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Structure-Activity Relationship of Truncated 4'-Selenonucleosides: A3 Adenosine Receptor Activity and Binding Selectivity.
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Seoul National University
Discovery of Benzo[d]oxazoles as Novel Dual Small-Molecule Inhibitors Targeting PD-1/PD-L1 and VISTA Pathway.
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China Pharmaceutical University
An Adenosine Analogue Library Reveals Insights into Active Sites of Protein Arginine Methyltransferases and Enables the Discovery of a Selective PRMT4 Inhibitor.
NA
Purdue University
Discovery of Orally Active Phenylquinoline-Based Soluble Epoxide Hydrolase Inhibitors with Anti-Inflammatory and Analgesic Activity.
NA
Beijing Institute of Technology
Discovery of Imidazo[1,2-a]pyrazine Derivatives as Potent ENPP1 Inhibitors.
NA
Shanghai Institute of Materia Medica
Discovery of CZL-046 with an (S)-3-Fluoropyrrolidin-2-one Scaffold as a p300 Bromodomain Inhibitor for the Treatment of Multiple Myeloma.
NA
Fudan University
Design, synthesis and biological evaluation of indazole derivatives as VEGFR-2 kinase inhibitors with anti-angiogenic properties.
NA
Anhui Medical University
Discovery of novel substituted pyridine carboxamide derivatives as potent allosteric SHP2 inhibitors.
NA
China Pharmaceutical University
Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors.
NA
AstraZeneca
Benign-by-Design SAHA Analogues for Human and Animal Vector-Borne Parasitic Diseases.
NA
University of Bologna
Nicotinic Acid Derivatives As Novel Noncompetitive α-Amylase and α-Glucosidase Inhibitors for Type 2 Diabetes Treatment.
NA
University of Milan
Novel Azepino[4,5-b]indolone as cGAS Inhibitors for Treating Immune-Mediated Diseases.
NA
Smith, Gambrell & Russell
Novel Triazolopyridine Derivatives as DGAT2 Inhibitors for Treating Multiple Diseases.
NA
Smith, Gambrell & Russell
Inhibitors of the Cyclic GMP-AMP Synthase (cGAS) as Potential Treatment for Autoimmune and Inflammatory Diseases.
NA
PI Health Sciences
Study of Chalcogen Aspirin Derivatives with Carbonic Anhydrase Inhibitory Properties for Treating Inflammatory Pain.
NA
University of Florence
Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) as Treatment for Inflammatory Diseases.
NA
PI Health Sciences
Synthesis and Optimization of Small Molecule Inhibitors of Prostate Specific Antigen.
NA
University of Missouri - Columbia
Virtual Screening and Molecular Docking: Discovering Novel METTL3 Inhibitors.
NA
Hangzhou Medical College
Current Trends in Psychedelic Science: Integrating Modified Lysergic Acid Derivatives and Psilocybin in Modern Medicine.
NA
Usona Institute
Quinolinonyl Derivatives as Dual Inhibitors of the HIV-1 Integrase Catalytic Site and Integrase-RNA interactions.
NA
"Sapienza" Universita di Roma
Highly Selective Novel Heme Oxygenase-1 Hits Found by DNA-Encoded Library Machine Learning beyond the DEL Chemical Space.
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WuXi AppTec (Shanghai) Co., Ltd.
Side Chain Investigation of Imidazopyridazine as a Hinge Binder for Targeting Actionable Mutations of RET Kinase.
NA
Gachon University
Asymmetric Dirhodium-Catalyzed Modification of Immunomodulatory Imide Drugs and Their Biological Assessment.
NA
Emory University
Advancements in Targeted Therapeutics: Integrating Metabolic Modulation, Immune Engineering, and Biologic Formulation Technologies.
NA
Usona Institute
Enhanced Recognition Memory through Dual Modulation of Brain Carbonic Anhydrases and Cholinesterases.
NA
University of Florence
Discovery, synthesis and biological evaluation of novel isoquinoline derivatives as potent indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase dual inhibitors.
NA
Sichuan University
Anticancer potential of active alkaloids and synthetic analogs derived from marine invertebrates.
NA
Chengdu University of Traditional Chinese Medicine
Targeting Thyroid-Stimulating Hormone Receptor: A Perspective on Small-Molecule Modulators and Their Therapeutic Potential.
NA
Shanghai Institute of Materia Medica
Design, Synthesis, and Bioevaluation of Novel NLRP3 Inhibitor with IBD Immunotherapy from the Virtual Screen.
NA
Fudan University
Discovery of 2-Aryl-4-aminoquinazolin-Based LSD1 Inhibitors to Activate Immune Response in Gastric Cancer.
NA
Zhengzhou University
Development of a First-in-Class DNMT1/HDAC Inhibitor with Improved Therapeutic Potential and Potentiated Antitumor Immunity.
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Shandong University
Inhibition of the EphA2-Sam/Ship2-Sam Association through Peptide Ligands: Studying the Combined Effect of Charge and Aromatic Character.
NA
Institute of Biostructures and Bioimaging
Preclinical Evaluation of Dihydropyrazole-Cored Positron Emission Tomography (PET) Ligands for Imaging of Receptor-Interacting Serine/Threonine Protein Kinase 1 (RIPK1) in the Brain.
NA
Beijing Normal University
Discovery of TYRA-300: First Oral Selective FGFR3 Inhibitor for the Treatment of Urothelial Cancers and Achondroplasia.
NA
Tyra Biosciences, Inc.
Tuning RXR Modulators for PGC1α Recruitment.
NA
Ludwig-Maximilians-Universitat (LMU) Munchen
Targeting HSP90 for Cancer Therapy: Current Progress and Emerging Prospects.
NA
Sichuan University
Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with In Vitro and In Vivo Activity in Neurodegenerative Diseases.
NA
Institute of General Organic Chemistry (CSIC)
Structure-Activity Relationship of Inositol Thiophosphate Analogs as Allosteric Activators of Clostridioides difficile Toxin B.
NA
McGill University
A Lysosome-Targeting hNEU1 Inhibitor Treats Myocardial Infarction: A Potential Therapeutic Breakthrough.
NA
Southeast University
The "Doorstop Pocket" In Thioredoxin Reductases─An Unexpected Druggable Regulator of the Catalytic Machinery.
NA
University of L'Aquila
Structure, Function, and Activity of Small Molecule and Peptide Inhibitors of Protein Arginine Methyltransferase 1.
NA
University of Manitoba
NRF2 inhibitors: Recent progress, future design and therapeutic potential.
NA
Nanjing University of Chinese Medicine
Merging Natural Product Structures with Pharmaceutical Leads: Unnatural Enantiomers of Estranes as Glucocorticoid Receptor Modulators That Suppress TNF-α and IL-6 Release.
NA
The Scripps Research Institute
Development of Tailless Homologue Receptor (TLX) Agonist Chemical Tools.
NA
Ludwig-Maximilians-Universitat (LMU) Munchen
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Antialphavirus Activity.
NA
University of North Carolina at Chapel Hill
Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors.
NA
Merck & Co.
Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis.
NA
Hangzhou Institute of Medicine (HIM)
Discovery of a Highly Potent and Selective Inhibitor Targeting Protein Lysine Methyltransferase NSD2.
NA
Sun Yat-Sen University
Re-Evaluating PIN1 as a Therapeutic Target in Oncology Using Neutral Inhibitors and PROTACs.
NA
Sichuan Kelun-Biotech Biopharmaceutical
Undescribed Amaryllidaceae Alkaloids from Zephyranthes citrina and Their Cytotoxicity.
NA
Charles University
Natural Product-Inspired Discovery of Naphthoquinone-Furo-Piperidine Derivatives as Novel STAT3 Inhibitors for the Treatment of Triple-Negative Breast Cancer.
NA
Zhejiang University
Structural Optimization and Structure-Activity Relationship of 1H-Pyrazole-4-carboxylic Acid Derivatives as DNA 6mA Demethylase ALKBH1 Inhibitors and Their Antigastric Cancer Activity.
NA
Sichuan University
Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.
NA
Aligos Belgium BV
Structure-Based Design and Development of Phosphine Oxides as a Novel Chemotype for Antibiotics that Dysregulate Bacterial ClpP Proteases.
NA
University of Toronto
Design, synthesis and biological evaluation of N-salicyloyl tryptamine derivatives as multifunctional neuroprotectants for the treatment of ischemic stroke.
NA
University of South China
Development of peptoid-based heteroaryl-decorated histone deacetylase (HDAC) inhibitors with dual-stage antiplasmodial activity.
NA
University of Bonn
Discovery of novel BCL6-Targeting PROTACs with effective antitumor activities against DLBCL in vitro and in vivo.
NA
East China Normal University
Discovery of novel dihydropyrrolidone-thiadiazole compound crosstalk between the YycG/F two-component regulatory pathway and cell membrane homeostasis to combat methicillin-resistant Staphylococcus aureus.
NA
Nanjing Tech University
Structure-Activity Relationship Studies of Substituted 2-Phenyl-1,2,4-triazine-3,5(2H,4H)-dione Analogues: Development of Potent eEF2K Degraders against Triple-Negative Breast Cancer.
NA
Soochow University
Harnessing Nitric Oxide-Donating Benzofuroxans for Targeted Inhibition of Carbonic Anhydrase IX in Cancer.
NA
University of Florence
Design, Synthesis, and Biological Evaluation of Potent EZH2/LSD1 Dual Inhibitors for Prostate Cancer.
NA
Sun Yat-sen University Cancer Center
Nonlipogenic ABCA1 Inducers (NLAI) for Alzheimer's Disease Validated in a Mouse Model Expressing Human APOE3/APOE4.
NA
University of Arizona
A Mitochondria-Targeting SIRT3 Inhibitor with Activity against Diffuse Large B Cell Lymphoma.
NA
Cornell University
Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents.
NA
University of Cambridge
Exploring Degradation of Intrinsically Disordered Protein Yes-Associated Protein Induced by Proteolysis TArgeting Chimeras.
NA
University of Florida
Cellular, Structural Basis, and Recent Progress for Targeting Murine Double Minute X (MDMX) in Tumors.
NA
Yantai University
Discovery of Novel Neo-Clerodane Derivatives as Potent Dual-Functional Antiosteoporosis Agents through Targeting Peroxisome Proliferator-Activated Receptor-γ.
NA
Sun Yat-sen University
Discovery of Covalent MLKL PROTAC Degraders via Optimization of a Theophylline Derivative Ligand for Treating Necroptosis.
NA
China Pharmaceutical University
Regulation of protein phosphorylation by PTPN2 and its small-molecule inhibitors/degraders as a potential disease treatment strategy.
NA
China Pharmaceutical University
Discovery of Novel 2-Aminopyridine-Based and 2-Aminopyrimidine-Based Derivatives as Potent CDK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors and Hematological Malignancies.
NA
University of Chinese Academy of Sciences
Discovery of Dehydrogenated Imipridone Derivatives as Activators of Human Caseinolytic Protease P.
NA
China Pharmaceutical University
The Missing Link(er): A Roadmap to Macrocyclization in Drug Discovery.
NA
Technical University of Darmstadt
Discovery of Potent, Specific, and Orally Available NLRP3 Inflammasome Inhibitors Based on Pyridazine Scaffolds for the Treatment of Septic Shock and Peritonitis.
NA
Sichuan University
Discovery of potent HIV-1 NNRTIs by CuAAC click-chemistry-based miniaturized synthesis, rapid screening and structure optimization.
NA
Shandong University
Design, Synthesis, and Biological Evaluation of 5-Amino-4-fluoro-1H-benzo[d]imidazole-6-carboxamide Derivatives as Novel and Potential MEK/RAF Complex Inhibitors Based on the "Clamp" Strategy.
NA
Sichuan University
Indole-core inhibitors of influenza a neuraminidase: iterative medicinal chemistry and molecular modeling.
NA
Federal Research Centre "Fundamentals of Biotechnology" of the Russian Academy of Sciences (Research Centre of Biotechnology RAS)
Discovery of novel 2-substituted 2, 3-dihydroquinazolin-4(1H)-one derivatives as tubulin polymerization inhibitors for anticancer therapy: The in vitro and in vivo biological evaluation.
NA
Renmin Hospital of Wuhan University
Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1-Amplified Breast Cancer.
NA
Jinan University
Development of Nitric Oxide-Donating Netarsudil Derivatives as a Synergistic Therapy for Glaucoma with Reduced Ocular Irritation.
NA
China Pharmaceutical University
Discovery of Pyrazolo[1,5-a]pyridine Derivatives as Potent and Selective PI3Kγ/δ Inhibitors.
NA
Chinese Academy of Sciences
Investigating Active Site Binding of Ligands to High and Low Activity Carbonic Anhydrase Enzymes Using Native Mass Spectrometry.
NA
Griffith University
Rational Design of a Novel 6H-Benzo[c]chromen Series as Selective PI3Kα Inhibitors.
NA
Xi'an Jiaotong University
Discovery of a Covalent Inhibitor of Pro-Caspase-1 Zymogen Blocking NLRP3 Inflammasome Activation and Pyroptosis.
NA
Chinese Academy of Sciences
Optimization of potent, broad-spectrum, and specific anti-influenza compounds targeting RNA polymerase PA-PB1 heterodimerization.
NA
University of Padua
Design, Synthesis, and Biological Activity of Novel Quinone Derivatives as Potent STAT3 Inhibitors for Psoriasis Treatment.
NA
Central South University
Evo312: An Evodiamine Analog and Novel PKCβI Inhibitor with Potent Antitumor Activity in Gemcitabine-Resistant Pancreatic Cancer.
NA
Seoul National University
Methyl-Transferase-Like Protein 16 (METTL16): The Intriguing Journey of a Key Epitranscriptomic Player Becoming an Emerging Biological Target.
NA
University of Naples Federico II
Small Molecular Inhibitors That Target ATM for Drug Discovery: Current Research and Potential Prospective.
NA
Sichuan University
Recent insights of PROTAC developments in inflammation-mediated and autoimmune targets: a critical review.
NA
National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad
New pyrazole-pyridazine hybrids as selective COX-2 inhibitors: design, synthesis, molecular docking, in silico studies and investigation of their anti-inflammatory potential by evaluation of TNF-α, IL-6, PGE-2 and NO in LPS-induced RAW264.7 macrophages.
NA
Cairo University
Phenylstyrylpyrimidine derivatives as potential multipotent therapeutics for Alzheimer's disease.
NA
Central University of Punjab
Targeted suppression of oral squamous cell carcinoma by pyrimidine-tethered quinoxaline derivatives.
NA
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)
Antitubercular evaluation of dihydropyridine-triazole conjugates: design, synthesis, in vitro screening, SAR and in silico ADME predictions.
NA
CSIR-Central Drug Research Institute
Discovery of novel coumarin triazolyl and phenoxyphenyl triazolyl derivatives targeting amyloid beta aggregation-mediated oxidative stress and neuroinflammation for enhanced neuroprotection.
NA
Mahidol University
Design, synthesis and biological evaluation of arylsulfonamides as ADAMTS7 inhibitors.
NA
University of Pisa
Exploiting spirooxindoles for dual DNA targeting/CDK2 inhibition and simultaneous mitigation of oxidative stress towards selective NSCLC therapy; synthesis, evaluation, and molecular modelling studies.
NA
King Saud University
Nonpeptidic Irreversible Inhibitors of SARS-CoV-2 Main Protease with Potent Antiviral Activity.
NA
University of Bonn
Allosteric Activation of Protein Phosphatase 5 with Small Molecules.
NA
China Pharmaceutical University
Discovery of a Novel Benzimidazole Derivative Targeting Histone Deacetylase to Induce Ferroptosis and Trigger Immunogenic Cell Death.
NA
Shandong University
Targeting Solvent-Front Mutations for Kinase Drug Discovery: From Structural Basis to Design Strategies.
NA
Jinan University
Design, synthesis and bioactivity evaluation of isobavachin derivatives as hURAT1 inhibitors for hyperuricemia agents.
NA
Southern Medical University
Acroamine A, a 2-Amino Adenine Alkaloid from the Marine Soft Coral Acrozoanthus australiae and Its Semisynthetic Derivatives That Inhibit cAMP-Dependent Protein Kinase A Catalytic Subunit Alpha.
NA
National Cancer Institute
Design and Evaluation of 3-Phenyloxetane Derivative Agonists of the Glucagon-Like Peptide-1 Receptor.
NA
Huadong Medicine Company Limited
Small Molecules Blocking the Assembly of TCAB1 and Telomerase Complexes: Lead Discovery and Biological Activity.
NA
Anhui University of Chinese Medicine
Design, Synthesis, and Biological Evaluation of 2,4-Diaminopyrimidine Derivatives as Potent CDK7 Inhibitors.
NA
Shanghai Institute of Materia Medica
Novel Compounds as NLRP3 Inhibitors for Treating Cardiovascular Diseases.
NA
Smith, Gambrell & Russell
Novel Papain-Like Protease Inhibitors for Treating Viral Infections, in particular, Coronavirus Infections.
NA
Smith, Gambrell & Russell
Treatment of Metabolic Disorders Using Novel DGAT2 Inhibitors: Pyrazolopyridine and Triazolopyridine Derivatives.
NA
Usona Institute
Design and Assessment of First-Generation Heterobifunctional PPARα/STING Modulators.
NA
University of Minnesota
Novel Cyanopyridine Compounds as KHK Inhibitors for Treating NAFLD, NASH, and Type II Diabetes.
NA
Smith, Gambrell & Russell
Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PLpro).
