BDBM50369965 CETRORELIX::Cetrotide

SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6]-[#6]-[#7]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@@H](-[#6]-c1cccnc1)-[#7]-[#6](=O)-[#6@@H](-[#6]-c1ccc(Cl)cc1)-[#7]-[#6](=O)-[#6@@H](-[#6]-c1ccc2ccccc2c1)-[#7]-[#6](-[#6])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@H](-[#6])-[#6](-[#7])=O

InChI Key InChIKey=SBNPWPIBESPSIF-MHWMIDJBSA-N

Data  1 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50369965   

TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Ferring Research Institute

Curated by ChEMBL
LigandPNGBDBM50369965(CETRORELIX | Cetrotide)
Affinity DataIC50:  4.20nMAssay Description:Antagonism of human GnHR receptor, determined in a reporter gene assay in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Ferring Research Institute

Curated by ChEMBL
LigandPNGBDBM50369965(CETRORELIX | Cetrotide)
Affinity DataKd:  0.135nMAssay Description:Inhibition of Tag-lite green-labeled agonist binding to terbium fluorophore-labeled human N-terminal SNAP-tag GnRh receptor expressed in HEK293 cells...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Ferring Research Institute

Curated by ChEMBL
LigandPNGBDBM50369965(CETRORELIX | Cetrotide)
Affinity DataKd:  0.00200nMAssay Description:Inhibition of Tag-lite green-labeled agonist binding to terbium fluorophore-labeled human N-terminal SNAP-tag GnRh receptor expressed in HEK293 cells...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Ferring Research Institute

Curated by ChEMBL
LigandPNGBDBM50369965(CETRORELIX | Cetrotide)
Affinity DataKd:  1.26nMAssay Description:Competitive antagonism of GnRH-induced response in the reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed