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Found 2275 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 8'
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataEC50:  10nMAssay Description:Inhibition of JNK1 in OVA-challenged and IgE-sensitized cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50352629(CHEMBL1822314)
Affinity DataEC50:  2.00E+3nMAssay Description:Inhibition of anisomycin-induced c-JUN phosphorylation in human HEK293T cells by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50392984(CHEMBL2152384)
Affinity DataEC50:  3.30E+3nMAssay Description:Inhibition of JNK1-mediated c-jun phosphorylation in TNF-alpha stimulated human HK-2 cells after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50392983(CHEMBL2152383)
Affinity DataEC50:  4.10E+3nMAssay Description:Inhibition of JNK1-mediated c-jun phosphorylation in TNF-alpha stimulated human HK-2 cells after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50392990(CHEMBL2152390)
Affinity DataEC50:  4.10E+3nMAssay Description:Inhibition of JNK1-mediated c-jun phosphorylation in TNF-alpha stimulated human HK-2 cells after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50392985(CHEMBL2152385)
Affinity DataEC50:  8.50E+3nMAssay Description:Inhibition of JNK1-mediated c-jun phosphorylation in TNF-alpha stimulated human HK-2 cells after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50392988(CHEMBL2152388)
Affinity DataEC50:  9.00E+3nMAssay Description:Inhibition of JNK1-mediated c-jun phosphorylation in TNF-alpha stimulated human HK-2 cells after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50392986(CHEMBL2152386)
Affinity DataEC50:  9.90E+3nMAssay Description:Inhibition of JNK1-mediated c-jun phosphorylation in TNF-alpha stimulated human HK-2 cells after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50392982(CHEMBL2152382)
Affinity DataEC50:  1.01E+4nMAssay Description:Inhibition of JNK1-mediated c-jun phosphorylation in TNF-alpha stimulated human HK-2 cells after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50392987(CHEMBL2152387)
Affinity DataEC50:  1.40E+4nMAssay Description:Inhibition of JNK1-mediated c-jun phosphorylation in TNF-alpha stimulated human HK-2 cells after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50352629(CHEMBL1822314)
Affinity DataEC50:  1.40E+4nMAssay Description:Inhibition of TNFalpha-induced c-JUN phosphorylation in mouse B16-F10 cells by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50392989(CHEMBL2152389)
Affinity DataEC50:  2.10E+4nMAssay Description:Inhibition of JNK1-mediated c-jun phosphorylation in TNF-alpha stimulated human HK-2 cells after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50392992(CHEMBL2152392)
Affinity DataEC50:  2.19E+4nMAssay Description:Inhibition of JNK1-mediated c-jun phosphorylation in TNF-alpha stimulated human HK-2 cells after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15956(Aminopyridine-Based Inhibitor 18b | N-(4-Amino-5-c...)
Affinity DataKi:  1nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50352629(CHEMBL1822314)
Affinity DataKi:  1.5nMAssay Description:Competitive inhibition of JNK1 using ATF2 substrate by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15908(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Affinity DataKi:  2nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50352629(CHEMBL1822314)
Affinity DataKi:  2nMAssay Description:Competitive inhibition of JNK1 using ATP by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15908(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Affinity DataKi:  2nMAssay Description:Inhibition of human JNK1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15976(Aminopyridine-Based Inhibitor 35 | N-(4-Amino-5-ch...)
Affinity DataKi:  3nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15939(Aminopyridine-Based Inhibitor 6s | N-(4-amino-5-cy...)
Affinity DataKi:  3nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50314147(CHEMBL1094014 | trans-4-(4-(1-benzyl-5-(dimethylam...)
Affinity DataKi:  3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50314148(CHEMBL1089007 | trans-4-(4-(3-(tetrahydro-2H-pyran...)
Affinity DataKi:  9nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277947(CHEMBL482559 | N-(4-(4-(2-(cyclopentylamino)pyrimi...)
Affinity DataKi:  9nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277909(CHEMBL483741 | N-cyclopentyl-4-(3-(tetrahydro-2H-p...)
Affinity DataKi:  12nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataKi:  12nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277869(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-cyclopent...)
Affinity DataKi:  26nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277838(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-cyclohexy...)
Affinity DataKi:  27nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277948(CHEMBL482753 | N-(4-(4-(2-(cyclopentylamino)pyrimi...)
Affinity DataKi:  28nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277946(3-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)
Affinity DataKi:  36nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277873(CHEMBL485365 | N-isopropyl-4-(3-(tetrahydro-2H-pyr...)
Affinity DataKi:  43nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataKi:  44nMAssay Description:Inhibition of hexa-His-tagged JNK1 expressed in baculoviral system using GST-tagged c-Jun as substrate preincubated for 15 mins prior ATP addition me...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277836(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-isopropyl...)
Affinity DataKi:  48nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277907(CHEMBL520488 | N-isopropyl-4-(3-(1-(methylsulfonyl...)
Affinity DataKi:  101nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277837(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-cycloprop...)
Affinity DataKi:  151nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277908(CHEMBL518996 | N-(1-methylpiperidin-4-yl)-4-(3-(6-...)
Affinity DataKi:  162nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277905(CHEMBL520332 | N-isopropyl-4-(3-(tetrahydro-2H-pyr...)
Affinity DataKi:  169nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15907(Aminopyridine-Based Inhibitor 6a | N-(4-Amino-5-cy...)
Affinity DataKi:  190nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277868((R)-3-(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)pyrim...)
Affinity DataKi:  315nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277872(CHEMBL485364 | N-isopropyl-4-(3-(tetrahydro-2H-pyr...)
Affinity DataKi:  381nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50297455(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  450nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277906(CHEMBL484326 | N-isopropyl-4-(3-(piperidin-3-yl)-1...)
Affinity DataKi:  530nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15968(Aminopyridine-Based Inhibitor 24 | N-(4-Amino-5-cy...)
Affinity DataKi:  550nMAssay Description:Ser/Thr-kinase selectivity assays were performed using a radioactive FlashPlate-based assay platform. Substrate incorporated radioactivity was counte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277870(4-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-N-(1-methyl...)
Affinity DataKi:  1.57E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50463479(CHEMBL4249925)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277835(4-methylpyrimidine-2-thiol | CHEMBL455772)
Affinity DataKi:  2.06E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50277871(CHEMBL485193 | N-isopropyl-4-(1H-pyrazol-4-yl)pyri...)
Affinity DataKi:  2.73E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50402020(CHEMBL2205426)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibition of recombinant JNK1A1 after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50463484(CHEMBL4248525)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM17697(2-aminobenzoxazole, 22 | 4-({2-[(4-chloro-3-{[(2S)...)
Affinity DataIC50: >4.00E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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