BDBM151953 US8987457, 147

SMILES CC(C)Oc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H]([C@H](N)C1)n1ccnn1

InChI Key InChIKey=VGTXZFMBNSOWGX-VZAVBHJOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 151953   

TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM151953(US8987457, 147)
Affinity DataIC50:  1.03nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM151953(US8987457, 147)
Affinity DataIC50:  1.69nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM151953(US8987457, 147)
Affinity DataIC50:  0.0300nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In DepthDetails US Patent