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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50244133
Substrate
n/a
Meas. Tech.
ChEMBL_554180 (CHEMBL963637)
IC50
50±n/a nM
Citation
 Pelletier, JC; Chengalvala, M; Cottom, J; Feingold, I; Garrick, L; Green, D; Hauze, D; Huselton, C; Jetter, J; Kao, W; Kopf, GS; Lundquist, JT; Mann, C; Mehlmann, J; Rogers, J; Shanno, L; Wrobel, J 2-phenyl-4-piperazinylbenzimidazoles: orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor. Bioorg Med Chem 16:6617-40 (2008) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50244133
Synonyms:
2-(4-tert-Butylphenyl)-4-(4-(2-(2-(trifluoromethyl)-1Hbenzo[d]imidazol-4-yloxy)ethyl)piperazin-1-yl)-1Hbenzo[d]imidazole | CHEMBL444509
Type:
Small organic molecule
Emp. Form.:
C31H33F3N6O
Mol. Mass.:
562.6285
SMILES:
CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(CCOc2cccc3nc([nH]c23)C(F)(F)F)CC1
Structure:
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