NA
Vanderbilt University
Novel Compounds as NLRP3 Inhibitors for Treating Alzheimer's Disease and Parkinson's Disease.
NA
Smith, Gambrell & Russell
Chemical Probes to Investigate Central Nervous System Disorders: Design, Synthesis and Mechanism of Action of a Potent Human Serine Racemase Inhibitor.
NA
University of Parma
Ligand-Based Pharmacophoric Design and Anti-inflammatory Evaluation of Triazole Linked Semisynthetic Labdane Conjugates.
NA
CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Innovative Therapeutic Approaches Targeting K-Ras: Analysis of Macrocyclic Compounds, Peptidomimetics, and Pyridopyrimidine Inhibitors.
NA
Usona Institute
Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships.
NA
Merck & Co.
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.
NA
University of North Carolina at Chapel Hill
Novel Imidazopyridine and Imidazopyridazine Derivatives as DGAT2 Inhibitors for Treating Multiple Diseases.
NA
Smith, Gambrell & Russell
Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket.
NA
Lund University
Development of Novel Bacterial Topoisomerase Inhibitors Assisted by Computational Screening.
NA
Ohio State University
A comprehensive review of new small molecule drugs approved by the FDA in 2022: Advance and prospect.
NA
Children's Hospital Affiliated to Zhengzhou University
Synthesis and Biological Evaluation of Pyrazole-Pyrimidones as a New Class of Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
NA
University of Padova
Synthesis and Biological Evaluation of Novel Psidium Meroterpenoid Derivatives against Cisplatin-Induced Acute Kidney Injury.
NA
Peking Union Medical College
Dual 5-HT2A and 5-HT2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis.
NA
Shionogi Pharmaceutical Research Center
Identification of an m6A Natural Inhibitor, Lobeline, That Reverses Lenvatinib Resistance in Hepatocellular Tumors.
NA
The First Hospital of China Medical University
Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators.
NA
St. Jude Children'S Research Hospital
Design and Synthesis of 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid Derivatives as PP5 Inhibitors To Reverse Temozolomide Resistance in Glioblastoma Multiforme.
NA
China Pharmaceutical University
Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.
NA
The University of Melbourne
Discovery of pyrrolo[2,3-d]pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy.
NA
Shanghai Institute of Materia Medica
Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5).
NA
University of Copenhagen
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design.
NA
AstraZeneca
Discovery of CW-3308 as a Potent, Selective, and Orally Efficacious PROTAC Degrader of BRD9.
NA
University of Michigan
Discovering New Metallo-Deubiquitinase CSN5 Inhibitors by a Non-Catalytic Activity Assay Platform.
NA
Sichuan University
Discovery of Novel Mcl-1 Inhibitors with a 3-Substituted-1H-indole-1-yl Moiety Binding to the P1-P3 Pockets to Induce Apoptosis in Acute Myeloid Leukemia Cells.
NA
Shenyang Pharmaceutical University
Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story.
NA
University of Southampton
A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model.
NA
University of Naples Federico II
Distinct Amino Acid-Based PROTACs Target Oncogenic Kinases for Degradation in Non-Small Cell Lung Cancer (NSCLC).
NA
Southern University of Science and Technology
Design, synthesis, and optimization of novel PD-L1 inhibitors and the identification of a highly potent and orally bioavailable PD-L1 inhibitor.
NA
Chulalongkorn University
Natural Derivatives of Selective HDAC8 Inhibitors with Potent in Vivo Antitumor Efficacy against Breast Cancer.
NA
Zhejiang University
Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment.
NA
Jacobio Pharmaceuticals
Discovery of 4-(Arylethynyl)piperidine Derivatives as Potent Nonsaccharide O-GlcNAcase Inhibitors for the Treatment of Alzheimer's Disease.
NA
Chinese Academy of Medical Sciences and Peking Union Medical College
Discovery of a Potent and Orally Bioavailable Xanthine Oxidase/Urate Transporter 1 Dual Inhibitor as a Potential Treatment for Hyperuricemia and Gout.
NA
HEC Research and Development Center
Thioamides in medicinal chemistry and as small molecule therapeutic agents.
NA
University of Michigan
Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.
NA
Albert Einstein College of Medicine
Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M5 Muscarinic Acetylcholine Receptor.
NA
Vanderbilt University
Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy.
NA
Gwangju Institute of Science and Technology
Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors.
NA
Vanderbilt University School of Medicine
Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin-3 Comprising 2-Methyl-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione.
NA
Bristol Myers Squibb
Discovery of Novel Imidazo[1,2-a]pyridine-Based HDAC6 Inhibitors as an Anticarcinogen with a Cardioprotective Effect.
NA
Zhengzhou University
Non-Covalent Inhibitors of SARS-CoV-2 Papain-Like Protease (PLpro): In Vitro and In Vivo Antiviral Activity.
NA
University of Arizona
Bioisosteres at C9 of 2-Deoxy-2,3-didehydro-N-acetyl Neuraminic Acid Identify Selective Inhibitors of NEU3.
NA
University of Alberta
Discovery of novel N2-indazole derivatives as phosphodiesterase 4 inhibitors for the treatment of inflammatory bowel disease.
NA
Southern Medical University
GPX4 allosteric activators inhibit ferroptosis and exert myocardial protection in doxorubicin-induced myocardial injury mouse model.
NA
Peking University
Identification and Characterization of a Blood-Brain Barrier Penetrant Inositol Hexakisphosphate Kinase (IP6K) Inhibitor.
NA
Johns Hopkins School of Medicine
Novel EGFR inhibitors against resistant L858R/T790M/C797S mutant for intervention of non-small cell lung cancer.
NA
Nankai University
FLT3-PROTACs for combating AML resistance: Analytical overview on chimeric agents developed, challenges, and future perspectives.
NA
Ain Shams University
Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors.
NA
University of Groningen
Structure-based screening, optimization and biological evaluation of novel chrysin-based derivatives as selective PPARγ modulators for the treatment of T2DM and hepatic steatosis.
NA
Guangzhou Medical University
Identification of 6,9-dihydro-5H-pyrrolo[3,2-h]quinazolines as a new class of F508del-CFTR correctors for the treatment of cystic fibrosis.
NA
University of Palermo
Discovery of Novel, Selective, and Nonbasic Agonists for the Kappa-Opioid Receptor Determined by Salvinorin A-Based Virtual Screening.
NA
Freie Universitat Berlin
Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy.
NA
Pfizer
Discovery of an Exceptionally Orally Bioavailable and Potent HPK1 PROTAC with Enhancement of Antitumor Efficacy of Anti-PD-L1 Therapy.
NA
Zhejiang University
Design, synthesis, and biological evaluation of novel 1-amido-2-one-4-thio-deoxypyranose as potential antitumor agents for multiple myeloma.
NA
Chinese Academy of Sciences
Discovery of Novel Azaphenothiazine Derivatives to Suppress Endometrial Cancer by Targeting GRP75 to Impair Its Interaction with IP3R and Mitochondrial Ca2+ Homeostasis.
NA
East China University of Science and Technology
Halogen Bonding Hot Spots as a Constraint in Virtual Screening: A Case Study of 5-HT7R.
NA
Polish Academy of Sciences
Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism.
NA
Ludwig-Maximilians-University of Munich
Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
NA
AstraZeneca
Synthesis of furanotriterpenoids from betulin and evaluation of Tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibitory properties of new semi-synthetic triterpenoids.
NA
Institute of Technical Chemistry UB RAS
Genomic Discovery and Structure-Activity Exploration of a Novel Family of Enzyme-Activated Covalent Cyclin-Dependent Kinase Inhibitors.
NA
LifeMine Therapeutics
Identification of the Clinical Candidate PF-07284890 (ARRY-461), a Highly Potent and Brain Penetrant BRAF Inhibitor for the Treatment of Cancer.
NA
Enliven Therapeutics
Hit-to-Lead Optimization of Heterocyclic Carbonyloxycarboximidamides as Selective Antagonists at Human Adenosine A3 Receptor.
NA
University of Cambridge
Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CLpro Inhibitors as anti-SARS-CoV-2 Drug Candidate.
NA
University of Chinese Academy of Sciences
N-acylbenzimidazoles as selective Acylators of the catalytic cystein of the coronavirus 3CL protease.
NA
Univ. Lille
Antibody-drug conjugates for targeted cancer therapy: Recent advances in potential payloads.
NA
Shaoxing University
Design, synthesis, and biological evaluation of novel highly selective non-carboxylic acid FABP1 inhibitors.
NA
Guangdong Pharmaceutical University
Biological and structural investigation of tetrahydro-β-carboline-based selective HDAC6 inhibitors with improved stability.
NA
University of Regensburg
Design, Synthesis and Antitumor Activity of a Novel Class of SHP2 Allosteric Inhibitors with a Furanyl Amide-Based Scaffold.
NA
Shandong University
Discovery and Optimization of Hsp110 and sGC Dual-Target Regulators for the Treatment of Pulmonary Arterial Hypertension.
NA
Central South University
Bipyridine Derivatives as NOP2/Sun RNA Methyltransferase 3 Inhibitors for the Treatment of Colorectal Cancer.
NA
Zhejiang University
Development of narrow-spectrum topoisomerase-targeting antibacterials against mycobacteria.
NA
University of Ljubljana
Exploring monocyclic core: Discovery of pyrrol-2-one derivatives as a new series of potent MCHR1 antagonists with in vivo efficacy.
NA
Biocon-Bristol Myers Squibb Research and Development Centre
Design, synthesis and biological evaluation of novel SIRT3 inhibitors targeting both NAD+ and substrate binding sites for the treatment of acute myeloid leukemia.
NA
Shihezi University
Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites.
NA
University of Naples "Federico II"
Discovery of Preclinical Candidate AD1058 as a Highly Potent, Selective, and Brain-Penetrant ATR Inhibitor for the Treatment of Advanced Malignancies.
NA
Shanghai Institute of Materia Medica
Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome.
NA
The Francis Crick Institute
Undobolins A-L, Ophiobolin-Type Sesterterpenoids from Aspergillus undulatus.
NA
Huazhong University of Science and Technology
Structure of Designer Antibody-like Peptides Binding to the Human C5a with Potential to Modulate the C5a Receptor Signaling.
NA
Indian Institute of Technology Bhubaneswar
Design, synthesis and biological evaluation of a new series of imidazothiazole-hydrazone hybrids as dual EGFR and Akt inhibitors for NSCLC therapy.
NA
Anadolu University
Design, synthesis, and biological activity evaluation of novel HDAC3 selective inhibitors for combination with Venetoclax against acute myeloid leukemia.
NA
Ocean University of China
Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity.
NA
Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)
New Class of Hsp90 C-Terminal Domain Inhibitors with Anti-tumor Properties against Triple-Negative Breast Cancer.
NA
University of Ljubljana
Discovery of ZJCK-6-46: A Potent, Selective, and Orally Available Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor for the Treatment of Alzheimer's Disease.
NA
Shenyang Pharmaceutical University
Discovery of Potent and Selective G9a Degraders for the Treatment of Pancreatic Cancer.
NA
Shanghai Institute of Materia Medica
A Comprehensive In Vitro Characterization of a New Class of Indole-Based Compounds Developed as Selective Haspin Inhibitors.
NA
University of Salerno
Natural Product-Inspired Dopamine Receptor Ligands.
NA
City University of New York
Discovery of Novel Pyrimidine-Based Derivatives as Nav1.2 Inhibitors with Efficacy in Mouse Models of Epilepsy.
NA
University of Chinese Academy of Sciences
Design, Synthesis, and Evaluation of the Selective and Orally Active LSD1 Inhibitor with the Potential of Treating Heart Failure.
NA
Zhengzhou University
Discovery of novel indazole derivatives as second-generation TRK inhibitors.
NA
Shenyang Pharmaceutical University
7-Amino-3-phenyl-2-methyl-pyrazolopyrimidine derivatives inhibit human rhinovirus replication.
NA
Korea Research Institute of Chemical Technology
Design, synthesis, and evaluation of antitumor activity of 2-arylmethoxy-4-(2-fluoromethyl-biphenyl-3-ylmethoxy) benzylamine derivatives as PD-1/PD-l1 inhibitors.
NA
Zhejiang University
Discovery of Novel HDAC3 Inhibitors with PD-L1 Downregulating/Degrading and Antitumor Immune Effects.
NA
Southern Medical University
Synthesis and evaluation of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate analogs as competitive partial agonists of butyrophilin 3A1.
NA
University of Connecticut
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors.
NA
Goethe University
Rational In Silico Design of Selective TMPRSS6 Peptidomimetic Inhibitors via Exploitation of the S2 Subpocket.
NA
Universite de Sherbrooke
Impact of atropisomerism on a non-steroidal glucocorticoid receptor agonist.
NA
WuXi AppTec
Design and synthesis of chromene-1,2,3-triazole benzene sulfonamide hybrids as potent carbonic anhydrase-IX inhibitors against prostate cancer.
NA
Taibah University
Rational design of small-sized peptidomimetic inhibitors disrupting protein-protein interaction.
NA
Ningxia Medical University
Inhibition of DXR in the MEP pathway with lipophilic N-alkoxyaryl FR900098 analogs.
NA
George Washington University
Novel flexible biphenyl PfDHFR inhibitors with improved antimalarial activity.
NA
National Center for Genetic Engineering and Biotechnology (BIOTEC)
Design, synthesis, and anticancer assessment of structural analogues of (E)-1-((3,4,5-trimethoxybenzylidene)amino)-4-(3,4,5-trimethoxyphenyl)imidazo[1,2-a]quinoxaline-2-carbonitrile (6b), an imidazo[1,2-a]quinoxaline-based non-covalent EGFR inhibitor.
NA
Central University of Punjab
Synthesis and in vitro evaluation of novel amino-phenylmethylene-imidazolone 5-HT2A receptor antagonists.
NA
Independent Researcher
Molecular understanding of the therapeutic potential of melanin inhibiting natural products.
NA
Tianjin University
N-Sulfonylphenoxazines as neuronal calcium ion channel blockers.
NA
Monash University
Synthesis of a new series of 4-pyrazolylquinolinones with apoptotic antiproliferative effects as dual EGFR/BRAFV600E inhibitors.
NA
Princess Nourah bint Abdulrahman University
Discovery of new 1,3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, in vivo and in silico studies.
NA
Tanta University
Deuterium Editing of Small Molecules: A Case Study on Antitumor Activity of 1,4-Benzodiazepine-2,5-dione Derivatives.
NA
Tsinghua University
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line.
NA
Universita di Parma
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.
NA
Johann Wolfgang Goethe-University
1,3,5-Triazine as a promising scaffold in the development of therapeutic agents against breast cancer.
NA
Monash University Malaysia
Farnesyl pyrophosphate synthase inhibitors with antiosteoporosis efficacy in ovariectomized rats: A mixed binding approach beyond bisphosphonates.
NA
National Research Centre
Discovery of GS-7682, a Novel 4'-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.
NA
Gilead Sciences
Toward Precision Oncology: The Role of TPD in Targeting CDK2 and Beyond.
NA
Usona Institute
Optimization of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors, Leading to the Potent DS08701581.
NA
Daiichi Sankyo Co., Ltd.
Novel Heterocyclic Compounds as Monoacylglycerol Lipase Inhibitors for Treating Multiple Diseases.
NA
Smith, Gambrell & Russell
Design Principle of Heparanase Inhibitors: A Combined In Vitro and In Silico Study.
NA
University of Florida
Novel AHR Agonists for Treating Psoriasis and Atopic Dermatitis.
NA
Smith, Gambrell & Russell
Synthesis and Evaluation of 1,3-Disubstituted Imidazolidine-2,4,5-triones as Inhibitors of Pyruvate Carboxylase.
NA
Marquette University
The synthesis of 1,2,3-triazoles as binders of D-dopachrome tautomerase (D-DT) for the development of dual-targeting inhibitors.
NA
University of Groningen
Novel neuroprotective 5,6-dihydropyrido[2',1':2,3]imidazo[4,5-c]quinoline derivatives acting through cholinesterase inhibition and CB2 signaling modulation.
NA
Palacky University Olomouc
Molecular Transformers: Adaptive Multitarget Ligands for Esterase-Induced Transition from Analgesics to Anesthetics.
NA
Sichuan University
ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights.
NA
University of Lille
Structure-Based Design and Discovery of a Potent and Cell-Active LC3A/B Covalent Inhibitor.
NA
Fudan University
Discovery of a Highly Potent Lysine Methyltransferases G9a/NSD2 Dual Inhibitor to Treat Solid Tumors.
NA
Sun Yat-Sen University
Identification of 6-Anilino Imidazo[4,5-c]pyridin-2-ones as Selective DNA-Dependent Protein Kinase Inhibitors and Their Application as Radiosensitizers.
NA
University of Auckland
Electrophile Determines Cellular Phenotypes among XPO1-Targeting Small Molecules.
NA
Case Western Reserve University
Discovery of the first selective, small-molecule GFRα2/3 inhibitors through DNA-encoded library technology.
NA
Cerevel Therapeutics
Synthesis and biological evaluation of O4'-benzyl-hispidol derivatives and analogs as dual monoamine oxidase-B inhibitors and anti-neuroinflammatory agents.
NA
Mansoura University
Novel compounds with dual inhibition activity against SARS-CoV-2 critical enzymes RdRp and human TMPRSS2.
NA
University of Sharjah
Discovery of bivalent small molecule degraders of cyclin-dependent kinase 7 (CDK7).
NA
Stanford University
Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases.
NA
Universita degli Studi di Bari
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