Reaction Details Report a problem with these data
Target
Parathyroid hormone/parathyroid hormone-related peptide receptor
Ligand
BDBM64569
Substrate
n/a
Meas. Tech.
cAMP Assay
pH
7.4±n/a
EC50
2300±n/a nM
Comments
extracted
Citation
 Nishimura, Y; Esaki, T; Tamura, T Hydantoin derivative US Patent  US9428505 Publication Date 8/30/2016 
Target
Name:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Synonyms:
PTH1R_RAT | Parathyroid hormone 1 receptor (PTH1R) | Parathyroid hormone/parathyroid hormone-related peptide receptor | Pth1r | Pthr | Pthr1
Type:
Enzyme
Mol. Mass.:
66273.93
Organism:
Rattus norvegicus (Rat)
Description:
P25961
Residue:
591
Sequence:
MGAARIAPSLALLLCCPVLSSAYALVDADDVFTKEEQIFLLHRAQAQCDKLLKEVLHTAANIMESDKGWTPASTSGKPRKEKASGKFYPESKENKDVPTGSRRRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVRATLANTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRETNAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIRKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLSLPLSPRLPPATTNGHSQLPGHAKPGAPATETETLPVTMAVPKDDGFLNGSCSGLDEEASGSARPPPLLQEEWETVM
  
Inhibitor
Name:
BDBM64569
Synonyms:
US9428505, Comparative: Example 1
Type:
n/a
Emp. Form.:
C26H26F3N5O6S
Mol. Mass.:
593.575
SMILES:
Cc1cc(ccc1CCS(=O)(=O)N1CCC2(CC1)N=C(NC2=O)c1cccc(OC(F)(F)F)c1)N1C(=O)CNC1=O |c:20|
Structure:
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