Affinity DataKi: 0.550nMAssay Description:Binding affinity to human 5HT1D receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.80nMAssay Description:Binding affinity to human 5HT1A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Binding affinity to human 5HT1A receptorMore data for this Ligand-Target Pair
TargetNeurotensin receptor type 1/2(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 28nMAssay Description:Binding ability to compete with [125I]Tyr3-NT (0.15 nM) for human NT receptors cloned in CHO cells.More data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:Binding affinity to human 5HT1B receptorMore data for this Ligand-Target Pair
Affinity DataKi: 230nMAssay Description:Binding affinity to 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 330nMAssay Description:Inhibition of human neurokinin NK2 receptorMore data for this Ligand-Target Pair
TargetNeurotensin receptor type 1/2(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: 450nMAssay Description:Binding ability to compete with [125I]Tyr3-NT (0.15 nM) for human NT receptors cloned in CHO cells.More data for this Ligand-Target Pair
Affinity DataKi: 850nMAssay Description:Inhibition of human histamine H2 receptorMore data for this Ligand-Target Pair
TargetNeurotensin receptor type 1/2(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding ability to compete with [125I]Tyr3-NT (0.15 nM) for human NT receptors cloned in CHO cells.More data for this Ligand-Target Pair
TargetNeurotensin receptor type 1(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Compound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Displacement of [D-Trp6]-GnRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to human 5HT1A receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Displacement of [D-Trp6]-GnRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
TargetNeurotensin receptor type 1(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Compound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol productionMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human recombinant GnRH receptor expressed in HEK293 cells assessed as reduction in (D-Trp6)-GnRH-stimulated IP production by w...More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Displacement of [D-Trp6]-GnRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human recombinant GNRH receptor assessed as inhibition of D-Trp6-GNRH-induced IP accumulation after 1 hr by rapid filtration a...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Displacement of [D-Trp6]-GnRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Displacement of [125I]D-Trp6-GnRH from rat recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 6.70nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 7.40nMAssay Description:Antagonist activity at human GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated [3H]IP reductionMore data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 8.70nMAssay Description:Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
TargetNeurotensin receptor type 1(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataIC50: 8.80nMAssay Description:Compound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetNeurotensin receptor type 1(Homo sapiens (Human))
Medical University Of South Carolina
Curated by ChEMBL
Medical University Of South Carolina
Curated by ChEMBL
Affinity DataIC50: 9.30nMAssay Description:Compound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol productionMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Antagonist activity at human GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated [3H]IP reductionMore data for this Ligand-Target Pair
Affinity DataIC50: 9.70nMAssay Description:Antagonist activity at human GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated [3H]IP reductionMore data for this Ligand-Target Pair
Affinity DataIC50: 9.80nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol productionMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Displacement of [D-Trp6]-GnRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptorMore data for this Ligand-Target Pair