BDBM12255 AZD0530::CHEMBL217092::Compound 33::N-(5-chloro-2H-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine::Saracatinib::med.21724, Compound 189

SMILES: CN1CCN(CC1)CCOc2cc3c(c(c2)OC4CCOCC4)c(ncn3)Nc5c(ccc6c5OCO6)Cl

InChI Key: InChIKey=OUKYUETWWIPKQR-UHFFFAOYSA-N

Data: 2 KI  28 IC50  2 Kd  1 EC50

PDB links: 5 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 12255   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Vascular endothelial growth factor receptor 2 (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase CSK (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Yes (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase CSK (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Yes (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Lck (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Yes (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Yes (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	418	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.82E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Orf1a protein (MERS-CoV)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Ephrin type-A receptor 2 [596-900] (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	338	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM12255 (CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...) Show SMILES Show InChI	GoogleScholar	UniChem		5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair