BindingDB BDBM37953 US10093631, Compound Lesinurad::US10336710, Lesinurad::US10752613, Compound Lesinurad::US11020397, Compound Lesinurad::US11149013, Compound lesinurad::US11161835, Compound Lesinurad

BDBM37953 US10093631, Compound Lesinurad::US10336710, Lesinurad::US10752613, Compound Lesinurad::US11020397, Compound Lesinurad::US11149013, Compound lesinurad::US11161835, Compound Lesinurad

SMILES OC(=O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12

InChI Key InChIKey=JHWDCJBLPGLDMI-UHFFFAOYSA-N

Data 45 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 37953

Solute carrier family 22 member 12(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 7.30E+3nMAssay Description:Inhibition of human URAT1 expressed in HEK293 cells assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric ac...More data for this Ligand-Target Pair

Reactome pathway KEGG
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Solute carrier family 22 member 12(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 1.51E+4nMAssay Description:Inhibition of human URAT1 expressed in HEK293 cells assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric ac...More data for this Ligand-Target Pair

Reactome pathway KEGG
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Cytochrome P450 1A2(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 1.73E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Cytochrome P450 1A2(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 1.73E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Cytochrome P450 2C9(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: >1.00E+5nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Cytochrome P450 2C9(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 7.87E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Cytochrome P450 2C9(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 7.87E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Cytochrome P450 2C19(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 6.17E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Cytochrome P450 2C19(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 6.17E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Cytochrome P450 2D6(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 3.26E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
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Cytochrome P450 2D6(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: >1.00E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
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GoogleScholar

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Cytochrome P450 3A4(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 7.44E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Cytochrome P450 3A4(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 7.44E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Cytochrome P450 1A2(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 3.93E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Cytochrome P450 2C19(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 6.17E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Cytochrome P450 2D6(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 3.26E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

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Cytochrome P450 3A4(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 7.44E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Solute carrier family 22 member 12(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL

PNG

BDBM37953(US10093631, Compound Lesinurad | US10336710, Lesin...)

IC50: 7.30E+3nMAssay Description:Inhibition of human URAT1 expressed in HEK293 cells assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric ac...More data for this Ligand-Target Pair

Reactome pathway KEGG
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Filter my 45 hits

Targets 9▿
- Solute carrier family 22 member 12 18
- Xanthine dehydrogenase/oxidase 7
- Cytochrome P450 1A2 3
- Cytochrome P450 2C9 3
- Cytochrome P450 2C19 3
- Cytochrome P450 2D6 3
- Potassium voltage-gated channel subfamily H member 2 3
- Cytochrome P450 3A4 3
- Solute carrier family 22 member 11 2
Publications 14▿
- ACS Med Chem Lett 8: 299-303 (2017) 21
- US Patent US11020397 (2021) 4
- US Patent US10093658 (2018) 3
- J Med Chem 63: 3834-3867 (2020) 2
- US Patent US10752613 (2020) 2
- Bioorg Med Chem Lett 29: 383-388 (2019) 2
- US Patent US10093631 (2018) 2
- Eur J Med Chem 166: 186-196 (2019) 2
- US Patent US10336710 (2019) 1
- J Med Chem 63: 10829-10854 (2020) 1
- US Patent US11168075 (2021) 1
- US Patent US11149013 (2021) 1
- US Patent US11161835 (2021) 1
- J Med Chem 65: 4218-4237 (2022) 1
Institutions 8▿
- Wuxi Apptec 21
- Acquist 13
- West China Hospital Of Sichuan University 2
- Tianjin Medical University 2
- The Scripps Research Institute 2
- Shandong University 2
- TBA 1
- Tianjin Institute of Pharmaceutical Research 1
Affinity: 9.4 to 3.0E+5 nM▿
- IC50 45
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1