BDBM249506 US10072016, Compound 104::US10407433, Compound 104::US10913746, Compound 104::US11649240, Compound 104::US9434727, 104::US9777010, Compound 104

SMILES Fc1ccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(Cc23)C(=O)c2cccnc2)c(c1F)C(F)(F)F

InChI Key InChIKey=AUBAPOMVEQJTIV-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 249506   

TargetRetinol-binding protein 4(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249506(US10072016, Compound 104 | US10407433, Compound 10...)
Affinity DataIC50:  18.9nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Columbia University

US Patent
LigandPNGBDBM249506(US10072016, Compound 104 | US10407433, Compound 10...)
Affinity DataIC50:  21.8nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent