Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50049106
Substrate
n/a
Meas. Tech.
ChEMBL_36773 (CHEMBL650295)
IC50
51±n/a nM
Citation
Yanagisawa, H; Amemiya, Y; Kanazaki, T; Shimoji, Y; Fujimoto, K; Kitahara, Y; Sada, T; Mizuno, M; Ikeda, M; Miyamoto, S; Furukawa, Y; Koike, H Nonpeptide angiotensin II receptor antagonists: synthesis, biological activities, and structure-activity relationships of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds. J Med Chem 39:323-38 (1996) [PubMed] Article
More Info.:
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_BOVIN | Angiotensin II type 1a (AT-1a) receptor
Type:
PROTEIN
Mol. Mass.:
41107.81
Organism:
Bos taurus
Description:
ChEMBL_36779
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFIMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVCAFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGLIRDCKIEDIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSENGNSSTKKPAPCIEVE
Inhibitor
Name:
BDBM50049106
Synonyms:
3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-propyl)-2-propyl-3H-imidazole-4-carboxylic acid | CHEMBL116102
Type:
Small organic molecule
Emp. Form.:
C25H28N2O5
Mol. Mass.:
436.5002
SMILES:
CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O)C(C)(O)CC