BDBM37953 US10093631, Compound Lesinurad::US10336710, Lesinurad::US10752613, Compound Lesinurad::US11020397, Compound Lesinurad::US11149013, Compound lesinurad::US11161835, Compound Lesinurad

SMILES: OC(=O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12

InChI Key: InChIKey=FGQFOYHRJSUHMR-UHFFFAOYSA-N

Data: 48 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 51 hits for monomerid = 37953   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 2C19 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 11 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.54E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.73E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.73E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.87E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.87E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.44E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.44E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.93E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.44E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Xanthine dehydrogenase/oxidase (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Xanthine dehydrogenase/oxidase (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Xanthine dehydrogenase/oxidase (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Xanthine dehydrogenase/oxidase (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Xanthine dehydrogenase/oxidase (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Xanthine dehydrogenase/oxidase (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Xanthine dehydrogenase/oxidase (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 11 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 11 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.54E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Human)	BDBM37953 (US10093631, Compound Lesinurad | US10336710, Lesin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair