    Pyrazole compounds as LSD1 inhibitors and applications thereof
    Medshine Discovery
    02/12/23
  807. 58
    CDPK1 inhibitors, compositions, and methods related thereto
    Vyera Pharmaceuticals
    02/05/23
  808. 11
    Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
    Kronos Bio
    02/05/23
  809. 50
    Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors
    Nikang Therapeutics
    02/05/23
  810. 8
    Inhibitors of DNMT1 as anticancer therapeutic agents
    Victoria Link
    02/05/23
  811. 15
    MTOR inhibitor compounds
    Galderma Research & Development
    02/05/23
  812. 2
    Macrocycle and composition comprising thereof
    Shenzhen Targetrx
    02/05/23
  813. 9
    Protacs based on VHL ligand targeting coronavirus 3CL protease and preparation method and application thereof
    Shaanxi Panlong Pharmaceutical
    02/05/23
  814. 10
    Radiolabeled pharmaceuticals and methods of making and using same
    Yale University
    02/05/23
  815. 370
    Substituted heteroaryls as inhibitors of the BCL6 BTB domain protein-protein interaction
    Ontario Institute For Cancer Research (Oicr)
    02/05/23
  816. 59
    Compounds useful in HIV therapy
    Glaxosmithkline Intellectual Property Development
    01/31/23
  817. 50
    Aminocyclobutanes as monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    01/28/23
  818. 250
    Anti-tumor effect potentiator using novel biphenyl compound
    Taiho Pharmaceutical
    01/28/23
  819. 16
    BRK inhibitory compound
    Ono Pharmaceutical
    01/28/23
  820. 102
    CRBN ligands and uses thereof
    Kymera Therapeutics
    01/28/23
  821. 139
    Compounds and methods for the enhanced degradation of targeted proteins
    Arvinas Operations
    01/28/23
  822. 1
    Substituted diamino heterocyclic carboxamide compound and a composition containing the compound and use thereof
    Shenzhen Targetrx
    01/28/23
  823. 107
    Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
    Takeda Pharmaceutical
    01/28/23
  824. 35
    2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy
    Thomas Helledays Stiftelse FÖR Medicinsk Forskning
    01/21/23
  825. 3
    Aryl-piperidine derivatives
    Artax Biopharma
    01/21/23
  826. 76
    Azaspirocycles as monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    01/21/23
  827. 159
    Compounds and methods for treating oxalate-related diseases
    Oxalurx
    01/21/23
  828. 138
    Dihydroorotate dehydrogenase inhibitors
    Janssen Biotech
    01/21/23
  829. 19
    HDAC8 inhibitors for treating cancer
    City Of Hope
    01/21/23
  830. 62
    Inhibitors of fibroblast activation protein
    Praxis Biotech
    01/21/23
  831. 81
    SSAO inhibitor
    Shandong Danhong Pharmaceutical
    01/21/23
  832. 3
    Tetrahydroquinoline derivatives and a process of preparation thereof
    King Abdulaziz University
    01/21/23
  833. 30
    Therapeutic compounds and methods of use thereof
    Ligature Therapeutics
    01/21/23
  834. 196
    1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
    H. Lundbeck
    01/20/23
  835. 150
    ACLY inhibitors and uses thereof
    Nimbus Artemis
    01/20/23
  836. 45
    Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
    Janssen Sciences Ireland
    01/20/23
  837. 120
    Benzisoxazole sulfonamide derivatives
    Pfizer
    01/20/23
  838. 23
    Cyclic dinucleotides as sting agonists
    Janssen Biotech
    01/20/23
  839. 24
    Cyclic peptide immunomodulators
    Bristol-Myers Squibb
    01/20/23
  840. 54
    Indazole compounds and uses thereof
    Incyte
    01/20/23
  841. 320
    MTA-cooperative PRMT5 inhibitors
    Mirati Therapeutics
    01/20/23
  842. 66
    N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors
    Nerviano Medical Sciences
    01/20/23
  843. 7
    Peptides for treatment of medical disorders
    Humanwell Pharmaceutical Us
    01/20/23
  844. 4
    Therapeutic methods and combinations
    Individual
    01/20/23
  845. 2
    Thieno[3,2-d]pyrimidine derivative compound having inhibitory activity for protein kinase
    Hanmi Pharm.
    01/20/23
  846. 153
    Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways
    Neuropore Therapies
    01/20/23
  847. 26
    Azaindolylpyridone and diazaindolylpyridone compounds
    Sprint Bioscience
    01/17/23
  848. 38
    Dopamine D2 receptor ligands
    The Broad Institute
    01/17/23
  849. 152
    Pyrimidine-fused cyclic compound, preparation method therefor and application thereof
    Blueray Therapeutics (Shanghai)
    01/17/23
  850. 275
    Tricyclic heterocycles as BET protein inhibitors
    Incyte
    01/17/23
  851. 368
    Amido spirocyclic amide and sulfonamide derivatives
    Valo Health
    01/06/23
  852. 137
    Compounds and methods useful in the treatment of a PRMT5-mediated disorder
    Argonaut Therapeutics
    01/06/23
  853. 140
    Compounds for inhibiting TNIK and medical uses thereof
    Korea Research Institute Of Chemical Technology
    01/06/23
  854. 127
    Compounds for treatment of PD-L1 diseases
    Chemocentryx
    01/06/23
  855. 2
    Deuterated compounds as rock inhibitors
    Fochon Pharmaceuticals
    01/06/23
  856. 82
    Mu opioid receptor modulators
    The Regents Of The University Of California
    01/06/23
  857. 35
    N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators
    Boehringer Ingelheim International
    01/06/23
  858. 222
    Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
    Mirati Therapeutics
    01/06/23
  859. 121
    Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (USP1) inhibitors
    Ksq Therapeutics
    01/06/23
  860. 5
    Synthesis of (+)-cannabinoids and their therapeutic effects
    Symrise
    01/06/23
  861. 222
    2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-7,8-dihydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one as a BTK inhibitor
    Hutchison Medipharma
    12/30/22
  862. 66
    5-5 fused rings as C5a inhibitors
    Chemocentryx
    12/30/22
  863. 6
    5-aminolevulinate synthase inhibitors and methods of use thereof
    University Of South Florida
    12/30/22
  864. 486
    Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors
    Chemocentryx
    12/30/22
  865. 38
    EP4 antagonist
    Ono Pharmaceutical
    12/30/22
  866. 49
    Heterocyclic RIP1 kinase inhibitors
    Rigel Pharmaceuticals
    12/30/22
  867. 71
    Inhibitors of Rho associated coiled-coil containing protein kinase
    Kadmon
    12/30/22
  868. 321
    MTA-cooperative PRMT5 inhibitors
    Mirati Therapeutics
    12/30/22
  869. 70
    Macrocyclic chlorine substituted indole derivatives
    Bayer Aktiengesellschaft
    12/30/22
  870. 6
    Method for treating inflammation
    King Faisal University
    12/30/22
  871. 225
    OX2R compounds
    University Of Texas System
    12/30/22
  872. 14
    Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
    The Johns Hopkins University
    12/30/22
  873. 154
    Small molecule modulators of the BTB domain of Keap1
    Medimmune
    12/30/22
  874. 4
    Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones as inhibitors of WEE-1 kinase
    Newave Pharmaceutical
    12/30/22
  875. 4
    Substituted piperidine compounds and their use
    Eisai R&D Management
    12/30/22
  876. 5
    Targeted drug rescue with novel compositions, combinations, and methods thereof
    Exciva
    12/30/22
  877. 24
    Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors
    Bristol-Myers Squibb
    12/30/22
  878. 94
    Urea-substituted aromatic ring-linked dioxinoquinoline compounds, preparation method and uses thereof
    Beijing Scitech-Mq Pharmaceuticals
    12/30/22
  879. 35
    1,4-diphenyl-1H-imidazole and 2,4-diphenylthiazole derivatives and preparation method therefor and use thereof
    Southern Medical University
    12/24/22
  880. 27
    1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
    Angelini Acraf
    12/24/22
  881. 52
    Acyclic antivirals
    Janssen Pharmaceutica
    12/24/22
  882. 14
    Cyclic dinucleotides as sting agonists
    Janssen Biotech
    12/24/22
  883. 111
    Imidazopyrazinones as PDE1 inhibitors
    H. Lundbeck
    12/24/22
  884. 67
    Inhibitors of blood coagulation factor XIII
    Zedira
    12/24/22
  885. 172
    Inhibitors of cysteine proteases and methods of use thereof
    Pardes Biosciences
    12/24/22
  886. 1
    Mcl-1 inhibitors and methods of use thereof
    Astrazeneca
    12/24/22
  887. 37
    Pyrazolo[1,5-a]pyrazin-4-yl derivatives
    Pfizer
    12/24/22
  888. 186
    Pyrazolotriazolopyrimidine derivatives as A2A receptor antagonist
    Beigene
    12/24/22
  889. 79
    Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    12/24/22
  890. 95
    Tricyclic compounds and their use as phosphodiesterase inhibitors
    Pfizer
    12/24/22
  891. 35
    Benzoimidazoles as selective inhibitors of indoleamine 2,3-dioxygenases
    Beigene
    12/23/22
  892. 11
    Compounds for treatment of hypoproliferative disorders
    Lu License
    12/23/22
  893. 27
    Diacylglycerol acyl transferase 2 inhibitor
    Pfizer
    12/23/22
  894. 5
    Docosahexaenoic acid endocannabinoid epoxide derivative compositions
    The Board Of Trustees Of The University Of Illinois
    12/23/22
  895. 279
    Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
    Incyte
    12/23/22
  896. 18
    Quinazolinones that inhibit the formation of tau oligomers and their method of use
    Oligomerix
    12/23/22
  897. 93
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals
    12/23/22
  898. 146
    SSAO inhibitors and use thereof
    Eccogene (Shanghai)
    12/23/22
  899. 19
    Sphingosine analogs and use thereof against bacterial lung infections
    Yeda Research And Development
    12/23/22
  900. 51
    3-substituted piperidine compounds for Cbl-b inhibition, and use thereof
    Nurix Therapeutics
    12/11/22
  901. 69
    Compound functioning as bromodomain protein inhibitor, and composition
    Betta Pharmaceuticals
    12/11/22
  902. 48
    Compound having ERK kinase inhibitory activity and use thereof
    Shanghai Haihe Pharmaceutical
    12/11/22
  903. 10
    Cyclic di-nucleotide compounds as sting agonists
    Merck Sharp & Dohme
    12/11/22
  904. 13
    Heterocyclic compounds as immunomodulators
    Incyte
    12/11/22
  905. 94
    Heterocyclic inhibitors of PTPN11
    Board Of Regents, The University Of Texas System
    12/11/22
  906. 16
    Modulators of the NMDA receptor
    H. Lundbeck
    12/11/22
  907. 60
    Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof
    Shanghai Yingli Pharmaceutical
    12/11/22
  908. 142
    Pharmaceutical compounds
    Otsuka Pharmaceutical
    12/11/22
  909. 31
    Pyridazines
    Boehringer Ingelheim International
    12/11/22
  910. 187
    Substituted lactams showing serotonin 5-HT receptor activity
    Sumitomo Pharma
    12/11/22
  911. 21
    Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors
    Enanta Pharmaceuticals
    12/11/22
  912. 27
    Tricyclic compounds
    Jacobio Pharmaceuticals
    12/11/22
  913. 15
    2-beta-naphthyl-acetic acid analogs as AKR1C3 inhibitors and methods of using same
    The Trustees Of The University Of Pennsylvania
    12/07/22
  914. 286
    6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors
    Novartis
    12/07/22
  915. 20
    Annulated glycosidase inhibitors
    Asceneuron
    12/07/22
  916. 30
    Antibacterial compounds
    Infex Therapeutics
    12/07/22
  917. 140
    Biaryl derivative, preparation method thereof and pharmaceutical application thereof
    Abbisko Therapeutics
    12/07/22
  918. 72
    Broad spectrum antiviral compositions and methods
    Evrys Bio
    12/07/22
  919. 74
    Broad spectrum inhibitors of filoviruses
    Microbiotix
    12/07/22
  920. 3
    Combination of pure 5-HT6 receptor antagonists with acetylcholinesterase inhibitors
    Suven Life Sciences
    12/07/22
  921. 3
    Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
    Pharmakea
    12/07/22
  922. 108
    Heterocyclic compounds for the inhibition of PASK
    Bioenergenix
    12/07/22
  923. 71
    Imidazopyridazine and imidazopyridine compounds and uses thereof
    Incyte
    12/07/22
  924. 48
    Isothiazolo[5,4-D]pyrimidine compound as IRAK4 inhibitor
    Chia Tai Tianqing Pharmaceutical Group
    12/07/22
  925. 227
    Modulators of methyl modifying enzymes, compositions and uses thereof
    Constellation Pharmaceuticals
    12/07/22
  926. 160
    N/O-linked Degrons and Degronimers for protein degradation
    C4 Therapeutics
    12/07/22
  927. 67
    Pyrazine carbamates and their use as GluN2B receptor modulators
    Janssen Pharmaceutica
    12/07/22
  928. 5
    Substituted pyrrolo[2,3-d]pyrimidines as JAK inhibitors
    Vimalan Biosciences
    12/07/22
  929. 229
    TEAD inhibitors and uses thereof
    Ikena Oncology
    12/07/22
  930. 36
    Tri-substituted heteroaryl derivatives as Src homology-2 phosphatase inhibitors
    Nikang Therapeutics
    12/07/22
  931. 15
    3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
    Mindset Pharma
    12/04/22
  932. 215
    Cyclic di-nucleotide compounds as sting agonists
    Merck Sharp & Dohme
    12/04/22
  933. 25
    JAK inhibitors containing a 4-membered heterocyclic amide
    Theravance Biopharma R&D Ip
    12/04/22
  934. 452
    KRas G12D inhibitors
    Mirati Therapeutics
    12/04/22
  935. 143
    Receptor inhibitor, pharmaceutical composition comprising same, and use thereof
    Beijing Tide Pharmaceutical
    12/04/22
  936. 576
    Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof
    Sanford Burnham Prebys Medical Discovery Institute
    12/04/22
  937. 16
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors
    Eli Lilly
    12/04/22
  938. 72
    Substituted eneoxindoles and uses thereof
    Gilead Sciences
    12/04/22
  939. 44
    Substituted propanamides as inhibitors of nucleases
    Masarykova Univerzita
    12/04/22
  940. 1
    Substituted pyrazolo[1,5-a]pyrimidines as tropomyosin receptor kinase inhibitors
    Shenzhen Targetrx
    12/04/22
  941. 29
    Tricyclic compounds useful to treat orthomyxovirus infections
    Novartis
    12/04/22
  942. 4
    (S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases
    Histogen
    11/20/22
  943. 66
    Galactoside inhibitor of galectins
    Galecto Biotech
    11/20/22
  944. 49
    Macrocyclic chlorine substituted indole derivatives
    Bayer Aktiengesellschaft
    11/20/22
  945. 225
    Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer
    Cancer Research Technology
    11/20/22
  946. 12
    Tricyclic amine compounds as CDK2 inhibitors
    Incyte
    11/20/22
  947. 360
    Aminoimidazopyridazines as kinase inhibitors
    Bristol-Myers Squibb
    11/19/22
  948. 116
    Anti-inflammatory compound, and preparation and use thereof
    E-Nitiate Biopharmaceuticals (Hangzhou)
    11/19/22
  949. 25
    Aromatic heterocyclic substituted olefin compound, preparation method for same, pharmaceutical composition of same, and applications thereof
    Shanghai Yingli Pharmaceutical
    11/19/22
  950. 83
    Compound exhibiting enteropeptidase inhibitory activity
    Lg Chem
    11/19/22
  951. 90
    Compounds, salts thereof and methods for treatment of diseases
    Acadia Pharmaceuticals
    11/19/22
  952. 64
    Cyclic compound having dopamine D3 receptor antagonistic effect
    Shionogi
    11/19/22
  953. 10
    Hetero ring-fused phenyl compounds for inhibiting TNIK and medical uses thereof
    Korea Research Institute Of Chemical Technology
    11/19/22
  954. 32
    Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors
    Recordati Industria Chimica E Farmacentica
    11/19/22
  955. 33
    Indoleamine-2,3-dioxygenase inhibitor, the preparative method and the use thereof
    Hinova Pharmaceuticals
    11/19/22
  956. 95
    Inhibitors of cyclin-dependent kinases
    Kinnate Biopharma
    11/19/22
  957. 118
    Pharmaceutical compounds for treatment of medical disorders
    Achillion Pharmaceuticals
    11/19/22
  958. 46
    Pyrimidine JAK inhibitors for the treatment of skin diseases
    Theravance Biopharma R&D Ip
    11/19/22
  959. 98
    Pyrimidine TBK/IKKe inhibitor compounds and uses thereof
    Merck Patent
    11/19/22
  960. 7
    Quinoline analogs as phosphatidylinositol 3-kinase inhibitors
    Nanjing Zhengxiang Pharmaceuticals
    11/19/22
  961. 5
    Selective A2A receptor antagonist
    Inxmed (Nanjing)
    11/19/22
  962. 94
    Spiroheptanyl hydantoins as rock inhibitors
    Bristol-Myers Squibb
    11/19/22
  963. 6
    Substituted 1,2,3,4-tetrahydroquinolines as inhibitors of repair enzyme 8-oxoguanine deoxyribonucleic acid glycosylase activity
    The Board Of Trustees Of The Leland Stanford Junior University
    11/19/22
  964. 79
    Substituted macrocyclic indole derivatives
    Bayer Aktiengesellschaft
    11/19/22
  965. 30
    Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof
    Milstein Zhang & Wu
    11/19/22
  966. 353
    Tetrahydroquinoline derivatives as P2X7 receptor antagonists
    Raqualia Pharma
    11/19/22
  967. 22
    Triazolo-azepine derivatives
    Hoffmann-La Roche
    11/19/22
  968. 32
    Tricyclic amine compounds as CDK2 inhibitors
    Incyte
    11/19/22
  969. 10
    p38α mitogen-activated protein kinase inhibitors
    Gen1E Lifesciences
    11/19/22
  970. 12
    ASK1 inhibitor compounds and uses thereof
    Seal Rock Therapeutics
    11/13/22
  971. 56
    ATR inhibitor and application thereof
    Wuxi Biocity Biopharmaceutics
    11/13/22
  972. 129
    Heterocyclic inhibitors of ATR kinase
    Board Of Regents, The University Of Texas System
    11/13/22
  973. 359
    Heterocyclylamines as PI3K inhibitors
    Incyte
    11/13/22
  974. 164
    LSD1 inhibitor and preparation method and application thereof
    Medshine Discovery
    11/13/22
  975. 70
    PDE9 inhibitor and use thereof
    Nanjing Transthera Biosciences
    11/13/22
  976. 17
    Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
    Genentech
    11/13/22
  977. 166
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi
    11/13/22
  978. 70
    Aryl cyclopropyl-amino-isoquinolinyl amide compounds
    Aerie Pharmaceuticals
    11/07/22
  979. 69
    Bromodomain inhibitor compound and use thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    11/07/22
  980. 124
    Composition and methods for inhibiting mammalian sterile 20-like kinase 1
    The Scripps Research Institute
    11/07/22
  981. 8
    Cycloalkyl-diamines for the treatment of inflammation
    Medisynergics
    11/07/22
  982. 291
    Dihydrooxadiazinones
    Bayer Aktiengesellschaft
    11/07/22
  983. 40
    IRAK4 inhibiting agents
    Biogen Ma
    11/07/22
  984. 84
    Imidazo-pyridine compounds as PAD inhibitors
    Jubilant Epipad
    11/07/22
  985. 465
    Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors
    Incyte
    11/07/22
  986. 312
    Immunomodulator compounds
    Chemocentryx
    11/07/22
  987. 332
    Indazoles and azaindazoles as LRRK2 inhibitors
    Escape Bio
    11/07/22
  988. 543
    Inhibitors of KEAP1-Nrf2 protein-protein interaction
    Janssen Pharmaceutica
    11/07/22
  989. 22
    JAK inhibitor and use thereof
    Zhuhai United Laboratories
    11/07/22
  990. 13
    Kinase inhibitors
    Insilico Medicine Ip
    11/07/22
  991. 24
    Prolyl hydroxylase inhibitors and methods of use
    Akebia Therapeutics
    11/07/22
  992. 4
    Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
    Mindset Pharma
    11/07/22
  993. 84
    Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) for the treatment of neurodegenerative diseases
    The Johns Hopkins University
    11/07/22
  994. 228
    Substituted pyrrolopyridine-derivatives
    Bayer Pharma Aktiengesellschaft
    11/07/22
  995. 1
    Substituted quinolines useful as kinase inhibitors
    Teligene
    11/07/22
  996. 22
    4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors
    Nerviano Medical Sciences
    11/06/22
  997. 208
    Amide substituted indole compounds useful as TLR inhibitors
    Bristol-Myers Squibb
    11/06/22
  998. 29
    Arginase inhibitors and methods of use thereof
    Astrazeneca
    11/06/22
  999. 452
    Aryl and heteroaryl substituted indole compounds
    Bristol-Myers Squibb
    11/06/22
  1000. 589
    Bcl-2 inhibitors
    Beigene
    11/06/22
  1001. 150
    Bicyclic compounds
    Vivace Therapeutics
    11/06/22
  1002. 18
    Compounds as neuronal histamine receptor-3 antagonists and uses thereof
    Xwpharma
    11/06/22
  1003. 26
    DACOS type NNRTIS amino acid ester derivative, preparation method thereof, pharmaceutical composition, and application thereof
    Yunnan University
    11/06/22
  1004. 145
    Dosage forms and regimens for amino acid compounds
    Pliant Therapeutics
    11/06/22
  1005. 67
    Heterocyclic compounds as anti-viral agents
    Enanta Pharmaceuticals
    11/06/22
  1006. 16
    Hypoxia inducible factor-2(alpha) inhibitors and their use in the treatment of diseases
    Nikang Therapeutics
    11/06/22
  1007. 316
    Piperidinyl-methyl-purineamines as NSD2 inhibitors and anti-cancer agents
    Novartis
    11/06/22
  1008. 39
    Substituted imidazo[1,5-a]pyrazines as Bruton's tyrosine kinase inhibitors
    Transthera Sciences (Nanjing)
    11/06/22
  1009. 67
    Substituted pyrrolopyridines as JAK inhibitors
    Aclaris Therapeutics
    11/06/22
  1010. 30
    Treatment of tachycardia
    Oslo University Hospital
    11/06/22
  1011. 53
    AMPK activators
    Kallyope
    11/05/22
  1012. 22
    Tryptophan hydroxylase inhibitor and pharmaceutical composition including same
    Gwangju Institute Of Science And Technology
    11/05/22
  1013. 149
    Compounds and uses thereof
    Foghorn Therapeutics
    10/30/22
  1014. 78
    Compounds for the treatment of BRAF-associated diseases and disorders
    Array Biopharma
    10/30/22
  1015. 5
    Compounds useful as immunomodulators
    Bristol-Myers Squibb
    10/30/22
  1016. 97
    Formulations of Tie-2 activators and methods of use thereof
    Eyepoint Pharmaceuticals
    10/30/22
  1017. 55
    Heterocyclic compound as JAK inhibitor, and salts and therapeutic use thereof
    Suzhou Longbiotech Pharmaceuticals
    10/30/22
  1018. 66
    Heterocyclic compounds as immunomodulators
    Incyte
    10/30/22
  1019. 136
    Heterocyclic compounds as modulators of mGluR7
    Pragma Therapeutics
    10/30/22
  1020. 212
    Inhibitors of protein kinases
    Alexion Pharmaceuticals
    10/30/22
  1021. 19
    Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
    Auckland Uniservices
    10/30/22
  1022. 103
    Oxoacridinyl acetic acid derivatives and methods of use
    Stingthera
    10/30/22
  1023. 379
    P300/CBP hat inhibitors
    Constellation Pharmaceuticals
    10/30/22
  1024. 1022
    Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors
    Nimbus Lakshmi
    10/30/22
  1025. 37
    Sulfonamide-substituted cyanopyrrolidines with activity as DUB inhibitors
    Mission Therapeutics
    10/30/22
  1026. 6
    Acetamide thienotriazolodiazepines and uses thereof
    Dana-Farber Cancer Institute
    10/28/22
  1027. 58
    Antibacterial compounds
    Forge Therapeutics
    10/28/22
  1028. 121
    Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
    Achillion Pharmaceuticals
    10/28/22
  1029. 80
    CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
    Amgen
    10/28/22
  1030. 3
    Derivatives of an FGFR inhibitor
    Incyte
    10/28/22
  1031. 36
    Dioxinoquinoline compounds, preparation method and uses thereof
    Beijing Scitech-Mq Pharmaceuticals
    10/28/22
  1032. 114
    Heterocycle compounds as Tyro3, Axl and MerTK (TAM) family of receptor tyrosine kinase inhibitors
    Development Center For Biotechnology
    10/28/22
  1033. 27
    Heterocyclic compounds as immunomodulators
    Incyte
    10/28/22
  1034. 85
    Inhibitors of RAF kinases
    Kinnate Biopharma
    10/28/22
  1035. 26
    JAK1 pathway inhibitors for the treatment of chronic lung allograft dysfunction
    Incyte
    10/28/22
  1036. 118
    Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
    Washington University
    10/28/22
  1037. 16
    Pyrazolopyridine compounds and uses thereof
    Incyte
    10/28/22
  1038. 208
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals
    10/28/22
  1039. 13
    Substituted piperidines as kinase inhibitors
    Daewoong Pharmaceutical
    10/28/22
  1040. 13
    Treatment of upper aerodigestive tract disorders and cough
    Individual
    10/28/22
  1041. 79
    Tropomyosin-related kinase (TRK) inhibitors
    Genzyme
    10/28/22
  1042. 22
    1-Pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
    Novartis
    10/23/22
  1043. 153
    Alcoxyamino derivatives for treating pain and pain related conditions
    Esteve Pharmaceuticals
    10/23/22
  1044. 1
    Biochemical binding of RET9 and VEGFR2 inhibitors
    Kala Pharmaceuticals
    10/23/22
  1045. 23
    Cyclic dinucleotide compound and uses thereof
    Shanghai Jemincare Pharmaceuticals
    10/23/22
  1046. 64
    Dihydroquinolinones for medical treatment
    C4 Therapeutics
    10/23/22
  1047. 307
    Heteroaryl inhibitors of PDE4
    Tetra Discovery Partners
    10/23/22
  1048. 138
    Heterocyclic compounds as LSD1 inhibitors
    Incyte
    10/23/22
  1049. 11
    Isoquinoline derivatives and use thereof
    Purdue Pharma
    10/23/22
  1050. 62
    Macrocyclic indole derivatives
    The Broad Institute
    10/23/22
  1051. 40
    Pyrido[3,2-d]pyrimidine compounds as immunomodulators
    Incyte
    10/23/22
  1052. 81
    Pyrimidinones as PI3K inhibitors
    Incyte Holdings
    10/23/22
  1053. 41
    Small molecule activators of Parkin enzyme function
    Mayo Foundation For Medical Education And Research
    10/23/22
  1054. 8
    [1,2,4]Triazolo derivatives as PDE1 inhibitors for the treatment of diabetes
    Eli Lilly
    10/23/22
  1055. 23
    1,4-substituted isoquinoline inhibitors of KEAP1/NRF2 protein-protein interaction
    The Board Of Trustees Of The University Of Illinois
    10/17/22
  1056. 34
    Amine compound for inhibiting SSAO/VAP-1 and use thereof
    Sunshine Lake Pharma
    10/17/22
  1057. 15
    Amino acid compounds with unbranched linkers and methods of use
    Pliant Therapeutics
    10/17/22
  1058. 21
    Aryl-phosphorus-oxygen compound as EGFR kinase inhibitor
    Chia Tai Tianqing Pharmaceutical Group
    10/17/22
  1059. 479
    Benzodiazepine derivatives as RSV inhibitors
    Enanta Pharmaceuticals
    10/17/22
  1060. 218
    CDK2/4/6 inhibitors
    Pfizer
    10/17/22
  1061. 45