BDBM8963 CHEMBL32823::Homodimeric Tacrine Analog 3b::N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-1,2,3,4-tetrahydroacridin-9-amine::Tacrine Dimer 3b::Tacrine-Based Inhibitor 2f::tacrine homobivalent compound 3a

SMILES: c1ccc2c(c1)c(c3c(n2)CCCC3)NCCCCCCCNc4c5ccccc5nc6c4CCCC6

InChI Key: InChIKey=ITZOKHKOFJOBFS-UHFFFAOYSA-N

Data: 9 KI  46 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 55 hits for monomerid = 8963   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Carboxylic ester hydrolase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	149	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.810	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Horse)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Horse)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.810	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	149	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Horse)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Electric eel)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.810	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Beta-secretase 1 (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Mouse)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.810	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Mouse)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Mouse)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	149	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.66	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.810	n/a	n/a	n/a	n/a	n/a	n/a
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Nitric oxide synthase, endothelial (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	149	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Mouse)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Rat)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		0.163	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Acetylcholinesterase (Bovine)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Human)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		1.30	-12.1	n/a	n/a	n/a	n/a	n/a	8.0	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholinesterase (Bovine)	BDBM8963 (N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...) Show SMILES Show InChI	GoogleScholar	UniChem		1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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