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Found 1221
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50059955(4-({[4-(2,4-Diamino-6-ethyl-pyrimidin-5-yl)-2-nitr...)
Affinity DataKi:  0.000350nMAssay Description:Inhibitory activity of compound against rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50059948(4-({[4-(2,4-Diamino-6-ethyl-pyrimidin-5-yl)-2-nitr...)
Affinity DataKi:  0.000400nMAssay Description:Inhibitory activity of compound against rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50058420((methylbenzoprim, MBP) 5-[4-(Benzyl-methyl-amino)-...)
Affinity DataKi:  0.00900nMAssay Description:Inhibitory activity of compound against rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50059957(4-({[4-(2,4-Diamino-6-ethyl-pyrimidin-5-yl)-2-nitr...)
Affinity DataKi:  0.0140nMAssay Description:Inhibitory activity of compound against rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50059956(5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE-2,4-DIAM...)
Affinity DataKi:  0.120nMAssay Description:Inhibitory activity of compound against rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50006906(2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-am...)
Affinity DataKi:  0.580nMAssay Description:Compound was evaluated for the inhibition of partially purified rat liver Dihydrofolate reductase (DHFR) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50017876(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Affinity DataKi:  3.90nMAssay Description:Compound was evaluated for the inhibition of partially purified rat liver Dihydrofolate reductase (DHFR) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50006907(2-{4-[(4-Oxo-3,4-dihydro-quinazolin-6-ylmethyl)-am...)
Affinity DataKi:  11nMAssay Description:Compound was evaluated for the inhibition of partially purified rat liver Dihydrofolate reductase (DHFR) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50017875(2-{4-[Ethyl-(4-oxo-3,4-dihydro-quinazolin-6-ylmeth...)
Affinity DataKi:  58nMAssay Description:Compound was evaluated for the inhibition of partially purified rat liver Dihydrofolate reductase (DHFR) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18771((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...)
Affinity DataKi:  75nMAssay Description:Inhibitory activity against Dihydrofolate reductase in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50008294(2-(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)m...)
Affinity DataKi:  75nMAssay Description:Compound was evaluated for the inhibition of partially purified rat liver Dihydrofolate reductase(DHFR) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50014480((S)-2-(4-(((4-oxo-3,4-dihydroquinazolin-6-yl)methy...)
Affinity DataKi:  2.25E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50011243(2-{4-[(4-Hydroxy-quinazolin-6-ylmethyl)-prop-2-yny...)
Affinity DataKi:  2.25E+3nMAssay Description:Compound was evaluated for the inhibition of partially purified rat liver Dihydrofolate reductase (DHFR) enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50006687((S)-2-(4-(((2-methyl-4-oxo-3,4-dihydroquinazolin-6...)
Affinity DataKi: >2.66E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50016325(2-{4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmeth...)
Affinity DataIC50:  0.00160nMAssay Description:Inhibition against rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50043393(2-({4-[(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmet...)
Affinity DataIC50:  0.00160nMAssay Description:Tested for inhibition against Dihydrofolate reductase from T. gondiiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50043394(2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-am...)
Affinity DataIC50:  0.00250nMAssay Description:Tested for inhibition against rat liver DHFR (dihydrofolate reductase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18229(5-[3-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...)
Affinity DataIC50:  0.320nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50067865(CHEMBL337603 | N*6*-(3,4-Dimethoxy-phenyl)-N*6*-me...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1nMAssay Description:Inhibition against Dihydrofolate reductase in rat liverMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50067861(CHEMBL140940 | N*6*-Methyl-N*6*-phenyl-pyrido[3,2-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of dihydrofolate reductase from rat liver.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity of the compound was tested against rat DHFR*More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of partially purified dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Dihydrofolate reductase (DHFR) of in rat liverMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Concentration inhibiting rat liver dihydrofolate reductase .More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inihibitory concentration against rat liver dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liver was evaluated using 90 microM dihydrofolic acid as substrateMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of rat liver dihydrofolate reductase.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Dihydrofolate Reductase of Rat Liver.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory concentration against Dihydrofolate reductase from Rat liver (rl)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from rat liver (rl)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory concentration against Rat liver Dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity of the compound against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18227(2,4-diamino-5-deazapteridine, 6 | 6-[3-({2,4-diami...)
Affinity DataIC50:  2nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50029772(5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from rat liver (rl)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50029772(5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)
Affinity DataIC50:  2.10nMAssay Description:Concentration inhibiting rat liver dihydrofolate reductase .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50029772(5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50029772(5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of dihydrofolate reductase from rat liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50029772(5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50134784(CHEMBL526243 | TCMDC-137820)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of rat DHFR extracted from liver using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluorom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM50029772(5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University

Curated by ChEMBL
LigandPNGBDBM18226(2,4-diamino-5-deazapteridine, 5 | 5-[3-({2,4-diami...)
Affinity DataIC50:  2.20nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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