BDBM376736 N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-((R)-2-methylpyrrolidin-1-yl)quinoline-8-carboxamide::US10450296, Example 68::US11053215, Example 68::US9920032, Example 68

SMILES C[C@@H]1CCCN1c1cnc2c(cccc2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1

InChI Key InChIKey=BQMTYMRMFIONOP-ZSXPUABSSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 376736   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM376736(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM376736(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM376736(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Affinity DataIC50: <100nMAssay Description:Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent