BDBM22319 (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid::Arachidonic acid::Arachidonic acid (AA)::CHEMBL15594::[1-14C]Arachidonic acid

SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

InChI Key InChIKey=YZXBAPSDXZZRGB-DOFZRALJSA-N

Data  6 KI  23 IC50  4 Kd  1 EC50  4 ITC

PDB links: 29 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 22319   

TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM22319((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid | ...)
Affinity DataKi:  330nMAssay Description:Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM22319((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid | ...)
Affinity DataKi:  820nMAssay Description:Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid-binding protein 5(Homo sapiens (Human))
Emory University

LigandPNGBDBM22319((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid | ...)
Affinity DataKi:  2.59E+3nM ΔG°:  -7.74kcal/molepH: 8.2 T: 2°CAssay Description:In brief, both wild-type and mutant hFABP5 were expressed and purified to homogeneity as described above and dialyzed in PBS (pH 8.2). Binding affini...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid-binding protein 5 [M35A,L60A](Homo sapiens (Human))
Emory University

LigandPNGBDBM22319((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid | ...)
Affinity DataKi:  5.01E+3nM ΔG°:  -7.35kcal/molepH: 8.2 T: 2°CAssay Description:In brief, both wild-type and mutant hFABP5 were expressed and purified to homogeneity as described above and dialyzed in PBS (pH 8.2). Binding affini...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid-binding protein 5 [K24A,R33A,K34A](Homo sapiens (Human))
Emory University

LigandPNGBDBM22319((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid | ...)
Affinity DataKi:  9.37E+3nM ΔG°:  -6.97kcal/molepH: 8.2 T: 2°CAssay Description:In brief, both wild-type and mutant hFABP5 were expressed and purified to homogeneity as described above and dialyzed in PBS (pH 8.2). Binding affini...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(MOUSE)
University of Edinburgh

Curated by PDSP Ki Database
LigandPNGBDBM22319((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid | ...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 4 hits for monomerid = 22319   

CellMannoprotein ligand-binding domain 2 (Mp1p-LBD2)(Talaromyces marneffei)
The University of Hong Kong

SyringePNGBDBM22319((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid | ...)
ITC DataΔG°: -11.2kcal/mole −TΔS°: 3.33kcal/mole ΔH°: -14.2kcal/mole logk: 7.69E+7
pH: 8.0 T: 37.00°C 
CellMannoprotein ligand-binding domain 2 (Mp1p-LBD2)(Talaromyces marneffei)
The University of Hong Kong

SyringePNGBDBM22319((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid | ...)
ITC DataΔG°: -12.3kcal/mole −TΔS°: 2.30kcal/mole ΔH°: -11.0kcal/mole logk: 4.35E+8
pH: 8.0 T: 37.00°C 
CellMannoprotein ligand-binding domain 2 (Mp1p-LBD2 I332A)(Talaromyces marneffei)
The University of Hong Kong

SyringePNGBDBM22319((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid | ...)
ITC DataΔG°: -8.18kcal/mole −TΔS°: 6.44kcal/mole ΔH°: -14.5kcal/mole logk: 5.88E+5
pH: 8.0 T: 37.00°C 
CellMannoprotein ligand-binding domain 2 (Mp1p-LBD2 V309D)(Talaromyces marneffei)
The University of Hong Kong

SyringePNGBDBM22319((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid | ...)
ITC DataΔG°: -7.69kcal/mole −TΔS°: 1.93kcal/mole ΔH°: -9.31kcal/mole logk: 2.63E+5
pH: 8.0 T: 37.00°C