BDBM50228403 (R)-8-(3-aminopiperidin-1-yl)-7-(but-2-ynyl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione::8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione::CHEMBL237500::LINAGLIPTIN::US10202383, Example 2(142)::US10358449, Linagliptin::US20240115577, Compound 5::US9255098, Linagliptin::US9321791, 2(142)::US9556175, 2(142)

SMILES: CC#CCn1c(nc2n(C)c(=O)n(Cc3nc(C)c4ccccc4n3)c(=O)c12)N1CCC[C@@H](N)C1

InChI Key: InChIKey=LTXREWYXXSTFRX-UHFFFAOYSA-N

Data: 55 IC50  2 Kd  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 59 hits for monomerid = 50228403   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prolyl endopeptidase FAP (Mouse)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	295	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	295	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prolyl endopeptidase FAP (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 8 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 8 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prolyl endopeptidase FAP (Mouse)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 8 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier organic anion transporter family member 1B1 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
POU domain, class 2, transcription factor 1 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
POU domain, class 2, transcription factor 1 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
POU domain, class 2, transcription factor 2 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 8 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acyl-protein thioesterase 1 (Rat)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 [K6R,T557I] (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	7.8	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase IV (Porphyromonas gingivalis)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Bovine)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 8 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	7.8	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.00660	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Human)	BDBM50228403 (8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair