BDBM164137 US9062078, 267::US9475819, 267::US9637496, 267::US9695183, 267

SMILES Fc1ccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c(c1)-c1ncccn1

InChI Key InChIKey=FJQHMTUDGQPMMX-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 164137   

TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164137(US9062078, 267 | US9475819, 267 | US9637496, 267 |...)
Affinity DataKi:  33nM ΔG°:  -9.48kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164137(US9062078, 267 | US9475819, 267 | US9637496, 267 |...)
Affinity DataKi:  61nM ΔG°:  -9.14kcal/moleT: 2°CAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM164137(US9062078, 267 | US9475819, 267 | US9637496, 267 |...)
Affinity DataKi:  1.70E+3nM ΔG°:  -8.26kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
In DepthDetails US Patent