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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM26705
Substrate
Biotinylated Substrate Peptide
Meas. Tech.
Pim Kinase Assay
pH
7.5±n/a
Temperature
295.15±n/a K
Ki
>1424±n/a nM
Citation
 Tong, Y; Stewart, KD; Thomas, S; Przytulinska, M; Johnson, EF; Klinghofer, V; Leverson, J; McCall, O; Soni, NB; Luo, Y; Lin, NH; Sowin, TJ; Giranda, VL; Penning, TD Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling. Bioorg Med Chem Lett 18:5206-8 (2008) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM26705
Synonyms:
7-chloro-9-ethyl-6-fluoro-1-(2-hydroxyethyl)-1H,3H,4H,9H-quinolino[2,3-c][1,2]oxazole-3,4-dione | Isoxazoloquinolinedione, 13
Type:
Small organic molecule
Emp. Form.:
C14H12ClFN2O4
Mol. Mass.:
326.707
SMILES:
CCn1c2n(CCO)oc(=O)c2c(=O)c2cc(F)c(Cl)cc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Ryanodine receptor 1 [4317-4329]
Synonyms:
Biotinylated Substrate Peptide | RYDR | RYR1 | RYR1_HUMAN
Type:
Peptide
Mol. Mass.:
2871.44
Organism:
n/a
Description:
P21817[4317-4329]
Residue:
24
Sequence:
ITINCLINKERVRRLRRLTAREAA