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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50334161
Substrate
n/a
Meas. Tech.
ChEMBL_698206 (CHEMBL1646511)
Ki
0.57±n/a nM
Citation
 Maestrup, EG; Wiese, C; Schepmann, D; Brust, P; Wünsch, B Synthesis, pharmacological activity and structure affinity relationships of spirocyclics(1) receptor ligands with a (2-fluoroethyl) residue in 3-position. Bioorg Med Chem 19:393-405 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50334161
Synonyms:
1'-(4-fluorobenzyl)-3-(2-fluoroethyl)-3H-spiro[isobenzofuran-1,4'-piperidine] | CHEMBL1645205
Type:
Small organic molecule
Emp. Form.:
C21H23F2NO
Mol. Mass.:
343.4102
SMILES:
FCCC1OC2(CCN(Cc3ccc(F)cc3)CC2)c2ccccc12
Structure:
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