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TargetBeta-1 adrenergic receptor
LigandBDBM50243543
Substrate/Competitorn/a
Meas. Tech.ChEMBL_492275
EC50 11±n/a nM
Citation Imanishi, MItou, SWashizuka, KHamashima, HNakajima, YAraki, TTomishima, YSakurai, MMatsui, SImamura, EUeshima, KYamamoto, TYamamoto, NIshikawa, HNakano, KUnami, NHamada, KMatsumura, YTakamura, FHattori, K Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. Part II. J Med Chem51:4002-20 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-1 adrenergic receptor
Name:Adrenergic receptor
Synonyms:B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:51338.40
Organism:Homo sapiens (Human)
Description:n/a
Residue:477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
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  Blast E-value cutoff:
BDBM50243543
NameBDBM50243543
Synonyms:4-[(2-{[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino}ethyl)amino]-3-propoxy-4-biphenylcarboxylic acid | CHEMBL459645
TypeSmall organic molecule
Emp. Form.C26H29ClN2O4
Mol. Mass.468.972
SMILESCCCOc1cc(ccc1C(O)=O)-c1ccc(NCCNC[C@H](O)c2cccc(Cl)c2)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a